5000009@unknown@formal@none@1@S@Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells.@(((:tag . "JJ") (:stem . "tandem") (:form . "Tandem") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "67-bp") (:form . "67-bp") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MnlI-AluI") (:form . "MnlI-AluI") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 81) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 99) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "conalbumin") (:form . "conalbumin") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 164) (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 193)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 195) (:start . 194)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 209) (:start . 205)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.3.1) (:span 202 204)))\n (:ncues ((:id . :x2.3.2) (:span 180 183)))\n (:hscopes ((:id . :x2.3.1) (:span 187 215)))\n (:nscopes ((:id . :x2.3.2) (:span 180 215)))\n (:identifiers (:sid . :s2.3) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000019@unknown@formal@none@1@S@The rate of transcription initiation directed by the long terminal repeat (LTR) of HIV-1 increases in response to mitogenic stimuli of T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 123)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s3.2) (:did . :|91101115|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000029@unknown@formal@none@1@S@In this study, we generated transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 80) (:start . 74)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 108) (:start . 94) (:id . 59))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.6) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000039@unknown@formal@none@1@S@TCF-1 mRNA was expressed uniquely in T lymphocytes.@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "RB") (:stem . "uniquely") (:form . "uniquely") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.7) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000049@unknown@formal@none@1@S@Thus, it appears that the T-cell-specific activation of the proenkephalin promoter is mediated by NF-kappa B.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 41) (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x6.8.1) (:span 9 16)))\n (:hscopes ((:id . :x6.8.1) (:span 9 108)))\n (:identifiers (:sid . :s6.8) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000059@unknown@formal@none@1@S@In this report we begin to uncover the influence of platelet-activating factor on B lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "begin") (:form . "begin") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "uncover") (:form . "uncover") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 71) (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s8.4) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000069@unknown@formal@none@1@S@The phenotypic differences observed were attributable, in large part, to changes affecting the viral LTR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 53)\n  (:start . 41) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s9.3) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000079@unknown@formal@none@1@S@Receptor transcripts were 4.6 kilobases (kb), and no variant sizes were observed.@(((:tag . "NN") (:stem . "receptor") (:form . "Receptor") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "CD") (:stem . "4.6") (:form . "4.6") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "size") (:form . "sizes") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x10.7.1) (:span 50 52)))\n (:nscopes ((:id . :x10.7.1) (:span 50 80)))\n (:identifiers (:sid . :s10.7) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000089@unknown@formal@none@1@S@Half-life (t1/2) of 1,25(OH)2D3 receptor RNA in T lymphocytes was short (1 hour) as determined by measuring decay of the message after addition of actinomycin D.@(((:tag . "NN") (:stem . "half-life") (:form . "Half-life") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t1/2") (:form . "t1/2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 94)\n  (:start . 84) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 107)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "decay") (:form . "decay") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 134)\n  (:start . 129) (:id . 67))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 143)\n  (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 158)\n  (:start . 147) (:id . 70))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s10.17) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000099@unknown@formal@none@1@S@Two proteins binding the kappa B sequence, NF-kappa B and KBF1, are constitutively expressed in IARC 301 nuclei and induced by PMA and PHA in Jurkat.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "KBF1") (:form . "KBF1") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 82) (:start . 68) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 148)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s11.8) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000109@unknown@formal@none@1@S@The kappa B sequence (GGGACTTTCC) binds a factor, NF-kappa B, that is constitutively found in its functional, DNA binding form only in B lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GGGACTTTCC") (:form . "GGGACTTTCC") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 57))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 84) (:start . 70) (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 108)\n  (:start . 98) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 65))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 126) (:start . 122)\n  (:id . 66))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 131) (:start . 127)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 148)\n  (:start . 137) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s13.2) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000119@unknown@formal@none@1@S@This probe was used to identify a rel-related complementary DNA that hybridized to a 2.6-kilobase messenger RNA present in human T and B lymphocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "rel-related") (:end . 45)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "hybridize") (:form . "hybridized") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "2.6-kilobase") (:form . "2.6-kilobase") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 148)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s14.3) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000129@unknown@formal@none@1@S@The number of glucocorticoid receptors was 63 % greater in the morning and 26 % greater in the afternoon in the patients with PTSD than in the normal subjects.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "63") (:form . "63") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "morning") (:form . "morning") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "afternoon") (:form . "afternoon") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 120)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s15.5) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000139@unknown@formal@none@1@S@The TCF-1 alpha cDNA contains a single 68-amino-acid domain that is homologous to a region conserved among high-mobility group (HMG) and nonhistone chromosomal proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "68-amino-acid") (:form . "68-amino-acid")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "high-mobility") (:form . "high-mobility")\n  (:end . 120) (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nonhistone") (:form . "nonhistone") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 159)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s16.4) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000149@unknown@formal@none@1@S@With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hbxag-specific") (:form . "HBxAg-specific")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 42)\n  (:start . 30) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 58)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s17.5) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000159@unknown@formal@none@1@S@For apoplexic patients with lesions localized to the base of the brain as indicated by computerized tomography, the diurnal variation of GR was abolished.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apoplexic") (:form . "apoplexic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "computerize") (:form . "computerized") (:end . 99)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "tomography") (:form . "tomography") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s18.7) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000169@unknown@formal@none@1@S@In cotransfection experiments we show that all the isoforms are able to activate an octamer containing promoter element in fibroblasts revealing an unexpected functional redundancy.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "VBG") (:stem . "reveal") (:form . "revealing") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 169)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 180)\n  (:start . 170) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s19.7) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000179@unknown@formal@none@1@S@Transcription of the human immunodeficiency virus type-1 (HIV-1) genome is regulated in part by cellular factors and is stimulated by activation of latently infected T cells.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 43) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type-1") (:form . "type-1") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 130)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s21.2) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000189@unknown@formal@none@1@S@Signal requirements and characterization by western blots and DNA sequencing.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "western") (:form . "western") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s22.2) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000199@unknown@formal@none@1@S@CD3-epsilon gene expression is confined to the T cell lineage.@(((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s23.2) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000209@unknown@formal@none@1@S@Second, by high stringency Northern blotting and in situ hybridization, TCF-1 expression was shown to be confined to the thymus and to the T cell areas of the spleen.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stringency") (:form . "stringency") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 165)\n  (:start . 159) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s23.12) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000219@unknown@formal@none@1@S@We show here that chronic HIV infection results in both induction of a nuclear factor with antigenic properties indistinguishable from those of NF-kappa B and permanently increased HIV enhancer activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 129) (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "RB") (:stem . "permanently") (:form . "permanently") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 193)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 202)\n  (:start . 194) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s24.8) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000229@unknown@formal@none@1@S@In addition, binding studies with ( 3H ) dexamethasone have been performed to determine the dissociation constant (Kd) and receptor numbers (Ro) in the monocytes of these two groups of subjects.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "3h") (:form . "3H") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 54) (:start . 41) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 139)\n  (:start . 132) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ro") (:form . "Ro") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 161)\n  (:start . 152) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 170)\n  (:start . 165) (:id . 73))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 181)\n  (:start . 175) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 193)\n  (:start . 185) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s26.3) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000239@unknown@formal@none@1@S@GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.@(((:tag . "NNP") (:stem . "GPIIb") (:form . "GPIIb") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "cytoadhesin") (:form . "cytoadhesin") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "GPIIb-IIIa") (:form . "GPIIb-IIIa") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 94) (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 135) (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GPIIIa") (:form . "GPIIIa") (:end . 186)\n  (:start . 180) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 200)\n  (:start . 191) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 209)\n  (:start . 204) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s27.5) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000249@unknown@formal@none@1@S@To examine the role of protein phosphatases in T cell activation, Jurkat cells were treated with okadaic acid, an inhibitor of type 1 and 2A phosphatases, and nuclear extracts were examined for the presence of AP1 as a measure of early T cell activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 123)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 153)\n  (:start . 141) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 166)\n  (:start . 159) (:id . 72))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 175)\n  (:start . 167) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 180) (:start . 176)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 189)\n  (:start . 181) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 193) (:start . 190)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 206)\n  (:start . 198) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 213) (:start . 210)\n  (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 216) (:start . 214)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 218) (:start . 217)\n  (:id . 82))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 226)\n  (:start . 219) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 235)\n  (:start . 230) (:id . 85))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 237) (:start . 236)\n  (:id . 86))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 242) (:start . 238)\n  (:id . 87))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 253)\n  (:start . 243) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s28.2) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000259@unknown@formal@none@1@S@We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "slide") (:form . "slide") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 167)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 182)\n  (:start . 173) (:id . 71))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s29.2) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000269@unknown@formal@none@1@S@In each cohort there was only one case with a negative reaction of the primary tumor and a positive reaction with the isolated tumor cells from the pleural effusions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cohort") (:form . "cohort") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "pleural") (:form . "pleural") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 165)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s29.12) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000279@unknown@formal@none@1@S@Nuclear run-on experiments demonstrated decreased transcription of kappa L chain.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 49)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 72) (:start . 67)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 74) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s30.9) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000289@unknown@formal@none@1@S@A differentiation-associated pattern of BZLF1 expression was observed, BZ1 reacting with nuclei of the upper spinous layer of the lesion.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "differentiation-associated")\n  (:form . "differentiation-associated") (:end . 28) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 36)\n  (:start . 29) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bz1") (:form . "BZ1") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "react") (:form . "reacting") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "upper") (:form . "upper") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "spinous") (:form . "spinous") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "layer") (:form . "layer") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lesion") (:form . "lesion") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s31.5) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000299@unknown@formal@none@1@S@A 21.4-kb DNA clone, pZVB70, showed the highest transactivating ability, while two other DNA fragments, pZVB10 (6.2 kb) and pZVH14 (8.7 kb), showed lower activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "21.4-kb") (:form . "21.4-kb") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pzvb70") (:form . "pZVB70") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 35) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 47)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "transactivating") (:form . "transactivating")\n  (:end . 63) (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pzvb10") (:form . "pZVB10") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "6.2") (:form . "6.2") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pzvh14") (:form . "pZVH14") (:end . 130)\n  (:start . 124) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 68))\n ((:tag . "CD") (:stem . "8.7") (:form . "8.7") (:end . 135) (:start . 132)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 138) (:start . 136)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 147)\n  (:start . 141) (:id . 73))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 153) (:start . 148)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 162)\n  (:start . 154) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s32.7) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000309@unknown@formal@none@1@S@all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene.@(((:tag . "DT") (:stem . "all") (:form . "all") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "breakpoint") (:form . "breakpoints") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "11p13") (:form . "11p13") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rhom-2") (:form . "Rhom-2") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s33.6) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000319@unknown@formal@none@1@S@To establish a model for 1,25-(OH)2D3 regulation of human monocyte monokine synthesis, three human cell lines (U-937, THP-1, and HL-60) were examined for : 1 ) the presence of functional 1,25-(OH)2D3 receptors; 2 ) the accumulation of interleukin-1 beta (IL-1 beta) mRNA and IL-1 beta protein in response to lipopolysaccharide (LPS); and 3 ) the regulation of this response by 1,25-(OH)2D3.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . 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5000329@unknown@formal@none@1@S@It has been shown recently that in wild-type CEM cells but not in a dex-resistant, glucocorticoid receptor ( GR ) -defective clone ICR-27 TK-3, dex induces GR mRNA.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 81) (:start . 68) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 97) (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "-defective") (:form . "-defective") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "icr-27") (:form . "ICR-27") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "tk-3") (:form . "TK-3") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dex") (:form . "dex") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x35.4.1) (:span 59 62)))\n (:nscopes ((:id . :x35.4.1) (:span 59 113)))\n (:identifiers (:sid . :s35.4) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000339@unknown@formal@none@1@S@Lavage T-lymphocytes from patients with tuberculosis or with sarcoidosis, but not those from normal control subjects, expressed 1,25(OH)2D3 receptors as demonstrated by binding of [3H]1,25(OH)2D3, which was inhibited by the presence of excess unlabeled 1,25(OH)2D3, but not by the presence of unlabeled 25(OH)D3 (receptor-positive lymphocytes: sarcoidosis, 20 ± 12%; tuberculosis, 31 ± 17%).@(((:tag . "NNP") (:stem . "Lavage") (:form . "Lavage") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 20) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . 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(:form . ".") (:end . 391) (:start . 390)\n  (:id . 108)))@@@1@67@((:ncues ((:id . :x36.4.1) (:span 270 273)) ((:id . :x36.4.2) (:span 78 81)))\n (:nscopes ((:id . :x36.4.1) (:span 270 342))\n  ((:id . :x36.4.2) (:span 78 116)))\n (:identifiers (:sid . :s36.4) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000349@unknown@formal@none@1@S@This protein reduces or abolishes in vitro the DNA binding activity of wild-type proteins of the same family (KBF1/p50, c- and v-rel).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "KBF1/p50") (:form . "KBF1/p50") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-") (:form . "c-") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "v-rel") (:form . "v-rel") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s37.6) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000359@unknown@formal@none@1@S@The two isozymes show little amino acid identity in their N-terminal signal sequences but have considerable sequence identity in the C-terminal two-thirds of their proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "isozyme") (:form . "isozymes") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 57)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 107)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "NNS") (:stem . "two-third") (:form . "two-thirds") (:end . 154)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 172)\n  (:start . 164) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s38.6) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000369@unknown@formal@none@1@S@Moreover, kappa 1-kappa 3 can each be deleted from the TNF-alpha promoter with little effect on the gene 's inducibility by PMA.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "1-kappa") (:form . "1-kappa") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 120)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s39.5) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000379@unknown@formal@none@1@S@However, the signaling events responsible for these effects remain unclear.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s41.3) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000389@unknown@formal@none@1@S@Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s42.1) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000399@unknown@formal@none@1@S@HB24 is likely to have an important role in lymphocytes as well as in certain developing tissues.@(((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x42.11.1) (:span 8 14)))\n (:hscopes ((:id . :x42.11.1) (:span 0 96)))\n (:identifiers (:sid . :s42.11) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000409@unknown@formal@none@1@S@Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s44.1) (:did . :|91292530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000419@unknown@formal@none@1@S@N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2.@(((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "counteract") (:form . "counteracts") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 122) (:start . 109) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s45.5) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000429@unknown@formal@none@1@S@Moreover, Tax1 activated expression of two other transcription factors having zinc finger motifs, Egr-1 and Egr-2, in the same cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "tax1") (:form . "Tax1") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 77) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "egr-2") (:form . "Egr-2") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s46.7) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000439@unknown@formal@none@1@S@Human immunodeficiency virus (HIV) expression and replication are under tight regulatory control.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s48.2) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000449@unknown@formal@none@1@S@However, inhibition of HIV-1 replication appears not to be directly correlated with GSH levels.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x49.6.2) (:span 41 48)))\n (:ncues ((:id . :x49.6.1) (:span 49 52)))\n (:hscopes ((:id . :x49.6.2) (:span 9 94)))\n (:nscopes ((:id . :x49.6.1) (:span 49 94)))\n (:identifiers (:sid . :s49.6) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000459@unknown@formal@none@1@S@The binding affinity was not different between patients and controls.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x50.7.1) (:span 25 28)))\n (:nscopes ((:id . :x50.7.1) (:span 25 68)))\n (:identifiers (:sid . :s50.7) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000469@unknown@formal@none@1@S@It was found that the number of ER in the patients was significantly decreased.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 68) (:start . 55) (:id . 54))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s52.4) (:did . :|91347784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000479@unknown@formal@none@1@S@In T lymphocytes these drugs disrupt an unknown step in the transmission of signals from the T-cell antigen receptor to cytokine genes that coordinate the immune response.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 16)\n  (:start . 5) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "disrupt") (:form . "disrupt") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "coordinate") (:form . "coordinate") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s54.3) (:did . :|91351285|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000489@unknown@formal@none@1@S@Although sensitivity to M-CSF can be modulated by regulation of receptor expression and function, M-CSF responsiveness is largely determined at a postreceptor level.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 118) (:start . 104) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "postreceptor") (:form . "postreceptor") (:end . 158)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s55.5) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000499@unknown@formal@none@1@S@In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 36)\n  (:start . 24) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 134)\n  (:start . 128) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 143) (:start . 140)\n  (:id . 70))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 152)\n  (:start . 144) (:id . 71))\n ((:tag . "NN") (:stem . "jct6") (:form . "JCT6") (:end . 157) (:start . 153)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 164)\n  (:start . 159) (:id . 74))\n ((:tag . "VBZ") (:stem . "present") (:form . "presents") (:end . 173)\n  (:start . 165) (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 175) (:start . 174)\n  (:id . 76))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 186)\n  (:start . 176) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 197) (:start . 194)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 210)\n  (:start . 198) (:id . 81))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 218)\n  (:start . 211) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s56.4) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000509@unknown@formal@none@1@S@Tax expressing T cell lines contained a constitutive level of NF-kappa B binding activity, detectable by mobility shift assay and uv cross-linking using a palindromic NF-kappa B probe homologous to the interferon beta PRDII site.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 52)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "uv") (:form . "uv") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 146) (:start . 133) (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 152) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "palindromic") (:form . "palindromic") (:end . 166)\n  (:start . 155) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 212)\n  (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 217) (:start . 213)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 223)\n  (:start . 218) (:id . 76))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 228) (:start . 224)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s57.3) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000519@unknown@formal@none@1@S@We also observed that ketoconazole was a weak competitor of GcR in intact cells, although it significantly inhibited [3H] dexamethasone binding in cytosolic preparations from rat tissues.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "competitor") (:form . "competitor") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gcr") (:form . "GcR") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 106) (:start . 93) (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "3h") (:form . "3H") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 135) (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 169)\n  (:start . 157) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 186)\n  (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s58.6) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000529@unknown@formal@none@1@S@RESULTS : In patients, both total and free plasma cortisol concentrations were higher than in the normal women, as was their urinary free cortisol;@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 73) (:start . 59) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 85) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "JJ") (:stem . "urinary") (:form . "urinary") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s59.7) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000539@unknown@formal@none@1@S@Within 2 to 4 h of PMA exposure, steady state levels of TNF mRNA are markedly elevated in all myelomonocytic cell lines studied.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 22) (:start . 19)\n  (:id . 48))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 31)\n  (:start . 23) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 39)\n  (:start . 33) (:id . 51))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 45) (:start . 40)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 64) (:start . 60)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 57))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 77)\n  (:start . 69) (:id . 58))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 86)\n  (:start . 78) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 93) (:start . 90)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 108) (:start . 94) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 119)\n  (:start . 114) (:id . 64))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 127)\n  (:start . 120) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s60.6) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000549@unknown@formal@none@1@S@The transcription factor HIV-TF1, which binds to a region about 60 bp upstream from the enhancer of the human immunodeficiency virus-1 (HIV-1), was purified from human B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "hiv-tf1") (:form . "HIV-TF1") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 126) (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s61.2) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000559@unknown@formal@none@1@S@Lymphocytes from patients who have received anti-estrogen therapy show similar enhancement of Ig-secreting cells after PWM stimulation.@(((:tag . "NNS") (:stem . "lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "receive") (:form . "received") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "anti-estrogen") (:form . "anti-estrogen")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ig-secreting") (:form . "Ig-secreting") (:end . 106)\n  (:start . 94) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 134)\n  (:start . 123) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s62.3) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000569@unknown@formal@none@1@S@In this paper, we demonstrate that the B2 factor is expressed in the cytosol of monocytes and macrophages as a DNA-binding protein, indicating that it is not associated with an inhibitor (IKB).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 61)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 122)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 142)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 168)\n  (:start . 158) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 176) (:start . 174)\n  (:id . 73))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 186)\n  (:start . 177) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IKB") (:form . "IKB") (:end . 191) (:start . 188)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x63.6.2) (:span 132 147)))\n (:ncues ((:id . :x63.6.1) (:span 154 157)))\n (:hscopes ((:id . :x63.6.2) (:span 132 192)))\n (:nscopes ((:id . :x63.6.1) (:span 154 192)))\n (:identifiers (:sid . :s63.6) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000579@unknown@formal@none@1@S@Such a process may have fundamental implications in AIDS pathogenesis in vivo and may be important in disease progression induced by opportunistic infections directly or indirectly involving macrophages.@(((:tag . "PDT") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "fundamental") (:form . "fundamental") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "opportunistic") (:form . "opportunistic")\n  (:end . 146) (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 190)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 202)\n  (:start . 191) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x64.7.1) (:span 167 169)) ((:id . :x64.7.2) (:span 82 85))\n  ((:id . :x64.7.3) (:span 15 18)))\n (:hscopes ((:id . :x64.7.1) (:span 158 180))\n  ((:id . :x64.7.2) (:span 82 202)) ((:id . :x64.7.3) (:span 15 77)))\n (:identifiers (:sid . :s64.7) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000589@unknown@formal@none@1@S@Furthermore, an antiserum against KBF1 (identical to 50 kDa NF-kappa B protein) reacted with the p50 of NF-GM2, indicating that the NF-GM2 polypeptide can not be immunologically differentiated from the 50 kDa subunit of NF-kappa B.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antiserum") (:form . "antiserum") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "react") (:form . "reacted") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 122)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 138)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 150)\n  (:start . 139) (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 177) (:start . 162) (:id . 72))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 192) (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 204) (:start . 202)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 208) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 216)\n  (:start . 209) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 228)\n  (:start . 220) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 230) (:start . 229)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x65.10.2) (:span 112 127)))\n (:ncues ((:id . :x65.10.1) (:span 151 158)))\n (:hscopes ((:id . :x65.10.2) (:span 112 230)))\n (:nscopes ((:id . :x65.10.1) (:span 128 230)))\n (:identifiers (:sid . :s65.10) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000599@unknown@formal@none@1@S@However, in normal subjects, the GR in MNL did not demonstrate circadian variation, in contrast to concentrations of plasma cortisol.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 62)\n  (:start . 51) (:id . 54))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 113) (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 123)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x66.8.1) (:span 47 50)))\n (:nscopes ((:id . :x66.8.1) (:span 47 82)))\n (:identifiers (:sid . :s66.8) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000609@unknown@formal@none@1@S@Prior studies have identified several elements that contribute to the activity of the IL-2 promoter in the stimulated T cell line, Jurkat.@(((:tag . "JJ") (:stem . "prior") (:form . "Prior") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s68.3) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000619@unknown@formal@none@1@S@An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s69.1) (:did . :|92020218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000629@unknown@formal@none@1@S@this effect was independent of the mode of lymphocyte activation and specific for the 1,25(OH)2D3 metabolite of vitamin D3.@(((:tag . "DT") (:stem . "this") (:form . "this") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s70.6) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000639@unknown@formal@none@1@S@Such segments accord well with empirically known T-cell determinants and our algorithm produces a lower number of false positive predictions than the principle based on discrete Fourier transformations previously described.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "accord") (:form . "accord") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "empirically") (:form . "empirically") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "principle") (:form . "principle") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 165)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "discrete") (:form . "discrete") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . "NNP") (:stem . "Fourier") (:form . "Fourier") (:end . 185)\n  (:start . 178) (:id . 68))\n ((:tag . "NNS") (:stem . "transformation") (:form . "transformations")\n  (:end . 201) (:start . 186) (:id . 69))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 212)\n  (:start . 202) (:id . 70))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 222)\n  (:start . 213) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s71.9) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000649@unknown@formal@none@1@S@There is a suitably located TATA box, but potential sites for CCAAT-box binding factors are far upstream, embedded in a 42-nucleotide repeat element.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "suitably") (:form . "suitably") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ccaat-box") (:form . "CCAAT-box") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "embed") (:form . "embedded") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "42-nucleotide") (:form . "42-nucleotide")\n  (:end . 133) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x72.10.1) (:span 42 51)))\n (:hscopes ((:id . :x72.10.1) (:span 42 87)))\n (:identifiers (:sid . :s72.10) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000659@unknown@formal@none@1@S@However, the C26 element alone, even when repeated, could not be activated by p40tax, unlike other NF-kappa B-binding elements.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 84)\n  (:start . 78) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 92)\n  (:start . 86) (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 98) (:start . 93)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 62))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x73.9.1) (:span 52 61)))\n (:nscopes ((:id . :x73.9.1) (:span 0 84)))\n (:identifiers (:sid . :s73.9) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000669@unknown@formal@none@1@S@T3 efficiently induced erythroid differentiation in these cells, thus overcoming the v-erbA-mediated differentiation arrest.@(((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "overcome") (:form . "overcoming") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "v-erba-mediated") (:form . "v-erbA-mediated")\n  (:end . 100) (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 116) (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 123)\n  (:start . 117) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s74.7) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000679@unknown@formal@none@1@S@Nuclear run-on assays demonstrate that : ( 1 ) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, ( 2 ) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and ( 3 ) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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5000709@unknown@formal@none@1@S@When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14 T lymphoma cells, but not in HeLa cells.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 30) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "proto-enhancer") (:form . "proto-enhancer")\n  (:end . 110) (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "e14") (:form . "E14") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 159) (:start . 155)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x78.3.1) (:span 148 151)))\n (:nscopes ((:id . :x78.3.1) (:span 148 165)))\n (:identifiers (:sid . :s78.3) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5000729@unknown@formal@none@1@S@Binding of the 65-kDa plus 50-kDa heterodimer to the HIV-1 enhancer can be negatively regulated in monocytes, providing one mechanism restricting HIV-1 gene expression.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "65-kda") (:form . "65-kDa") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "VBG") (:stem . "restrict") (:form . "restricting") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x79.12.1) (:span 68 71)))\n (:hscopes ((:id . :x79.12.1) (:span 68 108)))\n (:identifiers (:sid . :s79.12) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000739@unknown@formal@none@1@S@Cotransfection studies with this cDNA indicate that it can repress basal promoter activity.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x80.10.1) (:span 55 58)) ((:id . :x80.10.2) (:span 38 51)))\n (:hscopes ((:id . :x80.10.1) (:span 55 90))\n  ((:id . :x80.10.2) (:span 38 90)))\n (:identifiers (:sid . :s80.10) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000749@unknown@formal@none@1@S@However, upon transition from a proliferating (G1) to a resting state of the cell cycle the three genes were differently regulated.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating") (:end . 45)\n  (:start . 32) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "resting") (:form . "resting") (:end . 63)\n  (:start . 56) (:id . 54))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 97) (:start . 92)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 103) (:start . 98)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 63))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 120)\n  (:start . 109) (:id . 64))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 130)\n  (:start . 121) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s81.9) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000759@unknown@formal@none@1@S@These results demonstrate that the transcriptional activity of an AP-1-related protein is regulated by the cAMP-dependent second-messenger pathway and suggest that JunD and other AP-1-related proteins may play an important role in the regulation of gene expression by cAMP-dependent intracellular signaling pathways.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ap-1-related") (:form . "AP-1-related") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 121) (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "second-messenger") (:form . "second-messenger")\n  (:end . 138) (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 146)\n  (:start . 139) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 158)\n  (:start . 151) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 163) (:start . 159)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 168) (:start . 164)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 178)\n  (:start . 173) (:id . 65))\n ((:tag . "JJ") (:stem . "ap-1-related") (:form . "AP-1-related") (:end . 191)\n  (:start . 179) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 200)\n  (:start . 192) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 204) (:start . 201)\n  (:id . 68))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 209) (:start . 205)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 212) (:start . 210)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 222)\n  (:start . 213) (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 227) (:start . 223)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 245)\n  (:start . 235) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 253) (:start . 249)\n  (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 264)\n  (:start . 254) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 267) (:start . 265)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 282) (:start . 268) (:id . 80))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 296) (:start . 283) (:id . 81))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 306)\n  (:start . 297) (:id . 82))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 315)\n  (:start . 307) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x82.7.1) (:span 201 204))\n  ((:id . :x82.7.2) (:span 151 158)))\n (:hscopes ((:id . :x82.7.1) (:span 201 315))\n  ((:id . :x82.7.2) (:span 151 315)))\n (:identifiers (:sid . :s82.7) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000769@unknown@formal@none@1@S@These results suggest that clinical glucocorticoid resistance in chronic asthma does not reflect abnormal glucocorticoid clearance but may be due at least partly to a relative insensitivity of T lymphocytes to glucocorticoids.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 120) (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 130)\n  (:start . 121) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 134) (:start . 131)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 138) (:start . 135)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 161)\n  (:start . 155) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 189) (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 194) (:start . 193)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 206)\n  (:start . 195) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 225) (:start . 210) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x83.10.1) (:span 135 138))\n  ((:id . :x83.10.3) (:span 14 21)))\n (:ncues ((:id . :x83.10.2) (:span 85 88)))\n (:hscopes ((:id . :x83.10.1) (:span 135 225))\n  ((:id . :x83.10.3) (:span 14 225)))\n (:nscopes ((:id . :x83.10.2) (:span 85 130)))\n (:identifiers (:sid . :s83.10) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000779@unknown@formal@none@1@S@Two different proteins which independently bound to neighboring sequences within the negative regulatory element (NRE) of human immunodeficiency virus type 1 (HIV-1) were detected in the nuclear extract of a virus-infected human T cell line.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 112)\n  (:start . 105) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 144) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 207) (:start . 206)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "virus-infected") (:form . "virus-infected")\n  (:end . 222) (:start . 208) (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 228)\n  (:start . 223) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 230) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 235) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 240) (:start . 236)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s85.2) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000789@unknown@formal@none@1@S@In T cells and T cell lines, NF-kB is bound to a cytoplasmic proteic inhibitor, the IkB.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 27) (:start . 22)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 34) (:start . 29)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 43) (:start . 38)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 60)\n  (:start . 49) (:id . 55))\n ((:tag . "JJ") (:stem . "proteic") (:form . "proteic") (:end . 68)\n  (:start . 61) (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 78)\n  (:start . 69) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s86.3) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000799@unknown@formal@none@1@S@Differentiation assays using water soluble phorbol esters reveal that differentiation becomes irreversible soon after AP-1 appears.@(((:tag . "NNP") (:stem . "Differentiation") (:form . "Differentiation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 22)\n  (:start . 16) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "water") (:form . "water") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 85) (:start . 70) (:id . 51))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 93)\n  (:start . 86) (:id . 52))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 106)\n  (:start . 94) (:id . 53))\n ((:tag . "RB") (:stem . "soon") (:form . "soon") (:end . 111) (:start . 107)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 117)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 122) (:start . 118)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 130)\n  (:start . 123) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s87.6) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000809@unknown@formal@none@1@S@We have shown that the Z gene product, which binds to AP-1 sites as a homodimer and has sequence similarity to c-Fos, can efficiently activate the EBV early promoter, BMRF1, in certain cell types (i.e. , HeLa cells) but not others (i.e. , Jurkat cells).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Z") (:form . "Z") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 57))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 79)\n  (:start . 70) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 96)\n  (:start . 88) (:id . 61))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 107)\n  (:start . 97) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 116)\n  (:start . 111) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 121) (:start . 118)\n  (:id . 66))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 133)\n  (:start . 122) (:id . 67))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 150) (:start . 147)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 156)\n  (:start . 151) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 165)\n  (:start . 157) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "BMRF1") (:form . "BMRF1") (:end . 172)\n  (:start . 167) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 184)\n  (:start . 177) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 189) (:start . 185)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 195)\n  (:start . 190) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 80))\n ((:tag . 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",") (:end . 238) (:start . 237)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 245)\n  (:start . 239) (:id . 92))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 251)\n  (:start . 246) (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 252) (:start . 251)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 95)))@@@1@54@((:ncues ((:id . :x89.3.1) (:span 220 223)))\n (:nscopes ((:id . :x89.3.1) (:span 220 252)))\n (:identifiers (:sid . :s89.3) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000819@unknown@formal@none@1@S@A murine monoclonal antibody raised to an unidentified estrogen receptor-related 29-kDa protein selectively recognized these proteins as well as a more basic, unphosphorylated 27-kDa protein.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "receptor-related") (:form . "receptor-related")\n  (:end . 80) (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 107)\n  (:start . 96) (:id . 54))\n ((:tag . "VBD") (:stem . "recognize") (:form . "recognized") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 124)\n  (:start . 119) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 157)\n  (:start . 152) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unphosphorylated") (:form . "unphosphorylated")\n  (:end . 175) (:start . 159) (:id . 65))\n ((:tag . "JJ") (:stem . "27-kda") (:form . "27-kDa") (:end . 182)\n  (:start . 176) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 190)\n  (:start . 183) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s90.5) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000829@unknown@formal@none@1@S@The formation of a stable tetrameric DCoH-HNF-1 alpha complex, which required the dimerization domain of HNF-1 alpha, did not change the DNA binding characteristics of HNF-1 alpha, but enhanced its transcriptional activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "tetrameric") (:form . "tetrameric") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "dcoh-hnf-1") (:form . "DCoH-HNF-1") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hnf-1") (:form . "HNF-1") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "VB") (:stem . "change") (:form . "change") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 164) (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "hnf-1") (:form . "HNF-1") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 193)\n  (:start . 185) (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 213) (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 222)\n  (:start . 214) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x91.5.1) (:span 122 125)))\n (:nscopes ((:id . :x91.5.1) (:span 122 179)))\n (:identifiers (:sid . :s91.5) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000839@unknown@formal@none@1@S@These data are perfectly compatible with major properties of steroidal effects on the sodium-proton-antiport in HML and thus very likely represent membrane receptors for aldosterone.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "perfectly") (:form . "perfectly") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "steroidal") (:form . "steroidal") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sodium-proton-antiport")\n  (:form . "sodium-proton-antiport") (:end . 108) (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HML") (:form . "HML") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "represent") (:form . "represent") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 155)\n  (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 181)\n  (:start . 170) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x92.8.1) (:span 130 136)))\n (:hscopes ((:id . :x92.8.1) (:span 130 181)))\n (:identifiers (:sid . :s92.8) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000849@unknown@formal@none@1@S@Primary ( partial ) cortisol receptor resistance was previously reported in a total of 7 patients and 14 asymptomatic family members.@(((:tag . "JJ") (:stem . "primary") (:form . "Primary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s94.2) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000859@unknown@formal@none@1@S@There was a normal increase in ACTH, cortisol, and GH (except in one obese patient) in response to insulin-induced hypoglycemia, while cortisol production was elevated in three patients.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ACTH") (:form . "ACTH") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 61)\n  (:start . 55) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 68) (:start . 65)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "obese") (:form . "obese") (:end . 74) (:start . 69)\n  (:id . 58))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 82)\n  (:start . 75) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 95)\n  (:start . 87) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "insulin-induced") (:form . "insulin-induced")\n  (:end . 114) (:start . 99) (:id . 64))\n ((:tag . "NN") (:stem . "hypoglycemia") (:form . "hypoglycemia") (:end . 127)\n  (:start . 115) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 134)\n  (:start . 129) (:id . 67))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 143)\n  (:start . 135) (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 154)\n  (:start . 144) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 167)\n  (:start . 159) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 176)\n  (:start . 171) (:id . 73))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 185)\n  (:start . 177) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s94.12) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000869@unknown@formal@none@1@S@Therapy with dexamethasone was successful in female patients with acne and hirsutism, as the secondary increase in the production of adrenal androgens was effectively controlled.@(((:tag . "NN") (:stem . "therapy") (:form . "Therapy") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acne") (:form . "acne") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hirsutism") (:form . "hirsutism") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "androgen") (:form . "androgens") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 166)\n  (:start . 155) (:id . 66))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s94.22) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000879@unknown@formal@none@1@S@In contrast, mild oxidation with glucose oxidase selectively inhibits p75 and p85 binding while not blocking p50 and p55 interactions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mild") (:form . "mild") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p85") (:form . "p85") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 133)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x95.10.1) (:span 96 99)))\n (:nscopes ((:id . :x95.10.1) (:span 96 133)))\n (:identifiers (:sid . :s95.10) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000889@unknown@formal@none@1@S@Transient-transfection experiments in embryonal carcinoma cells demonstrate a functional cooperation between p50B and RelB or p65 in transactivation of a reporter plasmid dependent on a kappa B site.@(((:tag . "NN") (:stem . "transient-transfection")\n  (:form . "Transient-transfection") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 34)\n  (:start . 23) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "embryonal") (:form . "embryonal") (:end . 47)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 57)\n  (:start . 48) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 75)\n  (:start . 64) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 88)\n  (:start . 78) (:id . 50))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 100)\n  (:start . 89) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 108)\n  (:start . 101) (:id . 52))\n ((:tag . "NNP") (:stem . "p50B") (:form . "p50B") (:end . 113) (:start . 109)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 122) (:start . 118)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 129) (:start . 126)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 148) (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 61))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 162)\n  (:start . 154) (:id . 62))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 170)\n  (:start . 163) (:id . 63))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 180)\n  (:start . 171) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 183) (:start . 181)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 191)\n  (:start . 186) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 198) (:start . 194)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x96.9.1) (:span 123 125)))\n (:hscopes ((:id . :x96.9.1) (:span 118 129)))\n (:identifiers (:sid . :s96.9) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000899@unknown@formal@none@1@S@This may be the basis of the therapeutic effect on the disease.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 40)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x97.9.1) (:span 5 8)))\n (:hscopes ((:id . :x97.9.1) (:span 5 62)))\n (:identifiers (:sid . :s97.9) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000909@unknown@formal@none@1@S@In order to define the roles of these two factors, which bind to the same kappa B enhancers, in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a murine myeloma.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 73) (:start . 69)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 79) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 91)\n  (:start . 82) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 158)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 166)\n  (:start . 159) (:id . 71))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "CD") (:stem . "301.5") (:form . "301.5") (:end . 177)\n  (:start . 172) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 190)\n  (:start . 184) (:id . 76))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 198)\n  (:start . 191) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s99.3) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000919@unknown@formal@none@1@S@In addition, an adenocarcinoma reactive human-mouse chimeric monoclonal antibody (ING-1) was able to significantly boost in vivo generated LAK cell-mediated lysis of control, E2-treated, and TAM-treated ER+ and ER- cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenocarcinoma") (:form . "adenocarcinoma")\n  (:end . 30) (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "human-mouse") (:form . "human-mouse") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ing-1") (:form . "ING-1") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "VB") (:stem . "boost") (:form . "boost") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 156) (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "e2-treated") (:form . "E2-treated") (:end . 185)\n  (:start . 175) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "tam-treated") (:form . "TAM-treated") (:end . 202)\n  (:start . 191) (:id . 72))\n ((:tag . "JJ") (:stem . "er+") (:form . "ER+") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "NN") (:stem . "er-") (:form . "ER-") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s100.6) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000929@unknown@formal@none@1@S@To further characterize the protein-DNA interactions mediating IFN-beta induction, positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 91)\n  (:start . 83) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 102)\n  (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 109)\n  (:start . 103) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PRD") (:form . "PRD") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 176)\n  (:start . 169) (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 183)\n  (:start . 177) (:id . 67))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 191)\n  (:start . 184) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 211)\n  (:start . 205) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cycloheximide/polyinosinic-polycytidylic")\n  (:form . "cycloheximide/polyinosinic-polycytidylic") (:end . 253)\n  (:start . 213) (:id . 74))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 258) (:start . 254)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 266)\n  (:start . 259) (:id . 76))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 271) (:start . 267)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 274) (:start . 272)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 280)\n  (:start . 275) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s102.3) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000939@unknown@formal@none@1@S@Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH) 2D3) with substitutions on C-11 were synthesized.@(((:tag . "NNS") (:stem . "analog") (:form . "Analogs") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 38) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "alpha,25-(OH)") (:form . "alpha,25-(OH)")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "2d3") (:form . "2D3") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-11") (:form . "C-11") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s103.2) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000949@unknown@formal@none@1@S@In this article, transcriptional regulation of the archetypal T-cell-specific gene, alpha TCR, is discussed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "article") (:form . "article") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "archetypal") (:form . "archetypal") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 77) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s104.3) (:did . :|92153263|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000959@unknown@formal@none@1@S@the effect was significantly blunted (P less than 0.05) in group 1 patients, which suggests that activation of glucocorticoid receptor is impaired as a result of the glucocorticoid receptor abnormality.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "blunt") (:form . "blunted") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 125) (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 158)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 180) (:start . 166) (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 189)\n  (:start . 181) (:id . 73))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 201)\n  (:start . 190) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x105.9.1) (:span 83 91)))\n (:hscopes ((:id . :x105.9.1) (:span 83 201)))\n (:identifiers (:sid . :s105.9) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000969@unknown@formal@none@1@S@These proteins interacted specifically with the symmetric NF-kappa B site from the interferon beta (IFN-beta) promoter.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "symmetric") (:form . "symmetric") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s106.8) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000979@unknown@formal@none@1@S@We show that induction of a trimer of the NFAT and Oct sites is not sensitive to phorbol ester treatment, and that mutations in the NF-kappa B site have no effect on inducibility of the IL-2 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "trimer") (:form . "trimer") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 77)\n  (:start . 68) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 88)\n  (:start . 81) (:id . 59))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 94) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 104)\n  (:start . 95) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 124)\n  (:start . 115) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 152) (:start . 148)\n  (:id . 71))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 155) (:start . 153)\n  (:id . 72))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 162)\n  (:start . 156) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 165) (:start . 163)\n  (:id . 74))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 178)\n  (:start . 166) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 190) (:start . 186)\n  (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 199)\n  (:start . 191) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x107.7.1) (:span 153 155))\n  ((:id . :x107.7.2) (:span 64 67)))\n (:nscopes ((:id . :x107.7.1) (:span 153 199))\n  ((:id . :x107.7.2) (:span 64 104)))\n (:identifiers (:sid . :s107.7) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000989@unknown@formal@none@1@S@Binding of erythroid and non-erythroid nuclear proteins to the silencer of the human epsilon-globin-encoding gene.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "epsilon-globin-encoding")\n  (:form . "epsilon-globin-encoding") (:end . 108) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s109.1) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000999@unknown@formal@none@1@S@We have studied the impact of gangliosides on the expression of TNF in blood monocytes and in the monocytic cell line Mono Mac 6.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s110.3) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001009@unknown@formal@none@1@S@T cell-specific negative regulation of transcription of the human cytokine IL-4.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s111.1) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001019@unknown@formal@none@1@S@The regulatory effect of insulin on the specific binding power of glucocorticoid receptor (GR) of human leukocytes was assessed by the unoccupied receptor sites capable of combining with [3H] labelled dexamethasone measured at 3 and 24 h after incubation with various concentrations of insulin added to the medium.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5001029@unknown@formal@none@1@S@The increase in AP-1-binding activity was accompanied by the marked stimulation of the transcription of c-fos but not that of c-jun.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x113.7.1) (:span 114 117)))\n (:nscopes ((:id . :x113.7.1) (:span 114 131)))\n (:identifiers (:sid . :s113.7) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001039@unknown@formal@none@1@S@Furthermore, in vitro mutagenesis experiments demonstrated that inducible interleukin-2 enhancer function requires the presence of either EBS1 or EBS2.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 96)\n  (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 105)\n  (:start . 97) (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 127)\n  (:start . 119) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 137)\n  (:start . 131) (:id . 58))\n ((:tag . "NN") (:stem . "ebs1") (:form . "EBS1") (:end . 142) (:start . 138)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ebs2") (:form . "EBS2") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x114.6.1) (:span 131 137 143 145)))\n (:hscopes ((:id . :x114.6.1) (:span 131 150)))\n (:identifiers (:sid . :s114.6) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001049@unknown@formal@none@1@S@Furthermore, we evaluated the mineralocorticoid receptor (MR) status in mononuclear leukocytes in the 2 groups.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 47) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s115.3) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001059@unknown@formal@none@1@S@Mean values for plasma aldosterone were not different between the two groups, but significant differences were observed for MR (preeclampsia, 81 ± 44 receptors/cell; controls, 306 ± 168) and SPD (preeclampsia, 65 ± 7 mV; controls, 12 ± 5 mV).@(((:tag . "JJ") (:stem . "mean") (:form . "Mean") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . 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5001069@unknown@formal@none@1@S@In spite of its association with p50 in vitro, however, we found a lymphoid cell-specific nuclear factor in vivo that contains c-Rel but not p50 epitopes;@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "spite") (:form . "spite") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 75)\n  (:start . 67) (:id . 57))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 89) (:start . 76) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 153)\n  (:start . 145) (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 154) (:start . 153)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x117.6.1) (:span 137 140)))\n (:nscopes ((:id . :x117.6.1) (:span 137 153)))\n (:identifiers (:sid . :s117.6) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001079@unknown@formal@none@1@S@Interestingly, T3 strongly enhanced the action of RA, suggesting cooperative action of the two receptors in modulating erythroid differentiation.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 144) (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x118.7.1) (:span 54 64)))\n (:hscopes ((:id . :x118.7.1) (:span 54 144)))\n (:identifiers (:sid . :s118.7) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001089@unknown@formal@none@1@S@Stability of the c-fos and c-jun mRNA was not affected by LTB4, as assessed after actinomycin D treatment.@(((:tag . "NN") (:stem . "stability") (:form . "Stability") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x119.8.1) (:span 42 45)))\n (:nscopes ((:id . :x119.8.1) (:span 0 62)))\n (:identifiers (:sid . :s119.8) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001099@unknown@formal@none@1@S@The P sequence was located between positions -79 and -69 relative to the transcription start site of the human IL-4 gene, and this location was confirmed by base-substitution mutations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "CD") (:stem . "-79") (:form . "-79") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "CD") (:stem . "-69") (:form . "-69") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 86) (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 153)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "base-substitution") (:form . "base-substitution")\n  (:end . 174) (:start . 157) (:id . 70))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s120.7) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001109@unknown@formal@none@1@S@4 . The phenomenon of glucocorticoid resistance in major depressive disorder remains unexplained.@(((:tag . "LS") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 7) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 18)\n  (:start . 8) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "JJ") (:stem . "unexplained") (:form . "unexplained") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s121.5) (:did . :|92213189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001119@unknown@formal@none@1@S@Radiolabeled hormone/receptor complexes of nuclei isolated from cells exposed for 3 h to radiolabeled hormone--in contrast to identical experiments with intact cells--did not disappear from the nuclear compartment upon incubation of nuclei with identical concentrations of the unlabeled compound.@(((:tag . "VBN") (:stem . "radiolabele") (:form . "Radiolabeled") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hormone/receptor") (:form . "hormone/receptor")\n  (:end . 29) (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 39)\n  (:start . 30) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 49)\n  (:start . 43) (:id . 46))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 58)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 77)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "radiolabele") (:form . "radiolabeled") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "hormone–in") (:form . "hormone–in") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 122)\n  (:start . 114) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 135)\n  (:start . 126) (:id . 59))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 147)\n  (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . "VBD") (:stem . "cells–did") (:form . "cells–did") (:end . 170)\n  (:start . 160) (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 174) (:start . 171)\n  (:id . 64))\n ((:tag . "VB") (:stem . "disappear") (:form . "disappear") (:end . 184)\n  (:start . 175) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 189) (:start . 185)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 201)\n  (:start . 194) (:id . 68))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 213)\n  (:start . 202) (:id . 69))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 218) (:start . 214)\n  (:id . 70))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 229)\n  (:start . 219) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 239)\n  (:start . 233) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 244) (:start . 240)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 254)\n  (:start . 245) (:id . 75))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 269) (:start . 255) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 272) (:start . 270)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 276) (:start . 273)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 286)\n  (:start . 277) (:id . 79))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 295)\n  (:start . 287) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x122.10.1) (:span 171 174)))\n (:nscopes ((:id . :x122.10.1) (:span 171 295)))\n (:identifiers (:sid . :s122.10) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001129@unknown@formal@none@1@S@The promoter of the major histocompatibility class II gene DRA contains an octamer element (ATTTGCAT) that is required for efficient DRA expression in B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 44) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ATTTGCAT") (:form . "ATTTGCAT") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s123.2) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001139@unknown@formal@none@1@S@The rate of endogenous cholesterol synthesis in blood lymphocytes and skin fibroblasts from patients with type IIa hyperlipidemia was found to be increased in comparison with healthy donors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IIa") (:form . "IIa") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hyperlipidemia") (:form . "hyperlipidemia")\n  (:end . 129) (:start . 115) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 182)\n  (:start . 175) (:id . 68))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s124.2) (:did . :|92223210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001149@unknown@formal@none@1@S@Corticosteroid receptors and lymphocyte subsets in mononuclear leukocytes in aging.@(((:tag . "NN") (:stem . "corticosteroid") (:form . "Corticosteroid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 73)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s126.1) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001159@unknown@formal@none@1@S@A number of genes known to be induced following T cell activation and associated with cell growth were increased in the transfectants, including c-fos, c-myc, c-myb, HLA-DR, lck, NF-kappa B, interleukin-2 and interleukin-2 receptor alpha (IL-2R alpha).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 133) (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 172)\n  (:start . 166) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 73))\n ((:tag . "NN") (:stem . "lck") (:form . "lck") (:end . 177) (:start . 174)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 187)\n  (:start . 179) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 78))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 204) (:start . 191) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 80))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 222) (:start . 209) (:id . 81))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 231)\n  (:start . 223) (:id . 82))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 237)\n  (:start . 232) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 239) (:start . 238)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 244)\n  (:start . 239) (:id . 85))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 250)\n  (:start . 245) (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s127.4) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001169@unknown@formal@none@1@S@Thyroid hormones inhibit [3H]glycosaminoglycan synthesis by cultured human dermal fibroblasts, and T3SO4 displayed about 0.5% the activity of T3 at 72 h.@(((:tag . "JJ") (:stem . "thyroid") (:form . "Thyroid") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "3H]glycosaminoglycan")\n  (:form . "3H]glycosaminoglycan") (:end . 46) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 56)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dermal") (:form . "dermal") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s128.7) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001179@unknown@formal@none@1@S@Furthermore, we identify a pre-existing NF-AT-binding factor that is present in hypotonic extracts of unstimulated T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pre-existing") (:form . "pre-existing") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hypotonic") (:form . "hypotonic") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 114)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s129.7) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001189@unknown@formal@none@1@S@Although IFN-gamma alone does not induce ISG expression, IFN-gamma pretreatment markedly increases and hastens ISG expression and transcriptional induction.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "ISG") (:form . "ISG") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "hasten") (:form . "hastens") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "isg") (:form . "ISG") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 145) (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 155)\n  (:start . 146) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x130.9.1) (:span 30 33)))\n (:nscopes ((:id . :x130.9.1) (:span 30 55)))\n (:identifiers (:sid . :s130.9) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001199@unknown@formal@none@1@S@Plasma cortisol concentration and blood leukocyte content of glucocorticoid receptors (GCR) were assayed in 20 patients with deficiency syndromes, 10 cold in property (deficiency-cold), the other 10 hot in property (deficiency-heat), and also in 10 healthy individuals as normal control for the purpose of investigating the nature of cold and heat syndromes.@(((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . 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"cold") (:end . 338) (:start . 334)\n  (:id . 99))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 342) (:start . 339)\n  (:id . 100))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 347) (:start . 343)\n  (:id . 101))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 357)\n  (:start . 348) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 358) (:start . 357)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s132.2) (:did . :|92257680|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001209@unknown@formal@none@1@S@Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 40) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x134.1.1) (:span 66 69)))\n (:nscopes ((:id . :x134.1.1) (:span 66 89)))\n (:identifiers (:sid . :s134.1) (:did . :|92260679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001219@unknown@formal@none@1@S@Treatment of U-937 cells with TPA resulted in a rapid translocation of protein kinase C (PKC) from the cytosol to cell membrane fractions within 2-8 min.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 67) (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 127)\n  (:start . 119) (:id . 65))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 144)\n  (:start . 138) (:id . 67))\n ((:tag . "CD") (:stem . "2-8") (:form . "2-8") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s135.7) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001229@unknown@formal@none@1@S@In particular, a high-affinity BSAP-binding site instead of a TATA sequence is located in the -30 promoter region upstream of a cluster of heterogeneous transcription start sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "bsap-binding") (:form . "BSAP-binding") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-30") (:form . "-30") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 152) (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 166) (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x136.5.1) (:span 49 59)))\n (:nscopes ((:id . :x136.5.1) (:span 49 75)))\n (:identifiers (:sid . :s136.5) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001239@unknown@formal@none@1@S@Total cellular PKC enzymatic activity was found to be normal in these subclones.@(((:tag . "JJ") (:stem . "total") (:form . "Total") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s137.6) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001249@unknown@formal@none@1@S@In 19 patients with a malignant breast tumor, tumor tissue and blood were taken to determine the eicosanoid profile and platelet aggregation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "eicosanoid") (:form . "eicosanoid") (:end . 107)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s138.2) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001259@unknown@formal@none@1@S@between menopausal status and ADP aggregation; oestrogen receptor (+/-) and collagen and arachidonic acid aggregation, inflammatory cell infiltration score and arachidonic acid aggregation and fibrosis score and ADP aggregation.@(((:tag . "IN") (:stem . "between") (:form . "between") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADP") (:form . "ADP") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oestrogen") (:form . "oestrogen") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "+/-") (:form . "+/-") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "collagen") (:form . "collagen") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 131)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 171)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 188)\n  (:start . 177) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 201)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "ADP") (:form . "ADP") (:end . 215) (:start . 212)\n  (:id . 73))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 227)\n  (:start . 216) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s138.12) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001269@unknown@formal@none@1@S@c-myc did not correlate with c-fos and c-jun protein expression.@(((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x139.8.1) (:span 10 13)))\n (:nscopes ((:id . :x139.8.1) (:span 10 63)))\n (:identifiers (:sid . :s139.8) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001279@unknown@formal@none@1@S@Instead, regulation of activation involved a region of the cytoplasmic domain common to both the lymphocyte and macrophage receptor isoforms.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "involve") (:form . "involved") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s140.6) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001289@unknown@formal@none@1@S@Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.@(((:tag . "NNP") (:stem . "Heterodimerization") (:form . "Heterodimerization")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 38) (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 58) (:start . 53)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s142.1) (:did . :|92317168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001299@unknown@formal@none@1@S@This result indicates the involvement of either a B-cell-specific cofactor or a specific modification of a cofactor or the Oct2 protein in Oct2-mediated enhancer activation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 65) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "oct2-mediated") (:form . "Oct2-mediated")\n  (:end . 152) (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 161)\n  (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 172)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x143.6.1) (:span 41 47 75 77 116 118))\n  ((:id . :x143.6.4) (:span 12 21)))\n (:hscopes ((:id . :x143.6.1) (:span 41 135))\n  ((:id . :x143.6.4) (:span 12 172)))\n (:identifiers (:sid . :s143.6) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001309@unknown@formal@none@1@S@Oct-2 mRNA induction during antigen-driven T-cell activation was blocked by cyclosporin A, as well as by protein synthesis inhibitors.@(((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "antigen-driven") (:form . "antigen-driven")\n  (:end . 42) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s144.7) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001319@unknown@formal@none@1@S@Transcription factor AP-2 activates gene expression of HTLV-I.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s146.1) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001329@unknown@formal@none@1@S@Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cycle-dependent") (:form . "cycle-dependent")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lineage-dependent") (:form . "lineage-dependent")\n  (:end . 53) (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "abrogation") (:form . "abrogation") (:end . 64)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 74)\n  (:start . 68) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pure") (:form . "pure") (:end . 93) (:start . 89)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 109) (:start . 94) (:id . 53))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 123) (:start . 110) (:id . 54))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 135)\n  (:start . 124) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s147.1) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001339@unknown@formal@none@1@S@The mechanisms of hormone-receptor interactions in hypertension are activated:@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hormone-receptor") (:form . "hormone-receptor")\n  (:end . 34) (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 63)\n  (:start . 51) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 78) (:start . 77)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s148.3) (:did . :|92362919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001349@unknown@formal@none@1@S@In contrast, the class II-positive nonlymphoid glioblastoma cell line does not exhibit interactions at the octamer site despite the presence of the ubiquitous OTF-1 factor and an open binding site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ii-positive") (:form . "II-positive") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "exhibit") (:form . "exhibit") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 99)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 171)\n  (:start . 165) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x149.8.1) (:span 75 78)))\n (:nscopes ((:id . :x149.8.1) (:span 75 119)))\n (:identifiers (:sid . :s149.8) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001359@unknown@formal@none@1@S@This further fraction is distinct from the mediator of transcriptional activation described previously and represents a second component in addition to general initiation factors that may facilitate a response to acidic activators.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 70) (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 136)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 159)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 170)\n  (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 178)\n  (:start . 171) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 198)\n  (:start . 188) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 200) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 209)\n  (:start . 201) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 212) (:start . 210)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 219)\n  (:start . 213) (:id . 72))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 230)\n  (:start . 220) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x150.6.1) (:span 184 187)))\n (:hscopes ((:id . :x150.6.1) (:span 184 230)))\n (:identifiers (:sid . :s150.6) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001369@unknown@formal@none@1@S@The work reviewed in this article separates T cell development into four phases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "article") (:form . "article") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "separate") (:form . "separates") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s152.2) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001379@unknown@formal@none@1@S@Whereas peripheral T cells can undergo forms of positive selection (by antigen-driven clonal expansion) and negative selection (by abortive stimulation leading to anergy or death), neither is exactly the same phenomenon that occurs in the thymic cortex.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "antigen-driven") (:form . "antigen-driven")\n  (:end . 85) (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "abortive") (:form . "abortive") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 199)\n  (:start . 192) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 208) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 219)\n  (:start . 209) (:id . 77))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 231)\n  (:start . 225) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 245)\n  (:start . 239) (:id . 82))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 252)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x152.12.1) (:span 181 188)))\n (:nscopes ((:id . :x152.12.1) (:span 181 252)))\n (:identifiers (:sid . :s152.12) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001389@unknown@formal@none@1@S@Cyclosporin A (CsA) and FK506 inhibit the production of IL-2 in T lymphocytes at the level of gene transcription.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s153.4) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001399@unknown@formal@none@1@S@This interaction is believed to be an important component of the mechanism of transactivation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x154.6.1) (:span 20 28)))\n (:hscopes ((:id . :x154.6.1) (:span 0 93)))\n (:identifiers (:sid . :s154.6) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001409@unknown@formal@none@1@S@Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.@(((:tag . "NNP") (:stem . "Mitogen") (:form . "Mitogen") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 110) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s156.1) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001419@unknown@formal@none@1@S@The v-erb A oncogene of avian erythroblastosis virus is a mutated and virally transduced copy of a host cell gene encoding a thyroid hormone receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "avian") (:form . "avian") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "erythroblastosis") (:form . "erythroblastosis")\n  (:end . 46) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "copy") (:form . "copy") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s157.2) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001429@unknown@formal@none@1@S@BSAP is encoded by the Pax-5 gene and has been highly conserved between human and mouse.@(((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Pax-5") (:form . "Pax-5") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s158.4) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001439@unknown@formal@none@1@S@Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 158)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 169)\n  (:start . 162) (:id . 71))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 174) (:start . 170)\n  (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 187)\n  (:start . 178) (:id . 74))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 199)\n  (:start . 193) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s159.4) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001449@unknown@formal@none@1@S@Mutagenesis experiments demonstrated that these Elf-1 binding sites are required for induction of HIV-2 transcription following T-cell-receptor-mediated T-cell activation.@(((:tag . "NNP") (:stem . "Mutagenesis") (:form . "Mutagenesis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 36)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 47) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 53) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 117) (:start . 104) (:id . 56))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 127)\n  (:start . 118) (:id . 57))\n ((:tag . "JJ") (:stem . "t-cell-receptor-mediated")\n  (:form . "T-cell-receptor-mediated") (:end . 152) (:start . 128) (:id . 58))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 159)\n  (:start . 153) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s160.8) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001459@unknown@formal@none@1@S@Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hiv-1-") (:form . "HIV-1-") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "2-directed") (:form . "2-directed") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s161.7) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001469@unknown@formal@none@1@S@It is , however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 15)\n  (:start . 8) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 86)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 101)\n  (:start . 90) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 145)\n  (:start . 133) (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x163.3.1) (:span 73 75)) ((:id . :x163.3.2) (:span 31 38))\n  ((:id . :x163.3.3) (:span 23 30)))\n (:hscopes ((:id . :x163.3.1) (:span 64 86))\n  ((:id . :x163.3.2) (:span 31 155)) ((:id . :x163.3.3) (:span 23 155)))\n (:identifiers (:sid . :s163.3) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001479@unknown@formal@none@1@S@3 . Danazol bound to these sites in high concentration (10(-6) M, clinical serum concentration during danazol therapy) and decreased the number of both sites.@(((:tag . "CD") (:stem . "3") (:form . "3") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "Danazol") (:form . "Danazol") (:end . 11)\n  (:start . 4) (:id . 44))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 54) (:start . 41) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 94) (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "danazol") (:form . "danazol") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s164.4) (:did . :|93012816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001489@unknown@formal@none@1@S@Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.@(((:tag . "JJ") (:stem . "stable") (:form . "Stable") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transdominant") (:form . "transdominant")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 95) (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s166.1) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001499@unknown@formal@none@1@S@We investigated the clinical significance of glucocorticoid receptor determination in 20 patients with systemic lupus erythematosus (SLE) who afterwards developed nephrotic syndrome.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 59) (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 82) (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 117)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 131) (:start . 118) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sle") (:form . "SLE") (:end . 136) (:start . 133)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "RB") (:stem . "afterwards") (:form . "afterwards") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 162)\n  (:start . 153) (:id . 63))\n ((:tag . "JJ") (:stem . "nephrotic") (:form . "nephrotic") (:end . 172)\n  (:start . 163) (:id . 64))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 181)\n  (:start . 173) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s167.2) (:did . :|93020778|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001509@unknown@formal@none@1@S@Contrary to previous assumptions, we observed that p65 homodimers can interact with a subset of DNA sequences not recognized by p50 homodimers.@(((:tag . "JJ") (:stem . "contrary") (:form . "Contrary") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "assumption") (:form . "assumptions") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x168.7.1) (:span 110 113)))\n (:nscopes ((:id . :x168.7.1) (:span 110 142)))\n (:identifiers (:sid . :s168.7) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001519@unknown@formal@none@1@S@The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "bcl-3") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "alpha-locus") (:form . "alpha-locus") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 142)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "leukaemia") (:form . "leukaemias") (:end . 153)\n  (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s170.2) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001529@unknown@formal@none@1@S@Thus enabled to perform the test on multiple blood samples in parallel, we investigated cardiac infarction patients over a 12-day period to test if glucocorticoid receptor binding is altered in this ' stressful ' disease.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "enable") (:form . "enabled") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 87)\n  (:start . 75) (:id . 56))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "12-day") (:form . "12-day") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 162) (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 179)\n  (:start . 172) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 190)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 198) (:start . 194)\n  (:id . 73))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 200) (:start . 199)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "stressful") (:form . "stressful") (:end . 210)\n  (:start . 201) (:id . 75))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 220)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x171.5.1) (:span 145 147)))\n (:hscopes ((:id . :x171.5.1) (:span 145 220)))\n (:identifiers (:sid . :s171.5) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001539@unknown@formal@none@1@S@The half-life of c-jun mRNA was similar (45-50 min) in both untreated and okadaic acid-induced cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "45-50") (:form . "45-50") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 69)\n  (:start . 60) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 94)\n  (:start . 82) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s172.8) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001549@unknown@formal@none@1@S@Single point estimation of glucocorticoid receptors in lymphocytes of normal subjects and of children under long term glucocorticoid treatment.@(((:tag . "JJ") (:stem . "single") (:form . "Single") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "estimation") (:form . "estimation") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 41) (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "child") (:form . "children") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 132) (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 142)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s174.1) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001559@unknown@formal@none@1@S@The factor responsible for this activity was designated Oct coactivator from B cells (OCA-B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s175.3) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001569@unknown@formal@none@1@S@These AP-2 and AP-1 sites were each modified with a double point mutation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s176.7) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001579@unknown@formal@none@1@S@The anti-oxidative effect of BHA was accompanied by an increase in thiol, but not glutathione, content in stimulated and unstimulated T cell, whereas TNF stimulation itself barely modified the cellular thiol level.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "anti-oxidative") (:form . "anti-oxidative")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 133)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 172)\n  (:start . 166) (:id . 70))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 179)\n  (:start . 173) (:id . 71))\n ((:tag . "VBD") (:stem . "modify") (:form . "modified") (:end . 188)\n  (:start . 180) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 201)\n  (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 207)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x177.7.1) (:span 78 81)))\n (:nscopes ((:id . :x177.7.1) (:span 78 93)))\n (:identifiers (:sid . :s177.7) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001589@unknown@formal@none@1@S@However, c-jun mRNA levels decreased significantly (1.73 ± 0.08 vs. 1.16 ± 0.09 arbitrary units, P < 0.01, young vs. old) in PBL from elderly individuals activated with PHA.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1.73") (:form . "1.73") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "0.08") (:form . "0.08") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "vs.") (:form . "vs.") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1.16") (:form . "1.16") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0.09") (:form . "0.09") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "arbitrary") (:form . "arbitrary") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 112)\n  (:start . 107) (:id . 64))\n ((:tag . "CC") (:stem . "vs.") (:form . "vs.") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "old") (:form . "old") (:end . 120) (:start . 117)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 128) (:start . 125)\n  (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 133) (:start . 129)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 141)\n  (:start . 134) (:id . 71))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 153)\n  (:start . 142) (:id . 72))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 163)\n  (:start . 154) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 172) (:start . 169)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s178.6) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001599@unknown@formal@none@1@S@Corticosteroids are the preeminent antiinflammatory agents although the molecular mechanisms that impart their efficacy have not been defined.@(((:tag . "NNS") (:stem . "corticosteroid") (:form . "Corticosteroids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "preeminent") (:form . "preeminent") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 51) (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 58)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 67)\n  (:start . 59) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 92)\n  (:start . 82) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "impart") (:form . "impart") (:end . 104)\n  (:start . 98) (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 110)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 119)\n  (:start . 111) (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x180.2.1) (:span 125 128)))\n (:nscopes ((:id . :x180.2.1) (:span 68 141)))\n (:identifiers (:sid . :s180.2) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001609@unknown@formal@none@1@S@As in the adhesion studies, cortisol but not tetrahydrocortisol inhibited expression of ELAM-1 and ICAM-1 (both P < 0.005, n = 3 or 4)9.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tetrahydrocortisol") (:form . "tetrahydrocortisol")\n  (:end . 63) (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.005") (:form . "0.005") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4)9") (:form . "4)9") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x180.12.1) (:span 41 44)))\n (:nscopes ((:id . :x180.12.1) (:span 41 63)))\n (:identifiers (:sid . :s180.12) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001619@unknown@formal@none@1@S@Reticuloendotheliosis virus long terminal repeat elements are efficient promoters in cells of various species and tissue origin, including human lymphoid cells.@(((:tag . "NNP") (:stem . "Reticuloendotheliosis")\n  (:form . "Reticuloendotheliosis") (:end . 21) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 32) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 71)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 101)\n  (:start . 94) (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s182.1) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001629@unknown@formal@none@1@S@Another LTR size variation was observed in four patients in a region just upstream of the NF-kappa B enhancer.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s183.5) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001639@unknown@formal@none@1@S@Although activated in T cell leukemias, expression of SCL and LYL-1 is low or undetectable in normal T cell populations.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LYL-1") (:form . "LYL-1") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 90)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 119)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s184.4) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001649@unknown@formal@none@1@S@In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nonerythroid") (:form . "nonerythroid") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x185.6.1) (:span 97 100)))\n (:nscopes ((:id . :x185.6.1) (:span 97 111)))\n (:identifiers (:sid . :s185.6) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001659@unknown@formal@none@1@S@The constitutive transcription factor SP1 was unaffected by addition of TPA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s186.8) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001669@unknown@formal@none@1@S@Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas.@(((:tag . "NNS") (:stem . "mouse") (:form . "Mice") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ODN") (:form . "ODNs") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 53) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regression") (:form . "regression") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transplant") (:form . "transplanted") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "fibrosarcoma") (:form . "fibrosarcomas")\n  (:end . 100) (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s187.5) (:did . :|93101981|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001679@unknown@formal@none@1@S@3 . Although DEX and PGE2 were equipotent in suppressing T-cell proliferation, ISO was much less effective.@(((:tag . "LS") (:stem . "3") (:form . "3") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 12)\n  (:start . 4) (:id . 44))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "equipotent") (:form . "equipotent") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s188.9) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001689@unknown@formal@none@1@S@c-Jun protein isolated from phorbol ester-induced cells did not target c-Fos for degradation, which suggests that c-Fos is transiently stabilized after stimulation of cell growth.@(((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "VBN") (:stem . "stabilize") (:form . "stabilized") (:end . 145)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 163)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 178)\n  (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x189.6.1) (:span 100 108)))\n (:ncues ((:id . :x189.6.2) (:span 60 63)))\n (:hscopes ((:id . :x189.6.1) (:span 100 178)))\n (:nscopes ((:id . :x189.6.2) (:span 60 92)))\n (:identifiers (:sid . :s189.6) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001699@unknown@formal@none@1@S@No unifying hypothesis has yet emerged explaining this collection of data.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unifying") (:form . "unifying") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBG") (:stem . "explain") (:form . "explaining") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "collection") (:form . "collection") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x191.6.1) (:span 0 2)))\n (:nscopes ((:id . :x191.6.1) (:span 0 73)))\n (:identifiers (:sid . :s191.6) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001709@unknown@formal@none@1@S@The chemiluminescent (CL) response of interferon-gamma-treated U937 (IFN-U937) cells to sensitized target cells has been used to detect red cell, platelet and granulocyte antibodies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chemiluminescent") (:form . "chemiluminescent")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "interferon-gamma-treated")\n  (:form . "interferon-gamma-treated") (:end . 62) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "sensitize") (:form . "sensitized") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 170)\n  (:start . 159) (:id . 69))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s193.2) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001719@unknown@formal@none@1@S@They are part of the high affinity IgE receptor in mast cells, basophils, Langerhans cells, and possibly other cells; a component of the low affinity receptor for IgG (Fc gamma RIIIA or CD16) in natural killer cells and macrophages; and part of the T cell antigen receptor in subsets of T cells.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . 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")") (:end . 191) (:start . 190)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 202)\n  (:start . 195) (:id . 82))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 209)\n  (:start . 203) (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 231)\n  (:start . 220) (:id . 86))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 232) (:start . 231)\n  (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 88))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 241) (:start . 237)\n  (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . 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5001729@unknown@formal@none@1@S@To delineate the effects of these motifs on the replicative capacity of HIV and to explore the possibility of extending the virus host range, known heterologous enhancer/promoters were inserted into the HIV-1 LTR in place of the NF-kappa B and Sp1 binding sites.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 160)\n  (:start . 148) (:id . 68))\n ((:tag . "NNS") (:stem . "enhancer/promoter") (:form . "enhancer/promoters")\n  (:end . 179) (:start . 161) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 198) (:start . 194)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 208)\n  (:start . 203) (:id . 74))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 221)\n  (:start . 216) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 237)\n  (:start . 229) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 82))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 247) (:start . 244)\n  (:id . 83))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 255)\n  (:start . 248) (:id . 84))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 261)\n  (:start . 256) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s195.3) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001739@unknown@formal@none@1@S@Our report expands current knowledge of the radiation-induced signaling cascade by clarifying the chronological sequence of biochemical events that follow irradiation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "expand") (:form . "expands") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "radiation-induced") (:form . "radiation-induced")\n  (:end . 61) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "clarify") (:form . "clarifying") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "chronological") (:form . "chronological")\n  (:end . 111) (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 135)\n  (:start . 124) (:id . 58))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 142)\n  (:start . 136) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 154)\n  (:start . 148) (:id . 61))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 166)\n  (:start . 155) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s196.6) (:did . :|93126354|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001749@unknown@formal@none@1@S@Recent findings suggest an involvement of reactive oxygen species (ROS) in signal transduction pathways leading to NF-kappa B activation.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x198.4.1) (:span 16 23)))\n (:hscopes ((:id . :x198.4.1) (:span 16 136)))\n (:identifiers (:sid . :s198.4) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001759@unknown@formal@none@1@S@Group 1 contains G0S24 and the rat and mouse TIS11 genes (also known as TTP, Nup475, and Zfp36).@(((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "g0s24") (:form . "G0S24") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tis11") (:form . "TIS11") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TTP") (:form . "TTP") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Nup475") (:form . "Nup475") (:end . 83)\n  (:start . 77) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 61))\n ((:tag . "NN") (:stem . "zfp36") (:form . "Zfp36") (:end . 94) (:start . 89)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s199.6) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001769@unknown@formal@none@1@S@We studied the effect of interleukin-4 (IL-4) on the lipopolysaccharide (LPS) induction of two immediate early genes c-fos and c-jun.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 71) (:start . 53) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s200.2) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001779@unknown@formal@none@1@S@In the present study, we examined the relationship between ras transformation and differentiation of human B lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 50)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 97) (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s201.3) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001789@unknown@formal@none@1@S@We can now study regulatory regions and functional domains of the protein in the context of a true erythroid environment, experiments that have not been possible heretofore.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 133)\n  (:start . 122) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "RB") (:stem . "heretofore") (:form . "heretofore") (:end . 172)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x202.5.1) (:span 144 147)))\n (:nscopes ((:id . :x202.5.1) (:span 144 172)))\n (:identifiers (:sid . :s202.5) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001799@unknown@formal@none@1@S@We feel that these experiments are vital to understanding the function of GATA-1 during erythroid ontogeny.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "feel") (:form . "feel") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "vital") (:form . "vital") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "understand") (:form . "understanding") (:end . 57)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "ontogeny") (:form . "ontogeny") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x202.15.1) (:span 3 7)))\n (:hscopes ((:id . :x202.15.1) (:span 3 106)))\n (:identifiers (:sid . :s202.15) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001809@unknown@formal@none@1@S@Egr-1 antisense oligomers in the culture media blocked macrophage differentiation in both myeloid leukemia cell lines and normal myeloblasts.@(((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "oligomer") (:form . "oligomers") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 46)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 81) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "myeloblast") (:form . "myeloblasts") (:end . 140)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s203.5) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001819@unknown@formal@none@1@S@The production of the granulocyte-macrophage colony stimulating factor (GM-CSF) is completely dependent on the two signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 44) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s204.8) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001829@unknown@formal@none@1@S@Expression of tal-1 and GATA-binding proteins during human hematopoiesis.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s205.1) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001839@unknown@formal@none@1@S@In contrast, GATA-2 is strongly expressed in both most primitive and committed progenitors cells, whereas GATA-3 is mostly detected in most primitive ones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s205.11) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001849@unknown@formal@none@1@S@Interleukin-3 (IL-3) is exclusively expressed by activated T and natural killer cells, a function that is tightly controlled both in a lineage-specific and in a stimulation-dependent manner.@(((:tag . "NN") (:stem . "interleukin-3") (:form . "Interleukin-3")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 151) (:start . 135) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "stimulation-dependent")\n  (:form . "stimulation-dependent") (:end . 182) (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 189)\n  (:start . 183) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s207.2) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001859@unknown@formal@none@1@S@In contrast, NF-kappa B p50 alone fails to stimulate kappa B-directed transcription, and based on prior in vitro studies, is not directly regulated by I kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "b-directed") (:form . "B-directed") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 137)\n  (:start . 129) (:id . 66))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 147)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 158)\n  (:start . 153) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x208.4.1) (:span 125 128))\n  ((:id . :x208.4.2) (:span 34 39)))\n (:nscopes ((:id . :x208.4.1) (:span 122 160))\n  ((:id . :x208.4.2) (:span 34 83)))\n (:identifiers (:sid . :s208.4) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001869@unknown@formal@none@1@S@Studies in mice have shown that a monoclonal antibody, conjugated with palmitate to provide a lipid tail, can be inserted into the cell membrane to provide a " surrogate " antigen receptor.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conjugate") (:form . "conjugated") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "palmitate") (:form . "palmitate") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 159) (:start . 158)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 169)\n  (:start . 160) (:id . 72))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 188)\n  (:start . 180) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s209.3) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001879@unknown@formal@none@1@S@The Epstein-Barr virus protein EBNA2 acts as a transcriptional activator of cellular and viral genes and plays a crucial role in the immortalization of human primary B-cells by EBV.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 148) (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "b-cell") (:form . "B-cells") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s210.2) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001889@unknown@formal@none@1@S@ras protein activity is essential for T-cell antigen receptor signal transduction.@(((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s211.1) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001899@unknown@formal@none@1@S@Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "ester-inducible") (:form . "ester-inducible")\n  (:end . 104) (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 125)\n  (:start . 119) (:id . 58))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Jun/Fos") (:form . "Jun/Fos") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s212.4) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001909@unknown@formal@none@1@S@These kappa B enhancer elements are recognized by a structurally related family of interactive proteins that includes p50, p65, and the product of the c-rel protooncogene (c-Rel).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 64)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "interactive") (:form . "interactive") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 156)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 170) (:start . 157) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s213.3) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001919@unknown@formal@none@1@S@In addition to the wild-type B cell line Raji, two class II transcriptional mutant cell lines, SJO and RJ2.2.5, and Jurkat, a class II negative T cell line, were examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 75) (:start . 60) (:id . 55))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SJO") (:form . "SJO") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RJ2.2.5") (:form . "RJ2.2.5") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 122)\n  (:start . 116) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 143)\n  (:start . 135) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 145) (:start . 144)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 150) (:start . 146)\n  (:id . 72))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 155) (:start . 151)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 161) (:start . 157)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 170)\n  (:start . 162) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s214.5) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001929@unknown@formal@none@1@S@In previous transfection analyses using the chloramphenicol acetyltransferase reporter gene system, we determined that linker substitution (LS) mutations between -201 and -130 (relative to the transcription start site) of the human immunodeficiency virus type 1 long terminal repeat (LTR) caused moderate decreases in LTR transcriptional activity in a T-cell line (S.L.Zeichner, J.Y.H. Kim, and J.C.Alwine, J.Virol.65:2436-2444, 1991).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 59) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 77) (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 86)\n  (:start . 78) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 51))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 98)\n  (:start . 92) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "linker") (:form . "linker") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 138)\n  (:start . 126) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LS") (:form . "LS") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 153)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 161)\n  (:start . 154) (:id . 63))\n ((:tag . "CD") (:stem . "-201") (:form . "-201") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-130") (:form . "-130") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . 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")") (:end . 288) (:start . 287)\n  (:id . 87))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 295)\n  (:start . 289) (:id . 88))\n ((:tag . "JJ") (:stem . "moderate") (:form . "moderate") (:end . 304)\n  (:start . 296) (:id . 89))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 314)\n  (:start . 305) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 317) (:start . 315)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 321) (:start . 318)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 337) (:start . 322) (:id . 93))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 346)\n  (:start . 338) (:id . 94))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 349) (:start . 347)\n  (:id . 95))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 351) (:start . 350)\n  (:id . 96))\n ((:tag . "NN") (:stem . "t-cell") (:form . 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",") (:end . 406) (:start . 405)\n  (:id . 107))\n ((:tag . "NNP") (:stem . "J.Virol.65:2436-2444")\n  (:form . "J.Virol.65:2436-2444") (:end . 427) (:start . 407) (:id . 108))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 428) (:start . 427)\n  (:id . 109))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 433) (:start . 429)\n  (:id . 110))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 434) (:start . 433)\n  (:id . 111))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 435) (:start . 434)\n  (:id . 112)))@@@1@71@((:identifiers (:sid . :s215.2) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001939@unknown@formal@none@1@S@We have previously found that NFKB2(p49/p52) acts in concert with RelA(p65) to stimulate the HIV enhancer in Jurkat T-leukemia cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "NFKB2(p49/p52)") (:form . "NFKB2(p49/p52)")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "NNP") (:stem . "T-leukemia") (:form . "T-leukemia") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s216.4) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001949@unknown@formal@none@1@S@The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "prointerleukin") (:form . "prointerleukin")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 136) (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s217.1) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001959@unknown@formal@none@1@S@We have identified a putative transcription factor, designated PILOT, with an identical dual signal requirement for expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "PILOT") (:form . "PILOT") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x218.3.1) (:span 21 29)))\n (:hscopes ((:id . :x218.3.1) (:span 21 50)))\n (:identifiers (:sid . :s218.3) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001969@unknown@formal@none@1@S@Control peptides corresponding to the normal pml and RAR alpha proteins were not recognized.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 30)\n  (:start . 17) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "pml") (:form . "pml") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x219.5.1) (:span 77 80)))\n (:nscopes ((:id . :x219.5.1) (:span 0 91)))\n (:identifiers (:sid . :s219.5) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001979@unknown@formal@none@1@S@In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-1280") (:form . "-1280") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sre") (:form . "SRE") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "cross-compete") (:form . "cross-competed")\n  (:end . 71) (:start . 57) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x220.7.1) (:span 122 125)))\n (:nscopes ((:id . :x220.7.1) (:span 122 125)))\n (:identifiers (:sid . :s220.7) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001989@unknown@formal@none@1@S@TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element.@(((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 108) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s221.5) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001999@unknown@formal@none@1@S@Treatment of peripheral blood T cells with phorbol 12-myristate 13-acetate (PMA) and anti-CD28 monoclonal antibody (mAb) results in augmentation of nuclear c-Rel, p50, and p65, and this augmentation can occur in the presence of the immunosuppressant cyclosporin A.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 144)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 185) (:start . 181)\n  (:id . 75))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 198)\n  (:start . 186) (:id . 76))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 202) (:start . 199)\n  (:id . 77))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 80))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 224)\n  (:start . 216) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 249) (:start . 232) (:id . 84))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 261)\n  (:start . 250) (:id . 85))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 263) (:start . 262)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s222.6) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002009@unknown@formal@none@1@S@No such increase was observed in control U937 cells.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x223.8.1) (:span 0 2)))\n (:nscopes ((:id . :x223.8.1) (:span 0 51)))\n (:identifiers (:sid . :s223.8) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002019@unknown@formal@none@1@S@Furthermore, the substitution of this GATA binding site by a canonical TFIID binding site suppresses the promoter activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s224.9) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002029@unknown@formal@none@1@S@The stimulation of interleukin-1 alpha production by okadaic acid was more modest than that of interleukin-1 beta.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 108) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s225.8) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002039@unknown@formal@none@1@S@Southwestern blotting and UV cross-linking studies confirmed that the BAT box binding proteins were Oct-1 and Oct-2.@(((:tag . "NNP") (:stem . "Southwestern") (:form . "Southwestern") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s226.8) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002049@unknown@formal@none@1@S@Peripheral blood T-cells exhibited significant proliferation in response to a recombinant fragment of jun-B (amino acids 1-180) in 12 of 17 (71 %) recent-onset IDDM subjects, 8 of 16 (50 %) ICA-positive first-degree relatives of IDDM subjects who were at risk, 3 of 12 (25 %) other autoimmune disease subjects, and 0 of 10 healthy control subjects.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "proliferation") (:form . 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5002059@unknown@formal@none@1@S@These results should contribute to a better understanding of the regulation of IL3 gene expression in human T lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 43) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x228.7.1) (:span 14 20)))\n (:hscopes ((:id . :x228.7.1) (:span 14 121)))\n (:identifiers (:sid . :s228.7) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002069@unknown@formal@none@1@S@All sequence motifs within the functional core of HS-40, as mapped by transient expression analysis, appeared to bind a nuclear factor ( s ) in living K562 cells but not in nonerythroid cells.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 66) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 155) (:start . 151)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "nonerythroid") (:form . "nonerythroid") (:end . 185)\n  (:start . 173) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x229.10.2) (:span 101 109)))\n (:ncues ((:id . :x229.10.1) (:span 166 169)))\n (:hscopes ((:id . :x229.10.2) (:span 0 191)))\n (:nscopes ((:id . :x229.10.1) (:span 166 191)))\n (:identifiers (:sid . :s229.10) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002079@unknown@formal@none@1@S@The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 90) (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 103)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 174) (:start . 160) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s231.1) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002089@unknown@formal@none@1@S@The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 56)\n  (:start . 44) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 166)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s232.2) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002099@unknown@formal@none@1@S@Association with the precursors is sufficient for cytoplasmic retention of either p65 or c-Rel, both of which are otherwise nuclear.@(((:tag . "NNP") (:stem . "Association") (:form . "Association") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "retention") (:form . "retention") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s233.5) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002109@unknown@formal@none@1@S@Subsequently, I kappa B-alpha mRNA and protein levels are quickly induced by the activated NF-kappa B.@(((:tag . "RB") (:stem . "subsequently") (:form . "Subsequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "quickly") (:form . "quickly") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s234.8) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002119@unknown@formal@none@1@S@Electron microscopy revealed a marked increase in granules resembling those specific for eosinophils.@(((:tag . "NNP") (:stem . "Electron") (:form . "Electron") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "granule") (:form . "granules") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s235.9) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002129@unknown@formal@none@1@S@In vivo the Sp1 site is bound only in myeloid (U937) cells, not in cervical carcinoma (HeLa) cells.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cervical") (:form . "cervical") (:end . 75)\n  (:start . 67) (:id . 59))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 85)\n  (:start . 76) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 91) (:start . 87)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x236.7.1) (:span 60 63)))\n (:nscopes ((:id . :x236.7.1) (:span 60 98)))\n (:identifiers (:sid . :s236.7) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002139@unknown@formal@none@1@S@PBL constitutively express c-jun transcripts, and the level of c-jun mRNA is not altered by PHA activation in the absence or presence of EC.@(((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x237.8.1) (:span 77 80)))\n (:nscopes ((:id . :x237.8.1) (:span 50 139)))\n (:identifiers (:sid . :s237.8) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002149@unknown@formal@none@1@S@Nuclear factor of activated T cells (NF-AT) is a transcriptional activator involved in the induction of IL-2 gene expression.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 64) (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s238.2) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002159@unknown@formal@none@1@S@PMA induced the expression of both CD14 and CD23 mRNA and protein.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s239.4) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002169@unknown@formal@none@1@S@Two stable B cell lines were established:@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s240.4) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002179@unknown@formal@none@1@S@A new approach to facilitate immobilization and affinity purification of recombinant proteins and selected human B lymphocytes has been developed.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "immobilization") (:form . "immobilization")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 126)\n  (:start . 115) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s241.2) (:did . :|93228833|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002189@unknown@formal@none@1@S@Jurkat cells were transfected with plasmids containing either the intact IL-2 promoter or its AP-1, NF-AT, and NF-kB motifs.@(((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s242.7) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002199@unknown@formal@none@1@S@Human CD3-CD16+ natural killer cells express the hGATA-3 T cell transcription factor and an unrearranged 2.3-kb TcR delta transcript.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd3-cd16+") (:form . "CD3-CD16+") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 104)\n  (:start . 92) (:id . 56))\n ((:tag . "JJ") (:stem . "2.3-kb") (:form . "2.3-kb") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s244.1) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002209@unknown@formal@none@1@S@The expression of hGATA-3, a T cell-specific factor known to be involved in the regulation of the transcription of TcR delta locus, was analyzed by Northern blot, in cultured NK cell population and clones ( but not in freshly derived cell populations).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 44) (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 174)\n  (:start . 166) (:id . 73))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 75))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 193)\n  (:start . 183) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 204)\n  (:start . 198) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 79))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 210) (:start . 207)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 214) (:start . 211)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 82))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 225)\n  (:start . 218) (:id . 83))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 233)\n  (:start . 226) (:id . 84))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 238) (:start . 234)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 250)\n  (:start . 239) (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 88)))@@@1@47@((:ncues ((:id . :x244.11.1) (:span 211 214)))\n (:nscopes ((:id . :x244.11.1) (:span 211 250)))\n (:identifiers (:sid . :s244.11) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002219@unknown@formal@none@1@S@this binding activity was previously shown to be efficiently recognized by antiserum directed against E2A gene products.@(((:tag . "DT") (:stem . "this") (:form . "this") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "antiserum") (:form . "antiserum") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s245.8) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002229@unknown@formal@none@1@S@Mitogen-mediated transcriptional activation of the CAT gene in this construct was inhibited in Nef-expressing cells but not in control cells.@(((:tag . "JJ") (:stem . "mitogen-mediated") (:form . "Mitogen-mediated")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nef-expressing") (:form . "Nef-expressing")\n  (:end . 109) (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x246.7.1) (:span 120 123)))\n (:nscopes ((:id . :x246.7.1) (:span 120 140)))\n (:identifiers (:sid . :s246.7) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002239@unknown@formal@none@1@S@These results can not be explained by receptor down-regulation due to higher level of mineralocorticoids of the zona glomerulosa.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 104) (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "zona") (:form . "zona") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "glomerulosa") (:form . "glomerulosa") (:end . 128)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x247.9.1) (:span 14 21)))\n (:nscopes ((:id . :x247.9.1) (:span 0 128)))\n (:identifiers (:sid . :s247.9) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002249@unknown@formal@none@1@S@A second messenger cascade involved is the inositol 1,4,5-trisphosphate/calcium pathway which responds over the same rapid time course.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "1,4,5-trisphosphate/calcium")\n  (:form . "1,4,5-trisphosphate/calcium") (:end . 79) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 102)\n  (:start . 94) (:id . 53))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 116) (:start . 112)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s248.4) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002259@unknown@formal@none@1@S@IFN-MCP was not inhibited by infection with dl343, despite the production of large amounts of both early (E1B, p55) and late (hexon) Ad proteins.@(((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dl343") (:form . "dl343") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "E1B") (:form . "E1B") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hexon") (:form . "hexon") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ad") (:form . "Ad") (:end . 135) (:start . 133)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 144)\n  (:start . 136) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x249.7.1) (:span 12 15)))\n (:nscopes ((:id . :x249.7.1) (:span 0 49)))\n (:identifiers (:sid . :s249.7) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002269@unknown@formal@none@1@S@In contrast to the type I receptor, the type II IL-1R has a small cytoplasmic tail, and it is not clear whether this receptor is a signal-transducing or a regulatory molecule.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1R") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 65) (:start . 60)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 77)\n  (:start . 66) (:id . 57))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 90) (:start . 88)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 103) (:start . 98)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 111)\n  (:start . 104) (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 116) (:start . 112)\n  (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 125)\n  (:start . 117) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 149) (:start . 131) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 152) (:start . 150)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 165)\n  (:start . 155) (:id . 73))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 174)\n  (:start . 166) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x250.4.1) (:span 150 152))\n  ((:id . :x250.4.2) (:span 104 111)) ((:id . :x250.4.3) (:span 94 103)))\n (:hscopes ((:id . :x250.4.1) (:span 129 165))\n  ((:id . :x250.4.2) (:span 104 174)) ((:id . :x250.4.3) (:span 94 174)))\n (:identifiers (:sid . :s250.4) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002279@unknown@formal@none@1@S@When the wild-type hGR and hGR-Ile 729 were expressed in COS-1 cells and assayed for [3H]-Dexamethasone binding, the dissociation constants were 0.799 ± 0.068 and 1.54 ± 0.06 nM (mean ± SEM) (P < 0.01), respectively.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hgr-ile") (:form . "hGR-Ile") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "729") (:form . "729") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cos-1") (:form . "COS-1") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "3H]-Dexamethasone") (:form . "3H]-Dexamethasone")\n  (:end . 103) (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 129)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "constant") (:form . "constants") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "CD") (:stem . "0.799") (:form . "0.799") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.068") (:form . "0.068") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1.54") (:form . "1.54") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "CD") (:stem . "0.06") (:form . "0.06") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 183) (:start . 179)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 189) (:start . 186)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 193) (:start . 192)\n  (:id . 79))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 195) (:start . 194)\n  (:id . 80))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 200) (:start . 196)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 83))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 215)\n  (:start . 203) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s251.7) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002289@unknown@formal@none@1@S@In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tnfrp55-deficient") (:form . "TNFRp55-deficient")\n  (:end . 30) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VB") (:stem . "clear") (:form . "clear") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "L.") (:form . "L.") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocytogene") (:form . "monocytogenes")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "VBP") (:stem . "succumb") (:form . "succumb") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s252.8) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002299@unknown@formal@none@1@S@Deletions delineated a carboxy-terminal dimerization region containing two repeats of 15 amino acids that show similarity with the dimerization domains of basic-helix-loop-helix proteins.@(((:tag . "NNS") (:stem . "deletion") (:form . "Deletions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "delineate") (:form . "delineated") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 52)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 59)\n  (:start . 53) (:id . 47))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 70)\n  (:start . 60) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 74) (:start . 71)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 82)\n  (:start . 75) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 51))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 143)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 151)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "basic-helix-loop-helix")\n  (:form . "basic-helix-loop-helix") (:end . 177) (:start . 155) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 186)\n  (:start . 178) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s253.9) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002309@unknown@formal@none@1@S@In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both in vitro and in vivo.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "NNS") (:stem . "oncoprotein") (:form . "oncoproteins") (:end . 148)\n  (:start . 136) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 158)\n  (:start . 153) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "pocket") (:form . "pocket") (:end . 172)\n  (:start . 166) (:id . 72))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 179)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 77))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 199)\n  (:start . 194) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 79))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 80))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 211) (:start . 207)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s255.4) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002319@unknown@formal@none@1@S@Long-lasting IL-2 receptivity is associated with high-level expression of the inducible IL-2 receptor alpha chain (IL-2R alpha) gene that is regulated at both transcriptional and posttranscriptional levels.@(((:tag . "JJ") (:stem . "long-lasting") (:form . "Long-lasting") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptivity") (:form . "receptivity") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 174) (:start . 159) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 198) (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 205)\n  (:start . 199) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s256.4) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002329@unknown@formal@none@1@S@Oxidoreductive regulation of nuclear factor kappa B.@(((:tag . "JJ") (:stem . "oxidoreductive") (:form . "Oxidoreductive")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s257.1) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002339@unknown@formal@none@1@S@Using a human TSH receptor (TSH-R) cDNA probe, we investigated TSH-R transcript levels in 13 human thyroid fragments by Northern blot analysis;@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tsh") (:form . "TSH") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TSH-R") (:form . "TSH-R") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 49) (:start . 47)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 62)\n  (:start . 50) (:id . 54))\n ((:tag . "NN") (:stem . "tsh-r") (:form . "TSH-R") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 116)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s258.2) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002349@unknown@formal@none@1@S@We localized the LAM-, lipopolysaccharide (LPS)-, and TNF-alpha-inducible promoter activity to a -131/+15 (positions -131 to +15) DNA fragment of the IL-1 beta gene by deletion analysis and chloramphenicol acetyltransferase assay.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lam-") (:form . "LAM-") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 41) (:start . 23) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LPS)-") (:form . "LPS)-") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tnf-alpha-inducible")\n  (:form . "TNF-alpha-inducible") (:end . 73) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-131/+15") (:form . "-131/+15") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "CD") (:stem . "-131") (:form . "-131") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "CD") (:stem . "+15") (:form . "+15") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 205) (:start . 190) (:id . 75))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 223) (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 229)\n  (:start . 224) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s259.4) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002359@unknown@formal@none@1@S@The effect of transmembrane signaling of T cells with ionomycin, and/or sn-1,2 dioctanoyl glycerol, was also determined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "CD") (:stem . "sn-1,2") (:form . "sn-1,2") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "dioctanoyl") (:form . "dioctanoyl") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "glycerol") (:form . "glycerol") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s260.6) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002369@unknown@formal@none@1@S@Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.@(((:tag . "JJ") (:stem . "cell-specific") (:form . "Cell-specific")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "bifunctional") (:form . "bifunctional") (:end . 26)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 31) (:start . 27)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 80) (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "receptor-dependent") (:form . "receptor-dependent")\n  (:end . 99) (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 113) (:start . 100) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s262.1) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002379@unknown@formal@none@1@S@high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.@(((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 78) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x262.11.1) (:span 121 124)))\n (:nscopes ((:id . :x262.11.1) (:span 121 135)))\n (:identifiers (:sid . :s262.11) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002389@unknown@formal@none@1@S@Southern blot analysis of in situ lysing gels revealed that the cellular content of linear EBV DNA was also increased significantly after the initiation of the viral lytic cycle, while the amount of circular DNA remained approximately constant.@(((:tag . "NNP") (:stem . "Southern") (:form . "Southern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "lyse") (:form . "lysing") (:end . 40) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gel") (:form . "gels") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 131) (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 195)\n  (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "circular") (:form . "circular") (:end . 207)\n  (:start . 199) (:id . 76))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 211) (:start . 208)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 220)\n  (:start . 212) (:id . 78))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 234) (:start . 221) (:id . 79))\n ((:tag . "JJ") (:stem . "constant") (:form . "constant") (:end . 243)\n  (:start . 235) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s263.7) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002399@unknown@formal@none@1@S@These GATA/ER chimeric factors were shown to be hormone-inducible trans-activating proteins in transient transfection assays.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata/er") (:form . "GATA/ER") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hormone-inducible") (:form . "hormone-inducible")\n  (:end . 65) (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 82) (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 91)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 117)\n  (:start . 105) (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 124)\n  (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s265.5) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002409@unknown@formal@none@1@S@The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 88)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s266.7) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002419@unknown@formal@none@1@S@In contrast, there was no regulation by glucocorticoids of either the CD8 or CD4 antigens in the leukemic clone CEM C1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 55) (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "C1") (:form . "C1") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x267.8.1) (:span 23 25)))\n (:nscopes ((:id . :x267.8.1) (:span 23 118)))\n (:identifiers (:sid . :s267.8) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002429@unknown@formal@none@1@S@In contrast, CAT gene expression directed by a multimer of the OCT-1 proximal ( OCT-1p ) -binding site was equivalent in patient and controls.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "multimer") (:form . "multimer") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oct-1") (:form . "OCT-1") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "OCT-1p") (:form . "OCT-1p") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "-binding") (:form . "-binding") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s268.8) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002439@unknown@formal@none@1@S@The proliferative activity of tumors has been extensively investigated with different approaches, among which the use of the monoclonal antibody Ki-67 represents an easy and reliable means of assessing cell proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 135)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "easy") (:form . "easy") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "reliable") (:form . "reliable") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "assess") (:form . "assessing") (:end . 201)\n  (:start . 192) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 206) (:start . 202)\n  (:id . 72))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 220) (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s270.3) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002449@unknown@formal@none@1@S@Tumor proliferative activity as evaluated by the monoclonal antibody Ki-67 seems to be an effective indicator of prognosis in breast cancer for DFS and OS.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "indicator") (:form . "indicator") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "prognosis") (:form . "prognosis") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DFS") (:form . "DFS") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "OS") (:form . "OS") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x270.13.1) (:span 75 80)))\n (:hscopes ((:id . :x270.13.1) (:span 0 154)))\n (:identifiers (:sid . :s270.13) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002459@unknown@formal@none@1@S@Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 55)\n  (:start . 47) (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 69) (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 93)\n  (:start . 86) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s271.10) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002469@unknown@formal@none@1@S@Glucocorticoid receptors in mononuclear cells of patients with sepsis.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s273.1) (:did . :|93289270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002479@unknown@formal@none@1@S@The two lines also expressed comparable levels of Epo-R mRNA while the number of Epo-binding sites on UT-7 Epo cells was one-sixth the number of UT-7 cells (2400 ± 3 vs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Epo-R") (:form . "Epo-R") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "epo-binding") (:form . "Epo-binding") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "one-sixth") (:form . "one-sixth") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ut-7") (:form . "UT-7") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "CD") (:stem . "2400") (:form . "2400") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 163) (:start . 162)\n  (:id . 71))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "v") (:form . "vs") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s274.6) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002489@unknown@formal@none@1@S@Human peripheral blood monocytes (Mo) constitutively display the beta-chain of the receptor for IL-2, whereas expression of the IL-2R alpha-chain is not constitutive but inducible with IL-2.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Mo") (:form . "Mo") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 52) (:start . 38) (:id . 49))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 145)\n  (:start . 134) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 165)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x275.2.1) (:span 149 152)))\n (:nscopes ((:id . :x275.2.1) (:span 149 165)))\n (:identifiers (:sid . :s275.2) (:did . :|93294310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002499@unknown@formal@none@1@S@Purified recombinant Jun and Fos proteins failed to bind directly to the NFAT motif.@(((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 48) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s276.6) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002509@unknown@formal@none@1@S@Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 46) (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 49) (:start . 47)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 55) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ETS-domain") (:form . "ETS-domain") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s278.1) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002519@unknown@formal@none@1@S@In contrast to the decrease in GR mRNA seen in IM-9 cells after treatment with 1 microM dexamethasone for 16-18 h, treatment of 6TG1.1 cells resulted in an 8-fold increase in GR mRNA, as determined by Northern blot and RNase protection analysis, with a corresponding 3- to 4-fold increase in GR protein.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . 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"NN") (:stem . "northern") (:form . "Northern") (:end . 209)\n  (:start . 201) (:id . 80))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 214) (:start . 210)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 82))\n ((:tag . "NN") (:stem . "rnase") (:form . "RNase") (:end . 224)\n  (:start . 219) (:id . 83))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 235)\n  (:start . 225) (:id . 84))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 244)\n  (:start . 236) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 86))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 250) (:start . 246)\n  (:id . 87))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 252) (:start . 251)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 266) (:start . 253) (:id . 89))\n ((:tag . "CD") (:stem . "3-") (:form . "3-") (:end . 269) (:start . 267)\n  (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 272) (:start . 270)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "4-fold") (:form . "4-fold") (:end . 279)\n  (:start . 273) (:id . 92))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 288)\n  (:start . 280) (:id . 93))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 291) (:start . 289)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 294) (:start . 292)\n  (:id . 95))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 302)\n  (:start . 295) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s279.3) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002529@unknown@formal@none@1@S@Overproduced I kappa B, free from NF-kappa B, is rapidly degraded.@(((:tag . "VBN") (:stem . "overproduce") (:form . "Overproduced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 56)\n  (:start . 49) (:id . 53))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s280.3) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002539@unknown@formal@none@1@S@One of these activities was found to be a novel, less abundant, Rb-E2F complex.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 62)\n  (:start . 54) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Rb-E2F") (:form . "Rb-E2F") (:end . 70)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s281.6) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002549@unknown@formal@none@1@S@In the present study, analysis of the interleukin-2 (IL-2) gene activation shows that naive human helper T cells (cord blood CD4+ T cells, adult CD4+CD45RO- T cells) regulate IL-2 transcription by a mechanism involving both a silencer and an activator acting on the purine-rich IL-2 promoter elements (NF-AT binding sites).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 51) (:start . 38) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 144)\n  (:start . 139) (:id . 70))\n ((:tag . "JJ") (:stem . "cd4+cd45ro-") (:form . "CD4+CD45RO-") (:end . 156)\n  (:start . 145) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 158) (:start . 157)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 174)\n  (:start . 166) (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 179) (:start . 175)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 196) (:start . 194)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 198) (:start . 197)\n  (:id . 79))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 208)\n  (:start . 199) (:id . 80))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 218)\n  (:start . 209) (:id . 81))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 223) (:start . 219)\n  (:id . 82))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 225) (:start . 224)\n  (:id . 83))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 234)\n  (:start . 226) (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 238) (:start . 235)\n  (:id . 85))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 241) (:start . 239)\n  (:id . 86))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 251)\n  (:start . 242) (:id . 87))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 258)\n  (:start . 252) (:id . 88))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 261) (:start . 259)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 265) (:start . 262)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 277)\n  (:start . 266) (:id . 91))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 282) (:start . 278)\n  (:id . 92))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 291)\n  (:start . 283) (:id . 93))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 300)\n  (:start . 292) (:id . 94))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 302) (:start . 301)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 307)\n  (:start . 302) (:id . 96))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 315)\n  (:start . 308) (:id . 97))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 321)\n  (:start . 316) (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 322) (:start . 321)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 323) (:start . 322)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s282.3) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002559@unknown@formal@none@1@S@Exons 2 to 8 of the androgen receptor gene were analyzed using a combination of single strand conformation polymorphism analysis and direct DNA sequencing.@(((:tag . "NNP") (:stem . "Exon") (:form . "Exons") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 47))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 28)\n  (:start . 20) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 106)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s283.5) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002569@unknown@formal@none@1@S@In the present studies we have examined the signaling pathways by which this monocyte-specific response is induced.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 94) (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s284.3) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002579@unknown@formal@none@1@S@This function has been attributed to the coordinated binding of subunits of NF-kappa B to distinct regions of the promoter elements of numerous genes, including cytokines, growth factor receptors, and adhesion molecules.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 195)\n  (:start . 186) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 219)\n  (:start . 210) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s285.3) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002589@unknown@formal@none@1@S@In this report, we show that upon the stimulation of both pathways T lymphocytes became refractory to activation via the CD3/T cell receptor ( TcR ) complex.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 49)\n  (:start . 38) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "refractory") (:form . "refractory") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD3/T") (:form . "CD3/T") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 156)\n  (:start . 149) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s286.3) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002599@unknown@formal@none@1@S@This event is also triggered under various other conditions of biomedical importance.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "biomedical") (:form . "biomedical") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s287.4) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002609@unknown@formal@none@1@S@Cotransfection of an hGATA-3 expression plasmid with a reporter plasmid whose transcription is directed by the HIV-1 LTR resulted in 6- to 10-fold stimulation of LTR-mediated transcription, whereas site specific mutation of these GATA sites resulted in virtual abrogation of the activation by hGATA-3.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "CD") (:stem . "6-") (:form . "6-") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ltr-mediated") (:form . "LTR-mediated") (:end . 174)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 188) (:start . 175) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 197)\n  (:start . 190) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 202) (:start . 198)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 211)\n  (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 220)\n  (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 229)\n  (:start . 224) (:id . 75))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 234) (:start . 230)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 240)\n  (:start . 235) (:id . 77))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 249)\n  (:start . 241) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "virtual") (:form . "virtual") (:end . 260)\n  (:start . 253) (:id . 80))\n ((:tag . "NN") (:stem . "abrogation") (:form . "abrogation") (:end . 271)\n  (:start . 261) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 274) (:start . 272)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 278) (:start . 275)\n  (:id . 83))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 289)\n  (:start . 279) (:id . 84))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 292) (:start . 290)\n  (:id . 85))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 300)\n  (:start . 293) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s288.5) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002619@unknown@formal@none@1@S@The results are discussed in the context of a model relating the two nuclear NF-AT complexes to NF-ATp.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "relate") (:form . "relating") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s289.7) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002629@unknown@formal@none@1@S@Infection with the human immunodeficiency virus (HIV) has been shown to induce production of several cytokines both in vitro and in vivo.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 41) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s291.3) (:did . :|93350203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002639@unknown@formal@none@1@S@Enhanced TR75 expression on OM-10.1 cells followed the same TNF-alpha-dose dependency as that observed for HIV-1 production.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tr75") (:form . "TR75") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "om-10.1") (:form . "OM-10.1") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "follow") (:form . "followed") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tnf-alpha-dose") (:form . "TNF-alpha-dose")\n  (:end . 74) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "dependency") (:form . "dependency") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s292.8) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002649@unknown@formal@none@1@S@Hence, Ca2+ binds to calmodulin, leading to the binding of calmodulin to calcineurin; the activated calcineurin, in turn, may dephosphorylate the cytoplasmic subunit of NF-AT, resulting in its translocation from the cytoplasm into the nucleus to form a competent transcriptional activator.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "calmodulin") (:form . "calmodulin") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "lead") (:form . 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5002659@unknown@formal@none@1@S@We demonstrated , by applying the electrophoretic mobility shift assay, slightly impaired AP-1 DNA binding activity in NCL lymphocytes and strong in DS ones.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "apply") (:form . "applying") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NCL") (:form . "NCL") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DS") (:form . "DS") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s294.6) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002669@unknown@formal@none@1@S@ACH-2 can be converted to productive infection by stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), mitogen or cytokines (TNF-alpha), or infection with HSV.@(((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "convert") (:form . "converted") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 116) (:start . 80)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HSV") (:form . "HSV") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s295.9) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002679@unknown@formal@none@1@S@Dissociation of NF kappa B from Ig kappa B by cytokine and LPS stimulation, and possibly activated T cells, may represent a common pathway to induction of the TF and other inflammatory genes.@(((:tag . "NNP") (:stem . "Dissociation") (:form . "Dissociation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 74)\n  (:start . 63) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 121)\n  (:start . 112) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 130)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 138)\n  (:start . 131) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 151)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 171)\n  (:start . 166) (:id . 74))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 184)\n  (:start . 172) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 190)\n  (:start . 185) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x296.7.1) (:span 108 111))\n  ((:id . :x296.7.2) (:span 80 88)))\n (:hscopes ((:id . :x296.7.1) (:span 108 190))\n  ((:id . :x296.7.2) (:span 80 106)))\n (:identifiers (:sid . :s296.7) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002689@unknown@formal@none@1@S@The aim of this study was to determine whether NF-kappa B is related to a particular cell type and/or differentiation step during immunopoiesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 84)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 117) (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "immunopoiesis") (:form . "immunopoiesis")\n  (:end . 143) (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x297.3.1) (:span 95 101)) ((:id . :x297.3.2) (:span 39 46)))\n (:hscopes ((:id . :x297.3.1) (:span 72 122))\n  ((:id . :x297.3.2) (:span 39 143)))\n (:identifiers (:sid . :s297.3) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002699@unknown@formal@none@1@S@c-Rel protein was detected only in the cytoplasm of lymphocytes and not in the nucleus and cytoplasm of FDC.@(((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x297.13.1) (:span 68 71)))\n (:nscopes ((:id . :x297.13.1) (:span 68 107)))\n (:identifiers (:sid . :s297.13) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002709@unknown@formal@none@1@S@In vitro transcription and translation of 15B-7 cDNA produced a fusion protein which bound specifically to the HTLV-I +195 to +240 oligonucleotide.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "15b-7") (:form . "15B-7") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 103)\n  (:start . 91) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "CD") (:stem . "+195") (:form . "+195") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "CD") (:stem . "+240") (:form . "+240") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 146) (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s298.8) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002719@unknown@formal@none@1@S@It was evaluated whether any of the variables might be used as a biomarker of effects for this class of compounds.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "variable") (:form . "variables") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "biomarker") (:form . "biomarker") (:end . 74)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 113)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x299.7.1) (:span 46 51)) ((:id . :x299.7.2) (:span 17 24)))\n (:hscopes ((:id . :x299.7.1) (:span 25 113))\n  ((:id . :x299.7.2) (:span 17 113)))\n (:identifiers (:sid . :s299.7) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002729@unknown@formal@none@1@S@The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphotoxin") (:form . "lymphotoxin") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-beta") (:form . "TNF-beta") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s300.2) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002739@unknown@formal@none@1@S@Transient pseudohypoaldosteronism in obstructive renal disease with transient reduction of lymphocytic aldosterone receptors.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "pseudohypoaldosteronism")\n  (:form . "pseudohypoaldosteronism") (:end . 33) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "obstructive") (:form . "obstructive") (:end . 48)\n  (:start . 37) (:id . 45))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 54) (:start . 49)\n  (:id . 46))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 62)\n  (:start . 55) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 77)\n  (:start . 68) (:id . 49))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 87)\n  (:start . 78) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 102)\n  (:start . 91) (:id . 52))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 114)\n  (:start . 103) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 124)\n  (:start . 115) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s301.1) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002749@unknown@formal@none@1@S@Since one of the few transcription factors which have been implicated in the regulation of monocyte genes is the macrophage- and B-cell-specific PU.1 transcription factor, we investigated whether PU.1 binds and activates the M-CSF receptor promoter.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "macrophage-") (:form . "macrophage-") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 144) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 163) (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 187)\n  (:start . 175) (:id . 69))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 195)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 200) (:start . 196)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 206)\n  (:start . 201) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 220)\n  (:start . 211) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 230)\n  (:start . 225) (:id . 76))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 239)\n  (:start . 231) (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 248)\n  (:start . 240) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x302.5.1) (:span 188 195)))\n (:hscopes ((:id . :x302.5.1) (:span 188 248)))\n (:identifiers (:sid . :s302.5) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002759@unknown@formal@none@1@S@A Western blot analysis was used to investigate HER-2/neu expression, whereas a chromium-release assay using the K562 cell line as target was used to measure natural killer (NK) cell activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chromium-release") (:form . "chromium-release")\n  (:end . 96) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 108) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 172)\n  (:start . 166) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 191)\n  (:start . 183) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s303.6) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002769@unknown@formal@none@1@S@Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes.@(((:tag . "JJ") (:stem . "rapid") (:form . "Rapid") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 133) (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s304.2) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002779@unknown@formal@none@1@S@Moreover, induction of tyrosine phosphorylation appears sufficient per se to initiate a complete activation programme.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "FW") (:stem . "per") (:form . "per") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "FW") (:stem . "se") (:form . "se") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "programme") (:form . "programme") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x304.12.1) (:span 48 55)))\n (:hscopes ((:id . :x304.12.1) (:span 10 117)))\n (:identifiers (:sid . :s304.12) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002789@unknown@formal@none@1@S@However, incubation with a combination of IL-2 and IL-4 sustained this abnormality.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "sustain") (:form . "sustained") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s305.10) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002799@unknown@formal@none@1@S@Selection against such mutations may be the result of functional redundancy of these myogenic transcription factors.@(((:tag . "NN") (:stem . "selection") (:form . "Selection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myogenic") (:form . "myogenic") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x306.6.1) (:span 33 36)))\n (:hscopes ((:id . :x306.6.1) (:span 33 115)))\n (:identifiers (:sid . :s306.6) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002809@unknown@formal@none@1@S@This treatment also caused increased tyrosine phosphorylation of specific protein substrates.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 61) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s307.10) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002819@unknown@formal@none@1@S@The restricted pattern of SCL protein synthesis is consistent with the restricted expression of SCL mRNA documented previously.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s308.7) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002829@unknown@formal@none@1@S@In vitro mutagenesis experiments demonstrated that both the Ets and AP-1 sites are required for binding of the inducible PB1 nuclear protein complex and for the transcriptional activity of this element and the GM-CSF promoter in activated T cells.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "pb1") (:form . "PB1") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 176) (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 185)\n  (:start . 177) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 216)\n  (:start . 210) (:id . 75))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 225)\n  (:start . 217) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 238)\n  (:start . 229) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 240) (:start . 239)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 246)\n  (:start . 241) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s309.9) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002839@unknown@formal@none@1@S@Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100-mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tax-induced") (:form . "Tax-induced") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 145) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 192)\n  (:start . 182) (:id . 71))\n ((:tag . "JJ") (:stem . "p100-mediated") (:form . "p100-mediated")\n  (:end . 206) (:start . 193) (:id . 72))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 218)\n  (:start . 207) (:id . 73))\n ((:tag . "NN") (:stem . "sequestration") (:form . "sequestration")\n  (:end . 232) (:start . 219) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 76))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 248)\n  (:start . 240) (:id . 77))\n ((:tag . "RB") (:stem . "nuclearly") (:form . "nuclearly") (:end . 258)\n  (:start . 249) (:id . 78))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 268)\n  (:start . 259) (:id . 79))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 272) (:start . 269)\n  (:id . 80))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 280)\n  (:start . 273) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s310.9) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002849@unknown@formal@none@1@S@1-(5-Isoquinolinyl sulfonyl)-2-methylpiperazine, an inhibitor of PKC, inhibited the anti-Ig inducibility of Zp.@(((:tag . "NNP") (:stem . "1-(5-Isoquinolinyl") (:form . "1-(5-Isoquinolinyl")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sulfonyl)-2-methylpiperazine")\n  (:form . "sulfonyl)-2-methylpiperazine") (:end . 47) (:start . 19)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 61)\n  (:start . 52) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 68) (:start . 65)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 104)\n  (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s311.8) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002859@unknown@formal@none@1@S@In FCS- liquid-suspension culture supplemented with saturating Ep level and low-dose IL-3/GM-CSF, adult HPC undergo unilineage erythropoietic differentiation:@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fcs-") (:form . "FCS-") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "liquid-suspension") (:form . "liquid-suspension")\n  (:end . 25) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBN") (:stem . "supplement") (:form . "supplemented") (:end . 46)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "saturate") (:form . "saturating") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "NNP") (:stem . "Ep") (:form . "Ep") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low-dose") (:form . "low-dose") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NNP") (:stem . "IL-3/GM-CSF") (:form . "IL-3/GM-CSF") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "unilineage") (:form . "unilineage") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "JJ") (:stem . "erythropoietic") (:form . "erythropoietic")\n  (:end . 141) (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 157) (:start . 142) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 158) (:start . 157)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s312.6) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002869@unknown@formal@none@1@S@However, anti-CD45 antibodies inhibit these effects in cells from infected individuals.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "anti-cd45") (:form . "anti-CD45") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s313.4) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002879@unknown@formal@none@1@S@Here, we investigated the accumulation of cyclic AMP (cAMP), the hydrolysis of inositol phosphates, protein kinase C (PKC) activity and the induction of Egr-1 and c-fos mRNA expression by sIgM- and sIgD-crosslinking to examine differences in the signals mediated through sIgM and sIgD in B104 cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 21)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hydrolysis") (:form . "hydrolysis") (:end . 75)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "NNS") (:stem . "phosphate") (:form . 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5002889@unknown@formal@none@1@S@It is believed that induction of cytokine expression by bacterial cell wall components plays a role in the development and course of sepsis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s315.3) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002899@unknown@formal@none@1@S@Human interferon regulatory factor 2 gene .@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s316.1) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002909@unknown@formal@none@1@S@Stimulation of neutrophils with granulocyte-colony stimulating factor (G-CSF) results in an enhanced respiratory burst, prolonged survival, and increased tumor cell killing.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "granulocyte-colony") (:form . "granulocyte-colony")\n  (:end . 50) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 62)\n  (:start . 51) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 69)\n  (:start . 63) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "prolong") (:form . "prolonged") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "killing") (:form . "killing") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s317.2) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002919@unknown@formal@none@1@S@Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs.@(((:tag . "NN") (:stem . "autoregulation") (:form . "Autoregulation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s318.1) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002929@unknown@formal@none@1@S@Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the FK-506- and CsA-sensitive enzyme required for TcR mediated activation of the IL-2 promoter.@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 40) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 60)\n  (:start . 49) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fk-506-") (:form . "FK-506-") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 94) (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 101)\n  (:start . 95) (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s319.4) (:did . :|94155850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002939@unknown@formal@none@1@S@Cytogenetic studies of the primate Y chromosomes have suggested that extensive rearrangements have occurred during evolution of the great apes.@(((:tag . "JJ") (:stem . "cytogenetic") (:form . "Cytogenetic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "primate") (:form . "primate") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 93) (:start . 79) (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "occur") (:form . "occurred") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 114)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "ape") (:form . "apes") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x321.2.1) (:span 54 63)))\n (:hscopes ((:id . :x321.2.1) (:span 54 142)))\n (:identifiers (:sid . :s321.2) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002949@unknown@formal@none@1@S@We show that PML/RAR alpha mRNA was still detectable despite clinical remission following ATRA treatment, but undetectable following consolidation with chemotherapy.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pml/rar") (:form . "PML/RAR") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "remission") (:form . "remission") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "consolidation") (:form . "consolidation")\n  (:end . 146) (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 164)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s322.5) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002959@unknown@formal@none@1@S@Studies of cell lines representing endocrine, fibroblast, and lymphoid lineages using polyclonal antisera to detect E2A proteins have suggested that significant E2A protein expression is restricted to B-lymphocytes.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "endocrine") (:form . "endocrine") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "antiserum") (:form . "antisera") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 197)\n  (:start . 187) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "b-lymphocyte") (:form . "B-lymphocytes")\n  (:end . 214) (:start . 201) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x324.4.1) (:span 134 143)))\n (:hscopes ((:id . :x324.4.1) (:span 134 214)))\n (:identifiers (:sid . :s324.4) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002969@unknown@formal@none@1@S@The MNDA mRNA level in primary granulocytes was unaffected by addition of interferon alpha and other agents including interferon gamma, endotoxin, poly(I).poly(C), and FMLP.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "CD") (:stem . "poly(I).poly(C)") (:form . "poly(I).poly(C)")\n  (:end . 162) (:start . 147) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "FMLP") (:form . "FMLP") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s325.6) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002979@unknown@formal@none@1@S@The expression of GM-CSF and IL-2 is inhibited by immunosuppressive drugs such as cyclosporin A (CsA) and FK506.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 67) (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s326.4) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002989@unknown@formal@none@1@S@Functional studies in extra-renal, nonepithelial cells such as smooth muscle cells and more recently circulating human lymphocytes have provided increasing evidence that aldosterone produces not only classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "extra-renal") (:form . "extra-renal") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nonepithelial") (:form . "nonepithelial")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "smooth") (:form . "smooth") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 181)\n  (:start . 170) (:id . 65))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 190)\n  (:start . 182) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 194) (:start . 191)\n  (:id . 67))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 199) (:start . 195)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 209)\n  (:start . 200) (:id . 69))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 217)\n  (:start . 210) (:id . 70))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 225)\n  (:start . 218) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 235) (:start . 231)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 241)\n  (:start . 236) (:id . 75))\n ((:tag . "JJ") (:stem . "non-genomic") (:form . "non-genomic") (:end . 253)\n  (:start . 242) (:id . 76))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 261)\n  (:start . 254) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 264) (:start . 262)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 278) (:start . 265) (:id . 79))\n ((:tag . "NN") (:stem . "electrolyte") (:form . "electrolyte") (:end . 290)\n  (:start . 279) (:id . 80))\n ((:tag . "NNS") (:stem . "movement") (:form . "movements") (:end . 300)\n  (:start . 291) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s327.2) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002999@unknown@formal@none@1@S@To determine the mechanism of glucocorticoid ( GC ) -mediated inhibition of T cell functions, the effect of dexamethasone (DM) on T cell proliferation and interleukin-2 receptor (IL-2R) generation were studied.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "-mediated") (:form . "-mediated") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 121) (:start . 108) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 150) (:start . 137) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 168) (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 184)\n  (:start . 179) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 196)\n  (:start . 186) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 209)\n  (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s328.2) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003009@unknown@formal@none@1@S@In sum, DM regulates T cell membrane expression of IL-2R by more than one molecular mechanism.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sum") (:form . "sum") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 20)\n  (:start . 11) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s328.12) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003019@unknown@formal@none@1@S@The intracellular events that lead to the inactivation of I kappa B, i.e. the activation of NF-kappa B, are complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s329.10) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003029@unknown@formal@none@1@S@Dezube, suggest that use of this agent in combination with antiretroviral compounds may prove useful in the treatment of patients with HIV-1 infection.@(((:tag . "NNP") (:stem . "Dezube") (:form . "Dezube") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antiretroviral") (:form . "antiretroviral")\n  (:end . 73) (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x330.7.1) (:span 84 87)) ((:id . :x330.7.2) (:span 8 15)))\n (:hscopes ((:id . :x330.7.1) (:span 84 150))\n  ((:id . :x330.7.2) (:span 8 150)))\n (:identifiers (:sid . :s330.7) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003039@unknown@formal@none@1@S@Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "prolactin-responsive")\n  (:form . "prolactin-responsive") (:end . 29) (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 38)\n  (:start . 30) (:id . 44))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 46)\n  (:start . 39) (:id . 45))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 49) (:start . 47)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s332.1) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003049@unknown@formal@none@1@S@elements in the first 0.2 kb of the IRF-1 promoter region act during early activation, and elements between 0.2 and 1.7 kb act in concert with the proximal 0.2-kb region during S phase progression.@(((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1.7") (:form . "1.7") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 137)\n  (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 155)\n  (:start . 147) (:id . 70))\n ((:tag . "JJ") (:stem . "0.2-kb") (:form . "0.2-kb") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 169)\n  (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 176)\n  (:start . 170) (:id . 73))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 178) (:start . 177)\n  (:id . 74))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 184)\n  (:start . 179) (:id . 75))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 196)\n  (:start . 185) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s332.11) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003059@unknown@formal@none@1@S@Irrespective of the human cell partner used for fusion, a certain number of hybrids lost CD5 surface expression over a period of time in culture.@(((:tag . "JJ") (:stem . "irrespective") (:form . "Irrespective") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "VBD") (:stem . "lose") (:form . "lost") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 144)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s334.4) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003069@unknown@formal@none@1@S@Biomarkers included DNA ploidy, estrogen receptor (ER), and epidermal growth factor receptor (EGFR).@(((:tag . "NNPS") (:stem . "Biomarker") (:form . "Biomarkers") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ploidy") (:form . "ploidy") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "epidermal") (:form . "epidermal") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EGFR") (:form . "EGFR") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s335.7) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003079@unknown@formal@none@1@S@The results showed that the average number of GCR in asthmatics was significantly lower than that in healthy subjects (P < 0.01), and there was a linear correlation between the number of GCR and the course of asthma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 139)\n  (:start . 134) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 152)\n  (:start . 146) (:id . 71))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 164)\n  (:start . 153) (:id . 72))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 172)\n  (:start . 165) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 183)\n  (:start . 177) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 79))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 205)\n  (:start . 199) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 81))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 215)\n  (:start . 209) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s336.4) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003089@unknown@formal@none@1@S@These extrathymic T-cell populations include cells expressing elevated levels of V beta T-cell receptors that are normally deleted in thymic development.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "extrathymic") (:form . "extrathymic") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 77)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s337.6) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003099@unknown@formal@none@1@S@However, simultaneous incubation of RU 486 with dexamethasone caused a distinct interference of RU 486 with dexamethasone.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 92)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s338.10) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003109@unknown@formal@none@1@S@Alternative mechanisms include the possibility that NF-ATc operates on some cytoplasmic anchor or that other proteins that are controlled by calcineurin carry out the nuclear import of NF-ATc.@(((:tag . "JJ") (:stem . "alternative") (:form . "Alternative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 58)\n  (:start . 52) (:id . 48))\n ((:tag . "VBZ") (:stem . "operate") (:form . "operates") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "anchor") (:form . "anchor") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "VBP") (:stem . "carry") (:form . "carry") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 174)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 181)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 191)\n  (:start . 185) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x339.9.1) (:span 95 97)) ((:id . :x339.9.2) (:span 35 46)))\n (:hscopes ((:id . :x339.9.1) (:span 47 191))\n  ((:id . :x339.9.2) (:span 35 191)))\n (:identifiers (:sid . :s339.9) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003119@unknown@formal@none@1@S@The dissociation constant (Kd) and maximum binding capacity (MBC) of the NT3R values were log transformed to minimize between-subject variability.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MBC") (:form . "MBC") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NT3R") (:form . "NT3R") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 84)\n  (:start . 78) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "log") (:form . "log") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 105)\n  (:start . 94) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "VB") (:stem . "minimize") (:form . "minimize") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "JJ") (:stem . "between-subject") (:form . "between-subject")\n  (:end . 133) (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "variability") (:form . "variability") (:end . 145)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s340.8) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003129@unknown@formal@none@1@S@In addition to contributing to the understanding of DLCL pathogenesis, the identification of BCL-6 lesions may have relevant clinical implications.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "contribute") (:form . "contributing") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DLCL") (:form . "DLCL") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 146)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x341.5.1) (:span 107 110)))\n (:hscopes ((:id . :x341.5.1) (:span 107 146)))\n (:identifiers (:sid . :s341.5) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003139@unknown@formal@none@1@S@These findings, therefore, could have clinical significance to AIDS patients with malignancies who are undergoing radiotherapy and chemotherapy.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "radiotherapy") (:form . "radiotherapy") (:end . 126)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 143)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x342.6.1) (:span 27 32)))\n (:hscopes ((:id . :x342.6.1) (:span 27 143)))\n (:identifiers (:sid . :s342.6) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003149@unknown@formal@none@1@S@Both IL-4 and IL-10 were seen to inhibit IL-6 production and the expression of IL-6 mRNA in both monocytic cell lines studied.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s344.4) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003159@unknown@formal@none@1@S@IL-13 caused rapid phosphorylation of the three out of four members of the known Janus family of kinases (JAKs).@(((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 34) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "JAK") (:form . "JAKs") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s345.5) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003169@unknown@formal@none@1@S@Deactivation of mononuclear phagocytes is critical to limit the inflammatory response but can be detrimental in the face of progressive infection.@(((:tag . "NNP") (:stem . "Deactivation") (:form . "Deactivation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "VB") (:stem . "limit") (:form . "limit") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "detrimental") (:form . "detrimental") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "face") (:form . "face") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "progressive") (:form . "progressive") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x346.2.1) (:span 90 93)))\n (:hscopes ((:id . :x346.2.1) (:span 90 145)))\n (:identifiers (:sid . :s346.2) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003179@unknown@formal@none@1@S@Inhibition by IL-10 of proinflammatory cytokine release appears to occur at the level of gene transcription for TNF-alpha and both transcriptionally and posttranscriptionally for IL-1beta.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 148) (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "RB") (:stem . "posttranscriptionally")\n  (:form . "posttranscriptionally") (:end . 174) (:start . 153) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 178) (:start . 175)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 187)\n  (:start . 179) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x346.12.1) (:span 56 63)))\n (:hscopes ((:id . :x346.12.1) (:span 0 187)))\n (:identifiers (:sid . :s346.12) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003189@unknown@formal@none@1@S@Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT.@(((:tag . "JJ") (:stem . "age-related") (:form . "Age-related") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 124) (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s348.1) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003199@unknown@formal@none@1@S@Transcription factors of T and B lymphocytes--basic research and clinical perspectives for gastroenterology.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphocytes–basic") (:form . "lymphocytes–basic")\n  (:end . 51) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "perspective") (:form . "perspectives") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gastroenterology") (:form . "gastroenterology")\n  (:end . 107) (:start . 91) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s349.1) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003209@unknown@formal@none@1@S@In this work, we show that human peripheral blood T cells that are stimulated through the TCR and expanded with IL-2 are unresponsive to IFN-gamma, as determined by a lack of activation of jak kinases and the transcription factor, STAT1(alpha), a signal transducer and activator of transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . 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5003219@unknown@formal@none@1@S@When expressed in Jurkat T cells, recombinant NFAT1 is regulated, as expected, by the calmodulin-dependent phosphatase calcineurin, and its function is inhibited by the immunosuppressive agent cyclosporin A (CsA).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 45)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "calmodulin-dependent")\n  (:form . "calmodulin-dependent") (:end . 106) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 161)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 186) (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 204)\n  (:start . 193) (:id . 72))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 211) (:start . 208)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s351.4) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003229@unknown@formal@none@1@S@the induced p53 was transcriptionally active.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 37) (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s352.4) (:did . :|96256807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003239@unknown@formal@none@1@S@However, supershift analyses using the c-fos promoter sis-inducible element probe showed that IL-12 activated STAT4, STAT1 alpha, and STAT3, and induced complexes containing STAT4 only, STAT4 with STAT1 alpha, STAT3 with STAT1 alpha, or STAT1 alpha only in preactivated primary NK cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . 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5003249@unknown@formal@none@1@S@However, PHA/PMA but not oxidative signals induced the coordinate activation of reporter constructs containing the AP-1-TRE, NF-AT, and IL-2 promoter regions along with IL-2 mRNA expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "PHA/PMA") (:form . "PHA/PMA") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AP-1-TRE") (:form . "AP-1-TRE") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 189)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x354.7.1) (:span 21 24)))\n (:nscopes ((:id . :x354.7.1) (:span 21 42)))\n (:identifiers (:sid . :s354.7) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003259@unknown@formal@none@1@S@4 ± 1 U/mL in the AIDS-C group and 2 ± 0.5 U/mL in the C group; P < 0.01).@(((:tag . "CD") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 5) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u/ml") (:form . "U/mL") (:end . 10) (:start . 6)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AIDS-C") (:form . "AIDS-C") (:end . 24)\n  (:start . 18) (:id . 48))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 30) (:start . 25)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 36) (:start . 35)\n  (:id . 51))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 38) (:start . 37)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 42) (:start . 39)\n  (:id . 53))\n ((:tag . "NN") (:stem . "u/ml") (:form . "U/mL") (:end . 47) (:start . 43)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 56) (:start . 55)\n  (:id . 57))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 62) (:start . 57)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 63) (:start . 62)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 65) (:start . 64)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 67) (:start . 66)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 72) (:start . 68)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s355.7) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003269@unknown@formal@none@1@S@Activity of the CBF site is shown to be critically dependent on the adjacent activator site Act-1.@(((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 50)\n  (:start . 40) (:id . 51))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "act-1") (:form . "Act-1") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s356.5) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003279@unknown@formal@none@1@S@We have isolated TFIIH from cells derived from a patient (XP11BE) who carries this frameshift mutation (TFIIHmut) and from the mother of this patient (TFIIHwt) to determine the biochemical consequences of the mutation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "tfiih") (:form . "TFIIH") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "XP11BE") (:form . "XP11BE") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "carry") (:form . "carries") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "frameshift") (:form . "frameshift") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TFIIHmut") (:form . "TFIIHmut") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mother") (:form . "mother") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 149)\n  (:start . 142) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TFIIHwt") (:form . "TFIIHwt") (:end . 158)\n  (:start . 151) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 73))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 172)\n  (:start . 163) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 188)\n  (:start . 177) (:id . 76))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 201)\n  (:start . 189) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 79))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 217)\n  (:start . 209) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s357.4) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003289@unknown@formal@none@1@S@The activity was tested by quantitating the nuclear proteins binding to an oligonucleotide containing the consensus kappa B binding sequence (electrophoretic mobility shift assay).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 23) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "quantitate") (:form . "quantitating") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 90) (:start . 75) (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 157) (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 178)\n  (:start . 173) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s358.4) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003299@unknown@formal@none@1@S@The SH3 domains of Grb2 form a stable complex with SOS1 and two proteins of 75 kD and 120 kD, which undergo tyrosine phosphorylation in Fc gamma RIIA stimulated cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sh3") (:form . "SH3") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SOS1") (:form . "SOS1") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 89) (:start . 86)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 107)\n  (:start . 100) (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 116)\n  (:start . 108) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 132) (:start . 117) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 138) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 144)\n  (:start . 139) (:id . 69))\n ((:tag . "NNP") (:stem . "RIIA") (:form . "RIIA") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "stimulated") (:form . "stimulated") (:end . 160)\n  (:start . 150) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s359.6) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003309@unknown@formal@none@1@S@We show that ATRA directly activates IRF-1 gene expression, followed by activation of IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression with slower kinetics.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "2'-5") (:form . "2'-5") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oligoadenylate") (:form . "oligoadenylate")\n  (:end . 116) (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "synthetase") (:form . "synthetase") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "OAS") (:form . "OAS") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "slow") (:form . "slower") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s360.7) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003319@unknown@formal@none@1@S@In HeLa nonpituitary cells, c-Jun alone activated the rPRL promoter via the most proximal GHF-1/Pit-1 binding site, footprint I, and synergized with GHF-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nonpituitary") (:form . "nonpituitary") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rprl") (:form . "rPRL") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "ghf-1/pit-1") (:form . "GHF-1/Pit-1") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "synergize") (:form . "synergized") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ghf-1") (:form . "GHF-1") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s361.6) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003329@unknown@formal@none@1@S@Constitutive expression of specific interferon isotypes in peripheral blood leukocytes from normal individuals and in promonocytic U937 cells.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "isotype") (:form . "isotypes") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 86)\n  (:start . 76) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 98)\n  (:start . 92) (:id . 53))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 110)\n  (:start . 99) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 130)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 135) (:start . 131)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s363.1) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003339@unknown@formal@none@1@S@The activity of the NH2-terminal transactivation domain is modulated by an adjacent regulatory region that contains several conserved sequence motifs represented only in the NFAT family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 149)\n  (:start . 143) (:id . 61))\n ((:tag . "VBD") (:stem . "represent") (:form . "represented") (:end . 161)\n  (:start . 150) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 185)\n  (:start . 179) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s364.5) (:did . :|96305196|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003349@unknown@formal@none@1@S@In situ hybridization and Northern blot analysis suggest that Spi-B gene expression increases during B cell maturation and decreases during T cell maturation.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 139)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x365.9.1) (:span 49 56)))\n (:hscopes ((:id . :x365.9.1) (:span 49 157)))\n (:identifiers (:sid . :s365.9) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003359@unknown@formal@none@1@S@Circular permutation and phasing analyses demonstrated that PU.1 binding but not TFE3 or Ets-1 bends mu enhancer DNA toward the major groove.@(((:tag . "JJ") (:stem . "circular") (:form . "Circular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "permutation") (:form . "permutation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phasing") (:form . "phasing") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tfe3") (:form . "TFE3") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bend") (:form . "bends") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "groove") (:form . "groove") (:end . 140)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x366.7.1) (:span 77 80)))\n (:nscopes ((:id . :x366.7.1) (:span 77 94)))\n (:identifiers (:sid . :s366.7) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003369@unknown@formal@none@1@S@The E2A-HLF (for hepatic leukaemia factor) fusion gene, formed by action of the t(17;19) (q22;p13) chromosomal translocation, drives the leukaemic transformation of early B-cell precursors, but the mechanism of this activity remains unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 62) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "t(17;19)") (:form . "t(17;19)") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "CD") (:stem . "q22;p13") (:form . "q22;p13") (:end . 97)\n  (:start . 90) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 110)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 124) (:start . 111) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "drive") (:form . "drives") (:end . 132)\n  (:start . 126) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "leukaemic") (:form . "leukaemic") (:end . 146)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 161) (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 177)\n  (:start . 171) (:id . 71))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 188)\n  (:start . 178) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 207)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 77))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 215) (:start . 211)\n  (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 224)\n  (:start . 216) (:id . 79))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 232)\n  (:start . 225) (:id . 80))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 240)\n  (:start . 233) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s368.2) (:did . :|96320558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003379@unknown@formal@none@1@S@The inhibiting effect of IL-4 was slightly more pronounced than that of IL-10.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s369.7) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003389@unknown@formal@none@1@S@Activation of T cells results in a cascade of gene activation and subsequent proliferation and differentiation into effector phenotypes.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 90) (:start . 77) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s370.2) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003399@unknown@formal@none@1@S@Upon infection, Wp is initially active, followed by a switch to Cp for the duration of latency.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "initially") (:form . "initially") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cp") (:form . "Cp") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 83)\n  (:start . 75) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 94)\n  (:start . 87) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s371.3) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003409@unknown@formal@none@1@S@Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 39) (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "protein-mediated") (:form . "protein-mediated")\n  (:end . 56) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 77)\n  (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s372.1) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003419@unknown@formal@none@1@S@Moreover, ectopic Id1 repressed E(gre)-directed but not EA/S-directed MLV transcription in lymphoid cell lines.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "id1") (:form . "Id1") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "repress") (:form . "repressed") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "E(gre)-directed") (:form . "E(gre)-directed")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ea/s-directed") (:form . "EA/S-directed")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x372.11.1) (:span 52 55)))\n (:nscopes ((:id . :x372.11.1) (:span 52 87)))\n (:identifiers (:sid . :s372.11) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003429@unknown@formal@none@1@S@Constitutively active MAPKK-1 fully activates ERK-2 and the transcription factor Elk-1, but does not substitute for activated p21ras and synergize with calcium/calcineurin signals to induce NFAT.@(((:tag . "RB") (:stem . "constitutively") (:form . "Constitutively")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 21)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "mapkk-1") (:form . "MAPKK-1") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "erk-2") (:form . "ERK-2") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "calcium/calcineurin")\n  (:form . "calcium/calcineurin") (:end . 171) (:start . 152) (:id . 64))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 179)\n  (:start . 172) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 66))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 189)\n  (:start . 183) (:id . 67))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 194) (:start . 190)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x374.5.1) (:span 97 100)))\n (:nscopes ((:id . :x374.5.1) (:span 97 194)))\n (:identifiers (:sid . :s374.5) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003439@unknown@formal@none@1@S@Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 63) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 72)\n  (:start . 64) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 79)\n  (:start . 73) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 106)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 141) (:start . 128) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 152)\n  (:start . 146) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 62))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 165)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 173)\n  (:start . 166) (:id . 64))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 195)\n  (:start . 183) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 68))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 210)\n  (:start . 203) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 222)\n  (:start . 214) (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 229)\n  (:start . 223) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 238)\n  (:start . 230) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 242) (:start . 239)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 249)\n  (:start . 243) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 264)\n  (:start . 253) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 278) (:start . 265) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x375.4.1) (:span 166 173)))\n (:ncues ((:id . :x375.4.2) (:span 94 97)))\n (:hscopes ((:id . :x375.4.1) (:span 166 278)))\n (:nscopes ((:id . :x375.4.2) (:span 37 141)))\n (:identifiers (:sid . :s375.4) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003449@unknown@formal@none@1@S@To define the activation of the STAT5 homologues and lower molecular weight variant in human monocytes and monocytes differentiated into macrophages by culture in macrophage-CSF (M-CSF), we measured the GM-CSF induced tyrosine phosphorylation of STAT5A, STAT5B, and any lower molecular weight STAT5 isoforms.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "homologue") (:form . "homologues") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 131) (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 148)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "macrophage-CSF") (:form . "macrophage-CSF")\n  (:end . 177) (:start . 163) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 184)\n  (:start . 179) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 209)\n  (:start . 203) (:id . 74))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 217)\n  (:start . 210) (:id . 75))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 226)\n  (:start . 218) (:id . 76))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 242) (:start . 227) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 252)\n  (:start . 246) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 253) (:start . 252)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 260)\n  (:start . 254) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 265) (:start . 262)\n  (:id . 83))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 269) (:start . 266)\n  (:id . 84))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 275) (:start . 270)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 285)\n  (:start . 276) (:id . 86))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 292)\n  (:start . 286) (:id . 87))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 298)\n  (:start . 293) (:id . 88))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 307)\n  (:start . 299) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 308) (:start . 307)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s376.4) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003459@unknown@formal@none@1@S@The present study describes the cloning of a lymphoid-restricted gene, LYSP100, that is homologous to another protein that localizes to PML NBs, SP100.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoid-restricted")\n  (:form . "lymphoid-restricted") (:end . 64) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NB") (:form . "NBs") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "SP100") (:form . "SP100") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s377.4) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003469@unknown@formal@none@1@S@Abnormalities of p16, p15 and CDK4 genes in recurrent malignant astrocytomas.@(((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cdk4") (:form . "CDK4") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "astrocytoma") (:form . "astrocytomas") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s378.1) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003479@unknown@formal@none@1@S@The extent to which peptides containing chemically and post-translationally modified amino acid side chains are recognized by primed CTL has not been clearly defined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "RB") (:stem . "chemically") (:form . "chemically") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "post-translationally")\n  (:form . "post-translationally") (:end . 75) (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x379.3.1) (:span 141 144)))\n (:nscopes ((:id . :x379.3.1) (:span 0 165)))\n (:identifiers (:sid . :s379.3) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003489@unknown@formal@none@1@S@NGFI-B/nur77 and its related genes constitute a family and the NGFI-B/nur77 family consists of three subtypes, named nur77 alpha, nur77 beta, nur77 gamma.@(((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ngfi-b/nur77") (:form . "NGFI-B/nur77") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "subtype") (:form . "subtypes") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s380.3) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003499@unknown@formal@none@1@S@First, Tax was found to interact with the 35-kDa (alpha) subunit of TFIIA in the yeast two-hybrid interaction system.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "35-kda") (:form . "35-kDa") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 64)\n  (:start . 57) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 86) (:start . 81)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 97)\n  (:start . 87) (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 109)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s381.6) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003509@unknown@formal@none@1@S@We now report that vaccination with a CTL epitope derived from the human adenovirus type 5 E1A-region (Ad5E1A234-243), which can serve as a target for tumor-eradicating CTL, enhances rather than inhibits the growth of Ad5E1A-expressing tumors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vaccination") (:form . "vaccination") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "e1a-region") (:form . "E1A-region") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ad5E1A234-243") (:form . "Ad5E1A234-243")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 146)\n  (:start . 140) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "tumor-eradicating") (:form . "tumor-eradicating")\n  (:end . 168) (:start . 151) (:id . 70))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 203)\n  (:start . 195) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 77))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 214)\n  (:start . 208) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "ad5e1a-expressing") (:form . "Ad5E1A-expressing")\n  (:end . 235) (:start . 218) (:id . 80))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 242)\n  (:start . 236) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x382.3.1) (:span 183 194)))\n (:nscopes ((:id . :x382.3.1) (:span 183 203)))\n (:identifiers (:sid . :s382.3) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003519@unknown@formal@none@1@S@To evaluate the PML/RARalpha role in myelopoiesis, transgenic mice expressing PML/RARalpha were engineered.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 90)\n  (:start . 78) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "engineer") (:form . "engineered") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s383.5) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003529@unknown@formal@none@1@S@Lethality was associated with more severe leukopenia in transgenic versus control mice.@(((:tag . "NNP") (:stem . "Lethality") (:form . "Lethality") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "leukopenia") (:form . "leukopenia") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s383.15) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003539@unknown@formal@none@1@S@The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 127)\n  (:start . 118) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 143)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s385.2) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003549@unknown@formal@none@1@S@To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 167) (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 177) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 204) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 209) (:start . 205)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s386.4) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003559@unknown@formal@none@1@S@A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopeptide-induced immune cell signaling events.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "principal") (:form . "principal") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "objective") (:form . "objective") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "precisely") (:form . "precisely") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "divergence") (:form . "divergences") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 127) (:start . 109) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "LPS)-") (:form . "LPS)-") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lipoprotein-lipopeptide-induced")\n  (:form . "lipoprotein-lipopeptide-induced") (:end . 170) (:start . 139)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 177)\n  (:start . 171) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 192)\n  (:start . 183) (:id . 65))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 199)\n  (:start . 193) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s387.3) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003569@unknown@formal@none@1@S@A direct temporal correlation exists between HIV infection and the appearance of NF-kappaB DNA-binding activity in myelomonoblastic PLB-985 cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "myelomonoblastic") (:form . "myelomonoblastic")\n  (:end . 131) (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "plb-985") (:form . "PLB-985") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s388.3) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003579@unknown@formal@none@1@S@Although case-oriented evidence for an association of Epstein-Barr virus (EBV) with gastric carcinoma has been accumulating recently, the interaction ( s ) between EBV and gastric epithelial cells is/are largely unknown.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "case-oriented") (:form . "case-oriented")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 66)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "gastric") (:form . "gastric") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "accumulate") (:form . "accumulating") (:end . 123)\n  (:start . 111) (:id . 59))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 149)\n  (:start . 138) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "gastric") (:form . "gastric") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 190)\n  (:start . 180) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 72))\n ((:tag . "VBP") (:stem . "is/are") (:form . "is/are") (:end . 203)\n  (:start . 197) (:id . 73))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 211)\n  (:start . 204) (:id . 74))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 219)\n  (:start . 212) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s389.2) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003589@unknown@formal@none@1@S@Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B.@(((:tag . "JJ") (:stem . "sequence-specific") (:form . "Sequence-specific")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 21) (:start . 18)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 52) (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 64)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s390.1) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003599@unknown@formal@none@1@S@Recently, the egr-1 promoter has been shown to be highly responsive to the diverse biochemical signals generated by antigen and cytokines in cells of the immune system.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s391.5) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003609@unknown@formal@none@1@S@Cosmid probe of BCL6 hybridized to 14q11 and 3q27 by fluorescence in situ hybridization (FISH).@(((:tag . "NN") (:stem . "cosmid") (:form . "Cosmid") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "hybridize") (:form . "hybridized") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "14q11") (:form . "14q11") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "3q27") (:form . "3q27") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 87) (:start . 74) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "fish") (:form . "FISH") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s392.7) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003619@unknown@formal@none@1@S@Thus, select genetic aberrations in the apoptotic pathway reveal a cell autonomous coregulation of activation.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "select") (:form . "select") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "aberration") (:form . "aberrations") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "coregulation") (:form . "coregulation") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s393.8) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003629@unknown@formal@none@1@S@CsA and FK506 associate with intracellular binding proteins (i.e., CsA with cyclophilin A and FK506 with FKBP12) to form protein/drug complexes that suppress the immune system by preventing activation of T cells in response to antigen presentation.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fkbp12") (:form . "FKBP12") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein/drug") (:form . "protein/drug") (:end . 133)\n  (:start . 121) (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 143)\n  (:start . 134) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 168)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 175)\n  (:start . 169) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 189)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 200)\n  (:start . 190) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 211)\n  (:start . 206) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 223)\n  (:start . 215) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 79))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 234)\n  (:start . 227) (:id . 80))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 247)\n  (:start . 235) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s395.3) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003639@unknown@formal@none@1@S@Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, is a human herpesvirus associated with epithelial cell malignancies (nasopharyngeal carcinoma) as well as B-cell malignancies.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "causative") (:form . "causative") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "mononucleosis") (:form . "mononucleosis")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 142)\n  (:start . 130) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nasopharyngeal") (:form . "nasopharyngeal")\n  (:end . 158) (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 168)\n  (:start . 159) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 200)\n  (:start . 188) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s397.2) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003649@unknown@formal@none@1@S@In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases:@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "spite") (:form . "spite") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL13") (:form . "IL13") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 99) (:start . 98)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s398.4) (:did . :|96397528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003659@unknown@formal@none@1@S@This construct was only slightly reduced (1.3-fold) in its expression when stimulated under anergic conditions, while a whole mouse IL-2 enhancer construct showed a reduction of 4.3-fold.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "RB") (:stem . "1.3-fold") (:form . "1.3-fold") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 162)\n  (:start . 156) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 174)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "RB") (:stem . "4.3-fold") (:form . "4.3-fold") (:end . 186)\n  (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s400.4) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003669@unknown@formal@none@1@S@In addition, DNA methylation was revealed as one of the possible factors in establishing MNDA expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "establish") (:form . "establishing") (:end . 88)\n  (:start . 76) (:id . 56))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x401.6.1) (:span 56 64)))\n (:hscopes ((:id . :x401.6.1) (:span 56 104)))\n (:identifiers (:sid . :s401.6) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003679@unknown@formal@none@1@S@Stepwise deletions into the proximal promoter also revealed that the CBF site, but not the YY-1 site, was required for efficient induction of transcriptional activation.@(((:tag . "JJ") (:stem . "stepwise") (:form . "Stepwise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "yy-1") (:form . "YY-1") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 157) (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 168)\n  (:start . 158) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x402.8.1) (:span 83 86)))\n (:nscopes ((:id . :x402.8.1) (:span 83 100)))\n (:identifiers (:sid . :s402.8) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003689@unknown@formal@none@1@S@Tyloxapol also reduces the viscosity of CF sputum (from 463 ± 133 to 128 ± 52 centipoise).@(((:tag . "NNP") (:stem . "Tyloxapol") (:form . "Tyloxapol") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "viscosity") (:form . "viscosity") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CF") (:form . "CF") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sputum") (:form . "sputum") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "CD") (:stem . "463") (:form . "463") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "CD") (:stem . "128") (:form . "128") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "centipoise") (:form . "centipoise") (:end . 88)\n  (:start . 78) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s403.7) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003699@unknown@formal@none@1@S@Moreover, defective DNA binding was corrected by treatment with acid phosphatase.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "correct") (:form . "corrected") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s404.9) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003709@unknown@formal@none@1@S@Our results strongly suggest that this NF-AT/DNA binding defect is responsible for the multiple cytokine deficiency and the SCID phenotype observed in the two infant brothers.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-AT/DNA") (:form . "NF-AT/DNA") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 138)\n  (:start . 129) (:id . 61))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "infant") (:form . "infant") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "brother") (:form . "brothers") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x405.10.1) (:span 21 28)))\n (:hscopes ((:id . :x405.10.1) (:span 21 174)))\n (:identifiers (:sid . :s405.10) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003719@unknown@formal@none@1@S@The human tumor necrosis factor alpha (TNF-alpha) gene is one of the earliest genes transcribed after the stimulation of a B cell through its antigen receptor or via the CD-40 pathway.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 95)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 158)\n  (:start . 150) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cd-40") (:form . "CD-40") (:end . 175)\n  (:start . 170) (:id . 73))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 183)\n  (:start . 176) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s407.2) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003729@unknown@formal@none@1@S@Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s408.1) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003739@unknown@formal@none@1@S@The two mutations R217A and R294A caused an increased binding efficiency for antagonists but no change in agonist binding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "R217A") (:form . "R217A") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "R294A") (:form . "R294A") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x408.11.1) (:span 93 95)))\n (:nscopes ((:id . :x408.11.1) (:span 93 121)))\n (:identifiers (:sid . :s408.11) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003749@unknown@formal@none@1@S@Along with our previous demonstration of both physical interactions between PTF gamma/PTF delta and TBP and the involvement of TFIIIB90 in the transcription of class III snRNA genes, these results are consistent with the notion that a TBP-containing complex related to TFIIIB is required for the transcription of class III snRNA genes, and acts through weak interaction with the four-subunit PTF.@(((:tag . "IN") (:stem . "along") (:form . "Along") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . 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"acts") (:end . 344) (:start . 340)\n  (:id . 97))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 352)\n  (:start . 345) (:id . 98))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 357) (:start . 353)\n  (:id . 99))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 369)\n  (:start . 358) (:id . 100))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 374) (:start . 370)\n  (:id . 101))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 378) (:start . 375)\n  (:id . 102))\n ((:tag . "JJ") (:stem . "four-subunit") (:form . "four-subunit") (:end . 391)\n  (:start . 379) (:id . 103))\n ((:tag . "NN") (:stem . "ptf") (:form . "PTF") (:end . 395) (:start . 392)\n  (:id . 104))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 396) (:start . 395)\n  (:id . 105)))@@@1@64@((:identifiers (:sid . :s409.8) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003759@unknown@formal@none@1@S@Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bal-17") (:form . "BAL-17") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "anti-immunoglobulin")\n  (:form . "anti-immunoglobulin") (:end . 74) (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 100)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s410.10) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003769@unknown@formal@none@1@S@Abnormalities of retinoblastoma protein (pRB) and mutations of RB gene have been reported in up to 70% of MM patients and 80 % of MM-derived cell lines.@(((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 31) (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "pRB") (:form . "pRB") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RB") (:form . "RB") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 117)\n  (:start . 109) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 126) (:start . 125)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mm-derived") (:form . "MM-derived") (:end . 140)\n  (:start . 130) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 151)\n  (:start . 146) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s411.3) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003779@unknown@formal@none@1@S@AP-1 has been shown to behave as a redox-sensitive transcription factor that can be activated by both oxidant and antioxidant stimuli.@(((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "behave") (:form . "behave") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "redox-sensitive") (:form . "redox-sensitive")\n  (:end . 50) (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s412.2) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003789@unknown@formal@none@1@S@Cytomegalovirus modulates interleukin-6 gene expression.@(((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 39) (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s413.1) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003799@unknown@formal@none@1@S@Retinoic acid ( RA ) -induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implicated in myeloid development.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "-induced") (:form . "-induced") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 140)\n  (:start . 129) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s414.2) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003809@unknown@formal@none@1@S@The association of 20q deletions with myeloid " stem cell " disorders suggests that the deletions mark the site of one or more genes, loss or inactivation of which plays a role in the regulation of normal hematopoietic progenitors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "20q") (:form . "20q") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "VBP") (:stem . "mark") (:form . "mark") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 138) (:start . 134)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 154)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 169)\n  (:start . 164) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 176) (:start . 172)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 76))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 194)\n  (:start . 184) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 204)\n  (:start . 198) (:id . 79))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 218) (:start . 205) (:id . 80))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 230)\n  (:start . 219) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x415.3.2) (:span 139 141))\n  ((:id . :x415.3.3) (:span 119 121)) ((:id . :x415.3.4) (:span 70 78)))\n (:ncues ((:id . :x415.3.1) (:span 134 138)))\n (:hscopes ((:id . :x415.3.2) (:span 134 138))\n  ((:id . :x415.3.3) (:span 115 126)) ((:id . :x415.3.4) (:span 70 230)))\n (:nscopes ((:id . :x415.3.1) (:span 134 163)))\n (:identifiers (:sid . :s415.3) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003819@unknown@formal@none@1@S@Therefore, the human androgen receptor assay (HUMARA) was used to determine granulocyte clonality.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HUMARA") (:form . "HUMARA") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "clonality") (:form . "clonality") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s415.13) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003829@unknown@formal@none@1@S@Analysis of GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus revealed that even low level expression of these receptors resulted in both enhanced steroid sensitivity and MMTV induction, thus supporting a role for transactivation in apoptosis.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5003839@unknown@formal@none@1@S@More importantly, C-JUN AS oligonucleotides showed distinct effects on two markers of PMA-induced differentiation;@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "importantly") (:form . "importantly") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C-JUN") (:form . "C-JUN") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 43) (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 50) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 113) (:start . 98) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s417.6) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003849@unknown@formal@none@1@S@Uneven X inactivation in a female monozygotic twin pair with Fabry disease and discordant expression of a novel mutation in the alpha-galactosidase A gene.@(((:tag . "JJ") (:stem . "uneven") (:form . "Uneven") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "monozygotic") (:form . "monozygotic") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "twin") (:form . "twin") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Fabry") (:form . "Fabry") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "discordant") (:form . "discordant") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha-galactosidase")\n  (:form . "alpha-galactosidase") (:end . 147) (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s419.1) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003859@unknown@formal@none@1@S@These data suggest that the paternal X chromosome carries the de novo alpha-galactosidase A mutation and that uneven X inactivation is the underlying mechanism for disease expression in this novel female MZ twin pair.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "paternal") (:form . "paternal") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "carry") (:form . "carries") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha-galactosidase")\n  (:form . "alpha-galactosidase") (:end . 89) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "uneven") (:form . "uneven") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 131)\n  (:start . 119) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 182)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 203)\n  (:start . 197) (:id . 72))\n ((:tag . "NNP") (:stem . "MZ") (:form . "MZ") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "NN") (:stem . "twin") (:form . "twin") (:end . 211) (:start . 207)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 216) (:start . 212)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x419.11.1) (:span 11 18)))\n (:hscopes ((:id . :x419.11.1) (:span 11 216)))\n (:identifiers (:sid . :s419.11) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003869@unknown@formal@none@1@S@Eosinophils play an important role in the effector phase of allergic inflammation.@(((:tag . "NNS") (:stem . "eosinophil") (:form . "Eosinophils") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s421.2) (:did . :|97024832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003879@unknown@formal@none@1@S@The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "NF(kappa)B") (:form . "NF(kappa)B") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 121) (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s423.1) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003889@unknown@formal@none@1@S@The responses of lymphocytes to IL-2 and IL-12, involving proliferation, differentiation, and cytokine production, are only partially overlapping, and may depend on induced differential expression of specific sets of genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 88) (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 172)\n  (:start . 165) (:id . 69))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 185)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 196)\n  (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 208)\n  (:start . 200) (:id . 73))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 222)\n  (:start . 217) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x424.2.1) (:span 151 154)))\n (:hscopes ((:id . :x424.2.1) (:span 151 222)))\n (:identifiers (:sid . :s424.2) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003899@unknown@formal@none@1@S@DNase I hypersensitive site (DHS) mapping revealed that the perforin locus contained six DHS within 7.0 kb of the 5' upstream sequence (-7.0 kb) and two DHS in intron 2.@(((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DHS") (:form . "DHS") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dhs") (:form . "DHS") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "CD") (:stem . "7.0") (:form . "7.0") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 125)\n  (:start . 117) (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 134)\n  (:start . 126) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-7.0") (:form . "-7.0") (:end . 140) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 152) (:start . 149)\n  (:id . 72))\n ((:tag . "NN") (:stem . "dhs") (:form . "DHS") (:end . 156) (:start . 153)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 74))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 166)\n  (:start . 160) (:id . 75))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 168) (:start . 167)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s425.3) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003909@unknown@formal@none@1@S@Soluble factors secreted by activated T-lymphocytes modulate the transcription of the immunosuppressive cytokine TGF-beta 2 in glial cells.@(((:tag . "JJ") (:stem . "soluble") (:form . "Soluble") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 51) (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 103) (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 112)\n  (:start . 104) (:id . 54))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 121)\n  (:start . 113) (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 123) (:start . 122)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 132)\n  (:start . 127) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s426.1) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003919@unknown@formal@none@1@S@The key role of erythropoietin (Epo) for colony formation by early erythroid progenitors (burst-forming units-erythroid [BFU-E]) has been confirmed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 30) (:start . 16) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 47)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "burst-forming") (:form . "burst-forming")\n  (:end . 103) (:start . 90) (:id . 58))\n ((:tag . "JJ") (:stem . "units-erythroid") (:form . "units-erythroid")\n  (:end . 119) (:start . 104) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "BFU-E") (:form . "BFU-E") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 147)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s427.3) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003929@unknown@formal@none@1@S@Vitamin D3- and retinoic acid-induced monocytic differentiation: interactions between the endogenous vitamin D3 receptor, retinoic acid receptors, and retinoid X receptors in U-937 cells.@(((:tag . "NNP") (:stem . "Vitamin") (:form . "Vitamin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D3-") (:form . "D3-") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 63) (:start . 48) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 64) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 77)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 100)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 108)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 130)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 135) (:start . 131)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 145)\n  (:start . 136) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 161) (:start . 160)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s428.1) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003939@unknown@formal@none@1@S@In contrast, neither the RA-stimulated, RARE-mediated transcription nor the induced RAR-beta expression was suppressed by VitD3, suggesting that VitD3 selectively inhibited the retinoid-induced differentiation program but not the RARE-mediated signal.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ra-stimulated") (:form . "RA-stimulated")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rare-mediated") (:form . "RARE-mediated")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "RAR-beta") (:form . "RAR-beta") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 172)\n  (:start . 163) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "retinoid-induced") (:form . "retinoid-induced")\n  (:end . 193) (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 209) (:start . 194) (:id . 68))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 217)\n  (:start . 210) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 221) (:start . 218)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 225) (:start . 222)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "rare-mediated") (:form . "RARE-mediated")\n  (:end . 243) (:start . 230) (:id . 73))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 250)\n  (:start . 244) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x428.11.2) (:span 129 139)))\n (:ncues ((:id . :x428.11.1) (:span 222 225))\n  ((:id . :x428.11.3) (:span 13 20 68 71)))\n (:hscopes ((:id . :x428.11.2) (:span 129 250)))\n (:nscopes ((:id . :x428.11.1) (:span 222 250))\n  ((:id . :x428.11.3) (:span 13 127)))\n (:identifiers (:sid . :s428.11) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003949@unknown@formal@none@1@S@Many of Pb 's effects on the immune system could be explained through activation of the transcription factor, NF-kappa B.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 61)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x430.4.1) (:span 43 48)))\n (:hscopes ((:id . :x430.4.1) (:span 0 120)))\n (:identifiers (:sid . :s430.4) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003959@unknown@formal@none@1@S@p21(ras), a guanine nucleotide binding factor, mediates T-cell signal transduction through PKC-dependent and PKC-independent pathways.@(((:tag . "NNP") (:stem . "p21(ras)") (:form . "p21(ras)") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pkc-independent") (:form . "PKC-independent")\n  (:end . 124) (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 133)\n  (:start . 125) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s431.4) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003969@unknown@formal@none@1@S@Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P-LPS-mediated signal-transducing mechanism in the cells.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "p-lps-mediated") (:form . "P-LPS-mediated")\n  (:end . 122) (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 141) (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x432.4.1) (:span 40 47)))\n (:hscopes ((:id . :x432.4.1) (:span 40 89)))\n (:identifiers (:sid . :s432.4) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003979@unknown@formal@none@1@S@In this report, we demonstrate that engagement of the TCR results in tyrosine phosphorylation of SLP-76 in its amino-terminal acidic region.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 93) (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "slp-76") (:form . "SLP-76") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 125) (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s433.3) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003989@unknown@formal@none@1@S@Only the catalytic, but not the NH2 regulatory, domain of pp56(lck) was able to induce NF-AT region transactivation on its own and to cooperate with other intracellular signals to trigger this response.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nh2") (:form . "NH2") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 46)\n  (:start . 36) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 92) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 115) (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "VB") (:stem . "cooperate") (:form . "cooperate") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 154)\n  (:start . 149) (:id . 69))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 168) (:start . 155) (:id . 70))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 176)\n  (:start . 169) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 187)\n  (:start . 180) (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 201)\n  (:start . 193) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x434.7.1) (:span 24 27)))\n (:nscopes ((:id . :x434.7.1) (:span 24 46)))\n (:identifiers (:sid . :s434.7) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003999@unknown@formal@none@1@S@Induction of fra-1 following engagement of CD40 did not require protein synthesis, suggesting that the PKC-dependent linkage between CD40 and fra-1 is direct.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "linkage") (:form . "linkage") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x435.7.1) (:span 83 93)))\n (:ncues ((:id . :x435.7.2) (:span 52 55)))\n (:hscopes ((:id . :x435.7.1) (:span 83 157)))\n (:nscopes ((:id . :x435.7.2) (:span 52 81)))\n (:identifiers (:sid . :s435.7) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004009@unknown@formal@none@1@S@In contrast, interleukin-1beta-converting enzyme family protease inhibitors Ac-DEVD-CHO and CrmA blocked Fas-mediated apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "interleukin-1beta-converting")\n  (:form . "interleukin-1beta-converting") (:end . 41) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 55)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "NNP") (:stem . "Ac-DEVD-CHO") (:form . "Ac-DEVD-CHO") (:end . 87)\n  (:start . 76) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CrmA") (:form . "CrmA") (:end . 96) (:start . 92)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 104)\n  (:start . 97) (:id . 53))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 117)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 127)\n  (:start . 118) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s436.8) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004019@unknown@formal@none@1@S@Multiple TRAF3 binding sites containing a PXQXT/S core sequence can be identified in the simian EBV LMP1s by an in vitro binding assay.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PXQXT/S") (:form . "PXQXT/S") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1s") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s437.8) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004029@unknown@formal@none@1@S@Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells:@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferons") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic-acid") (:form . "retinoic-acid")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 112) (:start . 111)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s439.1) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004039@unknown@formal@none@1@S@All human adenoviruses transform rodent cells in vitro, but only cells transformed by serotypes belonging to subgroups A (Ad12) and B (Ad3) are tumorigenic for immunocompetent animals.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "adenovirus") (:form . "adenoviruses") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "transform") (:form . "transform") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "rodent") (:form . "rodent") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "serotype") (:form . "serotypes") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "subgroup") (:form . "subgroups") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ad3") (:form . "Ad3") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "tumorigenic") (:form . "tumorigenic") (:end . 155)\n  (:start . 144) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "immunocompetent") (:form . "immunocompetent")\n  (:end . 175) (:start . 160) (:id . 72))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 183)\n  (:start . 176) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s440.2) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004049@unknown@formal@none@1@S@We demonstrate that although the individual components of this element do not respond to IL-2, together they form a composite element capable of conferring IL-2 responsiveness to a heterologous promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "confer") (:form . "conferring") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 175) (:start . 161) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 193)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 202)\n  (:start . 194) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x441.4.1) (:span 74 77)))\n (:nscopes ((:id . :x441.4.1) (:span 74 93)))\n (:identifiers (:sid . :s441.4) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004059@unknown@formal@none@1@S@The use of the protein tyrosine kinase ( PTK )-specific inhibitor herbimycin A dramatically decreased cellular proliferation without altering the activity of the human immunodeficiency virus-1 long terminal repeat (HIV-1 LTR), a promoter largely dependent on the binding of nuclear factor kappa B (NF-kappa B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . 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"(") (:end . 298) (:start . 297)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 306)\n  (:start . 298) (:id . 89))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 308) (:start . 307)\n  (:id . 90))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 309) (:start . 308)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 310) (:start . 309)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x442.7.1) (:span 125 132)))\n (:nscopes ((:id . :x442.7.1) (:span 125 225)))\n (:identifiers (:sid . :s442.7) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004069@unknown@formal@none@1@S@Transfection of a cDNA containing the human CIITA coding sequence under the control of an heterologous promoter restores expression of human MHC class II genes in the hybrids and is responsible for de novo expression of mouse MHC class II genes in both the mouse plasmacytoma cell line and the hybrids.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . 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"the") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 193)\n  (:start . 182) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 216)\n  (:start . 206) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 225)\n  (:start . 220) (:id . 78))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 229) (:start . 226)\n  (:id . 79))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 235)\n  (:start . 230) (:id . 80))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 238) (:start . 236)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 244)\n  (:start . 239) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 83))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 252) (:start . 248)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 256) (:start . 253)\n  (:id . 85))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 262)\n  (:start . 257) (:id . 86))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 275)\n  (:start . 263) (:id . 87))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 280) (:start . 276)\n  (:id . 88))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 285) (:start . 281)\n  (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 289) (:start . 286)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 293) (:start . 290)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 301)\n  (:start . 294) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s443.6) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004079@unknown@formal@none@1@S@Distinct patterns of chromosome 1 abnormalities were found among the histologic types of breast carcinoma.@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 47)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "histologic") (:form . "histologic") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s444.6) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004089@unknown@formal@none@1@S@To examine the role of EKLF in the developmental regulation of the human gamma-globin gene we interbred EKLF heterozygotes ( ± ) with mice harboring a human beta-globin yeast artificial chromosome transgene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 48) (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "interbreed") (:form . "interbred") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "heterozygote") (:form . "heterozygotes")\n  (:end . 122) (:start . 109) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 138)\n  (:start . 134) (:id . 65))\n ((:tag . "VBG") (:stem . "harbor") (:form . "harboring") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 156)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 168)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . "JJ") (:stem . "artificial") (:form . "artificial") (:end . 185)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 196)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 206)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s445.5) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004099@unknown@formal@none@1@S@Norepinephrine and epinephrine alsosuppressed IL-12 production in a dose-dependent fashion and at physiological concentrations;@(((:tag . "NNP") (:stem . "Norepinephrine") (:form . "Norepinephrine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "epinephrine") (:form . "epinephrine") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "alsosuppresse") (:form . "alsosuppressed")\n  (:end . 45) (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 51) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 62)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 82) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 90)\n  (:start . 83) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 111) (:start . 98) (:id . 54))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 126) (:start . 112) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 127) (:start . 126)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s446.7) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004109@unknown@formal@none@1@S@In this study, EBV gene expression was determined in 23 cases of nasal lymphoma (NL) by in situ hybridisation (ISH), reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IH).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nasal") (:form . "nasal") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NL") (:form . "NL") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 61))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 95) (:start . 91)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hybridisation") (:form . "hybridisation")\n  (:end . 109) (:start . 96) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "ISH") (:form . "ISH") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 124)\n  (:start . 117) (:id . 68))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 149) (:start . 125) (:id . 69))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 155)\n  (:start . 150) (:id . 70))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 164)\n  (:start . 156) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 172)\n  (:start . 166) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 75))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 198) (:start . 178) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "IH") (:form . "IH") (:end . 202) (:start . 200)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s447.4) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004119@unknown@formal@none@1@S@In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "address") (:form . "addressed") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "reverse") (:form . "reverse") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "th1/th0") (:form . "Th1/Th0") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x448.3.1) (:span 50 57)) ((:id . :x448.3.2) (:span 24 49)))\n (:hscopes ((:id . :x448.3.1) (:span 50 177))\n  ((:id . :x448.3.2) (:span 24 177)))\n (:identifiers (:sid . :s448.3) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004129@unknown@formal@none@1@S@The monoclonal antibody (mAb) J393 induces apoptosis in Jurkat T-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s449.2) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004139@unknown@formal@none@1@S@Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "jak-stat") (:form . "JAK-STAT") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s450.2) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004149@unknown@formal@none@1@S@The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NB") (:form . "NB") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 35)\n  (:start . 27) (:id . 50))\n ((:tag . "NN") (:stem . "organelle") (:form . "organelle") (:end . 45)\n  (:start . 36) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 62)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 82)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 105) (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s451.2) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004159@unknown@formal@none@1@S@The TAL-1 gene specifies for a basic domain-helix-loop-helix protein, which is involved in the control of normal hematopoiesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tal-1") (:form . "TAL-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "specify") (:form . "specifies") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "domain-helix-loop-helix")\n  (:form . "domain-helix-loop-helix") (:end . 60) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s452.2) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004169@unknown@formal@none@1@S@These data indicate that TAL-1, expressed in T cells, is per se a potent oncogene, which may exert a key leukemogenetic role in the majority of T-cell acute lymphoblastic leukemias.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tal-1") (:form . "TAL-1") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "FW") (:stem . "per") (:form . "per") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "FW") (:stem . "se") (:form . "se") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 72)\n  (:start . 66) (:id . 57))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 81)\n  (:start . 73) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 98) (:start . 93)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 104) (:start . 101)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "leukemogenetic") (:form . "leukemogenetic")\n  (:end . 119) (:start . 105) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 68))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 140)\n  (:start . 132) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 150)\n  (:start . 144) (:id . 71))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 156)\n  (:start . 151) (:id . 72))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 170) (:start . 157) (:id . 73))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 180)\n  (:start . 171) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x452.12.1) (:span 89 92))\n  ((:id . :x452.12.2) (:span 11 24)))\n (:hscopes ((:id . :x452.12.1) (:span 89 180))\n  ((:id . :x452.12.2) (:span 11 180)))\n (:identifiers (:sid . :s452.12) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004179@unknown@formal@none@1@S@These findings indicate that T cells representing different activation and/or differentiation stages can be differentially responsive to ROI-mediated signals.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 93) (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 100)\n  (:start . 94) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 122) (:start . 108) (:id . 56))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 133)\n  (:start . 123) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "roi-mediated") (:form . "ROI-mediated") (:end . 149)\n  (:start . 137) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 157)\n  (:start . 150) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x453.10.1) (:span 101 104))\n  ((:id . :x453.10.2) (:span 15 28)))\n (:hscopes ((:id . :x453.10.1) (:span 101 157))\n  ((:id . :x453.10.2) (:span 15 157)))\n (:identifiers (:sid . :s453.10) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004189@unknown@formal@none@1@S@Whereas the hypercalcemic effect for ZK157202 is also increased 10-fold, ZK161422 has the same calcium-mobilizing potency as VD.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hypercalcemic") (:form . "hypercalcemic")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zk157202") (:form . "ZK157202") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ZK161422") (:form . "ZK161422") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "calcium-mobilizing") (:form . "calcium-mobilizing")\n  (:end . 113) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s454.10) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004199@unknown@formal@none@1@S@Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes.@(((:tag . "NNP") (:stem . "Generation") (:form . "Generation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cd1+relb+") (:form . "CD1+RelB+") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tartrate-resistant") (:form . "tartrate-resistant")\n  (:end . 62) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "phosphatase-positive")\n  (:form . "phosphatase-positive") (:end . 88) (:start . 68) (:id . 50))\n ((:tag . "JJ") (:stem . "osteoclast-like") (:form . "osteoclast-like")\n  (:end . 104) (:start . 89) (:id . 51))\n ((:tag . "JJ") (:stem . "multinucleated") (:form . "multinucleated")\n  (:end . 119) (:start . 105) (:id . 52))\n ((:tag . "JJ") (:stem . "giant") (:form . "giant") (:end . 125)\n  (:start . 120) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 152)\n  (:start . 143) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s456.1) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004209@unknown@formal@none@1@S@Taken together, these results provide a new aspect to our knowledge of monocyte differentiation and provide evidence that human monocytes are flexible in their differentiation potential and are precursors not only of macrophages but also of CD1+relB+DC and TRAP-positive MGC.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "aspect") (:form . "aspect") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 95) (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "flexible") (:form . "flexible") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 175) (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 204)\n  (:start . 194) (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 208) (:start . 205)\n  (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 213) (:start . 209)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 228)\n  (:start . 217) (:id . 75))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 232) (:start . 229)\n  (:id . 76))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 237) (:start . 233)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 240) (:start . 238)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "CD1+relB+DC") (:form . "CD1+relB+DC") (:end . 252)\n  (:start . 241) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 256) (:start . 253)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "trap-positive") (:form . "TRAP-positive")\n  (:end . 270) (:start . 257) (:id . 81))\n ((:tag . "NNP") (:stem . "MGC") (:form . "MGC") (:end . 274) (:start . 271)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s456.11) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004219@unknown@formal@none@1@S@The Rel/NF-kappa B proteins, p50, p52, p65, c-Rel, and RelB, constitute a family of transcription factors involved in the positive regulation of a variety of genes during the immune response.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 49) (:start . 44)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 59) (:start . 55)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 71)\n  (:start . 61) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 80)\n  (:start . 74) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 105)\n  (:start . 98) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 114)\n  (:start . 106) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 130)\n  (:start . 122) (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 141)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 154)\n  (:start . 147) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 163)\n  (:start . 158) (:id . 73))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 170)\n  (:start . 164) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 181)\n  (:start . 175) (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 190)\n  (:start . 182) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s458.2) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004229@unknown@formal@none@1@S@Cells with nuclear p50 were negative for the CD38, CD20 and CD2 markers.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd38") (:form . "CD38") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x458.12.1) (:span 28 36)))\n (:nscopes ((:id . :x458.12.1) (:span 28 71)))\n (:identifiers (:sid . :s458.12) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004239@unknown@formal@none@1@S@The gene encoding the Epstein-Barr virus ( EBV ) -specific dUTPase was amplified from virus DNA by PCR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "-specific") (:form . "-specific") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "dutpase") (:form . "dUTPase") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s460.2) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004249@unknown@formal@none@1@S@The enzyme might therefore be a potential target for drug therapy under conditions of active DNA replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x460.12.1) (:span 11 16)))\n (:hscopes ((:id . :x460.12.1) (:span 11 108)))\n (:identifiers (:sid . :s460.12) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004259@unknown@formal@none@1@S@Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels.@(((:tag . "NNP") (:stem . "Glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GCS") (:form . "GCS") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "profoundly") (:form . "profoundly") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 148) (:start . 133) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 172) (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 179)\n  (:start . 173) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s462.2) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004269@unknown@formal@none@1@S@Tissue and cell-type specific expression of the tuberous sclerosis gene, TSC2, in human tissues.@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tuberous") (:form . "tuberous") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "sclerosis") (:form . "sclerosis") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TSC2") (:form . "TSC2") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s464.1) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004279@unknown@formal@none@1@S@The gene is expressed in all hematopoietic cells with the exception of T-cells and plasma cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 42) (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s465.3) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004289@unknown@formal@none@1@S@Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene [published erratum appears in Mol Cell Biol 1997 Apr;17 ( 4 ):2351]@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 87) (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Mol") (:form . "Mol") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Cell") (:form . "Cell") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Biol") (:form . "Biol") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1997") (:form . "1997") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "NN") (:stem . "Apr;17") (:form . "Apr;17") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 167) (:start . 166)\n  (:id . 72))\n ((:tag . "CD") (:stem . "):2351") (:form . "):2351") (:end . 174)\n  (:start . 168) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 175) (:start . 174)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s466.1) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004299@unknown@formal@none@1@S@This putative human IL-2rE, designated PRRIII, confers IL-2 responsiveness on a heterologous promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2re") (:form . "IL-2rE") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "PRRIII") (:form . "PRRIII") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 74) (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x466.11.1) (:span 5 13)))\n (:hscopes ((:id . :x466.11.1) (:span 5 45)))\n (:identifiers (:sid . :s466.11) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004309@unknown@formal@none@1@S@Further deletional and alanine mutagenesis analyses and comparison with TRAF binding sequences in CD40, in CD30, and in the LMP1 of other lymphycryptoviruses provide the first evidence that PXQXT/S is a core TRAF binding motif.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "deletional") (:form . "deletional") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alanine") (:form . "alanine") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "lymphycryptovirus") (:form . "lymphycryptoviruses")\n  (:end . 157) (:start . 138) (:id . 66))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PXQXT/S") (:form . "PXQXT/S") (:end . 197)\n  (:start . 190) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 207) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "traf") (:form . "TRAF") (:end . 212) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 220)\n  (:start . 213) (:id . 77))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 226)\n  (:start . 221) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s467.5) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004319@unknown@formal@none@1@S@LPS stimulation did not give rise to a persistent nuclear accumulation of RelB and c-Rel, whereas nuclear c-Rel, but not RelB, accumulated after B cell receptor stimulation.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "give") (:form . "give") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "accumulate") (:form . "accumulated") (:end . 138)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 144)\n  (:start . 139) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 160)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 172)\n  (:start . 161) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x468.5.1) (:span 117 120))\n  ((:id . :x468.5.2) (:span 20 23)))\n (:nscopes ((:id . :x468.5.1) (:span 117 125))\n  ((:id . :x468.5.2) (:span 20 88)))\n (:identifiers (:sid . :s468.5) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004329@unknown@formal@none@1@S@However, this factor appeared when the CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "achieve") (:form . "achieved") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "haematological") (:form . "haematological")\n  (:end . 84) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "remission") (:form . "remission") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CHR") (:form . "CHR") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "alpha-interferon") (:form . "alpha-interferon")\n  (:end . 125) (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s469.5) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004339@unknown@formal@none@1@S@Thus, ceramide is not a positive signal for ERK activation in T-cell lines.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ceramide") (:form . "ceramide") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ERK") (:form . "ERK") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x470.8.1) (:span 18 21)))\n (:nscopes ((:id . :x470.8.1) (:span 18 74)))\n (:identifiers (:sid . :s470.8) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004349@unknown@formal@none@1@S@Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s472.1) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004359@unknown@formal@none@1@S@Within the region between -108 and -40 base pairs of the IFN-gamma promoter are two conserved and essential regulatory elements, which confer activation-specific expression in T cells.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "-108") (:form . "-108") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-40") (:form . "-40") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "VBP") (:stem . "confer") (:form . "confer") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "JJ") (:stem . "activation-specific")\n  (:form . "activation-specific") (:end . 161) (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 172)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s473.3) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004369@unknown@formal@none@1@S@Treatment of T cells with the protein kinase C activator PMA in combination with Ca2+ ionophores mimics this process, and the two agents are often substituted for TCR stimulation, bypassing the TCR.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ionophore") (:form . "ionophores") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "VBZ") (:stem . "mimic") (:form . "mimics") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "VBN") (:stem . "substitute") (:form . "substituted") (:end . 158)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "bypass") (:form . "bypassing") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s474.4) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004379@unknown@formal@none@1@S@The transcription factors Sp1 and PU.1 prime the CD11b promoter, but the nature of the factors responsible for its inducible expression are unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "prime") (:form . "prime") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s475.3) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004389@unknown@formal@none@1@S@HIV-1 LTR activity in human CD40-activated B lymphocytes is dependent on NF-kappaB.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cd40-activated") (:form . "CD40-activated")\n  (:end . 42) (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s476.1) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004399@unknown@formal@none@1@S@This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "tcr-induced") (:form . "TCR-induced") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 122) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ras-regulated") (:form . "Ras-regulated")\n  (:end . 157) (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 168)\n  (:start . 158) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 185) (:start . 172) (:id . 65))\n ((:tag . "JJ") (:stem . "signal-regulated") (:form . "signal-regulated")\n  (:end . 202) (:start . 186) (:id . 66))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 210)\n  (:start . 203) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s477.5) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004409@unknown@formal@none@1@S@We previously suggested that the measurement of corticosteroid receptors in lymphocytes is an index of an analogous pattern in brain.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "measurement") (:form . "measurement") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x478.4.1) (:span 14 23)))\n (:hscopes ((:id . :x478.4.1) (:span 14 132)))\n (:identifiers (:sid . :s478.4) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004419@unknown@formal@none@1@S@Deranged cellular cholesterol homeostasis has been widely recognized in the initiation as well as progression of various types of cancers including chronic myeloid leukaemia (CML).@(((:tag . "JJ") (:stem . "deranged") (:form . "Deranged") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 41)\n  (:start . 30) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 163)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 173)\n  (:start . 164) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s479.2) (:did . :|97119289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004429@unknown@formal@none@1@S@Therefore, to evaluate the mechanism of TPA responsiveness of the SNE motifs and of a related 16-bp SEE (SRF/ETS element) motif found in the HCMV and chimpanzee CMV MIE enhancers, we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the SCMV MIE or simian virus 40 minimal promoter regions in the U-937, K-562, HL-60, THP-1, and Jurkat cell lines.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . 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"related") (:form . "related") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "JJ") (:stem . "16-bp") (:form . "16-bp") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "see") (:form . "SEE") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "srf/ets") (:form . "SRF/ETS") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 127)\n  (:start . 122) (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . 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"wild-type") (:form . "wild-type") (:end . 278)\n  (:start . 269) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 282) (:start . 279)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 289)\n  (:start . 283) (:id . 90))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 298)\n  (:start . 290) (:id . 91))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 304) (:start . 299)\n  (:id . 92))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 313)\n  (:start . 305) (:id . 93))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 316) (:start . 314)\n  (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 320) (:start . 317)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "SCMV") (:form . "SCMV") (:end . 325) (:start . 321)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "MIE") (:form . "MIE") (:end . 329) (:start . 326)\n  (:id . 97))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 332) (:start . 330)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 339)\n  (:start . 333) (:id . 99))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 345)\n  (:start . 340) (:id . 100))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 348) (:start . 346)\n  (:id . 101))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 356)\n  (:start . 349) (:id . 102))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 365)\n  (:start . 357) (:id . 103))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 373)\n  (:start . 366) (:id . 104))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 376) (:start . 374)\n  (:id . 105))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 380) (:start . 377)\n  (:id . 106))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 386)\n  (:start . 381) (:id . 107))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 387) (:start . 386)\n  (:id . 108))\n ((:tag . "NNP") (:stem . "K-562") (:form . "K-562") (:end . 393)\n  (:start . 388) (:id . 109))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 394) (:start . 393)\n  (:id . 110))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 400)\n  (:start . 395) (:id . 111))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 401) (:start . 400)\n  (:id . 112))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 407)\n  (:start . 402) (:id . 113))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 408) (:start . 407)\n  (:id . 114))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 412) (:start . 409)\n  (:id . 115))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 419)\n  (:start . 413) (:id . 116))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 424) (:start . 420)\n  (:id . 117))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 430)\n  (:start . 425) (:id . 118))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 431) (:start . 430)\n  (:id . 119)))@@@1@78@((:identifiers (:sid . :s480.6) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004439@unknown@formal@none@1@S@These data may expand the understanding of the anti-thrombotic and anti-inflammatory effects of these drugs when activation of monocytes occurs.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "expand") (:form . "expand") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-thrombotic") (:form . "anti-thrombotic")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 84) (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 143)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x481.5.1) (:span 11 14)))\n (:hscopes ((:id . :x481.5.1) (:span 11 143)))\n (:identifiers (:sid . :s481.5) (:did . :|97127169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004449@unknown@formal@none@1@S@The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in regulating cell-cycle progression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "cell-cycle") (:form . "cell-cycle") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 106)\n  (:start . 95) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s483.2) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004459@unknown@formal@none@1@S@The chemokine RANTES has been implicated in the pathogenesis of allergic inflammatory diseases including asthma and rhinitis which are frequently treated with glucocorticoids.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rantes") (:form . "RANTES") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rhinitis") (:form . "rhinitis") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 153)\n  (:start . 146) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 174) (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s484.2) (:did . :|97131617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5004479@unknown@formal@none@1@S@In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation (IC50) and the binding affinity of dexamethasone to the GCR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 109) (:start . 96) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IC50") (:form . "IC50") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 158) (:start . 145) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s486.8) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004489@unknown@formal@none@1@S@Although inhibition of IL-4-driven germline C epsilon transcription by NAC was not sufficient, the agent remarkably diminished anti-CD40 mAb-mediated up-regulation of germline C epsilon transcription.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "il-4-driven") (:form . "IL-4-driven") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "JJ") (:stem . "mab-mediated") (:form . "mAb-mediated") (:end . 149)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 163) (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 175)\n  (:start . 167) (:id . 64))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 177) (:start . 176)\n  (:id . 65))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 185)\n  (:start . 178) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 199) (:start . 186) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x487.7.1) (:span 79 82)))\n (:nscopes ((:id . :x487.7.1) (:span 79 93)))\n (:identifiers (:sid . :s487.7) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004499@unknown@formal@none@1@S@The most extensively studied phenomenon is the progressive decline in the proliferative capacities of T lymphocytes with aging.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "progressive") (:form . "progressive") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "capacity") (:form . "capacities") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s488.6) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004509@unknown@formal@none@1@S@They fail to induce mRNA of TNF-alpha after 3 h of culture.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x489.5.1) (:span 5 9)))\n (:nscopes ((:id . :x489.5.1) (:span 5 58)))\n (:identifiers (:sid . :s489.5) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004519@unknown@formal@none@1@S@Levels of FOSB mRNA reach a maximum 40 min after the addition of lectin and decline to control levels over the next 6 hr.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "reach") (:form . "reach") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "decline") (:form . "decline") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s490.8) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004529@unknown@formal@none@1@S@Here, we have studied IL-2 and IL-4 signaling in B cell lines lacking JAK3.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x491.4.1) (:span 62 69)))\n (:nscopes ((:id . :x491.4.1) (:span 62 74)))\n (:identifiers (:sid . :s491.4) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004539@unknown@formal@none@1@S@Predicted peptide sequence of ORF2 contained a zinc finger domain which showed significant homology to GC box binding proteins BTEB2 and SP1.@(((:tag . "VBN") (:stem . "predict") (:form . "Predicted") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ORF2") (:form . "ORF2") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 78) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 90)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "bteb2") (:form . "BTEB2") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s492.6) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004549@unknown@formal@none@1@S@They later fuse, and , under the influence of the surrounding mesenchyme, the mature organ develops , being mainly composed of ductal, exocrine and endocrine compartments.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "later") (:form . "later") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "fuse") (:form . "fuse") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "surround") (:form . "surrounding") (:end . 61)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "mesenchyme") (:form . "mesenchyme") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "develop") (:form . "develops") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 107) (:start . 102)\n  (:id . 61))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 133)\n  (:start . 127) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "exocrine") (:form . "exocrine") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 157)\n  (:start . 148) (:id . 69))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 170)\n  (:start . 158) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s493.4) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004559@unknown@formal@none@1@S@The findings presented here link an atheogenic lipoprotein, LDL, with the induction of an adhesion molecule important in atherogenesis@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "atheogenic") (:form . "atheogenic") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 134) (:start . 121) (:id . 62)))@@@1@21@((:identifiers (:sid . :s494.5) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004569@unknown@formal@none@1@S@Here we report that tepoxalin selectively inhibits intercellular adhesion molecule-1 ( ICAM-1 , CD54 ) /MAC-1 ( CD11b/CD18 ) dependent adhesion of polymorphonuclear cells to IL-1 activated human umbilical vein endothelial cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD54") (:form . "CD54") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "/MAC-1") (:form . "/MAC-1") (:end . 109)\n  (:start . 103) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 164) (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 188)\n  (:start . 179) (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 204)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 209) (:start . 205)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 221)\n  (:start . 210) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 227)\n  (:start . 222) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s495.4) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004579@unknown@formal@none@1@S@These blast cells express lineage-specific transcription factors such as GATA-1 common to these lineages and frequently express erythroid-specific mRNAs such as gamma-globin and erythroid delta-aminolevulinate synthase (ALAS-E), indicating that most of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 42) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . 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(:form . ".") (:end . 329) (:start . 328)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x496.4.1) (:span 229 244)))\n (:hscopes ((:id . :x496.4.1) (:span 229 328)))\n (:identifiers (:sid . :s496.4) (:did . :|97182946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004589@unknown@formal@none@1@S@[The value of the clinical test of glucocorticoid receptors of peripheral blood leukocytes in patients with chronic pulmonary heart disease]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 49) (:start . 35) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "heart") (:form . "heart") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s498.1) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004599@unknown@formal@none@1@S@Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "trigger") (:form . "trigger") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "substance") (:form . "substances") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 127)\n  (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 137)\n  (:start . 128) (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 142) (:start . 138)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 185) (:start . 172) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s499.2) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004609@unknown@formal@none@1@S@In previous studies, it was shown that the fusion region of the pml/RAR-alpha protein, expressed by acute promyelocytic leukemia (APL) cells, can be specifically recognized in vitro by donor (D. E.) CD4 T cells in a HLA class II DR11-restricted fashion.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . 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5004619@unknown@formal@none@1@S@Since APL cells do not express HLA class II molecules, we tested in two donors (D.E. and C.H.R.) and in patients S.R.and P.G.whether the use of 9-mer peptides (BCR1/9) would generate a CD8/HLA class I-restricted response.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 64) (:start . 58)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 78)\n  (:start . 72) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D.E.") (:form . "D.E.") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "C.H.R.") (:form . "C.H.R.") (:end . 95)\n  (:start . 89) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 112)\n  (:start . 104) (:id . 65))\n ((:tag . "VBP") (:stem . "s.r.and") (:form . "S.R.and") (:end . 120)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "p.g.whether") (:form . "P.G.whether") (:end . 132)\n  (:start . 121) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 140) (:start . 137)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "NN") (:stem . "9-mer") (:form . "9-mer") (:end . 149)\n  (:start . 144) (:id . 71))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 158)\n  (:start . 150) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "BCR1/9") (:form . "BCR1/9") (:end . 166)\n  (:start . 160) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 75))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 173)\n  (:start . 168) (:id . 76))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 182)\n  (:start . 174) (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "CD8/HLA") (:form . "CD8/HLA") (:end . 192)\n  (:start . 185) (:id . 79))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 198)\n  (:start . 193) (:id . 80))\n ((:tag . "JJ") (:stem . "i-restricted") (:form . "I-restricted") (:end . 211)\n  (:start . 199) (:id . 81))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 220)\n  (:start . 212) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x500.12.1) (:span 168 173))\n  ((:id . :x500.12.2) (:span 125 132)))\n (:ncues ((:id . :x500.12.3) (:span 19 22)))\n (:hscopes ((:id . :x500.12.1) (:span 168 220))\n  ((:id . :x500.12.2) (:span 125 220)))\n (:nscopes ((:id . :x500.12.3) (:span 19 53)))\n (:identifiers (:sid . :s500.12) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004629@unknown@formal@none@1@S@In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROIs") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NADPH") (:form . "NADPH") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s501.8) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004639@unknown@formal@none@1@S@Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "unrecognized") (:form . "unrecognized") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 157)\n  (:start . 148) (:id . 63))\n ((:tag . "CD") (:stem . "-295") (:form . "-295") (:end . 162) (:start . 158)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-286") (:form . "-286") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s502.8) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004649@unknown@formal@none@1@S@While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RFLAT-1") (:form . "RFLAT-1") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 118) (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rantes") (:form . "RANTES") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s503.6) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004659@unknown@formal@none@1@S@This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "socs3") (:form . "SOCS3") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x504.10.1) (:span 5 8)))\n (:hscopes ((:id . :x504.10.1) (:span 5 120)))\n (:identifiers (:sid . :s504.10) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004669@unknown@formal@none@1@S@CTCF is a transcriptional repressor of the c-myc gene.@(((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 25) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s506.2) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004679@unknown@formal@none@1@S@The first intron acted as a strong transcriptional activator in a position-dependent manner and with no cell-type specificity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "position-dependent") (:form . "position-dependent")\n  (:end . 84) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x507.6.1) (:span 101 103)))\n (:nscopes ((:id . :x507.6.1) (:span 101 125)))\n (:identifiers (:sid . :s507.6) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004689@unknown@formal@none@1@S@Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "diabetic") (:form . "diabetic") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "nephropathy") (:form . "nephropathy") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oxidative-stress") (:form . "oxidative-stress")\n  (:end . 133) (:start . 117) (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 143)\n  (:start . 134) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 164)\n  (:start . 158) (:id . 60))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 174)\n  (:start . 165) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s509.1) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004699@unknown@formal@none@1@S@Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV.@(((:tag . "JJ") (:stem . "bacterial") (:form . "Bacterial") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "vaginosis") (:form . "vaginosis") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BV") (:form . "BV") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sexual") (:form . "sexual") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 84)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 110) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "FW") (:stem . "gardnerella") (:form . "Gardnerella") (:end . 146)\n  (:start . 135) (:id . 67))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 170)\n  (:start . 160) (:id . 70))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "genital") (:form . "genital") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "tract") (:form . "tracts") (:end . 203)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 212)\n  (:start . 207) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 217) (:start . 213)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "BV") (:form . "BV") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s510.2) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004709@unknown@formal@none@1@S@We have analyzed the expression of IL-2Ralpha, c-myc, and pim-1 genes in anti-CD3-activated human T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pim-1") (:form . "pim-1") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-cd3-activated") (:form . "anti-CD3-activated")\n  (:end . 91) (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 111)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s511.4) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004719@unknown@formal@none@1@S@Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.@(((:tag . "JJ") (:stem . "anti-rheumatic") (:form . "Anti-rheumatic")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "aurothioglucose") (:form . "aurothioglucose")\n  (:end . 39) (:start . 24) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 48)\n  (:start . 40) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 54) (:start . 49)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 63)\n  (:start . 55) (:id . 47))\n ((:tag . "JJ") (:stem . "factor-alpha-induced")\n  (:form . "factor-alpha-induced") (:end . 84) (:start . 64) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 90) (:start . 85)\n  (:id . 49))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 102)\n  (:start . 91) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 51))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 114)\n  (:start . 106) (:id . 52))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 123)\n  (:start . 115) (:id . 53))\n ((:tag . "NN") (:stem . "om10.1") (:form . "OM10.1") (:end . 130)\n  (:start . 124) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ach2") (:form . "Ach2") (:end . 139) (:start . 135)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s512.1) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004729@unknown@formal@none@1@S@Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "p0") (:form . "P0") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 192)\n  (:start . 186) (:id . 71))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s513.1) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004739@unknown@formal@none@1@S@Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "rheumatic") (:form . "rheumatic") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s514.1) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004749@unknown@formal@none@1@S@N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition.@(((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 28)\n  (:start . 20) (:id . 43))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 36)\n  (:start . 29) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s515.1) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5004769@unknown@formal@none@1@S@Activation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal transduction via sequential phosphorylation of kinases.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 43) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 87) (:start . 74) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 94)\n  (:start . 88) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 107)\n  (:start . 95) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 111) (:start . 108)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sequential") (:form . "sequential") (:end . 122)\n  (:start . 112) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 138) (:start . 123) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 149)\n  (:start . 142) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s517.2) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5004789@unknown@formal@none@1@S@Involvement of NF-kappaB p50/p65 heterodimer in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pro-interleukin-1beta")\n  (:form . "pro-interleukin-1beta") (:end . 93) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "subregion") (:form . "subregions") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 149)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s519.1) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004799@unknown@formal@none@1@S@Phosphorylation of TRAF2 inhibits binding to the CD40 cytoplasmic domain.@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s520.1) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004809@unknown@formal@none@1@S@We utilized CoCl2 as a mimetic molecule for hypoxia to study cellular signaling pathways.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "utilize") (:form . "utilized") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cocl2") (:form . "CoCl2") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mimetic") (:form . "mimetic") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s521.4) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004819@unknown@formal@none@1@S@Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "neutrophil-endothelial")\n  (:form . "neutrophil-endothelial") (:end . 46) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 60)\n  (:start . 52) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 68)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 77) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "imbalance") (:form . "imbalance") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s522.1) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004829@unknown@formal@none@1@S@Surface expression of intercellular adhesion molecule-1, P-selectin, and E-selectin on HUVECs correlated with the phase 1 and 2 neutrophil adhesion responses.@(((:tag . "NN") (:stem . "surface") (:form . "Surface") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 157)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s522.11) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004839@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s523.9) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004849@unknown@formal@none@1@S@Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "bp1") (:form . "BP1") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bp2") (:form . "BP2") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4-6") (:form . "4-6") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "fold") (:form . "fold") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 184)\n  (:start . 176) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 193)\n  (:start . 185) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s524.10) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004859@unknown@formal@none@1@S@This mechanism may contribute to delayed progression of the HIV-1 infection in vivo.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x525.8.1) (:span 15 18)))\n (:hscopes ((:id . :x525.8.1) (:span 15 83)))\n (:identifiers (:sid . :s525.8) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004869@unknown@formal@none@1@S@Thus HIV-1 gp41-induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70(S6)-kinase activation.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "gp41-induced") (:form . "gp41-induced") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "VB") (:stem . "operate") (:form . "operate") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "adenylate") (:form . "adenylate") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "cyclase") (:form . "cyclase") (:end . 179)\n  (:start . 172) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "pertussis-toxin-sensitive")\n  (:form . "pertussis-toxin-sensitive") (:end . 209) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Gi/Go") (:form . "Gi/Go") (:end . 215)\n  (:start . 210) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 223)\n  (:start . 216) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 74))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 233)\n  (:start . 227) (:id . 75))\n ((:tag . "NNP") (:stem . "p70(S6)-kinase") (:form . "p70(S6)-kinase")\n  (:end . 248) (:start . 234) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 259)\n  (:start . 249) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x526.9.1) (:span 128 131))\n  ((:id . :x526.9.3) (:span 57 60)))\n (:ncues ((:id . :x526.9.2) (:span 61 64)))\n (:hscopes ((:id . :x526.9.1) (:span 128 259))\n  ((:id . :x526.9.3) (:span 57 115)))\n (:nscopes ((:id . :x526.9.2) (:span 61 115)))\n (:identifiers (:sid . :s526.9) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004879@unknown@formal@none@1@S@Similarly, D3-induced monocyte differentiation of normal myeloid progenitor cells was associated with increased capacity to generate E1 from E2.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "d3-induced") (:form . "D3-induced") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 46) (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 60))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s527.10) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004889@unknown@formal@none@1@S@Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel, fresh ATL samples contained p50/p50 and p50/p65 heterodimers.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50/c-rel") (:form . "p50/c-Rel") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 161)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s528.7) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004899@unknown@formal@none@1@S@Thus, we could trace the deficit of the mutant cells to an inefficient NF-kappaB activation, evidencing a relevant role for NF-kappaB in the regulation of FasL expression in activated T cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "VB") (:stem . "trace") (:form . "trace") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "deficit") (:form . "deficit") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 46)\n  (:start . 40) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inefficient") (:form . "inefficient") (:end . 70)\n  (:start . 59) (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "evidence") (:form . "evidencing") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 133)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 151)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 185) (:start . 184)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s529.7) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004909@unknown@formal@none@1@S@Concanavalin A-activated cycling T cell blasts from mice that are transgenic for the dominant IkappaB molecule have increased sensitivity to Fas-mediated apoptosis, associated with a down-regulation of NF-kappaB complexes in the nucleus.@(((:tag . "NNP") (:stem . "Concanavalin") (:form . "Concanavalin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "a-activated") (:form . "A-activated") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "cycling") (:form . "cycling") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 137)\n  (:start . 126) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 153)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 175)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 182) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 198) (:start . 183) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 211)\n  (:start . 202) (:id . 70))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 221)\n  (:start . 212) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 73))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 236)\n  (:start . 229) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s530.9) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004919@unknown@formal@none@1@S@Functional DC characteristics include fluid phase macromolecule uptake (FITC-dextran) and activation of resting T cells.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "macromolecule") (:form . "macromolecule")\n  (:end . 63) (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 70)\n  (:start . 64) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FITC-dextran") (:form . "FITC-dextran") (:end . 84)\n  (:start . 72) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s531.8) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004929@unknown@formal@none@1@S@On the other hand, the growth factor does induce the activation of STAT3 and STAT5 in these cells, as has been previously demonstrated.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 110) (:start . 106)\n  (:id . 64))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 121)\n  (:start . 111) (:id . 65))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 134)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s532.8) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004939@unknown@formal@none@1@S@Human myeloid differentiation is accompanied by a decrease in cell proliferation.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s534.2) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004949@unknown@formal@none@1@S@Comparison of tumor specimen from MM precursor lesions, primary tumors, and metastases revealed that CD40 surface expression is down-regulated during tumor progression.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "specimen") (:form . "specimen") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "metastasis") (:form . "metastases") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 142) (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 167)\n  (:start . 156) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s535.3) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004959@unknown@formal@none@1@S@In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lung") (:form . "lungs") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "deplete") (:form . "depleted") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "airway") (:form . "airway") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "instillation") (:form . "instillation") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "liposome-encapsulated")\n  (:form . "liposome-encapsulated") (:end . 119) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "dichloromethylene") (:form . "dichloromethylene")\n  (:end . 137) (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "diphosphonate") (:form . "diphosphonate")\n  (:end . 151) (:start . 138) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s536.4) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004969@unknown@formal@none@1@S@However, only triflusal and aspirin inhibited purified COX-2 enzyme.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "cox-2") (:form . "COX-2") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s537.4) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004979@unknown@formal@none@1@S@We demonstrate the nuclear localization of I(kappa)B(alpha) in PBL by different techniques: Western blot, indirect immunofluorescence and electron microscopy.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 59) (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 133) (:start . 115) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "electron") (:form . "electron") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 157)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s538.5) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004989@unknown@formal@none@1@S@Electrophoretic mobility shift assays demonstrated that PGG-Glucan induced the activation of an NF-kappaB-like nuclear transcription factor in purified human neutrophils.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PGG-Glucan") (:form . "PGG-Glucan") (:end . 66)\n  (:start . 56) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 74)\n  (:start . 67) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nf-kappab-like") (:form . "NF-kappaB-like")\n  (:end . 110) (:start . 96) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 118)\n  (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 139)\n  (:start . 133) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 151)\n  (:start . 143) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 60))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 169)\n  (:start . 158) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s539.5) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004999@unknown@formal@none@1@S@Glucocorticoid receptors are also able to interact with transcriptional factors such as AP-1 (activator protein-1) of NF-kappa B (nuclear factor-kappa B).@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 150)\n  (:start . 138) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s540.7) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005009@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSAs) revealed specific binding of nuclear protein to the NF-kappaB site upon induction with M. tuberculosis.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 148)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s541.8) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005019@unknown@formal@none@1@S@Immunoblot analysis identified Fli-1 protein in lysates derived from platelets.@(((:tag . "NNP") (:stem . "Immunoblot") (:form . "Immunoblot") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s542.8) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005029@unknown@formal@none@1@S@These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "implicate") (:form . "implicate") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "traf") (:form . "TRAFs") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stp-c488-mediated") (:form . "STP-C488-mediated")\n  (:end . 47) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 62) (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rodent") (:form . "rodent") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 106)\n  (:start . 95) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s543.8) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005039@unknown@formal@none@1@S@A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 34) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 55)\n  (:start . 49) (:id . 46))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 66)\n  (:start . 56) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 72) (:start . 67)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 81)\n  (:start . 73) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 111) (:start . 110)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 121)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 129)\n  (:start . 122) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 141)\n  (:start . 131) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 159) (:start . 143) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 176)\n  (:start . 165) (:id . 63))\n ((:tag . "NN") (:stem . "assignment") (:form . "assignment") (:end . 187)\n  (:start . 177) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s545.1) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005049@unknown@formal@none@1@S@Finally, chromosomal localization using fluorescence in situ hybridization revealed that LITAF mapped to chromosome 16p12-16p13.3.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LITAF") (:form . "LITAF") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 101) (:start . 95)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "16p12-16p13.3") (:form . "16p12-16p13.3")\n  (:end . 129) (:start . 116) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s545.11) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005059@unknown@formal@none@1@S@First, we showed that viral binding induced a number of immunoregulatory genes (IL-1beta, A20, NF-kappaB-p105/p50, and IkappaBalpha) in unactivated monocytes and that neutralizing Abs to the major HCMV glycoproteins, gB (UL55) and gH (UL75), inhibited the induction of these genes.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 16) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . 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"UL55") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 226) (:start . 225)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "gH") (:form . "gH") (:end . 233) (:start . 231)\n  (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 235) (:start . 234)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "UL75") (:form . "UL75") (:end . 239) (:start . 235)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 240) (:start . 239)\n  (:id . 86))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 241) (:start . 240)\n  (:id . 87))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 251)\n  (:start . 242) (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 89))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 265)\n  (:start . 256) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 268) (:start . 266)\n  (:id . 91))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 274)\n  (:start . 269) (:id . 92))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 280)\n  (:start . 275) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s547.3) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005069@unknown@formal@none@1@S@Chlamydia pneumoniae is an important respiratory pathogen.@(((:tag . "FW") (:stem . "chlamydia") (:form . "Chlamydia") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "pneumoniae") (:form . "pneumoniae") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "pathogen") (:form . "pathogen") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s548.2) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005079@unknown@formal@none@1@S@The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ERK") (:form . "ERK") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pathway-specific") (:form . "pathway-specific")\n  (:end . 24) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "pd98059") (:form . "PD98059") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s549.4) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005089@unknown@formal@none@1@S@In contrast, another inducible gene expression of monocyte chemotactic protein-1 (a CC chemokine) and the activation of the transcriptional factor (FcRFgamma) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . 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5005099@unknown@formal@none@1@S@Thus, STAT1 may be a useful target in the development of new immunosuppressive and antineoplastic agents.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 53)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 78) (:start . 61) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "antineoplastic") (:form . "antineoplastic")\n  (:end . 97) (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x551.9.1) (:span 12 15)))\n (:hscopes ((:id . :x551.9.1) (:span 12 104)))\n (:identifiers (:sid . :s551.9) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005109@unknown@formal@none@1@S@RESULTS: With the exception of indomethacin, the used immunosuppressive and anti-inflammatory agents significantly inhibited T cell proliferation in response to influenza virus antigen in a dose-dependent manner.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "With") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 71) (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 93) (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 126) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 145) (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 157)\n  (:start . 149) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 63))\n ((:tag . "NN") (:stem . "influenza") (:form . "influenza") (:end . 170)\n  (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 176)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 184)\n  (:start . 177) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 189) (:start . 188)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 204) (:start . 190) (:id . 69))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 211)\n  (:start . 205) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x552.10.1) (:span 9 30)))\n (:nscopes ((:id . :x552.10.1) (:span 9 43)))\n (:identifiers (:sid . :s552.10) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005119@unknown@formal@none@1@S@The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . 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5005129@unknown@formal@none@1@S@Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells.@(((:tag . "NNS") (:stem . "effort") (:form . "Efforts") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VB") (:stem . "pinpoint") (:form . "pinpoint") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . 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5005139@unknown@formal@none@1@S@This ANG II effect was blocked by the angiotensin AT1 receptor antagonist losartan.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "angiotensin") (:form . "angiotensin") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "at1") (:form . "AT1") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "losartan") (:form . "losartan") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s555.7) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005149@unknown@formal@none@1@S@Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SIT") (:form . "SIT") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "downmodulate") (:form . "downmodulates")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor-") (:form . "receptor-") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-mediated")\n  (:form . "phytohemagglutinin-mediated") (:end . 100) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 126)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 133)\n  (:start . 127) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 146)\n  (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 177)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 182) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 192)\n  (:start . 183) (:id . 69))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 202)\n  (:start . 193) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 207) (:start . 203)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 220)\n  (:start . 212) (:id . 73))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 228)\n  (:start . 221) (:id . 74))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 237)\n  (:start . 229) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 240) (:start . 238)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 251)\n  (:start . 241) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 254) (:start . 252)\n  (:id . 78))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 268) (:start . 255) (:id . 79))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 270) (:start . 269)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x556.6.1) (:span 212 220)))\n (:hscopes ((:id . :x556.6.1) (:span 212 270)))\n (:identifiers (:sid . :s556.6) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005159@unknown@formal@none@1@S@These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s557.9) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005169@unknown@formal@none@1@S@However, like normal Ter 119 erythroid cells, these Ter 119 positive cells from transgenic mice still expressed high levels of beta-globin and very low or undetectable glycoprotein IIb and platelet factor 4 megakaryocytic transcripts.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "Ter") (:form . "Ter") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "119") (:form . "119") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ter") (:form . "Ter") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "119") (:form . "119") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 138)\n  (:start . 127) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 167)\n  (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 180)\n  (:start . 168) (:id . 70))\n ((:tag . "NNP") (:stem . "IIb") (:form . "IIb") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 221) (:start . 207) (:id . 76))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 233)\n  (:start . 222) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s558.9) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005179@unknown@formal@none@1@S@RESULTS: LPS increased NF-kappaB DNA binding and TNF-alpha release in human monocytes.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s559.9) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005189@unknown@formal@none@1@S@2. Flow cytometry revealed binding of N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX, but not of SMX itself, to the surface of viable white blood cells.@(((:tag . "LS") (:stem . "2.") (:form . "2.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "N-hydroxy") (:form . "N-hydroxy") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SMX-NHOH") (:form . "SMX-NHOH") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nitroso") (:form . "nitroso") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "smx-no") (:form . "SMX-NO") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 121)\n  (:start . 115) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 68))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 137)\n  (:start . 130) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 147)\n  (:start . 141) (:id . 71))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 153)\n  (:start . 148) (:id . 72))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 159)\n  (:start . 154) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x560.4.1) (:span 104 107)))\n (:nscopes ((:id . :x560.4.1) (:span 104 121)))\n (:identifiers (:sid . :s560.4) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005199@unknown@formal@none@1@S@Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade.@(((:tag . "NNP") (:stem . "Beta-catenin") (:form . "Beta-catenin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "vertebrate") (:form . "vertebrate") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "polarity") (:form . "polarity") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Armadillo") (:form . "Armadillo") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cell-cell") (:form . "cell-cell") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 148)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "wnt") (:form . "Wnt") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s561.2) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005209@unknown@formal@none@1@S@The transactivator CIITA behaves as a master controller of constitutive and inducible MHC class II gene activation, but its exact mechanism of action is not known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "master") (:form . "master") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "controller") (:form . "controller") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x562.3.1) (:span 153 162)))\n (:hscopes ((:id . :x562.3.1) (:span 120 162)))\n (:identifiers (:sid . :s562.3) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005219@unknown@formal@none@1@S@PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties.@(((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "triptolide") (:form . "triptolide") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "diterpene") (:form . "diterpene") (:end . 33)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "triepoxide") (:form . "triepoxide") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 74) (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 95) (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s563.2) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005229@unknown@formal@none@1@S@This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "release") (:form . "releases") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lyso-phospholipid") (:form . "lyso-phospholipids")\n  (:end . 60) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "metabolize") (:form . "metabolized") (:end . 97)\n  (:start . 86) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "eicosanoid") (:form . "eicosanoids") (:end . 112)\n  (:start . 101) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "platelet-activating-factor")\n  (:form . "platelet-activating-factor") (:end . 143) (:start . 117)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s564.3) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005239@unknown@formal@none@1@S@On first encounter with antigen, naive CD4+ T helper (Th) cells differentiate into cytokine-producing effector cells.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "encounter") (:form . "encounter") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 77) (:start . 64) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cytokine-producing") (:form . "cytokine-producing")\n  (:end . 101) (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s565.3) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005249@unknown@formal@none@1@S@Reporter luciferase gene vectors containing the human gamma 3 ECS were used to transfect CL-01 cells, which have been shown to undergo Smu-->S gamma 3 DNA recombination, upon engagement of CD40 by CD40 ligand (CD40L) and exposure to IL-4.@(((:tag . "NN") (:stem . "reporter") (:form . "Reporter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ecs") (:form . "ECS") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VB") (:stem . "transfect") (:form . "transfect") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "cl-01") (:form . "CL-01") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "NNP") (:stem . "Smu–>S") (:form . "Smu–>S") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 168) (:start . 155) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 185)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 196) (:start . 194)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 208)\n  (:start . 202) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 215)\n  (:start . 210) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 81))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 229)\n  (:start . 221) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 232) (:start . 230)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 237) (:start . 233)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s566.5) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005259@unknown@formal@none@1@S@NF-kappa B-directed luciferase activity increased approximately 3-fold when cells transfected with the plasmid pNF-kappa BLUC containing five copies of consensus NF-kappa B site linked to a minimal adenovirus E1B promoter-luciferase gene were exposed to thrombin, indicating that activation of NF-kappa B was essential for thrombin response.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "b-directed") (:form . "B-directed") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 49)\n  (:start . 40) (:id . 46))\n ((:tag . "RB") (:stem . "approximately") (:form . 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"containing") (:end . 136)\n  (:start . 126) (:id . 57))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 141) (:start . 137)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 148)\n  (:start . 142) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 60))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 161)\n  (:start . 152) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 170)\n  (:start . 162) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 177) (:start . 173)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 184)\n  (:start . 178) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 189) (:start . 188)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 197)\n  (:start . 190) (:id . 68))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 208)\n  (:start . 198) (:id . 69))\n ((:tag . "NN") (:stem . "e1b") (:form . "E1B") (:end . 212) (:start . 209)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter-luciferase")\n  (:form . "promoter-luciferase") (:end . 232) (:start . 213) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 237) (:start . 233)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 242) (:start . 238)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 250)\n  (:start . 243) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 253) (:start . 251)\n  (:id . 75))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 262)\n  (:start . 254) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . 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"thrombin") (:end . 331)\n  (:start . 323) (:id . 87))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 340)\n  (:start . 332) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 341) (:start . 340)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x567.5.1) (:span 264 279)))\n (:hscopes ((:id . :x567.5.1) (:span 264 340)))\n (:identifiers (:sid . :s567.5) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005269@unknown@formal@none@1@S@Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise.@(((:tag . "NNP") (:stem . "Fas/FasL") (:form . "Fas/FasL") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "pathologic") (:form . "pathologic") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "VBP") (:stem . "arise") (:form . "arise") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s568.7) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005279@unknown@formal@none@1@S@Here, we have analyzed the mechanisms involved in CTLA-4-mediated inhibition of T cell activation of naive CD4+ T cells using Ab cross-linking.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ctla-4-mediated") (:form . "CTLA-4-mediated")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 125) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 142) (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s570.3) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005289@unknown@formal@none@1@S@These experiments show that FGF-1 stimulation of Jurkat T cells provides a second signal that augments TCR-mediated IL-2 production.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fgf-1") (:form . "FGF-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 115)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s571.6) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005299@unknown@formal@none@1@S@Furthermore, HIV-1 replication is cooperatively stimulated when the distinct LT-betaR and TNF receptor systems are simultaneously engaged by their specific ligands.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "lt-betar") (:form . "LT-betaR") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 129) (:start . 115) (:id . 58))\n ((:tag . "VBN") (:stem . "engage") (:form . "engaged") (:end . 137)\n  (:start . 130) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 163)\n  (:start . 156) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s572.5) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005309@unknown@formal@none@1@S@Our data showed that TNF resistance in vitro correlates with the increased level of transcription factor NF-kappaB.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s573.6) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005319@unknown@formal@none@1@S@These results suggest that NF-kappaB activation is required for C5a-induced IL-8 gene expression and that this response is mediated primarily through a pertussis toxin-insensitive pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pertussis") (:form . "pertussis") (:end . 161)\n  (:start . 152) (:id . 64))\n ((:tag . "JJ") (:stem . "toxin-insensitive") (:form . "toxin-insensitive")\n  (:end . 179) (:start . 162) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 187)\n  (:start . 180) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x574.9.1) (:span 14 21)))\n (:hscopes ((:id . :x574.9.1) (:span 14 187)))\n (:identifiers (:sid . :s574.9) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005329@unknown@formal@none@1@S@An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s576.1) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005339@unknown@formal@none@1@S@Single-cell reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was applied to this culture system to investigate gene expression of diverse receptors, markers of differentiation, and transcription factors (EKLF, GATA-1, GATA-2, p45 NF-E2, PU.1, and SCL/Tal1) at discrete stages of erythropoietic development.@(((:tag . "JJ") (:stem . "single-cell") (:form . "Single-cell") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 44) (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 50) (:start . 45)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 59)\n  (:start . 51) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 47))\n ((:tag . "NNP") (:stem . 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5005349@unknown@formal@none@1@S@By comparing the expression of genes controlling apoptosis, including those encoding several members of the BCL-2 family of proteins, the known relative resistance of EBV-immortalized B-cell lines to apoptosis induced by low serum was found to correlate with expression of both BCL-2 and A20.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ebv-immortalized") (:form . "EBV-immortalized")\n  (:end . 183) (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 190)\n  (:start . 184) (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 209)\n  (:start . 200) (:id . 72))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 217)\n  (:start . 210) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 220) (:start . 218)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 224) (:start . 221)\n  (:id . 75))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 230)\n  (:start . 225) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 234) (:start . 231)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 240)\n  (:start . 235) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 243) (:start . 241)\n  (:id . 79))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 253)\n  (:start . 244) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 258) (:start . 254)\n  (:id . 81))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 269)\n  (:start . 259) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 272) (:start . 270)\n  (:id . 83))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 277) (:start . 273)\n  (:id . 84))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 283)\n  (:start . 278) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 287) (:start . 284)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "A20") (:form . "A20") (:end . 291) (:start . 288)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s578.5) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005359@unknown@formal@none@1@S@HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cdr2-loop") (:form . "CDR2-loop") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 160) (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 167)\n  (:start . 161) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s580.1) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005369@unknown@formal@none@1@S@Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "oligomerization") (:form . "oligomerization")\n  (:end . 84) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "D1/CDR2-loop") (:form . "D1/CDR2-loop")\n  (:end . 111) (:start . 99) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 142)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 166)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x580.11.1) (:span 12 25)))\n (:hscopes ((:id . :x580.11.1) (:span 12 166)))\n (:identifiers (:sid . :s580.11) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005379@unknown@formal@none@1@S@Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MCM") (:form . "MCM") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 119)\n  (:start . 113) (:id . 63))\n ((:tag . "VBP") (:stem . "peak") (:form . "peak") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "G1/S") (:form . "G1/S") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s582.3) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005389@unknown@formal@none@1@S@In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . 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5005399@unknown@formal@none@1@S@Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Id3") (:form . "Id3") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "impede") (:form . "impedes") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "downregulate") (:form . "downregulates")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "pre-talpha") (:form . "pre-Talpha") (:end . 98)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s584.4) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005409@unknown@formal@none@1@S@Importantly, jagged1 transcripts were also upregulated by endogenous NF-kappaB activation and this effect was inhibited by a dominant mutant of IkappaBalpha, a physiological inhibitor of NF-kappaB.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jagged1") (:form . "jagged1") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 156) (:start . 144) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 173) (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 183)\n  (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s585.6) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005419@unknown@formal@none@1@S@METHODS: Allergen-specific T-cell clones and T-cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the transcriptional regulation of the IL-5 gene was investigated with transient transfection and electrophoretic mobility shift analysis.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "Allergen-specific")\n  (:end . 26) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 79)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 129)\n  (:start . 121) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 166) (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 177)\n  (:start . 167) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 189) (:start . 185)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 194) (:start . 190)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 198) (:start . 195)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 211)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 226)\n  (:start . 217) (:id . 73))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 239)\n  (:start . 227) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 259) (:start . 244) (:id . 76))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 268)\n  (:start . 260) (:id . 77))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 274)\n  (:start . 269) (:id . 78))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 283)\n  (:start . 275) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s586.5) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005429@unknown@formal@none@1@S@Here we investigate the hypothesis that low shear-induced activation of NF-kappaB is responsible for enhanced expression of vascular cell adhesion molecule (VCAM-1) resulting in augmented endothelial cell-monocyte (EC-Mn) adhesion and that this activation is dependent on intracellular oxidant activity.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "shear-induced") (:form . "shear-induced")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 163)\n  (:start . 157) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 187)\n  (:start . 178) (:id . 68))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 199)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "cell-monocyte") (:form . "cell-monocyte")\n  (:end . 213) (:start . 200) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 215) (:start . 214)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "EC-Mn") (:form . "EC-Mn") (:end . 220)\n  (:start . 215) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 73))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 230)\n  (:start . 222) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 234) (:start . 231)\n  (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 239) (:start . 235)\n  (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 244) (:start . 240)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 255)\n  (:start . 245) (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 258) (:start . 256)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 268)\n  (:start . 259) (:id . 80))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 271) (:start . 269)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 285) (:start . 272) (:id . 82))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 293)\n  (:start . 286) (:id . 83))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 302)\n  (:start . 294) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x587.3.1) (:span 24 34)))\n (:hscopes ((:id . :x587.3.1) (:span 24 302)))\n (:identifiers (:sid . :s587.3) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005439@unknown@formal@none@1@S@We have introduced a small deletion within beta-catenin (Delta19) that disrupts binding to LEF-1, E-cadherin, and APC but not axin.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "delta19") (:form . "Delta19") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "disrupt") (:form . "disrupts") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LEF-1") (:form . "LEF-1") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "E-cadherin") (:form . "E-cadherin") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "axin") (:form . "axin") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x588.5.1) (:span 122 125)))\n (:nscopes ((:id . :x588.5.1) (:span 122 130)))\n (:identifiers (:sid . :s588.5) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005449@unknown@formal@none@1@S@Monocytes and peripheral blood mononuclear cells (PBMC) prepared from whole blood maintained for 20 h at 37 degrees C in the presence of recombinant human IL-10 had an enhanced capacity to produce TNF in response to LPS.@(((:tag . "NNP") (:stem . "Monocyte") (:form . "Monocytes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 133)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 148)\n  (:start . 137) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 196)\n  (:start . 189) (:id . 75))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 200) (:start . 197)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 212)\n  (:start . 204) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s589.4) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005459@unknown@formal@none@1@S@The lineage-restricted transcription factor GATA-1 is required for differentiation of erythroid and megakaryocytic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lineage-restricted") (:form . "lineage-restricted")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 50)\n  (:start . 44) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 82) (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 95)\n  (:start . 86) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 114) (:start . 100) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s590.2) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005469@unknown@formal@none@1@S@Monocyte arrest and transmigration on inflamed endothelium in shear flow is inhibited by adenovirus-mediated gene transfer of IkappaB-alpha.@(((:tag . "NNP") (:stem . "Monocyte") (:form . "Monocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transmigration") (:form . "transmigration")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inflamed") (:form . "inflamed") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adenovirus-mediated")\n  (:form . "adenovirus-mediated") (:end . 108) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 122)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 139) (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s591.1) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005479@unknown@formal@none@1@S@SLP-76 and Vav, two hematopoietic cell specific molecules, are critical for T cell development and activation.@(((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 33) (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s592.2) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005489@unknown@formal@none@1@S@The chromatin structure of the human beta-globin gene locus assumes a transcriptionally-active conformation in erythroid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "assume") (:form . "assumes") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptionally-active")\n  (:form . "transcriptionally-active") (:end . 94) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 107)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s593.2) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005499@unknown@formal@none@1@S@To understand the role of NF-kappa B complexes in T cell development and activation, we have generated transgenic mice in which RelA and c-Rel complexes were selectively inhibited in the T-lineage cells by specific expression of a trans-dominant form of I kappa B alpha.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 118)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 169)\n  (:start . 158) (:id . 69))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t-lineage") (:form . "T-lineage") (:end . 196)\n  (:start . 187) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 225)\n  (:start . 215) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 230) (:start . 229)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "trans-dominant") (:form . "trans-dominant")\n  (:end . 245) (:start . 231) (:id . 80))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 250) (:start . 246)\n  (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 253) (:start . 251)\n  (:id . 82))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 255) (:start . 254)\n  (:id . 83))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 261)\n  (:start . 256) (:id . 84))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 263) (:start . 262)\n  (:id . 85))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 269)\n  (:start . 264) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s594.2) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005509@unknown@formal@none@1@S@Previous studies have characterized the CD28 augmentation of TCR-mediated signaling in peripheral blood T cells through transcriptional activation of an IL-2 promoter CD28 response element (CD28RE), along with enhanced mRNA stability.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 73)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 103) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 135) (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 166)\n  (:start . 158) (:id . 63))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 171) (:start . 167)\n  (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 180)\n  (:start . 172) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 188)\n  (:start . 181) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 196)\n  (:start . 190) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 70))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 204)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 209) (:start . 205)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 233)\n  (:start . 224) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s595.5) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005519@unknown@formal@none@1@S@This function is mediated through two repression domains and is dependent upon the promoter context and cell type.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s596.3) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005529@unknown@formal@none@1@S@We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x597.7.1) (:span 28 31)))\n (:nscopes ((:id . :x597.7.1) (:span 28 70)))\n (:identifiers (:sid . :s597.7) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005539@unknown@formal@none@1@S@We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s598.6) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005549@unknown@formal@none@1@S@These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LKLF") (:form . "LKLF") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNPS") (:stem . "Ets") (:form . "Ets") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "NNP") (:stem . "B/Rel/NFAT") (:form . "B/Rel/NFAT") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LEF1") (:form . "LEF1") (:end . 195) (:start . 191)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TCF1") (:form . "TCF1") (:end . 201) (:start . 197)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 80))\n ((:tag . "NN") (:stem . "sox4") (:form . "Sox4") (:end . 211) (:start . 207)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s599.4) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005559@unknown@formal@none@1@S@Functional analysis indicates that the BRs are involved in control of hIL-5 promoter activity.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNPS") (:stem . "BR") (:form . "BRs") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hil-5") (:form . "hIL-5") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x600.8.1) (:span 20 34)))\n (:hscopes ((:id . :x600.8.1) (:span 20 93)))\n (:identifiers (:sid . :s600.8) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005569@unknown@formal@none@1@S@Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 89) (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s601.6) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005579@unknown@formal@none@1@S@Based on the simian immunodeficiency virus (SIV) model for AIDS, loss-of-function (e.g. deletion of accessory genes such as nef) has been forwarded as a primary approach for creating enfeebled, but replication-competent, HIV-1/SIV.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SIV") (:form . "SIV") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 81) (:start . 65) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "forward") (:form . "forwarded") (:end . 147)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 160)\n  (:start . 153) (:id . 71))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 169)\n  (:start . 161) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "create") (:form . "creating") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "VBN") (:stem . "enfeeble") (:form . "enfeebled") (:end . 192)\n  (:start . 183) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "replication-competent")\n  (:form . "replication-competent") (:end . 219) (:start . 198) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "HIV-1/SIV") (:form . "HIV-1/SIV") (:end . 230)\n  (:start . 221) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s602.3) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005589@unknown@formal@none@1@S@Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ref-1") (:form . "REF-1") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s603.1) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005599@unknown@formal@none@1@S@Genetic variation in cytokine promoter regions is postulated to influence susceptibility to infection, but the molecular mechanisms by which such polymorphisms might affect gene regulation are unknown.@(((:tag . "JJ") (:stem . "genetic") (:form . "Genetic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 88) (:start . 74) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "polymorphism") (:form . "polymorphisms")\n  (:end . 159) (:start . 146) (:id . 63))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 172)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 188)\n  (:start . 178) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 192) (:start . 189)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 200)\n  (:start . 193) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x604.2.2) (:span 193 200))\n  ((:id . :x604.2.1) (:span 160 165)))\n (:hscopes ((:id . :x604.2.1) (:span 160 188))\n  ((:id . :x604.2.2) (:span 107 200)))\n (:identifiers (:sid . :s604.2) (:did . :|10369255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005609@unknown@formal@none@1@S@Clinicians are only just beginning to recognize subclinical markers of response, and it may soon be possible to predict response on the basis of genetic composition.@(((:tag . "NNPS") (:stem . "Clinician") (:form . "Clinicians") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "begin") (:form . "beginning") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "subclinical") (:form . "subclinical") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "soon") (:form . "soon") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x605.8.1) (:span 100 108))\n  ((:id . :x605.8.2) (:span 88 91)))\n (:hscopes ((:id . :x605.8.1) (:span 100 164))\n  ((:id . :x605.8.2) (:span 88 164)))\n (:identifiers (:sid . :s605.8) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005619@unknown@formal@none@1@S@Pretreatment of cultured human ECs with the PPARalpha activators fenofibrate or WY14643 inhibited TNF-alpha-induced VCAM-1 in a time- and concentration-dependent manner, an effect not seen with PPARgamma activators.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "fenofibrate") (:form . "fenofibrate") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "WY14643") (:form . "WY14643") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 115) (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 122)\n  (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "time-") (:form . "time-") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 161) (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 168)\n  (:start . 162) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 179)\n  (:start . 173) (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 188) (:start . 184)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 203)\n  (:start . 194) (:id . 69))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 214)\n  (:start . 204) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x606.7.1) (:span 180 183)))\n (:nscopes ((:id . :x606.7.1) (:span 180 214)))\n (:identifiers (:sid . :s606.7) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005629@unknown@formal@none@1@S@The biological significance of NF-kappaB activation in T. parva-infected cells, however, has not yet been defined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "FW") (:stem . "t.") (:form . "T.") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "parva-infected") (:form . "parva-infected")\n  (:end . 72) (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x607.5.1) (:span 93 96)))\n (:nscopes ((:id . :x607.5.1) (:span 0 113)))\n (:identifiers (:sid . :s607.5) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005639@unknown@formal@none@1@S@In this study, each of the four different isoforms of WT1 was constitutively overexpressed in the leukemic cell line K562.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 41)\n  (:start . 32) (:id . 50))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "WT1") (:form . "WT1") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 76) (:start . 62) (:id . 55))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s608.6) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005649@unknown@formal@none@1@S@In addition, we show that erythropoietin, which is also required for erythroid cell survival, cooperates with GATA-1 to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 40) (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 193)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 209)\n  (:start . 201) (:id . 74))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 220)\n  (:start . 210) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s609.7) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005659@unknown@formal@none@1@S@Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "function") (:form . "functioning") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proapoptotic") (:form . "proapoptotic") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x610.9.1) (:span 33 36)) ((:id . :x610.9.2) (:span 9 17)))\n (:hscopes ((:id . :x610.9.1) (:span 33 158))\n  ((:id . :x610.9.2) (:span 9 158)))\n (:identifiers (:sid . :s610.9) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005669@unknown@formal@none@1@S@STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules.@(((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s612.1) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005679@unknown@formal@none@1@S@Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "caspase-dependent") (:form . "caspase-dependent")\n  (:end . 82) (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "NN") (:stem . "caspase-1") (:form . "caspase-1") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-3") (:form . "-3") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x613.1.1) (:span 93 100)))\n (:nscopes ((:id . :x613.1.1) (:span 93 142)))\n (:identifiers (:sid . :s613.1) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005689@unknown@formal@none@1@S@Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "Toll-like") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s614.2) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005699@unknown@formal@none@1@S@The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 183)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 196)\n  (:start . 187) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 208)\n  (:start . 201) (:id . 74))\n ((:tag . "JJ") (:stem . "tonsillar") (:form . "tonsillar") (:end . 218)\n  (:start . 209) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s615.3) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005709@unknown@formal@none@1@S@The pattern of kappaB-binding activity in T cells of RCC patient was altered as compared to that seen in T cells obtained from normal volunteers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "kappab-binding") (:form . "kappaB-binding")\n  (:end . 29) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 133)\n  (:start . 127) (:id . 65))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s616.4) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005719@unknown@formal@none@1@S@Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "select") (:form . "select") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mAECA") (:form . "mAECA") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "igg-aeca") (:form . "IgG-AECA") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Takayasu") (:form . "Takayasu") (:end . 164)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 174)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 182)\n  (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s617.5) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005729@unknown@formal@none@1@S@In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s617.15) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005739@unknown@formal@none@1@S@Despite constitutive association with TRADD or RIP, LMP1 does not induce apoptosis in EBV-negative Burkitt lymphoma or human embryonic kidney 293 cells.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 32)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ebv-negative") (:form . "EBV-negative") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 141)\n  (:start . 135) (:id . 62))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x618.9.1) (:span 62 65)))\n (:nscopes ((:id . :x618.9.1) (:span 62 151)))\n (:identifiers (:sid . :s618.9) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005749@unknown@formal@none@1@S@ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.@(((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s620.1) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005759@unknown@formal@none@1@S@Numerous cellular and biochemical abnormalities in immune regulation have been described in patients with systemic lupus erythematosus (SLE), including surface Ag receptor-initiated signaling events and lymphokine production.@(((:tag . "JJ") (:stem . "numerous") (:form . "Numerous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 47)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 134) (:start . 121) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 151)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "receptor-initiated") (:form . "receptor-initiated")\n  (:end . 181) (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 191)\n  (:start . 182) (:id . 67))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 198)\n  (:start . 192) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 213)\n  (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 224)\n  (:start . 214) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s621.2) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005769@unknown@formal@none@1@S@Possible differences in the mechanism(s) of action of different glucocorticoid hormone compounds.@(((:tag . "JJ") (:stem . "possible") (:form . "Possible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 78) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x622.1.1) (:span 0 8)))\n (:hscopes ((:id . :x622.1.1) (:span 0 96)))\n (:identifiers (:sid . :s622.1) (:did . :|10415609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005779@unknown@formal@none@1@S@In this paper we shall advance the hypothesis that: (i) TNF-alpha indirectly controls immune surveillance; and (ii) TNF-alpha controls DNA repair and tumor suppression through the regulation of wild type p53.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "MD") (:stem . "shall") (:form . "shall") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VB") (:stem . "advance") (:form . "advance") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 65)\n  (:start . 56) (:id . 55))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 85)\n  (:start . 77) (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "surveillance") (:form . "surveillance") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 65))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 134)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 145)\n  (:start . 139) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 69))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 155)\n  (:start . 150) (:id . 70))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 167)\n  (:start . 156) (:id . 71))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 190)\n  (:start . 180) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 198) (:start . 194)\n  (:id . 76))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 203) (:start . 199)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x623.5.1) (:span 23 45)))\n (:hscopes ((:id . :x623.5.1) (:span 23 207)))\n (:identifiers (:sid . :s623.5) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005789@unknown@formal@none@1@S@In addition, stimulation with MBP prolonged the stability of IL-8 mRNA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "prolong") (:form . "prolonged") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s624.9) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005799@unknown@formal@none@1@S@These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 88) (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "well-characterized") (:form . "well-characterized")\n  (:end . 137) (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "adipocyte") (:form . "adipocytes") (:end . 156)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x625.7.1) (:span 45 48)) ((:id . :x625.7.2) (:span 11 18)))\n (:hscopes ((:id . :x625.7.1) (:span 45 156))\n  ((:id . :x625.7.2) (:span 11 156)))\n (:identifiers (:sid . :s625.7) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005809@unknown@formal@none@1@S@These data suggest a ROI-dependent NF-kappaB mediated transcription of inflammatory cytokines in bronchial epithelial cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "roi-dependent") (:form . "ROI-dependent")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 83)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 93)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 106)\n  (:start . 97) (:id . 54))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 117)\n  (:start . 107) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x626.10.1) (:span 11 18)))\n (:hscopes ((:id . :x626.10.1) (:span 11 123)))\n (:identifiers (:sid . :s626.10) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005819@unknown@formal@none@1@S@BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2).@(((:tag . "NNP") (:stem . "BLP") (:form . "BLPs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "Toll-like") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "receptor-2") (:form . "receptor-2") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "htlr2") (:form . "hTLR2") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s628.4) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005829@unknown@formal@none@1@S@Electrophoretic mobility shift assay analysis of proteins binding to the CRE site identified both ATF-1 and ATF-2 in Jurkat cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "atf-1") (:form . "ATF-1") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "atf-2") (:form . "ATF-2") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s629.7) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005839@unknown@formal@none@1@S@Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "proceed") (:form . "proceeds") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 95) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 109) (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 133)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x630.8.1) (:span 18 25)))\n (:hscopes ((:id . :x630.8.1) (:span 18 133)))\n (:identifiers (:sid . :s630.8) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005849@unknown@formal@none@1@S@Bcl-2 inhibits apoptosis induced by a variety of stimuli, including chemotherapy drugs and glucocorticoids.@(((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s632.2) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005859@unknown@formal@none@1@S@Phosphorylated Bcl-2 cannot bind calcineurin, and NFAT activation, FasL expression, and apoptosis can occur after Bcl-2 phosphorylation.@(((:tag . "VBN") (:stem . "phosphorylate") (:form . "Phosphorylated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 20) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 135) (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x632.12.1) (:span 98 101)))\n (:ncues ((:id . :x632.12.2) (:span 21 27)))\n (:hscopes ((:id . :x632.12.1) (:span 98 135)))\n (:nscopes ((:id . :x632.12.2) (:span 21 82)))\n (:identifiers (:sid . :s632.12) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005869@unknown@formal@none@1@S@The nuclear factor of kappaB (NF-kappaB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 56)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 121)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 147)\n  (:start . 135) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s634.2) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005879@unknown@formal@none@1@S@Further analysis of the MBP promoter region identified a C/EBP (CCAAT/enhancer-binding protein) consensus binding site 6 bp upstream of the functional GATA-binding site in the MBP gene.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ccaat/enhancer-binding")\n  (:form . "CCAAT/enhancer-binding") (:end . 86) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 163)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s635.4) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005889@unknown@formal@none@1@S@This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "aim") (:form . "aims") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "subpopulation") (:form . "subpopulation")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 96) (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "microenvironment") (:form . "microenvironment")\n  (:end . 180) (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s636.2) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005899@unknown@formal@none@1@S@Although the role of CD28 in T cell costimulation is firmly established, the mechanisms by which it exerts its costimulatory actions are less clear.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 49) (:start . 36) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "firmly") (:form . "firmly") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 124) (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s637.2) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005909@unknown@formal@none@1@S@Nevertheless how the protective response is exerted by flavonoids is not well characterized.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 91) (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s638.3) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005919@unknown@formal@none@1@S@M0/M1 leukemic cells are not sensitive to differentiating agents, whereas M3 leukemic cells are induced to undergo granulocytic differentiation after ATRA treatment but are not sensitive to VD.@(((:tag . "NN") (:stem . "m0/m1") (:form . "M0/M1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "m3") (:form . "M3") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 143) (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 149)\n  (:start . 144) (:id . 62))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x639.3.1) (:span 173 176))\n  ((:id . :x639.3.2) (:span 25 28)))\n (:nscopes ((:id . :x639.3.1) (:span 173 192))\n  ((:id . :x639.3.2) (:span 25 64)))\n (:identifiers (:sid . :s639.3) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005929@unknown@formal@none@1@S@OBJECTIVE: We sought to investigate the molecular mechanisms regulating this early inflammatory response.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s640.4) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005939@unknown@formal@none@1@S@IkappaBalpha degradation and NF-kappaB nuclear translocation correlate with transcriptional activation of the inflammatory cytokines TNF-alpha and IL-1beta.@(((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 60) (:start . 47) (:id . 47))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 70)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 91) (:start . 76) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 122)\n  (:start . 110) (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 132)\n  (:start . 123) (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 142)\n  (:start . 133) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 155)\n  (:start . 147) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s640.14) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005949@unknown@formal@none@1@S@We further explored the effect of dopamine in the presence of phorbol esters or tumor necrosis factor-alpha (TNF-alpha) known to activate NF-kappaB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "explore") (:form . "explored") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s641.9) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005959@unknown@formal@none@1@S@The endogenous levels of the signalsome components were unaffected by stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "signalsome") (:form . "signalsome") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s642.7) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005969@unknown@formal@none@1@S@Furthermore, in vitro binding analysis revealed that the AML1 runt DNA-binding domain physically interacts with the paired DNA-binding domain of BSAP, a B cell-specific transcription factor.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 168) (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 182) (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s643.5) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005979@unknown@formal@none@1@S@Elevated levels of c-Maf protein led to marked increases in Myb:Maf complexes and the accumulation of monocyte/macrophage cells, followed by eventual programmed cell death.@(((:tag . "JJ") (:stem . "elevated") (:form . "Elevated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Myb:Maf") (:form . "Myb:Maf") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 121) (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "eventual") (:form . "eventual") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 171)\n  (:start . 166) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s644.7) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005989@unknown@formal@none@1@S@Surprisingly, however, DMSO has no effect on inducible Rel A binding.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dmso") (:form . "DMSO") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x645.9.1) (:span 32 34)))\n (:nscopes ((:id . :x645.9.1) (:span 32 68)))\n (:identifiers (:sid . :s645.9) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005999@unknown@formal@none@1@S@Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "Bcl-x(L)") (:form . "Bcl-x(L)") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "apoptosis-resistant")\n  (:form . "apoptosis-resistant") (:end . 115) (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 136) (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s647.1) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006009@unknown@formal@none@1@S@Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.@(((:tag . "NNS") (:stem . "interferon") (:form . "Interferons") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "socs-1") (:form . "SOCS-1") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s648.1) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006019@unknown@formal@none@1@S@These findings demonstrate that IFNs inhibit IL-4-induced activation of STAT6 and STAT6-dependent gene expression, at least in part, by inducing expression of SOCS-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stat6-dependent") (:form . "STAT6-dependent")\n  (:end . 97) (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "socs-1") (:form . "SOCS-1") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s648.11) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006029@unknown@formal@none@1@S@This decrease was observed at 2 hr, reached a nadir at 4 hr, and returned to baseline levels at 24 hr.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reach") (:form . "reached") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nadir") (:form . "nadir") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 59) (:start . 57)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 73)\n  (:start . 65) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 59))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 85)\n  (:start . 77) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 92)\n  (:start . 86) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 101) (:start . 99)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s649.10) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006039@unknown@formal@none@1@S@Indeed, we detected gangliosides in supernatants from RCC explants and not from adjacent normal kidney tissue.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "explant") (:form . "explants") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x650.6.1) (:span 71 74)))\n (:nscopes ((:id . :x650.6.1) (:span 71 109)))\n (:identifiers (:sid . :s650.6) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006049@unknown@formal@none@1@S@Expression cloning of c-Jun.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 28) (:start . 27)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s652.2) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006059@unknown@formal@none@1@S@Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 105) (:start . 91) (:id . 55))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s653.1) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006069@unknown@formal@none@1@S@Human immunodeficiency virus (HIV) often causes latent infection.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s654.2) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006079@unknown@formal@none@1@S@Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats (LTRs), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 92)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTRs") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 161)\n  (:start . 153) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 179)\n  (:start . 169) (:id . 74))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 188)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 77))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 201)\n  (:start . 196) (:id . 78))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 205) (:start . 202)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s655.3) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006089@unknown@formal@none@1@S@Sequences related to the TCF-1 alpha binding motif (5'-GGCACCCTTTGA-3') are also found in the human TCR delta (and possibly TCR beta) enhancers.@(((:tag . "NNS") (:stem . "sequence") (:form . "Sequences") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "5'-GGCACCCTTTGA-3") (:form . "5'-GGCACCCTTTGA-3")\n  (:end . 69) (:start . 52) (:id . 51))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 123)\n  (:start . 115) (:id . 64))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 143)\n  (:start . 134) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x656.5.1) (:span 115 123)))\n (:hscopes ((:id . :x656.5.1) (:span 115 132)))\n (:identifiers (:sid . :s656.5) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006099@unknown@formal@none@1@S@Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 138) (:start . 123) (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 154) (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "T-Cell") (:form . "T-Cell") (:end . 182)\n  (:start . 176) (:id . 68))\n ((:tag . "NNP") (:stem . "Factor-1") (:form . "Factor-1") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 228) (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 237)\n  (:start . 229) (:id . 76))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 245)\n  (:start . 238) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 247) (:start . 246)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "TCE") (:form . "TCE") (:end . 250) (:start . 247)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 259)\n  (:start . 252) (:id . 81))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 266)\n  (:start . 260) (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 275) (:start . 271)\n  (:id . 84))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 284)\n  (:start . 276) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s657.3) (:did . :|2088505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006109@unknown@formal@none@1@S@Like other enhancers, the Ig heavy chain enhancer contains several short sequence motifs that bind specific transcription factors.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s659.3) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006119@unknown@formal@none@1@S@We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 120) (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s660.3) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006129@unknown@formal@none@1@S@These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 109) (:start . 94) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 145) (:start . 130) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 170) (:start . 150) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 181)\n  (:start . 171) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x660.13.1) (:span 15 24)))\n (:hscopes ((:id . :x660.13.1) (:span 15 181)))\n (:identifiers (:sid . :s660.13) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006139@unknown@formal@none@1@S@Based on these results, we propose that NTF and OTF2 interactions (both with their cognate DNA elements and possibly at the protein-protein level) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NTF") (:form . "NTF") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "otf2") (:form . "OTF2") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 65)\n  (:start . 53) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 82)\n  (:start . 77) (:id . 57))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 139) (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 181) (:start . 166) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 201) (:start . 197)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 207)\n  (:start . 202) (:id . 76))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 220)\n  (:start . 208) (:id . 77))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 228)\n  (:start . 221) (:id . 78))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 239)\n  (:start . 229) (:id . 79))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 248)\n  (:start . 240) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 252) (:start . 249)\n  (:id . 81))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 263)\n  (:start . 253) (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 268) (:start . 264)\n  (:id . 83))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 279)\n  (:start . 269) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x661.10.1) (:span 147 150))\n  ((:id . :x661.10.2) (:span 108 116)) ((:id . :x661.10.3) (:span 27 34)))\n (:hscopes ((:id . :x661.10.1) (:span 147 192))\n  ((:id . :x661.10.2) (:span 108 145)) ((:id . :x661.10.3) (:span 27 279)))\n (:identifiers (:sid . :s661.10) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006149@unknown@formal@none@1@S@The expression of c-fos, c-jun, and c-myc genes is regulated by heat shock in human lymphoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 92)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s663.1) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006159@unknown@formal@none@1@S@This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an enhancerless construct.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 56) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 81) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "promoter/luciferase")\n  (:form . "promoter/luciferase") (:end . 114) (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "RB") (:stem . "170-fold") (:form . "170-fold") (:end . 142)\n  (:start . 134) (:id . 59))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "enhancerless") (:form . "enhancerless") (:end . 163)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 173)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s664.3) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006169@unknown@formal@none@1@S@After in vitro adherence, human monocytes had a biphasic increase in PDGF(B) mRNA with peaks at 6 h and 13 d.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "peak") (:form . "peaks") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s665.5) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006179@unknown@formal@none@1@S@Interferon-gamma and the sexual dimorphism of autoimmunity.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "sexual") (:form . "sexual") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "dimorphism") (:form . "dimorphism") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "autoimmunity") (:form . "autoimmunity") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s666.1) (:did . :|2122173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006189@unknown@formal@none@1@S@Further results, in which beta-gal activity is correlated with NF-AT-binding activity, indicate that the concentration of NF-AT must exceed a critical threshold before transcription initiates.@(((:tag . "JJR") (:stem . "far") (:form . "Further") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "beta-gal") (:form . "beta-gal") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 118) (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "VB") (:stem . "exceed") (:form . "exceed") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 67))\n ((:tag . "NNS") (:stem . "initiate") (:form . "initiates") (:end . 191)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x667.7.1) (:span 87 100)))\n (:hscopes ((:id . :x667.7.1) (:span 87 191)))\n (:identifiers (:sid . :s667.7) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006199@unknown@formal@none@1@S@The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the immunophilin FKBP.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "immunophilin") (:form . "immunophilin") (:end . 148)\n  (:start . 136) (:id . 67))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x668.8.1) (:span 48 51)))\n (:hscopes ((:id . :x668.8.1) (:span 0 153)))\n (:identifiers (:sid . :s668.8) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006209@unknown@formal@none@1@S@The latter one appears to be mediated by a rapidly calcium-dependent induced gene product.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "one") (:form . "one") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 68) (:start . 51) (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x669.7.1) (:span 15 22)))\n (:hscopes ((:id . :x669.7.1) (:span 0 89)))\n (:identifiers (:sid . :s669.7) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006219@unknown@formal@none@1@S@We also observed the induction of the myelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 52) (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "hck") (:form . "hck") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 101) (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s670.10) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006229@unknown@formal@none@1@S@The two latter signals were nevertheless able to induce NF-kappa B translocation with a pattern in the band-shift assay indistinguishable from that observed using phorbol ester.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "band-shift") (:form . "band-shift") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 137) (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 162) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 170)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s671.6) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006239@unknown@formal@none@1@S@We also tested for the ability of defensins NP-1, NP-5, and HNP-1 to activate pag expression and found that these peptides have no effect.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "defensin") (:form . "defensins") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "np-1") (:form . "NP-1") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NP-5") (:form . "NP-5") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hnp-1") (:form . "HNP-1") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "pag") (:form . "pag") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 137)\n  (:start . 131) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x672.8.1) (:span 128 130)))\n (:nscopes ((:id . :x672.8.1) (:span 128 137)))\n (:identifiers (:sid . :s672.8) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006249@unknown@formal@none@1@S@LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 33)\n  (:start . 21) (:id . 47))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "monocyte/macrophage-like")\n  (:form . "monocyte/macrophage-like") (:end . 112) (:start . 88) (:id . 55))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 119)\n  (:start . 113) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "U1") (:form . "U1") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 174)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s674.5) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006259@unknown@formal@none@1@S@The kappa B-binding activity with the HIV enhancer is inhibited only if it is activated via the mitogen phytohemagglutinin whereas phorbol myristate acetate-mediated activation is completely insensitive to the drug.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 122) (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "JJ") (:stem . "acetate-mediated") (:form . "acetate-mediated")\n  (:end . 165) (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 66))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 190)\n  (:start . 180) (:id . 67))\n ((:tag . "JJ") (:stem . "insensitive") (:form . "insensitive") (:end . 202)\n  (:start . 191) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 214) (:start . 210)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s675.6) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006269@unknown@formal@none@1@S@TNF-alpha was able to increase expression of the HIV LTR in T cells, but in monocytic cells, TNF-alpha did not induce the HIV LTR above a constitutive level of activity.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 85)\n  (:start . 76) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 102)\n  (:start . 93) (:id . 61))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 117)\n  (:start . 111) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 150)\n  (:start . 138) (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 156)\n  (:start . 151) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 168)\n  (:start . 160) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x676.9.1) (:span 107 110)))\n (:nscopes ((:id . :x676.9.1) (:span 107 168)))\n (:identifiers (:sid . :s676.9) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006279@unknown@formal@none@1@S@The nervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the Oct-1 and Oct-2A proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "system-derived") (:form . "system-derived")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "N-Oct") (:form . "N-Oct") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 116) (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s677.8) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006289@unknown@formal@none@1@S@This gene is yet another in a growing list of important regulatory molecules whose expression is transcriptionally induced upon cellular activation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 114) (:start . 97) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s678.6) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006299@unknown@formal@none@1@S@Differences in transcriptional enhancers of HIV-1 and HIV-2.@(((:tag . "NNS") (:stem . "difference") (:form . "Differences") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s680.1) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006309@unknown@formal@none@1@S@An in vitro globin gene switching model based on differentiated embryonic stem cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 63) (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s681.1) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006319@unknown@formal@none@1@S@This "octamer" in the context of DRA appears capable of binding both the ubiquitous (OTF-1) and lymphoid-specific (OTF-2) "octamer" binding proteins, but at least one other distinct "octamer" complex was found.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 113) (:start . 96) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 148)\n  (:start . 140) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 156) (:start . 154)\n  (:id . 71))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 162)\n  (:start . 157) (:id . 72))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 166) (:start . 163)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 172)\n  (:start . 167) (:id . 74))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 181)\n  (:start . 173) (:id . 75))\n ((:tag . "NN") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 190)\n  (:start . 182) (:id . 76))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 191) (:start . 190)\n  (:id . 77))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 199)\n  (:start . 192) (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 203) (:start . 200)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 209)\n  (:start . 204) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x682.4.1) (:span 37 44)))\n (:hscopes ((:id . :x682.4.1) (:span 0 148)))\n (:identifiers (:sid . :s682.4) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006329@unknown@formal@none@1@S@Bivalent cations such as Mg2+ and Zn2+ differentially affect their binding to oligonucleotides which contain the HIV-enhancer domain.@(((:tag . "JJ") (:stem . "bivalent") (:form . "Bivalent") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cation") (:form . "cations") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Mg2+") (:form . "Mg2+") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Zn2+") (:form . "Zn2+") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 53) (:start . 39) (:id . 49))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 66)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 94) (:start . 78) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 100)\n  (:start . 95) (:id . 55))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hiv-enhancer") (:form . "HIV-enhancer") (:end . 125)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s683.6) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006339@unknown@formal@none@1@S@Furthermore, OFT-1 appeared to have approximately the same transactivation ability as OTF-2 when normalized for binding activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "OFT-1") (:form . "OFT-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 74) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "normalize") (:form . "normalized") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x684.8.1) (:span 19 27)))\n (:hscopes ((:id . :x684.8.1) (:span 13 128)))\n (:identifiers (:sid . :s684.8) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006349@unknown@formal@none@1@S@Fourth, extensive purification by several cycles of TRE-DNA affinity chromatography resulted in the 32, 36 to 42 and 110 kD proteins and to less extent the 50 kD factor.@(((:tag . "JJ") (:stem . "fourth") (:form . "Fourth") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "cycle") (:form . "cycles") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TRE-DNA") (:form . "TRE-DNA") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "CD") (:stem . "110") (:form . "110") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 168)\n  (:start . 162) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s685.9) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006359@unknown@formal@none@1@S@By targeting NFAT-1-dependent gene expression in transgenic mice we discovered new sites of NFAT-1 activity.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "nfat-1-dependent") (:form . "NFAT-1-dependent")\n  (:end . 29) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "discover") (:form . "discovered") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s686.7) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006369@unknown@formal@none@1@S@A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1, but no NF-kappa B-binding motifs were identified.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Miyatake") (:form . "Miyatake") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "FW") (:stem . "et") (:form . 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"that") (:end . 190) (:start . 186)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 200)\n  (:start . 191) (:id . 81))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 207)\n  (:start . 201) (:id . 82))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 220)\n  (:start . 208) (:id . 83))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 223) (:start . 221)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "t-cell-activating") (:form . "T-cell-activating")\n  (:end . 241) (:start . 224) (:id . 85))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 249)\n  (:start . 242) (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 253) (:start . 250)\n  (:id . 87))\n ((:tag . "NN") (:stem . "tax1") (:form . "tax1") (:end . 258) (:start . 254)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 259) (:start . 258)\n  (:id . 89))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 263) (:start . 260)\n  (:id . 90))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 266) (:start . 264)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 275)\n  (:start . 267) (:id . 92))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 285)\n  (:start . 276) (:id . 93))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 292)\n  (:start . 286) (:id . 94))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 297) (:start . 293)\n  (:id . 95))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 308)\n  (:start . 298) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 97)))@@@1@56@((:ncues ((:id . :x687.5.1) (:span 264 266)))\n (:nscopes ((:id . :x687.5.1) (:span 264 308)))\n (:identifiers (:sid . :s687.5) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006379@unknown@formal@none@1@S@The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Oct-2B") (:form . "Oct-2B") (:end . 89)\n  (:start . 83) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 123)\n  (:start . 112) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s688.6) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006389@unknown@formal@none@1@S@Here we describe the ability of these factors to interact with a site (GM5), located within the CLE0 element, -47 to -40 upstream of the GM-CSF transcription initiation site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM5") (:form . "GM5") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 84)\n  (:start . 77) (:id . 59))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 91)\n  (:start . 85) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cle0") (:form . "CLE0") (:end . 100) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 108)\n  (:start . 101) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-47") (:form . "-47") (:end . 113) (:start . 110)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-40") (:form . "-40") (:end . 120) (:start . 117)\n  (:id . 67))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 129)\n  (:start . 121) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 143)\n  (:start . 137) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 72))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 168)\n  (:start . 158) (:id . 73))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s689.6) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006399@unknown@formal@none@1@S@The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA, which contains nine binding sites for a nuclear factor present in non-erythroid cells but not in erythroid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 49) (:start . 43)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "900") (:form . "900") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 84)\n  (:start . 76) (:id . 59))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 104)\n  (:start . 96) (:id . 63))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 109) (:start . 105)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 123)\n  (:start . 118) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 137)\n  (:start . 130) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 144)\n  (:start . 138) (:id . 70))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 152)\n  (:start . 145) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 169) (:start . 156) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 74))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 196)\n  (:start . 187) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x690.5.1) (:span 180 183)))\n (:nscopes ((:id . :x690.5.1) (:span 180 202)))\n (:identifiers (:sid . :s690.5) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006409@unknown@formal@none@1@S@T cells lack active NF-kappa B but express Sp1 as expected.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x691.8.1) (:span 8 12)))\n (:nscopes ((:id . :x691.8.1) (:span 8 30)))\n (:identifiers (:sid . :s691.8) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006419@unknown@formal@none@1@S@The effect of the hormone on the levels of p50 was demonstrable in the cytosolic and nuclear compartments; it required between 4 and 8 hr and was specific, as 25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 were ineffective.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "demonstrable") (:form . "demonstrable") (:end . 63)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 154)\n  (:start . 146) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "25-hydroxyvitamin") (:form . "25-hydroxyvitamin")\n  (:end . 176) (:start . 159) (:id . 73))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 179) (:start . 177)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 75))\n ((:tag . "NN") (:stem . "24,25-dihydroxyvitamin")\n  (:form . "24,25-dihydroxyvitamin") (:end . 206) (:start . 184) (:id . 76))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 209) (:start . 207)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 214) (:start . 210)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 226)\n  (:start . 215) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s692.5) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006429@unknown@formal@none@1@S@Furthermore, in activated T cells, the kinetics of the two phosphorylation events are essentially similar.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 74) (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "RB") (:stem . "essentially") (:form . "essentially") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s693.6) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006439@unknown@formal@none@1@S@Cu2+ was found to inhibit the activation of NF kappa B induced by TNF-alpha, TPA, or H2O2.@(((:tag . "NNP") (:stem . "Cu2+") (:form . "Cu2+") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 89) (:start . 85)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s694.4) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006449@unknown@formal@none@1@S@In contrast, two other nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not inhibit LPS induction of the TF gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nonsteroidal") (:form . "nonsteroidal") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 53) (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ibuprofen") (:form . "ibuprofen") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 87)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x695.7.1) (:span 93 96)))\n (:nscopes ((:id . :x695.7.1) (:span 93 133)))\n (:identifiers (:sid . :s695.7) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006459@unknown@formal@none@1@S@Nuclear factor kappa B (NF-kappa B) is stored in the cytoplasm as an inactive form through interaction with I kappa B.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "store") (:form . "stored") (:end . 45)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 62)\n  (:start . 53) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 102)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s697.2) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006469@unknown@formal@none@1@S@Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 109)\n  (:start . 103) (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "VBD") (:stem . "seem") (:form . "seemed") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 185)\n  (:start . 175) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 203)\n  (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x698.3.1) (:span 162 168)))\n (:hscopes ((:id . :x698.3.1) (:span 136 203)))\n (:identifiers (:sid . :s698.3) (:did . :|7499267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006479@unknown@formal@none@1@S@Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 44) (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 55)\n  (:start . 48) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "CD") (:stem . "130") (:form . "130") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s699.6) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006489@unknown@formal@none@1@S@FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.@(((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 27) (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s700.2) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006499@unknown@formal@none@1@S@In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 70)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 85)\n  (:start . 78) (:id . 58))\n ((:tag . "NNP") (:stem . "EcoRI") (:form . "EcoRI") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "digest") (:form . "digested") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 111)\n  (:start . 101) (:id . 61))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s701.3) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006509@unknown@formal@none@1@S@When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "preculture") (:form . "precultured") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 69) (:start . 67)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 75) (:start . 70)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 85)\n  (:start . 77) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 100)\n  (:start . 89) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 112) (:start . 108)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 117) (:start . 113)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 124) (:start . 121)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 127) (:start . 126)\n  (:id . 70))\n ((:tag . "NN") (:stem . "microgram/ml") (:form . "microgram/ml") (:end . 140)\n  (:start . 128) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 164) (:start . 161)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 180)\n  (:start . 173) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 81))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 186) (:start . 182)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 84))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 200) (:start . 197)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 209)\n  (:start . 201) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s702.3) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006519@unknown@formal@none@1@S@Antioxidants have been proposed to be anti-atherosclerotic agents; however, the mechanisms underlying their beneficial effects are poorly understood.@(((:tag . "NNS") (:stem . "antioxidant") (:form . "Antioxidants") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-atherosclerotic")\n  (:form . "anti-atherosclerotic") (:end . 58) (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 148)\n  (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s703.2) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006529@unknown@formal@none@1@S@It has been hypothesized that alpha-tcp acts as an anti-atherosclerotic molecule by inhibiting generation of oxidized LDL--a putative triggering molecule in the atherosclerotic process.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "hypothesize") (:form . "hypothesized") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-atherosclerotic")\n  (:form . "anti-atherosclerotic") (:end . 71) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "NNP") (:stem . "LDL–a") (:form . "LDL–a") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "VBG") (:stem . "trigger") (:form . "triggering") (:end . 144)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 153)\n  (:start . 145) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 176) (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 184)\n  (:start . 177) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x703.12.1) (:span 125 133))\n  ((:id . :x703.12.2) (:span 12 24)))\n (:hscopes ((:id . :x703.12.1) (:span 125 184))\n  ((:id . :x703.12.2) (:span 12 184)))\n (:identifiers (:sid . :s703.12) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006539@unknown@formal@none@1@S@In the same experiments, all three non-B-cell lines showed NF-kappa B activation and ICAM-1 upregulation but never any effect upon Bcl-2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "non-b-cell") (:form . "non-B-cell") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 58) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 104)\n  (:start . 92) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "RB") (:stem . "never") (:form . "never") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x704.9.1) (:span 109 114)))\n (:nscopes ((:id . :x704.9.1) (:span 109 136)))\n (:identifiers (:sid . :s704.9) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006549@unknown@formal@none@1@S@We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x705.8.1) (:span 23 25)))\n (:hscopes ((:id . :x705.8.1) (:span 23 69)))\n (:identifiers (:sid . :s705.8) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006559@unknown@formal@none@1@S@We have recently cloned the CD14 5' upstream sequence and demonstrated its tissue-specific promoter activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 90) (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s706.5) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006569@unknown@formal@none@1@S@One gene product, when overexpressed in Jurkat T cells, specifically induced transcription from the interleukin-2 enhancer, by activating the T-cell-specific transcription factors NF-AT and NF-IL2A.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 68)\n  (:start . 56) (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 157) (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 185)\n  (:start . 180) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-IL2A") (:form . "NF-IL2A") (:end . 197)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s707.5) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006579@unknown@formal@none@1@S@Upon stimulation of the cells, this protein no longer prevents binding of DNA by Band A, and suppression of binding is restored within 30 min.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "RB") (:stem . "no") (:form . "no") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "longer") (:form . "longer") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Band") (:form . "Band") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 104)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "restore") (:form . "restored") (:end . 127)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 134)\n  (:start . 128) (:id . 66))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x708.8.1) (:span 44 53)))\n (:nscopes ((:id . :x708.8.1) (:span 44 87)))\n (:identifiers (:sid . :s708.8) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006589@unknown@formal@none@1@S@In day 7 and day 10 erythroid precursors cultured with Steel factor, SCL protein was increased significantly compared to control.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 19) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 29)\n  (:start . 20) (:id . 48))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s709.9) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006599@unknown@formal@none@1@S@The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 111)\n  (:start . 105) (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 128)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x710.8.1) (:span 105 111)))\n (:hscopes ((:id . :x710.8.1) (:span 105 128)))\n (:identifiers (:sid . :s710.8) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006609@unknown@formal@none@1@S@Transcription-independent turnover of I kappa B alpha during monocyte adherence: implications for a translational component regulating I kappa B alpha/MAD-3 mRNA levels.@(((:tag . "JJ") (:stem . "transcription-independent")\n  (:form . "Transcription-independent") (:end . 25) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 34)\n  (:start . 26) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 39) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 93)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 113) (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 134)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 142)\n  (:start . 137) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 156)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 168)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s712.1) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006619@unknown@formal@none@1@S@Moreover, since inhibition of protein synthesis leads to accumulation of I kappa B alpha/MAD-3 mRNA without stimulating I kappa B alpha/MAD-3 gene transcription, we suggest that low cytoplasmic levels of I kappa B alpha/MAD-3 mRNA are maintained by a translation-dependent degradation mechanism.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . 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(:end . 295) (:start . 294)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x712.11.1) (:span 165 172)))\n (:ncues ((:id . :x712.11.2) (:span 100 107)))\n (:hscopes ((:id . :x712.11.1) (:span 165 294)))\n (:nscopes ((:id . :x712.11.2) (:span 100 160)))\n (:identifiers (:sid . :s712.11) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006629@unknown@formal@none@1@S@Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells.@(((:tag . "NN") (:stem . "aspirin") (:form . "Aspirin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 88)\n  (:start . 78) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 106)\n  (:start . 95) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s714.1) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006639@unknown@formal@none@1@S@Signal integration and NF-kappa B translocation [see comments]@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 62) (:start . 61)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s715.2) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006649@unknown@formal@none@1@S@4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.@(((:tag . "LS") (:stem . "4.") (:form . "4.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Danazol") (:form . "Danazol") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "expression") (:form . "expressions") (:end . 151)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x716.5.1) (:span 11 14)))\n (:hscopes ((:id . :x716.5.1) (:span 11 91)))\n (:identifiers (:sid . :s716.5) (:did . :|7540578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006659@unknown@formal@none@1@S@Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "aspect") (:form . "aspect") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 88)\n  (:start . 76) (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s718.3) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006669@unknown@formal@none@1@S@To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 (VCAM-1).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "limit") (:form . "limits") (:end . 52)\n  (:start . 46) (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 64)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "treat") (:form . "treated") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "cytokine-stimulated")\n  (:form . "cytokine-stimulated") (:end . 107) (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "saphenous") (:form . "saphenous") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "assess") (:form . "assessed") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 196)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 224)\n  (:start . 214) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 236)\n  (:start . 228) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 241) (:start . 237)\n  (:id . 78))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 250)\n  (:start . 242) (:id . 79))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 261)\n  (:start . 251) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 263) (:start . 262)\n  (:id . 81))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 269)\n  (:start . 263) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 270) (:start . 269)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x719.3.1) (:span 12 22)))\n (:hscopes ((:id . :x719.3.1) (:span 12 75)))\n (:identifiers (:sid . :s719.3) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006679@unknown@formal@none@1@S@We demonstrate that CD4 triggering delivers signals capable of activating the NF-AT transcription factor which is required for interleukin-2 gene expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "deliver") (:form . "delivers") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 140) (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s720.4) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006689@unknown@formal@none@1@S@These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rbpi21") (:form . "rBPI21") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VB") (:stem . "reverse") (:form . "reverse") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 127)\n  (:start . 115) (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "interrupt") (:form . "interrupting") (:end . 166)\n  (:start . 154) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "on-going") (:form . "on-going") (:end . 179)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 183) (:start . 180)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 190)\n  (:start . 184) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x721.7.1) (:span 14 27)))\n (:hscopes ((:id . :x721.7.1) (:span 14 190)))\n (:identifiers (:sid . :s721.7) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006699@unknown@formal@none@1@S@The AP-1 binding proteins contained c-Jun, Jun-D, and Fra-1, but marginal amounts of Jun-B and c-Fos.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jun-D") (:form . "Jun-D") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fra-1") (:form . "Fra-1") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "marginal") (:form . "marginal") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jun-B") (:form . "Jun-B") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s722.10) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006709@unknown@formal@none@1@S@The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNasel") (:form . "DNasel") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 117) (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 174)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 183)\n  (:start . 175) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 199)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s723.8) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006719@unknown@formal@none@1@S@Anti-CD28 MoAb costimulation increased NF kappa B levels in neonates, albeit to levels lower than that of adults.@(((:tag . "JJ") (:stem . "anti-cd28") (:form . "Anti-CD28") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "MoAb") (:form . "MoAb") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neonate") (:form . "neonates") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "albeit") (:form . "albeit") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s724.9) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006729@unknown@formal@none@1@S@Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "N-") (:form . "N-") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducer-mediated") (:form . "inducer-mediated")\n  (:end . 84) (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s725.8) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006739@unknown@formal@none@1@S@We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3-mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element, NF-AT-1, which is bound by a T-cell-specific transcription factor, NFATp, as well as by AP-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "delineate") (:form . "delineated") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBG") (:stem . "confer") (:form . "conferring") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3-mediated")\n  (:form . "1,25(OH)2D3-mediated") (:end . 102) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 113)\n  (:start . 103) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "40-bp") (:form . "40-bp") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 158)\n  (:start . 146) (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 171)\n  (:start . 162) (:id . 67))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 180)\n  (:start . 172) (:id . 68))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 199)\n  (:start . 192) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-AT-1") (:form . "NF-AT-1") (:end . 208)\n  (:start . 201) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 215)\n  (:start . 210) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 227) (:start . 225)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 229) (:start . 228)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 245) (:start . 230) (:id . 79))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 259) (:start . 246) (:id . 80))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 266)\n  (:start . 260) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 267) (:start . 266)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 273)\n  (:start . 268) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 274) (:start . 273)\n  (:id . 84))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 277) (:start . 275)\n  (:id . 85))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 282) (:start . 278)\n  (:id . 86))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 285) (:start . 283)\n  (:id . 87))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 288) (:start . 286)\n  (:id . 88))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 293) (:start . 289)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 294) (:start . 293)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s726.5) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006749@unknown@formal@none@1@S@Nuclear run-on analysis revealed that the rate of Fc gamma RI transcription was increased by IFN-gamma.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s727.5) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006759@unknown@formal@none@1@S@They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x728.3.1) (:span 173 180)))\n (:hscopes ((:id . :x728.3.1) (:span 125 180)))\n (:identifiers (:sid . :s728.3) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006769@unknown@formal@none@1@S@The inverse relation between high density lipoprotein (HDL) and atherosclerotic events may in part be due to enzymes associated with HDL that destroy the biologically active lipids generated in LDL.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HDL") (:form . "HDL") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 79) (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HDL") (:form . "HDL") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "destroy") (:form . "destroy") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 166)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 173)\n  (:start . 167) (:id . 69))\n ((:tag . "NNS") (:stem . "lipid") (:form . "lipids") (:end . 180)\n  (:start . 174) (:id . 70))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 190)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x729.7.1) (:span 87 90)))\n (:hscopes ((:id . :x729.7.1) (:span 87 197)))\n (:identifiers (:sid . :s729.7) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006779@unknown@formal@none@1@S@We previously identified the DNA consensus binding site recognized by the two DNA binding domains.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s731.4) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006789@unknown@formal@none@1@S@Activation of CD34 expression in hematopoietic cell lines is dependent on the presence of intact MZF-1 binding sites.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s731.14) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006799@unknown@formal@none@1@S@CD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "factor/nerve") (:form . "factor/nerve") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s733.2) (:did . :|7589085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006809@unknown@formal@none@1@S@Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B.@(((:tag . "JJ") (:stem . "hematopoietic") (:form . "Hematopoietic")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 150)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x734.4.2) (:span 127 134)))\n (:ncues ((:id . :x734.4.1) (:span 112 115)))\n (:hscopes ((:id . :x734.4.2) (:span 102 164)))\n (:nscopes ((:id . :x734.4.1) (:span 112 119)))\n (:identifiers (:sid . :s734.4) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006819@unknown@formal@none@1@S@This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of alpha-tocopherol.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intravenous") (:form . "intravenous") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "water-soluble") (:form . "water-soluble")\n  (:end . 100) (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "emulsion") (:form . "emulsion") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 129) (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s735.5) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006829@unknown@formal@none@1@S@In purified human peripheral blood T cells, nuclear STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3 Abs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 131)\n  (:start . 119) (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s736.5) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006839@unknown@formal@none@1@S@While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "RB") (:stem . "sequentially") (:form . "sequentially") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 71) (:start . 56) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 104)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "co-activation") (:form . "co-activation")\n  (:end . 148) (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 168) (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "VBZ") (:stem . "accelerate") (:form . "accelerates") (:end . 189)\n  (:start . 178) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 198) (:start . 194)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 205) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 211)\n  (:start . 206) (:id . 72))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 227) (:start . 212) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 239)\n  (:start . 232) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 242) (:start . 240)\n  (:id . 76))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 246) (:start . 243)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 255)\n  (:start . 247) (:id . 78))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 267)\n  (:start . 256) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s737.6) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006849@unknown@formal@none@1@S@Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti-CR1 or anti-CR3 Abs or with C3 fragments.@(((:tag . "JJ") (:stem . "monocytic") (:form . "Monocytic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "F(ab')2") (:form . "F(ab')2") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 153)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "JJ") (:stem . "anti-cr1") (:form . "anti-CR1") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "anti-cr3") (:form . "anti-CR3") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c3") (:form . "C3") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 213)\n  (:start . 204) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x738.6.1) (:span 125 132)))\n (:nscopes ((:id . :x738.6.1) (:span 125 213)))\n (:identifiers (:sid . :s738.6) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006859@unknown@formal@none@1@S@NF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10, but not in Th1 clone 29.@(((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "d10") (:form . "D10") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 92) (:start . 89)\n  (:id . 62))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 98) (:start . 93)\n  (:id . 63))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 101) (:start . 99)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x739.4.1) (:span 82 85)))\n (:nscopes ((:id . :x739.4.1) (:span 82 101)))\n (:identifiers (:sid . :s739.4) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006869@unknown@formal@none@1@S@alpha B is the mouse homologue of human AML1 gene detected at the breakpoints of t(8;21) and t(3;21) myeloid leukemias.@(((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "breakpoint") (:form . "breakpoints") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "t(8;21)") (:form . "t(8;21)") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "t(3;21)") (:form . "t(3;21)") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s740.4) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006879@unknown@formal@none@1@S@Human immunodeficiency virus type 2 (HIV-2), like HIV-1, causes AIDS and is associated with AIDS cases primarily in West Africa.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 86)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 112)\n  (:start . 103) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "West") (:form . "West") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Africa") (:form . "Africa") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s741.2) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006889@unknown@formal@none@1@S@Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.@(((:tag . "NN") (:stem . "thapsigargin") (:form . "Thapsigargin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "c-independent") (:form . "C-independent")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s742.1) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006899@unknown@formal@none@1@S@Stimulation of the T-cell antigen receptor (TCR) induces activation of multiple tyrosine kinases, resulting in phosphorylation of numerous intracellular substrates.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 126) (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 152) (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 163)\n  (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s743.2) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006909@unknown@formal@none@1@S@To further dissect p95vav involvement in TCR signaling, we analyzed various Jurkat mutants deficient in TCR signaling function or TCR expression and showed that an intact TCR signaling pathway is required for p95vav to function.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 184)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 204)\n  (:start . 196) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 215)\n  (:start . 209) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 218) (:start . 216)\n  (:id . 76))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 227)\n  (:start . 219) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s743.12) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006919@unknown@formal@none@1@S@We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tnf-alpha-") (:form . "TNF-alpha-") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calyculin") (:form . "calyculin") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "a-induced") (:form . "A-induced") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 90)\n  (:start . 79) (:id . 54))\n ((:tag . "VBZ") (:stem . "exhibit") (:form . "exhibits") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "sensitivity") (:form . "sensitivities")\n  (:end . 139) (:start . 126) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x744.8.1) (:span 112 115)))\n (:nscopes ((:id . :x744.8.1) (:span 112 125)))\n (:identifiers (:sid . :s744.8) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006929@unknown@formal@none@1@S@Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 130) (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "JJ") (:stem . "site-like") (:form . "site-like") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 169)\n  (:start . 161) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 186)\n  (:start . 179) (:id . 68))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 204) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 214) (:start . 210)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s746.1) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006939@unknown@formal@none@1@S@The human granulocyte-macrophage CSF (GM-CSF) gene is expressed in T cells in response to TCR activation that can be mimicked by treatment of the cells with PMA and Ca2+ ionophore.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 32) (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "mimic") (:form . "mimicked") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 169) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 179)\n  (:start . 170) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s747.2) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006949@unknown@formal@none@1@S@These results imply that at least three signals are required to activate the GM-CSF proximal promoter, and that the signals impinge on distinct transcription factors that bind to the hCLEO and NF-kappa B regions of the promoter.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "VBP") (:stem . "impinge") (:form . "impinge") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hcleo") (:form . "hCLEO") (:end . 188)\n  (:start . 183) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 201)\n  (:start . 193) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 203) (:start . 202)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 211)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 227)\n  (:start . 219) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x747.12.1) (:span 14 19)))\n (:hscopes ((:id . :x747.12.1) (:span 14 227)))\n (:identifiers (:sid . :s747.12) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006959@unknown@formal@none@1@S@In addition, HU stimulates the synthesis of fetal hemoglobin in sickle cell anemia patients.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hu") (:form . "HU") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "anemia") (:form . "anemia") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s749.3) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006969@unknown@formal@none@1@S@Organizational analysis and mapping of protein kinase C--responsive elements regulating expression in platelets.@(((:tag . "JJ") (:stem . "organizational") (:form . "Organizational")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "C–responsive") (:form . "C–responsive") (:end . 67)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 111)\n  (:start . 102) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s750.2) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006979@unknown@formal@none@1@S@These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 88)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 112)\n  (:start . 101) (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 128)\n  (:start . 123) (:id . 57))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . "JJ") (:stem . "myocardial") (:form . "myocardial") (:end . 145)\n  (:start . 135) (:id . 59))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 156)\n  (:start . 146) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 169)\n  (:start . 160) (:id . 62))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 181)\n  (:start . 170) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 190)\n  (:start . 182) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 195) (:start . 191)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 209) (:start . 196) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 67))\n ((:tag . "NN") (:stem . "platelet-progenitor")\n  (:form . "platelet-progenitor") (:end . 232) (:start . 213) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 238)\n  (:start . 233) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x750.12.1) (:span 24 31)))\n (:hscopes ((:id . :x750.12.1) (:span 24 238)))\n (:identifiers (:sid . :s750.12) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006989@unknown@formal@none@1@S@Several studies have established that Tat releases an elongation block to the transcription of HIV long terminal repeat (LTR); however, it is not known whether this mechanism alone is sufficient to explain the block to HIV replication in human T cells when Tat is absent.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "release") (:form . "releases") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . 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"absent") (:end . 270)\n  (:start . 264) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x752.4.2) (:span 152 159))\n  ((:id . :x752.4.3) (:span 142 151)))\n (:ncues ((:id . :x752.4.1) (:span 264 270)))\n (:hscopes ((:id . :x752.4.2) (:span 152 270))\n  ((:id . :x752.4.3) (:span 142 270)))\n (:nscopes ((:id . :x752.4.1) (:span 257 270)))\n (:identifiers (:sid . :s752.4) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006999@unknown@formal@none@1@S@Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CD16") (:form . "CD16") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s753.1) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007009@unknown@formal@none@1@S@However, supershift assays using the available mAb recognizing the T cell NFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester-stimulated cells at any time tested, up to 4 h.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "recognize") (:form . "recognizing") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "nfatc") (:form . "NFATc") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cd16-") (:form . "CD16-") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 174)\n  (:start . 167) (:id . 68))\n ((:tag . "JJ") (:stem . "ester-stimulated") (:form . "ester-stimulated")\n  (:end . 191) (:start . 175) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 209) (:start . 205)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 216)\n  (:start . 210) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 75))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 220) (:start . 218)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 223) (:start . 221)\n  (:id . 77))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 225) (:start . 224)\n  (:id . 78))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 227) (:start . 226)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x753.11.1) (:span 89 91)))\n (:nscopes ((:id . :x753.11.1) (:span 89 227)))\n (:identifiers (:sid . :s753.11) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007019@unknown@formal@none@1@S@Both phosphorylation and proliferation were inhibited by IL-6 neutralizing antibodies.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 38) (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 74)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s754.9) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007029@unknown@formal@none@1@S@Interestingly, when we mutated the Sp1 site, resulting in a marked decrease in hEpoR promoter activity, we could restore transactivation by increasing GATA-1 levels in OCIM1 cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "mutate") (:form . "mutated") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 136) (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 150)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ocim1") (:form . "OCIM1") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 179)\n  (:start . 174) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s755.9) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007039@unknown@formal@none@1@S@These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcl1") (:form . "TCL1") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "preleukemic") (:form . "preleukemic") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "14q11") (:form . "14q11") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x756.8.1) (:span 11 24)))\n (:hscopes ((:id . :x756.8.1) (:span 11 163)))\n (:identifiers (:sid . :s756.8) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007049@unknown@formal@none@1@S@Similarly, a human immunodeficiency virus promoter, whose activity is controlled through chi B factors, was found to be active in the IL-2 producing EBV-B cells, but inactive in the non-IL-2-producing cells.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 35) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "chi") (:form . "chi") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "ebv-b") (:form . "EBV-B") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "non-il-2-producing") (:form . "non-IL-2-producing")\n  (:end . 200) (:start . 182) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s757.9) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007059@unknown@formal@none@1@S@It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ubiquitin-proteasome")\n  (:form . "ubiquitin-proteasome") (:end . 51) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 166)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "spar") (:form . "spared") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 213) (:start . 209)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 218) (:start . 214)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "obscure") (:form . "obscure") (:end . 226)\n  (:start . 219) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x758.7.1) (:span 219 226))\n  ((:id . :x758.7.2) (:span 12 21)))\n (:hscopes ((:id . :x758.7.1) (:span 96 226))\n  ((:id . :x758.7.2) (:span 0 85)))\n (:identifiers (:sid . :s758.7) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007069@unknown@formal@none@1@S@We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 127)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 181)\n  (:start . 171) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 199) (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 206)\n  (:start . 200) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s759.6) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007079@unknown@formal@none@1@S@Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s760.4) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007089@unknown@formal@none@1@S@The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "s-nitrosylation") (:form . "S-nitrosylation")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s761.6) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007099@unknown@formal@none@1@S@Primer extension and ribonuclease protection analyses indicate a single major transcriptional start site.@(((:tag . "NNP") (:stem . "Primer") (:form . "Primer") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ribonuclease") (:form . "ribonuclease") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 93) (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 104) (:start . 100)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x762.7.1) (:span 54 62)))\n (:hscopes ((:id . :x762.7.1) (:span 54 104)))\n (:identifiers (:sid . :s762.7) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007109@unknown@formal@none@1@S@Similar inhibition of NFAT-1-mediated gene expression was observed in a second cell line, which is stably transfected with NFAT-1 regulatory elements linked to the reporter gene for sCD8.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nfat-1-mediated") (:form . "NFAT-1-mediated")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 172)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "scd8") (:form . "sCD8") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s763.7) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007119@unknown@formal@none@1@S@The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell Ag receptor complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tinur") (:form . "TINUR") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 78) (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s764.4) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007129@unknown@formal@none@1@S@The antagonists, however, had no effect on phorbol ester-induced up-regulation of HB-EGF mRNA and kappa B binding activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 64) (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "kappa") (:form . "kappa") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x765.7.1) (:span 30 32)))\n (:nscopes ((:id . :x765.7.1) (:span 30 122)))\n (:identifiers (:sid . :s765.7) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007139@unknown@formal@none@1@S@The IL-1-induced NF-kappa B DNA nuclear localization is transient and can be prolonged either by an antigen receptor-initiated signal or by inhibiting protein synthesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "prolong") (:form . "prolonged") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "receptor-initiated") (:form . "receptor-initiated")\n  (:end . 126) (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 133)\n  (:start . 127) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s766.7) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007149@unknown@formal@none@1@S@The expression of AP-1 depended on calcium mobilization and PKC activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "depend") (:form . "depended") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s767.8) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007159@unknown@formal@none@1@S@Furthermore, compounds such as tosylphenylalanyl chloromethyl ketone and pyrrolidinedithiocarbamate that are known to selectively inhibit NF kappa B activation block cytokine gene transcription in LPS-stimulated monocytes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tosylphenylalanyl") (:form . "tosylphenylalanyl")\n  (:end . 48) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 61)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pyrrolidinedithiocarbamate")\n  (:form . "pyrrolidinedithiocarbamate") (:end . 99) (:start . 73) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 108) (:start . 105)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 114)\n  (:start . 109) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 55))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 129)\n  (:start . 118) (:id . 56))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 137)\n  (:start . 130) (:id . 57))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 140) (:start . 138)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 146)\n  (:start . 141) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 159)\n  (:start . 149) (:id . 61))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 165)\n  (:start . 160) (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 174)\n  (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 179) (:start . 175)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 211) (:start . 197) (:id . 67))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 221)\n  (:start . 212) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s768.7) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007169@unknown@formal@none@1@S@It was identified as NF-E1 (YY1).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "YY1") (:form . "YY1") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 33) (:start . 32)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s769.6) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007179@unknown@formal@none@1@S@IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "78-nucleotide") (:form . "78-nucleotide")\n  (:end . 66) (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "CD") (:stem . "1.3") (:form . "1.3") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s770.9) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007189@unknown@formal@none@1@S@However, this deletion mutation prevented the induced phosphorylation, degradative loss, and functional release of I kappa B alpha from NF-kappa B in Tax-expressing cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "degradative") (:form . "degradative") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 164) (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s771.7) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007199@unknown@formal@none@1@S@The limited activation of NF-kappa B by HIV protease appears unlikely to have a significant effect on virus expression or T cell function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "unlikely") (:form . "unlikely") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x772.7.1) (:span 61 69)) ((:id . :x772.7.2) (:span 53 60)))\n (:hscopes ((:id . :x772.7.1) (:span 61 137))\n  ((:id . :x772.7.2) (:span 0 137)))\n (:identifiers (:sid . :s772.7) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007209@unknown@formal@none@1@S@Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VB") (:stem . "infect") (:form . "infect") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 66)\n  (:start . 56) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s774.2) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007219@unknown@formal@none@1@S@These observations suggest that de novo EBV infection of thymocytes differs from infection of B cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x774.12.1) (:span 19 26)))\n (:hscopes ((:id . :x774.12.1) (:span 19 101)))\n (:identifiers (:sid . :s774.12) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007229@unknown@formal@none@1@S@Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "carboxyl") (:form . "carboxyl") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 132)\n  (:start . 124) (:id . 65))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 150)\n  (:start . 140) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s776.1) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007239@unknown@formal@none@1@S@Interaction between the stage selector element (SSE) in the proximal gamma-globin promoter and hypersensitivity site 2 in the locus control region partly mediates the competitive silencing of the beta-globin promoter in the fetal developmental stage.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "selector") (:form . "selector") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SSE") (:form . "SSE") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 111) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 178)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 207)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 216)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 229)\n  (:start . 224) (:id . 76))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 243) (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 249)\n  (:start . 244) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s777.2) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007249@unknown@formal@none@1@S@Abnormal regulation of the IL-2 promoter in lpr CD4-CD8- T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lpr") (:form . "lpr") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4-cd8-") (:form . "CD4-CD8-") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cells-binding") (:form . "cells-binding")\n  (:end . 160) (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s778.1) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007259@unknown@formal@none@1@S@Upon mitogenic stimulation, the binding activity of the novel NF-AT-binding factor is rapidly down-regulated in normal T cells, but persists at high levels in Ipr CD4-8- T cells.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 108) (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "persist") (:form . "persists") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CD4-8-") (:form . "CD4-8-") (:end . 169)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s778.11) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007269@unknown@formal@none@1@S@This region is termed the CK-1 or CD28RE and appears to bind specific members of the NF-kappa B family of transcription factors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 21) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ck-1") (:form . "CK-1") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x779.9.1) (:span 45 52)))\n (:hscopes ((:id . :x779.9.1) (:span 45 127)))\n (:identifiers (:sid . :s779.9) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007279@unknown@formal@none@1@S@It also induces chemotaxis and inflammatory responses in mature cell types.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "chemotaxis") (:form . "chemotaxis") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s780.4) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007289@unknown@formal@none@1@S@Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "response-1") (:form . "response-1") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pokeweed") (:form . "pokeweed") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s781.1) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007299@unknown@formal@none@1@S@NF kappa B controls many immunologically important genes, so our studies suggest that the immune system may be sensitive not only against a cysteine and glutathione deficiency but also against an excess of cysteine.@(((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 40) (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 175)\n  (:start . 165) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "excess") (:form . "excess") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x782.5.1) (:span 104 107))\n  ((:id . :x782.5.2) (:span 73 80)))\n (:hscopes ((:id . :x782.5.1) (:span 104 214))\n  ((:id . :x782.5.2) (:span 73 214)))\n (:identifiers (:sid . :s782.5) (:did . :|7781927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007309@unknown@formal@none@1@S@The HEL cells also exhibited a similar elevation of AhR mRNA level, when they had differentiated toward monocyte-macrophage cells by these combined inducers, but little change in the mRNA level was observed when the cells were induced to differentiate into other cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HEL") (:form . "HEL") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 96) (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophage") (:end . 123) (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 168)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 187) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 206)\n  (:start . 198) (:id . 75))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 211) (:start . 207)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 221)\n  (:start . 216) (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 226) (:start . 222)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 234)\n  (:start . 227) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 237) (:start . 235)\n  (:id . 81))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 251) (:start . 238) (:id . 82))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 256) (:start . 252)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 262)\n  (:start . 257) (:id . 84))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 267) (:start . 263)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 273)\n  (:start . 268) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s783.10) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007319@unknown@formal@none@1@S@Epstein-Barr virus (EBV) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48, characteristically expressed on normal activated B cells.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "drive") (:form . "drives") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 96)\n  (:start . 84) (:id . 58))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd48") (:form . "CD48") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "RB") (:stem . "characteristically") (:form . "characteristically")\n  (:end . 179) (:start . 161) (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 189)\n  (:start . 180) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 192) (:start . 190)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 199)\n  (:start . 193) (:id . 74))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 211) (:start . 210)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 217)\n  (:start . 212) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s785.2) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007329@unknown@formal@none@1@S@We have reconstituted ligand-dependent activation of the receptor to a DNA-binding form by using the dioxin receptor and its bHLH-PAS partner factor Arnt expressed by in vitro translation in reticulocyte lysate.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "ligand-dependent") (:form . "ligand-dependent")\n  (:end . 38) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "bhlh-pas") (:form . "bHLH-PAS") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "NNP") (:stem . "Arnt") (:form . "Arnt") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 175)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 187)\n  (:start . 176) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 203)\n  (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 210)\n  (:start . 204) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s786.5) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007339@unknown@formal@none@1@S@The human interleukin-3 (IL-3) gene is expressed almost exclusively in activated T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s787.2) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007349@unknown@formal@none@1@S@IL-6 increases junB mRNA in a biphasic fashion.@(((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s788.3) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007359@unknown@formal@none@1@S@Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha.@(((:tag . "JJ") (:stem . "biphasic") (:form . "Biphasic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s789.1) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007369@unknown@formal@none@1@S@These results indicate that the regulation of NF-kappa B activation during T cell activation by TcR/CD3 signals is biphasic: TcR/CD3 triggers its immediate translocation, which is transient if no TNF-alpha is present.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tcr/cd3") (:form . "TcR/CD3") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TcR/CD3") (:form . "TcR/CD3") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 169) (:start . 156) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 205)\n  (:start . 196) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x789.11.2) (:span 14 27)))\n (:ncues ((:id . :x789.11.1) (:span 193 195)))\n (:hscopes ((:id . :x789.11.2) (:span 14 216)))\n (:nscopes ((:id . :x789.11.1) (:span 193 216)))\n (:identifiers (:sid . :s789.11) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007379@unknown@formal@none@1@S@A wide spectrum of levels of HIV-1 expression have been demonstrated in various cells, both in cell culture and in vivo.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "spectrum") (:form . "spectrum") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 68)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s791.3) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007389@unknown@formal@none@1@S@In contrast to parental U937 cells, PKC-zeta cells constitutively expressed mRNA transcripts for c-jun and a low mobility AP-1 binding activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 65) (:start . 51) (:id . 51))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s792.5) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007399@unknown@formal@none@1@S@Western blot analysis showed that N-acetyl-cysteine reduced the accumulation of the 47-kD mature glycoprotein in LPS-treated cells, a finding consistent with the results of the immunofluorescence studies.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "N-acetyl-cysteine") (:form . "N-acetyl-cysteine")\n  (:end . 51) (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 76)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "47-kd") (:form . "47-kD") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 109)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lps-treated") (:form . "LPS-treated") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 195) (:start . 177) (:id . 68))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 203)\n  (:start . 196) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s793.8) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007409@unknown@formal@none@1@S@First, we show that persistent HIV infection results in the activation of NF-kappa B not only in monocytic cells but also in macrophages.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 136)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s794.6) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007419@unknown@formal@none@1@S@Aims of the study were to (1) assess the potential role of the expression of these genes in the maintenance and expansion of the neoplastic clones and (2) search for constitutional losses or rearrangements of one allele followed by a deletion of the second allele of the same genes in the leukemic cells.@(((:tag . "NNS") (:stem . "aim") (:form . "Aims") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . 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5007429@unknown@formal@none@1@S@Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2, but not those of Oct-4 and Oct-6.@(((:tag . "JJ") (:stem . "biochemical") (:form . "Biochemical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "obf-1") (:form . "OBF-1") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "oct-4") (:form . "Oct-4") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Oct-6") (:form . "Oct-6") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x796.4.1) (:span 136 139))\n  ((:id . :x796.4.2) (:span 47 49)))\n (:nscopes ((:id . :x796.4.1) (:span 136 164))\n  ((:id . :x796.4.2) (:span 47 80)))\n (:identifiers (:sid . :s796.4) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007439@unknown@formal@none@1@S@Therefore, the primary effect of the receptor in glucocorticoid-mediated apoptosis correlates with transcriptional repression rather than activation and could be mediated by interference with other transcription factors required for cell survival.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "glucocorticoid-mediated") (:end . 72) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 125)\n  (:start . 115) (:id . 56))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 132)\n  (:start . 126) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 137) (:start . 133)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 148)\n  (:start . 138) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 60))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 158)\n  (:start . 153) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 161) (:start . 159)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 170)\n  (:start . 162) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 186)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 197)\n  (:start . 192) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 211) (:start . 198) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 219)\n  (:start . 212) (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 228)\n  (:start . 220) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 232) (:start . 229)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 237) (:start . 233)\n  (:id . 72))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 246)\n  (:start . 238) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x797.7.1) (:span 153 158)))\n (:ncues ((:id . :x797.7.2) (:span 126 137)))\n (:hscopes ((:id . :x797.7.1) (:span 153 246)))\n (:nscopes ((:id . :x797.7.2) (:span 126 148)))\n (:identifiers (:sid . :s797.7) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007449@unknown@formal@none@1@S@Transcripts of mouse AML1/PEBP2 alpha B were also detected in day 12 fetal hematopoietic liver and in the bone marrow cells of newborn mice.@(((:tag . "NNS") (:stem . "transcript") (:form . "Transcripts") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aml1/pebp2") (:form . "AML1/PEBP2") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "newborn") (:form . "newborn") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 139)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s798.10) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007459@unknown@formal@none@1@S@This is the first report of a physical interaction between an Ets family member and NF-kappa B family proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 50)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s799.9) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007469@unknown@formal@none@1@S@Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937.@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "kruppel-related") (:form . "Kruppel-related")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monoblast") (:form . "monoblast") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s801.1) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007479@unknown@formal@none@1@S@Increased [Ca2+]i activates Ca2+/calmodulin-dependent kinases including the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II), as well as calcineurin, a type 2B protein phosphatase.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 53) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 61)\n  (:start . 54) (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 71)\n  (:start . 62) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multifunctional") (:form . "multifunctional")\n  (:end . 91) (:start . 76) (:id . 50))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 117) (:start . 92) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 125)\n  (:start . 118) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 132)\n  (:start . 126) (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 135) (:start . 133)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CaM-K") (:form . "CaM-K") (:end . 142)\n  (:start . 137) (:id . 56))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 145) (:start . 143)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 155) (:start . 151)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 62))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 170)\n  (:start . 159) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 65))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "2b") (:form . "2B") (:end . 181) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 189)\n  (:start . 182) (:id . 68))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 201)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s802.3) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007489@unknown@formal@none@1@S@gamma B*CaM-K also downregulated the activation of AP-1 in response to transfection with a constitutively active mutant of PKC or stimulation with PMA.@(((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b*cam-k") (:form . "B*CaM-K") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 105) (:start . 91) (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 141)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s802.13) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007499@unknown@formal@none@1@S@Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys.@(((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "primate") (:form . "primate") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "lentivirus") (:form . "lentiviruses") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "viremia") (:form . "viremia") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monkey") (:form . "monkeys") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s804.2) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007509@unknown@formal@none@1@S@LMP-1 induces the expression of bcl2, an oncogene which protects cells from apoptosis, as well as of genes encoding other proteins involved in cell regulation and growth control.@(((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl2") (:form . "bcl2") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 158)\n  (:start . 148) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 169)\n  (:start . 163) (:id . 70))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 177)\n  (:start . 170) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s805.3) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007519@unknown@formal@none@1@S@The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s806.1) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007529@unknown@formal@none@1@S@After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RXR") (:form . "RXR") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x806.11.1) (:span 82 85)))\n (:nscopes ((:id . :x806.11.1) (:span 82 98)))\n (:identifiers (:sid . :s806.11) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007539@unknown@formal@none@1@S@Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.@(((:tag . "NN") (:stem . "mapping") (:form . "Mapping") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 110) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "clone-13") (:form . "clone-13") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "NNP") (:stem . "X2-box") (:form . "X2-box") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s808.1) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007549@unknown@formal@none@1@S@These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "x2-box") (:form . "X2-box") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 88) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "influence") (:form . "influencing") (:end . 145)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 158)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 182)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 188)\n  (:start . 183) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "isotype") (:form . "isotypes") (:end . 200)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x808.11.1) (:span 14 21)))\n (:hscopes ((:id . :x808.11.1) (:span 14 200)))\n (:identifiers (:sid . :s808.11) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007559@unknown@formal@none@1@S@To identify ets-related transcriptional regulators expressed in pre-B lymphocytes that may interact with either the pi or the microB site, we have used a PCR approach with degenerate oligonucleotides encoding conserved sequences in all members of the ets family.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "ets-related") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 60)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 99)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pi") (:form . "pi") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 166)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 182)\n  (:start . 172) (:id . 70))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 199) (:start . 183) (:id . 71))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 208)\n  (:start . 200) (:id . 72))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 218)\n  (:start . 209) (:id . 73))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 228)\n  (:start . 219) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 231) (:start . 229)\n  (:id . 75))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 235) (:start . 232)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 243)\n  (:start . 236) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 254) (:start . 251)\n  (:id . 80))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 261)\n  (:start . 255) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x810.4.1) (:span 105 111 119 121))\n  ((:id . :x810.4.3) (:span 87 90)))\n (:hscopes ((:id . :x810.4.1) (:span 105 137))\n  ((:id . :x810.4.3) (:span 87 137)))\n (:identifiers (:sid . :s810.4) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007569@unknown@formal@none@1@S@J delta K cells were isolated as a chronically infected survivor cell line, following infection of Jurkat CD4+ T cells with dl-NF, a mutated strain of human immunodeficiency virus type 1 (HIV-1) containing a deletion of the long terminal repeat (LTR) NF-kappa B sites.@(((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . 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"JJ") (:stem . "human") (:form . "human") (:end . 156)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 173) (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 193)\n  (:start . 188) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 205)\n  (:start . 195) (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 207) (:start . 206)\n  (:id . 79))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 216)\n  (:start . 208) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 228) (:start . 224)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 237)\n  (:start . 229) (:id . 84))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 244)\n  (:start . 238) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 246) (:start . 245)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 249) (:start . 246)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 259)\n  (:start . 251) (:id . 89))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 261) (:start . 260)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 267)\n  (:start . 262) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s811.2) (:did . :|7913275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007579@unknown@formal@none@1@S@This resulted in only a partial inhibition of TNF- or PMA- induced HIV replication in U1 cells, and no detectable effect on HIV replication in chronically infected U937 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-") (:form . "TNF-") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PMA-") (:form . "PMA-") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 113)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 139)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 154)\n  (:start . 143) (:id . 68))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x812.6.1) (:span 100 102)))\n (:nscopes ((:id . :x812.6.1) (:span 100 174)))\n (:identifiers (:sid . :s812.6) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007589@unknown@formal@none@1@S@Role of HIV-1 Nef expression in activation pathways in CD4+ T cells.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s814.1) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007599@unknown@formal@none@1@S@In a human malignant melanoma study NM23 expression was found to be significantly lower in metastases that developed less than 24 months after diagnosis of the primary tumours.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nm23") (:form . "NM23") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "metastasis") (:form . "metastases") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "NNS") (:stem . "tumour") (:form . "tumours") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s815.4) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007609@unknown@formal@none@1@S@The second abnormality in kappa B-binding activity in T cells from these patients is that RelA, a member of the Rel homology family which is part of the normal NF-kappa B complex, was not induced in the nucleus following activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 131)\n  (:start . 125) (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 159)\n  (:start . 153) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 168)\n  (:start . 160) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 178)\n  (:start . 171) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 183) (:start . 180)\n  (:id . 76))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 195)\n  (:start . 188) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 80))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 210)\n  (:start . 203) (:id . 81))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 220)\n  (:start . 211) (:id . 82))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 231)\n  (:start . 221) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x816.7.1) (:span 184 187)))\n (:nscopes ((:id . :x816.7.1) (:span 90 231)))\n (:identifiers (:sid . :s816.7) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007619@unknown@formal@none@1@S@As an in vitro model we show that phosphorylation of p105 impedes its ability to interact with NF-kappa B, as has been shown before for I kappa B alpha.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 49) (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "impede") (:form . "impedes") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 131)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 137) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 143)\n  (:start . 138) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 145) (:start . 144)\n  (:id . 70))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 151)\n  (:start . 146) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s817.8) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007629@unknown@formal@none@1@S@These events are accompanied by marked increases in the expression of RAG-1 and RAG-2 RNAs.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag-1") (:form . "RAG-1") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rag-2") (:form . "RAG-2") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s818.6) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007639@unknown@formal@none@1@S@To make clear the roles of RA and RAR alpha in the normal hematopoiesis, I have introduced the construct of human RAR alpha (hRAR alpha) into murine bone marrow cells with retroviral vector, and selected infected cells with drug resistant marker (Neo(r)) cultured on the stroma cell line (PA6-neo), and analyzed the behavior of infected cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "make") (:form . "make") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . 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"introduce") (:form . "introduced") (:end . 90)\n  (:start . 80) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 104)\n  (:start . 95) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 129) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . 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"cultured") (:end . 263)\n  (:start . 255) (:id . 89))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 266) (:start . 264)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 91))\n ((:tag . "NN") (:stem . "stroma") (:form . "stroma") (:end . 277)\n  (:start . 271) (:id . 92))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 282) (:start . 278)\n  (:id . 93))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 287) (:start . 283)\n  (:id . 94))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 289) (:start . 288)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "PA6-neo") (:form . "PA6-neo") (:end . 296)\n  (:start . 289) (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 297) (:start . 296)\n  (:id . 97))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 298) (:start . 297)\n  (:id . 98))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 302) (:start . 299)\n  (:id . 99))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 311)\n  (:start . 303) (:id . 100))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 315) (:start . 312)\n  (:id . 101))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 324)\n  (:start . 316) (:id . 102))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 327) (:start . 325)\n  (:id . 103))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 336)\n  (:start . 328) (:id . 104))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 342)\n  (:start . 337) (:id . 105))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 343) (:start . 342)\n  (:id . 106)))@@@1@65@((:identifiers (:sid . :s819.7) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007649@unknown@formal@none@1@S@Treatment of human resting T cells with phorbol esters strongly induced the expression of IL-2R alpha and the activation of NF.kappa B.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF.kappa") (:form . "NF.kappa") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s820.4) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007659@unknown@formal@none@1@S@The protease inhibitors N alpha-tosylphenylalanyl chloromethyl ketone (TPCK) and N alpha-tosyl-L-lysine chloromethyl ketone (TLCK) block activation of NF-kappa B/Rel proteins by preventing degradation of I kappa B alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha-tosylphenylalanyl")\n  (:form . "alpha-tosylphenylalanyl") (:end . 49) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 62)\n  (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 69)\n  (:start . 63) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha-tosyl-l-lysine")\n  (:form . "alpha-tosyl-L-lysine") (:end . 103) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 116)\n  (:start . 104) (:id . 55))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 123)\n  (:start . 117) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TLCK") (:form . "TLCK") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 188)\n  (:start . 178) (:id . 67))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 200)\n  (:start . 189) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 69))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 205) (:start . 204)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 211)\n  (:start . 206) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 213) (:start . 212)\n  (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 219)\n  (:start . 214) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s821.5) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007669@unknown@formal@none@1@S@Stimulation of plus clones liberated the classical p50-p65 complex from cytoplasmic pools, whereas minus clones produced an apparently novel, faster-migrating complex, as judged by electrophoretic mobility shift assays.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "liberate") (:form . "liberated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "pool") (:form . "pools") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "minus") (:form . "minus") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "faster-migrating") (:form . "faster-migrating")\n  (:end . 158) (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 177)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 196) (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 205)\n  (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 211)\n  (:start . 206) (:id . 71))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 218)\n  (:start . 212) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s822.5) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007679@unknown@formal@none@1@S@The protein tyrosine kinase activity of the v-abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-abl") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VB") (:stem . "subvert") (:form . "subvert") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 161)\n  (:start . 155) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 181) (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s823.2) (:did . :|7945272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007689@unknown@formal@none@1@S@HS I, IV, and V were exclusively observed in the erythroid/megakaryocytic cell lines that express tal-1 from the promoters 1a and 1b.@(((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 8) (:start . 6)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 15) (:start . 14)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 49))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 32)\n  (:start . 21) (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 41)\n  (:start . 33) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid/megakaryocytic")\n  (:form . "erythroid/megakaryocytic") (:end . 73) (:start . 49) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "1a") (:form . "1a") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "1b") (:form . "1b") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s824.7) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007699@unknown@formal@none@1@S@The effector phase of cytotoxic T cell responses and IL-2-dependent functions are inhibited even by a partial depletion of the intracellular GSH pool.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "il-2-dependent") (:form . "IL-2-dependent")\n  (:end . 67) (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s825.7) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007709@unknown@formal@none@1@S@Thus, erythroid development of M-TAT cells is promoted by EPO and suppressed by GM-CSF.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M-TAT") (:form . "M-TAT") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s826.8) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007719@unknown@formal@none@1@S@Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Myc-Max") (:form . "Myc-Max") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 65) (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 75)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s828.1) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007729@unknown@formal@none@1@S@EBNA-2 is able to trans-activate the expression of the LMP gene in several cell lines.@(((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "trans-activate") (:form . "trans-activate")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s829.5) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007739@unknown@formal@none@1@S@Infection with a variant of simian immunodeficiency virus, SIVsmmPBj14, leads to severe acute disease in macaques.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 51) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "macaque") (:form . "macaques") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s830.2) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007749@unknown@formal@none@1@S@These studies are consistent with the hypothesis that LTR mutations assist SIVsmmPBj14 in responding efficiently to cellular stimulation and allow it to replicate to high titers during the acute phase of viral infection.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "VBP") (:stem . "assist") (:form . "assist") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "respond") (:form . "responding") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 136)\n  (:start . 125) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "titer") (:form . "titers") (:end . 177)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 184)\n  (:start . 178) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 200)\n  (:start . 195) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 209)\n  (:start . 204) (:id . 73))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 219)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x830.12.1) (:span 38 48)))\n (:hscopes ((:id . :x830.12.1) (:span 38 219)))\n (:identifiers (:sid . :s830.12) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007759@unknown@formal@none@1@S@Furthermore, multimerized region II sequence elements enhanced the activity of a heterologous thymidine kinase promoter in monocytic cells but not other cell types tested.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 93)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 110)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x831.10.1) (:span 143 146)))\n (:nscopes ((:id . :x831.10.1) (:span 143 170)))\n (:identifiers (:sid . :s831.10) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007769@unknown@formal@none@1@S@This protein appears to require both the S and J elements, which are separated by 10 bp for optimal binding.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 99)\n  (:start . 92) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x832.9.1) (:span 13 20)))\n (:hscopes ((:id . :x832.9.1) (:span 0 107)))\n (:identifiers (:sid . :s832.9) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007779@unknown@formal@none@1@S@Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat-mediated transactivation in T-cell lines, as well as in a monocyte line, U937.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "tat-mediated") (:form . "Tat-mediated") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 105) (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s834.4) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007789@unknown@formal@none@1@S@Treatment of a human promyelocytic leukemia cell line, HL-60, with 10 micrograms/mL etoposide or 2 microM 1-beta-D-arabinofuranosylcytosine induced NF-kappa B activation within 1 hr and subsequently caused apoptosis within 3-4 hr.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "micrograms/ml") (:form . "micrograms/mL")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "1-beta-d-arabinofuranosylcytosine")\n  (:form . "1-beta-D-arabinofuranosylcytosine") (:end . 139) (:start . 106)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 147)\n  (:start . 140) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 156)\n  (:start . 148) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 158) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 176)\n  (:start . 170) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 178) (:start . 177)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 181) (:start . 179)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 68))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 198)\n  (:start . 186) (:id . 69))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 205)\n  (:start . 199) (:id . 70))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 215)\n  (:start . 206) (:id . 71))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 222)\n  (:start . 216) (:id . 72))\n ((:tag . "CD") (:stem . "3-4") (:form . "3-4") (:end . 226) (:start . 223)\n  (:id . 73))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 229) (:start . 227)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s835.3) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007799@unknown@formal@none@1@S@In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "calcium-independent")\n  (:form . "calcium-independent") (:end . 124) (:start . 105) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cd28-specific") (:form . "CD28-specific")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x836.4.1) (:span 85 90)))\n (:hscopes ((:id . :x836.4.1) (:span 54 147)))\n (:identifiers (:sid . :s836.4) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007809@unknown@formal@none@1@S@Protein-DNA complexes of constitutive NF-kappa B are similar in mobility to the LPS-induced NF-kappa B and both are recognized by an antibody specific to the p50 subunit of NF-kappa B.@(((:tag . "JJ") (:stem . "protein-dna") (:form . "Protein-DNA") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s837.6) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007819@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 400 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s837.16) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007829@unknown@formal@none@1@S@Activation of the dPRL promoter construct in these undifferentiated cells could however be induced by the addition of cAMP, in the absence of progesterone, suggesting that a signal transduced through the cAMP signaling pathway is a primary inducer of decidual PRL gene expression.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . 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5007839@unknown@formal@none@1@S@Moreover, rapamycin, an inhibitor of pp70S6K activation, had no effect on induction of EGR-1 expression.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pp70s6k") (:form . "pp70S6K") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x839.10.1) (:span 61 63)))\n (:nscopes ((:id . :x839.10.1) (:span 61 103)))\n (:identifiers (:sid . :s839.10) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007849@unknown@formal@none@1@S@When cells were stimulated with anti-CD3 mAb or PMA/A23187, a complex formation of NF-kappa B (p50/p65) heterodimer with the kappa B sequence was induced.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PMA/A23187") (:form . "PMA/A23187") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s840.8) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007859@unknown@formal@none@1@S@We found that tyrosine kinase activity was similar for both mAbs over a period of hours.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s841.5) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007869@unknown@formal@none@1@S@We have examined the role of cell surface molecules in these responses.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s842.4) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007879@unknown@formal@none@1@S@The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 163)\n  (:start . 151) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 177)\n  (:start . 168) (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 187)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 201) (:start . 188) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 214) (:start . 210)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 228)\n  (:start . 220) (:id . 78))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 238)\n  (:start . 229) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s843.2) (:did . :|8052854|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007889@unknown@formal@none@1@S@Two other sites display disparate effects on IL-2 gene expression in different T leukemia cell lines: the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128).@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "disparate") (:form . "disparate") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "purine") (:form . "purine") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-291") (:form . "-291") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-277") (:form . "-277") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 155)\n  (:start . 147) (:id . 70))\n ((:tag . "NN") (:stem . "purine") (:form . "purine") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 172)\n  (:start . 167) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 74))\n ((:tag . "CD") (:stem . "-145") (:form . "-145") (:end . 178) (:start . 174)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 76))\n ((:tag . "CD") (:stem . "-128") (:form . "-128") (:end . 186) (:start . 182)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s844.7) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007899@unknown@formal@none@1@S@Our results suggest that superantigens and other MHC class II ligands may activate HIV-1 gene expression in monocytes/macrophages.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 129) (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x845.7.1) (:span 70 73)) ((:id . :x845.7.2) (:span 12 19)))\n (:hscopes ((:id . :x845.7.1) (:span 70 129))\n  ((:id . :x845.7.2) (:span 12 129)))\n (:identifiers (:sid . :s845.7) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007909@unknown@formal@none@1@S@Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s847.1) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007919@unknown@formal@none@1@S@Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "deliver") (:form . "delivers") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 158)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 188)\n  (:start . 180) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 199)\n  (:start . 192) (:id . 70))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 210)\n  (:start . 200) (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 216)\n  (:start . 211) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s848.3) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007929@unknown@formal@none@1@S@These results indicate that the IL-5 gene is positively regulated by cAMP in a manner opposite to that for the IL-2 gene.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x849.6.1) (:span 14 27)))\n (:hscopes ((:id . :x849.6.1) (:span 14 120)))\n (:identifiers (:sid . :s849.6) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007939@unknown@formal@none@1@S@To understand GATA3 gene regulation, we cloned the human gene and the 5' end of the mouse GATA3 gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 95) (:start . 90)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s850.3) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007949@unknown@formal@none@1@S@In this report, we demonstrate that NFKB2 (lyt-10) and c-Rel are overexpressed in HTLV-I infected and Tax-expressing cells and, together, account for the majority of the constitutive NF-kappa B binding activity in these cells before and after PMA stimulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lyt-10") (:form . "lyt-10") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 78) (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 88)\n  (:start . 82) (:id . 58))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 116) (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "account") (:form . "account") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 182)\n  (:start . 170) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 191)\n  (:start . 183) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 201)\n  (:start . 194) (:id . 76))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 210)\n  (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 213) (:start . 211)\n  (:id . 78))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 219)\n  (:start . 214) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 80))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 232)\n  (:start . 226) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 82))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 242)\n  (:start . 237) (:id . 83))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 246) (:start . 243)\n  (:id . 84))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 258)\n  (:start . 247) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s851.5) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007959@unknown@formal@none@1@S@When cotransfected with the HIV LTR CAT into CV-1 cells, both the pCD41 and pGD41 clones trans-activated the HIV LTR.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cv-1") (:form . "CV-1") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pgd41") (:form . "pGD41") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 88)\n  (:start . 82) (:id . 58))\n ((:tag . "VBD") (:stem . "trans-activate") (:form . "trans-activated")\n  (:end . 104) (:start . 89) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s852.7) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007969@unknown@formal@none@1@S@LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes.@(((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s853.6) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007979@unknown@formal@none@1@S@We examined whether signal transducing components in T cells can activate transcription of the GM-CSF gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "transducing") (:form . "transducing") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x854.5.1) (:span 12 19)))\n (:hscopes ((:id . :x854.5.1) (:span 12 106)))\n (:identifiers (:sid . :s854.5) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007989@unknown@formal@none@1@S@In EMSAs, NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF-AT contained an activity that bound to the P sequence.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "NF(P)") (:form . "NF(P)") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 156)\n  (:start . 148) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 176) (:start . 175)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 185)\n  (:start . 177) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x855.5.1) (:span 78 81)))\n (:nscopes ((:id . :x855.5.1) (:span 78 115)))\n (:identifiers (:sid . :s855.5) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007999@unknown@formal@none@1@S@In comparison to other activators of NF-kappa B such as phorbol myristate acetate or tumor necrosis factor, we did not detect changes in the tyrosine phosphorylation status of I kappa B alpha following treatment with either of these agents.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 165) (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 172)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 201)\n  (:start . 192) (:id . 75))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 216) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 223)\n  (:start . 217) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 79))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 232)\n  (:start . 227) (:id . 80))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 239)\n  (:start . 233) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x856.7.1) (:span 115 118)))\n (:nscopes ((:id . :x856.7.1) (:span 115 239)))\n (:identifiers (:sid . :s856.7) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008009@unknown@formal@none@1@S@A GC box containing a binding site for Sp1 was identified (nt 4623 to 4631).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 4) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "nt") (:form . "nt") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4623") (:form . "4623") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "CD") (:stem . "4631") (:form . "4631") (:end . 74) (:start . 70)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s857.9) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008019@unknown@formal@none@1@S@As a functional correlate of this finding, transient co-transfection of HIV-1 LTR reporter constructs in a different T cell line demonstrated that v-src activated this promoter in a kappa B-dependent manner.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 15)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "correlate") (:form . "correlate") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 68) (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 141)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "v-src") (:form . "v-src") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 187)\n  (:start . 182) (:id . 71))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 199)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 206)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s858.8) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008029@unknown@formal@none@1@S@The nuclear factor kappa B (NF-kappa B) is a eukaryotic transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 55)\n  (:start . 45) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s860.2) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008039@unknown@formal@none@1@S@Thus, NF-kappa B activation was not required for neuroblastoma cell differentiation.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 83) (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x860.12.1) (:span 32 35)))\n (:nscopes ((:id . :x860.12.1) (:span 32 83)))\n (:identifiers (:sid . :s860.12) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008049@unknown@formal@none@1@S@Hypoxic induction of interleukin-8 gene expression in human endothelial cells.@(((:tag . "JJ") (:stem . "hypoxic") (:form . "Hypoxic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s862.1) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008059@unknown@formal@none@1@S@Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits.@(((:tag . "NN") (:stem . "function") (:form . "Function") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 72) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "invariant") (:form . "invariant") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 144) (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 180)\n  (:start . 175) (:id . 66))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s863.1) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008069@unknown@formal@none@1@S@Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 43) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 71)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 90) (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 100)\n  (:start . 91) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s864.1) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008079@unknown@formal@none@1@S@Elements necessary for the steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) to induce a biological response include the presence of specific intracellular receptors (vitamin D3 receptors (VDR)) and modulation of gene expression via hormone-activated receptor binding to regulatory regions of target genes.@(((:tag . "NNS") (:stem . "element") (:form . "Elements") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . 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5008089@unknown@formal@none@1@S@Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c-fos and c-jun mRNA.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x866.4.1) (:span 16 23)))\n (:hscopes ((:id . :x866.4.1) (:span 16 154)))\n (:identifiers (:sid . :s866.4) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008099@unknown@formal@none@1@S@The I kappa B gamma isoforms also display differences in specificity and affinity for Rel/NF-kappa B proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s867.7) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008109@unknown@formal@none@1@S@However, for each time examined, the expression of NF-kappa B was maximum after the 0.5-Gy exposure.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "0.5-gy") (:form . "0.5-Gy") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s868.8) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008119@unknown@formal@none@1@S@THP decreased the concentration of the transcription factors NF-kappa B and AP-1 detected in nuclear extracts of PBMC cultured in the presence or absence of LPS.@(((:tag . "NNP") (:stem . "THP") (:form . "THP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x869.9.1) (:span 146 153)))\n (:nscopes ((:id . :x869.9.1) (:span 146 160)))\n (:identifiers (:sid . :s869.9) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008129@unknown@formal@none@1@S@The novel astrocyte-derived kappa B-binding activity is retained on an HIV-1 Tat affinity column, while prototypical NF-kappa B from Jurkat T cells is not.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "astrocyte-derived") (:form . "astrocyte-derived")\n  (:end . 27) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "prototypical") (:form . "prototypical") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x870.7.1) (:span 151 154)))\n (:nscopes ((:id . :x870.7.1) (:span 151 154)))\n (:identifiers (:sid . :s870.7) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008139@unknown@formal@none@1@S@Using a series of constructs containing deletions and mutations in this region, we found that the 3'-most site alone was sufficient for binding GA-binding protein alpha (GABP alpha)/GABP beta and for a low level of transcriptional activation.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "3'-most") (:form . "3'-most") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "ga-binding") (:form . "GA-binding") (:end . 154)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "alpha)/GABP") (:form . "alpha)/GABP") (:end . 186)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 191) (:start . 187)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 211)\n  (:start . 206) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 230) (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 241)\n  (:start . 231) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s871.7) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008149@unknown@formal@none@1@S@TF is the primary cellular initiator of the coagulation protease cascades.@(((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coagulation") (:form . "coagulation") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s872.3) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008159@unknown@formal@none@1@S@Dysregulation of cytokines secreted by T cells may play an important role in the pathogenesis of AIDS.@(((:tag . "NN") (:stem . "dysregulation") (:form . "Dysregulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x873.2.1) (:span 47 50)))\n (:hscopes ((:id . :x873.2.1) (:span 47 101)))\n (:identifiers (:sid . :s873.2) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008169@unknown@formal@none@1@S@The molecular mechanisms regulating human immunodeficiency virus (HIV) persistence in a major cell reservoir such as the macrophage remain unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 58) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 64) (:start . 59)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x874.2.1) (:span 139 146)))\n (:hscopes ((:id . :x874.2.1) (:span 0 146)))\n (:identifiers (:sid . :s874.2) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008179@unknown@formal@none@1@S@Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isoenzyme") (:form . "isoenzymes") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 162)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 192)\n  (:start . 184) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 203)\n  (:start . 198) (:id . 73))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 235)\n  (:start . 224) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x874.12.1) (:span 26 33)))\n (:hscopes ((:id . :x874.12.1) (:span 26 235)))\n (:identifiers (:sid . :s874.12) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008189@unknown@formal@none@1@S@A survey of genes potentially regulated by this family of factors primarily revealed genes involved in growth-related metabolism.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "survey") (:form . "survey") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "growth-related") (:form . "growth-related")\n  (:end . 117) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x875.10.1) (:span 18 29)))\n (:hscopes ((:id . :x875.10.1) (:span 18 128)))\n (:identifiers (:sid . :s875.10) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008199@unknown@formal@none@1@S@B cell-specific transcriptional promoter activity mediated by the octamer motif requires the Oct1 or Oct2 protein and additional B cell-restricted cofactors.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 31) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 58)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-restricted") (:form . "cell-restricted")\n  (:end . 146) (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "cofactor") (:form . "cofactors") (:end . 156)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s877.2) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008209@unknown@formal@none@1@S@Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene.@(((:tag . "JJ") (:stem . "polymorphic") (:form . "Polymorphic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 30)\n  (:start . 24) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 82) (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s878.1) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008219@unknown@formal@none@1@S@IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "RB") (:stem . "acutely") (:form . "acutely") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 113) (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 121)\n  (:start . 114) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s879.1) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008229@unknown@formal@none@1@S@The product of the B-cell-specific B29 gene (B29, Ig beta, CD79b) is essential for Ig-mediated B-cell activation via the B-cell antigen receptor complex (BCR) on human and murine B lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 34) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B29") (:form . "B29") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD79b") (:form . "CD79b") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 78)\n  (:start . 69) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ig-mediated") (:form . "Ig-mediated") (:end . 94)\n  (:start . 83) (:id . 60))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cell") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 135)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "BCR") (:form . "BCR") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 178)\n  (:start . 172) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 180) (:start . 179)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 192)\n  (:start . 181) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s880.2) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008239@unknown@formal@none@1@S@These findings indicate that B29 gene expression is controlled by the complex interplay of positive and negative regulatory elements.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x880.12.1) (:span 15 28)))\n (:hscopes ((:id . :x880.12.1) (:span 15 132)))\n (:identifiers (:sid . :s880.12) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008249@unknown@formal@none@1@S@Inhibition of NF-AT signal transduction events by a dominant-negative form of calcineurin.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 69) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s882.1) (:did . :|8561779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008259@unknown@formal@none@1@S@Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1-LTR-driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking.@(((:tag . "NNP") (:stem . "Anti-TNF-alpha") (:form . "Anti-TNF-alpha")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-il-1") (:form . "anti-IL-1") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hiv-1-ltr-driven") (:form . "HIV-1-LTR-driven")\n  (:end . 113) (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 145)\n  (:start . 136) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 157)\n  (:start . 149) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "r") (:form . "R") (:end . 173) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 187) (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x883.5.1) (:span 28 31)))\n (:nscopes ((:id . :x883.5.1) (:span 28 55)))\n (:identifiers (:sid . :s883.5) (:did . :|8562512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008269@unknown@formal@none@1@S@Results from site-directed mutations and electrophoretic mobility shift assays strongly suggest that this sequence mediates the ionomycin-induced activation of the TCRG enhancer.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 56) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 78)\n  (:start . 72) (:id . 50))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 95)\n  (:start . 88) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 114)\n  (:start . 106) (:id . 55))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 123)\n  (:start . 115) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ionomycin-induced") (:form . "ionomycin-induced")\n  (:end . 145) (:start . 128) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TCRG") (:form . "TCRG") (:end . 168) (:start . 164)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 177)\n  (:start . 169) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x885.5.1) (:span 88 95)))\n (:hscopes ((:id . :x885.5.1) (:span 88 177)))\n (:identifiers (:sid . :s885.5) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008279@unknown@formal@none@1@S@Furthermore, ADT treated Wurzburg cells had significantly higher glutathione levels as compared with untreated cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 64) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s886.9) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008289@unknown@formal@none@1@S@Large amounts of AP-1 and NF-kappa B and significant quantities of NF-AT were induced in SEA-activated CD4+ spleen T cells, whereas Oct-1 and Oct-2 DNA binding activity was similar in both resting and activated T cells.@(((:tag . "JJ") (:stem . "large") (:form . "Large") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "quantity") (:form . "quantities") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sea-activated") (:form . "SEA-activated")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 159)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 188) (:start . 184)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 210)\n  (:start . 201) (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 212) (:start . 211)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s887.8) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008299@unknown@formal@none@1@S@Electrophoretic mobility shift assays showed that both surfactants decreased activation of NF-kappa B.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "surfactant") (:form . "surfactants") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s888.7) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008309@unknown@formal@none@1@S@To investigate the regulation of IL-13 gene expression by T cells, we isolated and sequenced the human IL-13 gene, analyzed its 5'-flanking region for potential transcriptional activation elements, and examined its expression in nontransformed T-lineage cell populations.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "sequence") (:form . "sequenced") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 139)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 160)\n  (:start . 151) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 176) (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 187)\n  (:start . 177) (:id . 70))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 196)\n  (:start . 188) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 225)\n  (:start . 215) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "nontransformed") (:form . "nontransformed")\n  (:end . 243) (:start . 229) (:id . 78))\n ((:tag . "NN") (:stem . "t-lineage") (:form . "T-lineage") (:end . 253)\n  (:start . 244) (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 258) (:start . 254)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 270)\n  (:start . 259) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x890.3.1) (:span 151 160)))\n (:hscopes ((:id . :x890.3.1) (:span 151 196)))\n (:identifiers (:sid . :s890.3) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008319@unknown@formal@none@1@S@IL-1alpha promoter constructs drive transcription of the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells, which constitutively produce IL-1alpha.@(((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "drive") (:form . "drive") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 72) (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 90) (:start . 73) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 95) (:start . 92)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "htlv-i-positive") (:form . "HTLV-I-positive")\n  (:end . 129) (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "mt-2") (:form . "MT-2") (:end . 134) (:start . 130)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 162) (:start . 148) (:id . 62))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 170)\n  (:start . 163) (:id . 63))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 180)\n  (:start . 171) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s891.4) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008329@unknown@formal@none@1@S@Maximal inhibition of p24 antigen production in T-lymphocytic ACH-2 cells was 47% with r-hTBP-1 and 42% with rhu TNFR:Fc.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "t-lymphocytic") (:form . "T-lymphocytic")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "r-htbp-1") (:form . "r-hTBP-1") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rhu") (:form . "rhu") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TNFR:Fc") (:form . "TNFR:Fc") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s892.4) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008339@unknown@formal@none@1@S@We show here that AM580, a stable retinobenzoic derivative originally synthesized as a RAR alpha agonist, is a powerful inducer of granulocytic maturation in NB4, an APL-derived cell line, and in freshly isolated APL blasts.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 33)\n  (:start . 27) (:id . 49))\n ((:tag . "JJ") (:stem . "retinobenzoic") (:form . "retinobenzoic")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 143)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 154)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NB4") (:form . "NB4") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "apl-derived") (:form . "APL-derived") (:end . 177)\n  (:start . 166) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 72))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 203)\n  (:start . 196) (:id . 77))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 212)\n  (:start . 204) (:id . 78))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 216) (:start . 213)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 223)\n  (:start . 217) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s893.4) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008349@unknown@formal@none@1@S@Studies included structural comparison of the promoters for human and mouse inducible NO synthase (iNOS) genes, transfection and assay of human and mouse iNOS promoter regions in response to LPS ± IFN-gamma, and electrophoretic mobility shift assays of kappa B response elements.@(((:tag . "NNPS") (:stem . "Study") (:form . "Studies") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 124)\n  (:start . 112) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 175)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 196) (:start . 195)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 206)\n  (:start . 197) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 227) (:start . 212) (:id . 79))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 236)\n  (:start . 228) (:id . 80))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 242)\n  (:start . 237) (:id . 81))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 249)\n  (:start . 243) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 252) (:start . 250)\n  (:id . 83))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 258)\n  (:start . 253) (:id . 84))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 260) (:start . 259)\n  (:id . 85))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 269)\n  (:start . 261) (:id . 86))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 278)\n  (:start . 270) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s894.3) (:did . :|8613707|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008359@unknown@formal@none@1@S@This pattern of distribution is, thus far, unique to the GATA transcription factors and suggests a protein-protein interaction with other components of the nuclear bodies via the GATA zinc finger domain.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 114) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 126)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 195)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x895.8.1) (:span 88 96)))\n (:hscopes ((:id . :x895.8.1) (:span 88 202)))\n (:identifiers (:sid . :s895.8) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008369@unknown@formal@none@1@S@Thus, the balance between an endogenously produced viral inducer (IL-1 beta ) and an inhibitor (IL-1ra) may represent an important pathway leading to modulation of HIV expression from monocytic cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "endogenously") (:form . "endogenously") (:end . 41)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-1ra") (:form . "IL-1ra") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 130)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 160)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x896.10.1) (:span 104 107)))\n (:hscopes ((:id . :x896.10.1) (:span 104 199)))\n (:identifiers (:sid . :s896.10) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008379@unknown@formal@none@1@S@Ca2+-modulating cyclophilin ligand (CAML) was originally described as a cyclophilin B-binding protein whose overexpression in T cells causes a rise in intracellular calcium, thus activating transcription factors responsible for the early immune response.@(((:tag . "JJ") (:stem . "ca2+-modulating") (:form . "Ca2+-modulating")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 27)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 34)\n  (:start . 28) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 122) (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 164) (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 189)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 203) (:start . 190) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 211)\n  (:start . 204) (:id . 71))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 223)\n  (:start . 212) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 227) (:start . 224)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 237)\n  (:start . 232) (:id . 75))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 244)\n  (:start . 238) (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 253)\n  (:start . 245) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s898.2) (:did . :|8621480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008389@unknown@formal@none@1@S@Authentic NFAT and NF-kappaB targets did not compete for the META(D+) binding factor(s).@(((:tag . "JJ") (:stem . "authentic") (:form . "Authentic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "META(D+)") (:form . "META(D+)") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "factor(s)") (:form . "factor(s)") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x899.7.1) (:span 41 44)))\n (:nscopes ((:id . :x899.7.1) (:span 41 87)))\n (:identifiers (:sid . :s899.7) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008399@unknown@formal@none@1@S@Mutagenesis of the activator protein-1 [AP-1] site at -72 abolished basal promoter activity and LPS/zymosan inducibility, while mutagenesis of an NF-kappaB-like site at -20 to -10 had no effect.@(((:tag . "NNP") (:stem . "Mutagenesis") (:form . "Mutagenesis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-72") (:form . "-72") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lps/zymosan") (:form . "LPS/zymosan") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 120)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nf-kappab-like") (:form . "NF-kappaB-like")\n  (:end . 160) (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-20") (:form . "-20") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "CD") (:stem . "-10") (:form . "-10") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 186) (:start . 184)\n  (:id . 72))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x900.7.1) (:span 184 186)))\n (:nscopes ((:id . :x900.7.1) (:span 184 193)))\n (:identifiers (:sid . :s900.7) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008409@unknown@formal@none@1@S@E3330 inhibited this induced promoter activity in a dose-dependent manner.@(((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 66) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s901.7) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008419@unknown@formal@none@1@S@Although a role of p16 in this regulation has been presumed, there is no proof so far that loss of this tumor suppressor gene really affects E2F-mediated regulations.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "presume") (:form . "presumed") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proof") (:form . "proof") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 60))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 103) (:start . 99)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 109)\n  (:start . 104) (:id . 64))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 120)\n  (:start . 110) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 66))\n ((:tag . "RB") (:stem . "really") (:form . "really") (:end . 132)\n  (:start . 126) (:id . 67))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 140)\n  (:start . 133) (:id . 68))\n ((:tag . "JJ") (:stem . "e2f-mediated") (:form . "E2F-mediated") (:end . 153)\n  (:start . 141) (:id . 69))\n ((:tag . "NNS") (:stem . "regulation") (:form . "regulations") (:end . 165)\n  (:start . 154) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x902.4.1) (:span 70 78)))\n (:hscopes ((:id . :x902.4.1) (:span 70 165)))\n (:identifiers (:sid . :s902.4) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008429@unknown@formal@none@1@S@The expression of cell surface markers including the interleukin 2 receptor alpha (IL-2R alpha) chain (CD25), CD69 and L-selectin (CD62) is normal in mitogen-activated Rel-/- T cells, but cytokine production is impaired.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd25") (:form . "CD25") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD69") (:form . "CD69") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "L-selectin") (:form . "L-selectin") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd62") (:form . "CD62") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 139) (:start . 137)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 146)\n  (:start . 140) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 167) (:start . 150) (:id . 72))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 174)\n  (:start . 168) (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 76))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 196)\n  (:start . 188) (:id . 78))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 207)\n  (:start . 197) (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 210) (:start . 208)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 219)\n  (:start . 211) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s903.5) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008439@unknown@formal@none@1@S@We now report that galectin-3 is abundantly expressed in a number of human T lymphotropic virus (HTLV)-I-infected human T cell lines, including F6T, HUT 102, K3T, MT-2, and SLB-I, but is not expressed in non-HTLV-I-infected T cell lines such as Jurkat, CEM, and MOLT-4.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . 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"102") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "K3T") (:form . "K3T") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "MT-2") (:form . "MT-2") (:end . 167) (:start . 163)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "SLB-I") (:form . "SLB-I") (:end . 178)\n  (:start . 173) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 183) (:start . 180)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . 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",") (:end . 252) (:start . 251)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 256) (:start . 253)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 257) (:start . 256)\n  (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 261) (:start . 258)\n  (:id . 93))\n ((:tag . "NN") (:stem . "molt-4") (:form . "MOLT-4") (:end . 268)\n  (:start . 262) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 95)))@@@1@54@((:ncues ((:id . :x904.5.1) (:span 187 190)))\n (:nscopes ((:id . :x904.5.1) (:span 187 268)))\n (:identifiers (:sid . :s904.5) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008449@unknown@formal@none@1@S@The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 98)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s905.3) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008459@unknown@formal@none@1@S@A variety of cytokines and growth factors act through an induction of gene expression mediated by a family of latent transcription factors called STAT (signal transducers and activators of transcription) proteins.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 185)\n  (:start . 175) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 202) (:start . 189) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 212)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s906.2) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008469@unknown@formal@none@1@S@For this purpose, we used three main approaches.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s907.3) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008479@unknown@formal@none@1@S@Ten mutants of the simian immunodeficiency virus (SIV) SIVmac239 bearing deletions (delta) or substitutions (subst) in the NF-kappaB and/or Sp1 binding elements were created, and the replicative capacities of the mutants were analyzed.@(((:tag . "CD") (:stem . "ten") (:form . "Ten") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 42) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SIV") (:form . "SIV") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SIVmac239") (:form . "SIVmac239") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "delta") (:form . "delta") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 107) (:start . 94) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "subst") (:form . "subst") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 132)\n  (:start . 123) (:id . 65))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 194)\n  (:start . 183) (:id . 75))\n ((:tag . "NNS") (:stem . "capacity") (:form . "capacities") (:end . 205)\n  (:start . 195) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 220)\n  (:start . 213) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 234)\n  (:start . 226) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s908.2) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008489@unknown@formal@none@1@S@Therefore, the surprisingly high replicative capacity of NF-kappaB and Sp1 binding site mutants of SIVmac is due to unique features or the enhancer/promoter region.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "surprisingly") (:form . "surprisingly") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SIVmac") (:form . "SIVmac") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "enhancer/promoter") (:form . "enhancer/promoter")\n  (:end . 156) (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s908.12) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008499@unknown@formal@none@1@S@Consequently, IkappaBbeta protein expression is chronically downregulated in HTLV-1-infected T lymphocytes.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 73) (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "htlv-1-infected") (:form . "HTLV-1-infected")\n  (:end . 92) (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 106)\n  (:start . 95) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s909.10) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008509@unknown@formal@none@1@S@These studies identify EGR1 as an intermediary linking BCR-derived signals to the induction of CD44.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intermediary") (:form . "intermediary") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "VBG") (:stem . "link") (:form . "linking") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "bcr-derived") (:form . "BCR-derived") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s910.9) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008519@unknown@formal@none@1@S@Studies of the kinetics of induction showed that the NFAT EMSA binding complex appeared earlier than the CMAT complex.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s911.9) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008529@unknown@formal@none@1@S@Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 32)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "5'-deletion") (:form . "5'-deletion") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 57)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 113)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "CD") (:stem . "158") (:form . "158") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 186)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 191) (:start . 187)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 196) (:start . 192)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 207)\n  (:start . 197) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 210) (:start . 208)\n  (:id . 71))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 217)\n  (:start . 211) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 239) (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 253) (:start . 240) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 256) (:start . 254)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 260) (:start . 257)\n  (:id . 77))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 269)\n  (:start . 261) (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 274) (:start . 270)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s912.6) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008539@unknown@formal@none@1@S@Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p93fes") (:form . "p93fes") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s913.6) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008549@unknown@formal@none@1@S@Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chloram-phenicol") (:form . "chloram-phenicol")\n  (:end . 104) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 122) (:start . 105) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 150)\n  (:start . 140) (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 159)\n  (:start . 151) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 180) (:start . 176)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 193)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 214) (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 225)\n  (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s914.7) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008559@unknown@formal@none@1@S@Specific antibodies directed against the individual STAT proteins were used in supershift experiments.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s915.8) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008569@unknown@formal@none@1@S@The maximum levels of these markers induced by ML-9 were comparable to those induced by VD3, but after removal of ML-9 from the medium by washing the cells, the expressions of theses markers decreased within 4 hours and reached basal levels in 1 day, indicating that ML-9's induction of expression of differentiation-associated phenotypes was reversible.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . 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"VBD") (:stem . "be") (:form . "was") (:end . 342) (:start . 339)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 353)\n  (:start . 343) (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 354) (:start . 353)\n  (:id . 101)))@@@1@60@((:hcues ((:id . :x916.7.1) (:span 251 266)))\n (:hscopes ((:id . :x916.7.1) (:span 251 353)))\n (:identifiers (:sid . :s916.7) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008579@unknown@formal@none@1@S@In view of these findings, we analyzed the effects of IFN-gamma on the expression of different transcription factors in activated human monocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s917.3) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008589@unknown@formal@none@1@S@However, the combined stimulation did not result in enhanced p50 and p65 protein expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x917.13.1) (:span 38 41)))\n (:nscopes ((:id . :x917.13.1) (:span 38 91)))\n (:identifiers (:sid . :s917.13) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008599@unknown@formal@none@1@S@Nuclei of unstimulated PBL from different donors expressed p62c-fos and p39c-jun, but AP-1 was not detected in the majority of samples.@(((:tag . "NNP") (:stem . "Nucleus") (:form . "Nuclei") (:end . 6)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x918.8.1) (:span 95 98)))\n (:nscopes ((:id . :x918.8.1) (:span 86 134)))\n (:identifiers (:sid . :s918.8) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008609@unknown@formal@none@1@S@Results of this study indicate that a sustained elevated [Ca2+]i is a significant factor in oxidant-induced NF-kappaB activation.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "sustain") (:form . "sustained") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "oxidant-induced") (:form . "oxidant-induced")\n  (:end . 107) (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x919.7.1) (:span 22 35)))\n (:hscopes ((:id . :x919.7.1) (:span 22 128)))\n (:identifiers (:sid . :s919.7) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008619@unknown@formal@none@1@S@Heat shock induces HIV-1 replication in chronically infected promyelocyte cell line OM10.1.@(((:tag . "NNP") (:stem . "Heat") (:form . "Heat") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 73)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "om10.1") (:form . "OM10.1") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s921.1) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008629@unknown@formal@none@1@S@Abundant expression of erythroid transcription factor P45 NF-E2 mRNA in human peripheral granurocytes.@(((:tag . "JJ") (:stem . "abundant") (:form . "Abundant") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 47))\n ((:tag . "NNP") (:stem . "P45") (:form . "P45") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-E2") (:form . "NF-E2") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "granurocyte") (:form . "granurocytes") (:end . 101)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s922.1) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008639@unknown@formal@none@1@S@The expression of p45 mRNA in the neutrophils declined rapidly after transfer of the cells to in vitro culture and G-CSF could not sustain the expression from the down-regulation, suggesting the E2 may also participate in the regulation of neutrophil-specific gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 45)\n  (:start . 34) (:id . 49))\n ((:tag . "VBD") (:stem . "decline") (:form . "declined") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "VB") (:stem . "sustain") (:form . "sustain") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 178) (:start . 163) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 190)\n  (:start . 180) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 206) (:start . 202)\n  (:id . 76))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 218)\n  (:start . 207) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 79))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 236)\n  (:start . 226) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "neutrophil-specific")\n  (:form . "neutrophil-specific") (:end . 259) (:start . 240) (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 264) (:start . 260)\n  (:id . 83))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 275)\n  (:start . 265) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x922.11.1) (:span 198 201))\n  ((:id . :x922.11.2) (:span 180 190)))\n (:ncues ((:id . :x922.11.3) (:span 127 130)))\n (:hscopes ((:id . :x922.11.1) (:span 198 275))\n  ((:id . :x922.11.2) (:span 180 275)))\n (:nscopes ((:id . :x922.11.3) (:span 127 178)))\n (:identifiers (:sid . :s922.11) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008649@unknown@formal@none@1@S@Together, these studies demonstrate that the processing and inducible degradation of p105 are differentially regulated.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 108) (:start . 94) (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 118)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s923.10) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008659@unknown@formal@none@1@S@Translocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma.@(((:tag . "NNS") (:stem . "translocation") (:form . "Translocations")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "diffuse") (:form . "diffuse") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "subtype") (:form . "subtype") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "non-hodgkin") (:form . "non-Hodgkin") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s925.2) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008669@unknown@formal@none@1@S@An element upstream from the human delta-globin-encoding gene specifically enhances beta-globin reporter gene expression in murine erythroleukemia cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "delta-globin-encoding")\n  (:form . "delta-globin-encoding") (:end . 56) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 74)\n  (:start . 62) (:id . 50))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 95)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 104)\n  (:start . 96) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 130)\n  (:start . 124) (:id . 57))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 146) (:start . 131) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s926.1) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008679@unknown@formal@none@1@S@When the HTLV-1 tax gene was expressed or phorbol myristake acetate-A23187 stimulation was used, ICSAT expression was induced in Jurkat cells which otherwise do not express ICSAT.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "myristake") (:form . "myristake") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "acetate-a23187") (:form . "acetate-A23187")\n  (:end . 74) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x927.5.1) (:span 161 164)))\n (:nscopes ((:id . :x927.5.1) (:span 161 178)))\n (:identifiers (:sid . :s927.5) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008689@unknown@formal@none@1@S@An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 64) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 198) (:start . 197)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x928.4.1) (:span 84 91)))\n (:hscopes ((:id . :x928.4.1) (:span 0 204)))\n (:identifiers (:sid . :s928.4) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008699@unknown@formal@none@1@S@The cytoplasmic domain of the receptor for interleukin 10 (IL-10R) contains two box 3 sequence motifs that have been identified in the signal-transducing receptor subunits for IL-6-type cytokines and noted to be required for activating STAT3 and inducing transcription through IL-6-responsive elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 153) (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "il-6-type") (:form . "IL-6-type") (:end . 185)\n  (:start . 176) (:id . 70))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 205)\n  (:start . 200) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 220)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 224) (:start . 221)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 235)\n  (:start . 225) (:id . 78))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 241)\n  (:start . 236) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 245) (:start . 242)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 254)\n  (:start . 246) (:id . 81))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 268) (:start . 255) (:id . 82))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 276)\n  (:start . 269) (:id . 83))\n ((:tag . "JJ") (:stem . "il-6-responsive") (:form . "IL-6-responsive")\n  (:end . 292) (:start . 277) (:id . 84))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 301)\n  (:start . 293) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s929.2) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008709@unknown@formal@none@1@S@These receptor functions required the presence of the box 3 motifs, as shown by the analysis of the mouse IL-10R constructs containing progressively truncated cytoplasmic domains.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "RB") (:stem . "progressively") (:form . "progressively")\n  (:end . 148) (:start . 135) (:id . 65))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s929.12) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008719@unknown@formal@none@1@S@Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.@(((:tag . "NNP") (:stem . "Octamer") (:form . "Octamer") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 33)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "spi-1") (:form . "spi-1") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s931.1) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008729@unknown@formal@none@1@S@A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 73) (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 124) (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s932.3) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008739@unknown@formal@none@1@S@We demonstrated that IL-9 gene expression is controlled, at least in part, by transcriptional activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 93) (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s933.3) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008749@unknown@formal@none@1@S@Structure/function analysis of various Oct-2a effector regions in the context of the GAL4 DNA-binding domain revealed that Oct-2a contains two functionally different activation domains at the N and the C termini.@(((:tag . "NNP") (:stem . "Structure/function") (:form . "Structure/function")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 45)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 54)\n  (:start . 46) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 155)\n  (:start . 143) (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 165)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 64))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 184)\n  (:start . 177) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 187) (:start . 185)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 203) (:start . 202)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 211)\n  (:start . 204) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s934.3) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008759@unknown@formal@none@1@S@In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pax-5") (:form . "Pax-5") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 143) (:start . 139)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 152)\n  (:start . 147) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 72))\n ((:tag . "NN") (:stem . "lymphopoiesis") (:form . "lymphopoiesis")\n  (:end . 168) (:start . 155) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s935.3) (:did . :|8664547|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008769@unknown@formal@none@1@S@These results suggest that both common mechanisms, such as the one mediated by the CIITA trans-activator, and distinct tissue-specific constraints contribute to the transcriptional control of constitutive and IFN-gamma-induced MHC class II gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 104) (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 134) (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "constraint") (:form . "constraints") (:end . 146)\n  (:start . 135) (:id . 63))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 180) (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 204)\n  (:start . 192) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 226) (:start . 209) (:id . 72))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 236)\n  (:start . 231) (:id . 74))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 239) (:start . 237)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 244) (:start . 240)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 255)\n  (:start . 245) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x936.9.1) (:span 14 21)))\n (:hscopes ((:id . :x936.9.1) (:span 14 255)))\n (:identifiers (:sid . :s936.9) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008779@unknown@formal@none@1@S@Interleukin 10 induced c-fos expression in human B cells by activation of divergent protein kinases.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s938.1) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008789@unknown@formal@none@1@S@The effect of IL-10 was dose-dependent with a maximum stimulation using 100 ng/ml of IL-10.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 38) (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s938.11) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008799@unknown@formal@none@1@S@The maximal effect is observed at the IL-10 concentration of 20 U/ml.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s939.5) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008809@unknown@formal@none@1@S@Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CaMKIV/Gr") (:form . "CaMKIV/Gr") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 149)\n  (:start . 143) (:id . 68))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 161)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s940.3) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008819@unknown@formal@none@1@S@Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the cytokines IL-2, IL-6 and TNF alpha (IC50 = 10-12 microM).@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 87)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "SYM") (:stem . "alpha") (:form . "alpha") (:end . 112)\n  (:start . 107) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 118) (:start . 114)\n  (:id . 66))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 120) (:start . 119)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10-12") (:form . "10-12") (:end . 126)\n  (:start . 121) (:id . 68))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 133)\n  (:start . 127) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s941.6) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008829@unknown@formal@none@1@S@Transcription factors, such as NF kappa B and AP-1, are activated upon stimulation of the cells with several chemoattractants at physiologically relevant concentrations.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 65)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 82)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "chemoattractant") (:form . "chemoattractants")\n  (:end . 125) (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 144) (:start . 129) (:id . 64))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 168) (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s942.4) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008839@unknown@formal@none@1@S@We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 182)\n  (:start . 171) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 199)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 206) (:start . 203)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s944.3) (:did . :|8739563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008849@unknown@formal@none@1@S@The integrin alpha 4 beta 1 can provide a costimulus to induce IL-2 secretion and IL-2R expression leading to enhanced proliferation of purified, peripheral blood T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "costimulus") (:form . "costimulus") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 132) (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s946.2) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008859@unknown@formal@none@1@S@Expression of the human immunodeficiency virus type 1 (HIV) protease in cultured cells leads to apoptosis, preceded by cleavage of bcl-2, a key negative regulator of cell death.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 40) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 152)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 162)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 176)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s947.2) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008869@unknown@formal@none@1@S@These results suggest that an age-associated decline in the induction of NF kappa B in activated T cells from elderly individuals may be attributable to altered regulation of the inhibitor, I kappa B, and may play an important role in immune dysregulation accompanying aging.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "age-associated") (:form . "age-associated")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . 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(:end . 275) (:start . 274)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x948.6.1) (:span 205 208))\n  ((:id . :x948.6.2) (:span 130 133)) ((:id . :x948.6.3) (:span 14 21)))\n (:hscopes ((:id . :x948.6.1) (:span 205 274))\n  ((:id . :x948.6.2) (:span 130 199)) ((:id . :x948.6.3) (:span 14 274)))\n (:identifiers (:sid . :s948.6) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008879@unknown@formal@none@1@S@Similarly, the p105 precursor of the NF-kappa B p50 subunit is also post-translationally processed in the proteasome.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "post-translationally")\n  (:form . "post-translationally") (:end . 88) (:start . 68) (:id . 55))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s949.10) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008889@unknown@formal@none@1@S@Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.@(((:tag . "NNP") (:stem . "Sialoadhesin") (:form . "Sialoadhesin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "rbc") (:form . "RBCs") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s950.7) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008899@unknown@formal@none@1@S@Various antioxidants inhibit NF-kappa B activation in response to these stimuli.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s951.4) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008909@unknown@formal@none@1@S@By using run-on assays, ACLA was shown to induce an enhancement of the transcription of erythroid genes, including gamma-globin, PBGD, erythropoietin receptor, and GATA-1 transcription factor.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ACLA") (:form . "ACLA") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 63)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 127)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBGD") (:form . "PBGD") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 149) (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 184) (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 191)\n  (:start . 185) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s952.4) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008919@unknown@formal@none@1@S@Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "b7-transfected") (:form . "B7-transfected")\n  (:end . 70) (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "CHO") (:form . "CHO") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "measurable") (:form . "measurable") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 179)\n  (:start . 169) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x953.4.1) (:span 134 137)))\n (:nscopes ((:id . :x953.4.1) (:span 134 179)))\n (:identifiers (:sid . :s953.4) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008929@unknown@formal@none@1@S@We have demonstrated that the level of CRE binding protein (CREB) was the same in all cell lines and that the putative AR-CRE forms specific and compatible protein interactions with CREB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 96) (:start . 91)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 118)\n  (:start . 110) (:id . 65))\n ((:tag . "NN") (:stem . "ar-cre") (:form . "AR-CRE") (:end . 125)\n  (:start . 119) (:id . 66))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 131)\n  (:start . 126) (:id . 67))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 140)\n  (:start . 132) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 155)\n  (:start . 145) (:id . 70))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 71))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 176)\n  (:start . 164) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 181) (:start . 177)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 186) (:start . 182)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x954.4.1) (:span 110 118)))\n (:hscopes ((:id . :x954.4.1) (:span 110 186)))\n (:identifiers (:sid . :s954.4) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008939@unknown@formal@none@1@S@The NFAT-controlled luciferase gene system distinguishes CIF from other T cell inhibitory activities present in colostrum, in particular, TGF beta 1 and TGF beta 2 and the glucocorticoids.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nfat-controlled") (:form . "NFAT-controlled")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "VBZ") (:stem . "distinguish") (:form . "distinguishes") (:end . 56)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "cif") (:form . "CIF") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "colostrum") (:form . "colostrum") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TGF") (:form . "TGF") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TGF") (:form . "TGF") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 187) (:start . 172) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s955.8) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008949@unknown@formal@none@1@S@IL-4 had no significant effect on HIV reverse transcription.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x956.8.1) (:span 9 11)))\n (:nscopes ((:id . :x956.8.1) (:span 9 59)))\n (:identifiers (:sid . :s956.8) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008959@unknown@formal@none@1@S@CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.@(((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 37) (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 61) (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 66) (:start . 62)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "beta-actin") (:form . "beta-actin") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 167)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x957.6.1) (:span 91 93)))\n (:nscopes ((:id . :x957.6.1) (:span 91 155)))\n (:identifiers (:sid . :s957.6) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008969@unknown@formal@none@1@S@This suppressive effect was also seen in IL-2-driven cell growth of CD8-positive lymphocytes purified from 7-day PHA-blasts, indicating that CD4 molecules were not required for the suppression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "il-2-driven") (:form . "IL-2-driven") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd8-positive") (:form . "CD8-positive") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "7-day") (:form . "7-day") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "pha-blast") (:form . "PHA-blasts") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 172)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x958.4.2) (:span 125 140)))\n (:ncues ((:id . :x958.4.1) (:span 160 163)))\n (:hscopes ((:id . :x958.4.2) (:span 125 192)))\n (:nscopes ((:id . :x958.4.1) (:span 141 192)))\n (:identifiers (:sid . :s958.4) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008979@unknown@formal@none@1@S@In this study we have investigated the effect of FCM on the LPS-induced DNA-binding activity of NF-kappaB, by means of electrophoretic shift assay (EMSA).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FCM") (:form . "FCM") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 134) (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s959.4) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008989@unknown@formal@none@1@S@Also, gel mobility shift analyses using specific antiserum revealed decrease in the DNA-binding activity of an insulin gene transcription factor, PDX-1/IPF1/STF-1.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "antiserum") (:form . "antiserum") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PDX-1/IPF1/STF-1") (:form . "PDX-1/IPF1/STF-1")\n  (:end . 162) (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s960.6) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008999@unknown@formal@none@1@S@In the IL-4-producing Th0-like human Jurkat and mouse EL-4 cells, POS-1 (designated POS-1a) contains NF-IL6beta and Jun.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "il-4-producing") (:form . "IL-4-producing")\n  (:end . 21) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "th0-like") (:form . "Th0-like") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "POS-1") (:form . "POS-1") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "NNP") (:stem . "POS-1a") (:form . "POS-1a") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-IL6beta") (:form . "NF-IL6beta") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s961.8) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009009@unknown@formal@none@1@S@Inhibition of TNF-alpha secretion by LPS-stimulated THP-1-hGH cells was associated with a decrease in nuclear translocation of nuclear factor-kappaB.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "THP-1-hGH") (:form . "THP-1-hGH") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 123) (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 148) (:start . 135) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s962.7) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009019@unknown@formal@none@1@S@These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "aberrancy") (:form . "aberrancies") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-fos/c-jun") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 98)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "NNS") (:stem . "impairment") (:form . "impairments") (:end . 172)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 180) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 191)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 200)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 208)\n  (:start . 203) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x963.9.1) (:span 127 130))\n  ((:id . :x963.9.2) (:span 14 21)))\n (:hscopes ((:id . :x963.9.1) (:span 127 208))\n  ((:id . :x963.9.2) (:span 14 208)))\n (:identifiers (:sid . :s963.9) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009029@unknown@formal@none@1@S@Carboxylesterases play an important role in defense and clearance mechanisms of the monocyte/macrophage system.@(((:tag . "NNS") (:stem . "carboxylesteras") (:form . "Carboxylesterases")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 22) (:start . 18)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 103) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s965.2) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009039@unknown@formal@none@1@S@Analysis of the sequence immediately upstream from the transcription initiation site (TIS) showed no canonical TATA or CAAT elements, however an initiator element commonly found in TATA-less promoters encompassed the TIS.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TIS") (:form . "TIS") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 97) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CAAT") (:form . "CAAT") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "tata-less") (:form . "TATA-less") (:end . 190)\n  (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 200)\n  (:start . 191) (:id . 72))\n ((:tag . "VBD") (:stem . "encompass") (:form . "encompassed") (:end . 212)\n  (:start . 201) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "NN") (:stem . "tis") (:form . "TIS") (:end . 220) (:start . 217)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x966.5.1) (:span 98 100)))\n (:nscopes ((:id . :x966.5.1) (:span 98 132)))\n (:identifiers (:sid . :s966.5) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009049@unknown@formal@none@1@S@A 1.2-kb cDNA encoding full-length human C/EBP-epsilon was cloned from a promyelocyte-late myeloblast-derived lambda gt11 library.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "1.2-kb") (:form . "1.2-kb") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c/ebp-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "promyelocyte-late") (:form . "promyelocyte-late")\n  (:end . 90) (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "myeloblast-derived") (:form . "myeloblast-derived")\n  (:end . 109) (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "lambda") (:form . "lambda") (:end . 116)\n  (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "gt11") (:form . "gt11") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 129)\n  (:start . 122) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s967.6) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009059@unknown@formal@none@1@S@The ferritin H-chain gene promoter regulation was analyzed in heme-treated Friend leukemia cells (FLCs) and during monocyte-to-macrophage differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "H-chain") (:form . "H-chain") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heme-treated") (:form . "heme-treated") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "Friend") (:form . "Friend") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NNPS") (:stem . "FLC") (:form . "FLCs") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "monocyte-to-macrophage")\n  (:form . "monocyte-to-macrophage") (:end . 137) (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 153) (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s968.2) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009069@unknown@formal@none@1@S@Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x969.1.1) (:span 49 52)))\n (:nscopes ((:id . :x969.1.1) (:span 49 103)))\n (:identifiers (:sid . :s969.1) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009079@unknown@formal@none@1@S@Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "reveal") (:form . "reveal") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "70z/3") (:form . "70Z/3") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x969.11.1) (:span 43 46)))\n (:nscopes ((:id . :x969.11.1) (:span 43 89)))\n (:identifiers (:sid . :s969.11) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009089@unknown@formal@none@1@S@However, although NFAT DNA binding is similarly induced in both eTh1 and eTh2 cells upon antigen stimulation, only the NFAT complexes present in eTh2 cells are able to mediate high-level transcription, and relatively little NFAT transcriptional activity was induced in eTh1 cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 133)\n  (:start . 124) (:id . 64))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 186)\n  (:start . 176) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 200) (:start . 187) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 216)\n  (:start . 206) (:id . 77))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 223)\n  (:start . 217) (:id . 78))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 228) (:start . 224)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 244) (:start . 229) (:id . 80))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 253)\n  (:start . 245) (:id . 81))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 257) (:start . 254)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 265)\n  (:start . 258) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 268) (:start . 266)\n  (:id . 84))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 273) (:start . 269)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 279)\n  (:start . 274) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s970.6) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009099@unknown@formal@none@1@S@HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs.@(((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 39) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x971.7.1) (:span 33 39)))\n (:nscopes ((:id . :x971.7.1) (:span 33 73)))\n (:identifiers (:sid . :s971.7) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009109@unknown@formal@none@1@S@Western blot analysis of the NF-kappaB inhibitory subunits (IkappaB) demonstrated that both IkappaB-alpha proteolysis and p105 processing were induced by the treatment.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 105) (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 117)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 150)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s973.5) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009119@unknown@formal@none@1@S@However, its activity becomes lower in the double-positive and a fraction of the CD4+ CD8int/- cell population, indicating that an additional enhancer, located in either the first or the third intron of the CD4 gene, is required for CD4 gene expression in this population.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . 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5009129@unknown@formal@none@1@S@c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation.@(((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pentoxifylline-mediated")\n  (:form . "pentoxifylline-mediated") (:end . 44) (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s976.1) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009139@unknown@formal@none@1@S@Interleukin-3 (IL-3) is a cytokine that is expressed primarily in activated T cells.@(((:tag . "NN") (:stem . "interleukin-3") (:form . "Interleukin-3")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s977.2) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009149@unknown@formal@none@1@S@However, little is known about negative regulation of IL-1beta expression at the transcriptional level, which may play an important role in anti-inflammatory and immunosuppressive effects.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 96) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 157) (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 179) (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x978.4.1) (:span 110 113)))\n (:hscopes ((:id . :x978.4.1) (:span 110 187)))\n (:identifiers (:sid . :s978.4) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009159@unknown@formal@none@1@S@The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "organization") (:form . "organization") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "CD") (:stem . "393") (:form . "393") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tramp") (:form . "TRAMP") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s979.3) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009169@unknown@formal@none@1@S@In this manuscript we have investigated the molecular mechanisms by which T cell lines stimulated with phorbol 12-myristate 13-acetate (PMA) and phytohemagglutin (PHA) display significantly higher levels of NF-kappa B1 encoding transcripts than cells stimulated with tumor necrosis factor-alpha, despite the fact that both stimuli activate NF-kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phorbol") (:form . 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")") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 189) (:start . 176) (:id . 70))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 196)\n  (:start . 190) (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 203)\n  (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 215)\n  (:start . 207) (:id . 74))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 227)\n  (:start . 219) (:id . 76))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 239)\n  (:start . 228) (:id . 77))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 244) (:start . 240)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 250)\n  (:start . 245) (:id . 79))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 261)\n  (:start . 251) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 266) (:start . 262)\n  (:id . 81))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 272)\n  (:start . 267) (:id . 82))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 281)\n  (:start . 273) (:id . 83))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 294)\n  (:start . 282) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 295) (:start . 294)\n  (:id . 85))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 303)\n  (:start . 296) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 307) (:start . 304)\n  (:id . 87))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 312) (:start . 308)\n  (:id . 88))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 317) (:start . 313)\n  (:id . 89))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 322) (:start . 318)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 330)\n  (:start . 323) (:id . 91))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 339)\n  (:start . 331) (:id . 92))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 348)\n  (:start . 340) (:id . 93))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 350) (:start . 349)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 351) (:start . 350)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s980.5) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009179@unknown@formal@none@1@S@By contrast, ICRF-193 only provoked a late activation (from hours 72 to 96) of the total enzyme.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ICRF-193") (:form . "ICRF-193") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "provoke") (:form . "provoked") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "CD") (:stem . "96") (:form . "96") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 95)\n  (:start . 89) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s981.7) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009189@unknown@formal@none@1@S@Immunochemical and immunofluorescent staining of thymus sections using specific Abs allowed visualization of nuclear NF-kappa B proteins in both thymocytes and nonthymocyte cells.@(((:tag . "JJ") (:stem . "immunochemical") (:form . "Immunochemical")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immunofluorescent") (:form . "immunofluorescent")\n  (:end . 36) (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 45)\n  (:start . 37) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 55)\n  (:start . 49) (:id . 47))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "visualization") (:form . "visualization")\n  (:end . 105) (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 144) (:start . 140)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 155)\n  (:start . 145) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nonthymocyte") (:form . "nonthymocyte") (:end . 172)\n  (:start . 160) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s982.6) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009199@unknown@formal@none@1@S@The mutant, containing a serine-to-alanine substitution in the DNA-binding domain of the protein, bound to several known ZEBRA-binding sites and activated transcription from reporters bearing known ZEBRA-responsive promoters but did not disrupt latency in EBV-infected cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "serine-to-alanine") (:form . "serine-to-alanine")\n  (:end . 42) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "JJ") (:stem . "zebra-binding") (:form . "ZEBRA-binding")\n  (:end . 134) (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "reporter") (:form . "reporters") (:end . 183)\n  (:start . 174) (:id . 67))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 191)\n  (:start . 184) (:id . 68))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 197)\n  (:start . 192) (:id . 69))\n ((:tag . "JJ") (:stem . "zebra-responsive") (:form . "ZEBRA-responsive")\n  (:end . 214) (:start . 198) (:id . 70))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 224)\n  (:start . 215) (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 228) (:start . 225)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 232) (:start . 229)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 236) (:start . 233)\n  (:id . 74))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 244)\n  (:start . 237) (:id . 75))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 252)\n  (:start . 245) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 255) (:start . 253)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 268)\n  (:start . 256) (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 273) (:start . 269)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 279)\n  (:start . 274) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x983.6.1) (:span 233 236)))\n (:nscopes ((:id . :x983.6.1) (:span 233 279)))\n (:identifiers (:sid . :s983.6) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009209@unknown@formal@none@1@S@This finding indicates that phospholipase A2 and 5-lipoxygenase are also involved.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 63) (:start . 49) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x984.8.1) (:span 13 27)))\n (:hscopes ((:id . :x984.8.1) (:span 13 81)))\n (:identifiers (:sid . :s984.8) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009219@unknown@formal@none@1@S@T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.@(((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "filarial") (:form . "filarial") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 57)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 80)\n  (:start . 71) (:id . 50))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 97) (:start . 81) (:id . 51))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 107)\n  (:start . 98) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 116)\n  (:start . 111) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s986.1) (:did . :|9073544|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009229@unknown@formal@none@1@S@In addition, both inducible nitric oxide synthase-mRNA level and NO generation in mouse peritoneal macrophages were suppressed by 10(-5) M Azeptin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthase-mrna") (:form . "synthase-mRNA")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peritoneal") (:form . "peritoneal") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "10(-5)") (:form . "10(-5)") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s987.6) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009239@unknown@formal@none@1@S@Interleukin-4 (IL-4) and interleukin-12 (IL-12) control the differentiation of T-helper cells.@(((:tag . "NN") (:stem . "interleukin-4") (:form . "Interleukin-4")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-12") (:form . "interleukin-12")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s989.2) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009249@unknown@formal@none@1@S@Tissue factor (TF) expression by peripheral blood monocytes during sepsis initiates intravascular thrombosis.@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "intravascular") (:form . "intravascular")\n  (:end . 97) (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "thrombosis") (:form . "thrombosis") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s990.3) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009259@unknown@formal@none@1@S@Synergistic transactivation of the LPS response element in Drosophila Schneider cells by coexpression of c-Fos, c-Jun, c-Rel, and p65 or c-Jun and p65 required the transactivation domains of c-Jun and p65.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "Schneider") (:form . "Schneider") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 101)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 179) (:start . 164) (:id . 70))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s990.13) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009269@unknown@formal@none@1@S@Taken together, these findings suggest that evolutionarily conserved physical interactions between Ets and NF-kappaB/NFAT proteins are important in regulating the inducible expression of T-cell genes and viruses.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 90)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . "NF-kappaB/NFAT")\n  (:end . 121) (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 134) (:start . 131)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 144)\n  (:start . 135) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 158)\n  (:start . 148) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 172)\n  (:start . 163) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 193)\n  (:start . 187) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 199)\n  (:start . 194) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 211)\n  (:start . 204) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x991.9.1) (:span 31 38)))\n (:hscopes ((:id . :x991.9.1) (:span 31 211)))\n (:identifiers (:sid . :s991.9) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009279@unknown@formal@none@1@S@Chromosomal translocation resulting in abnormal expression of the LAZ3/BCL6 gene in B cells has been implicated in the tumorigenesis of non-Hodgkin lymphoma (NHL).@(((:tag . "JJ") (:stem . "chromosomal") (:form . "Chromosomal") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 25) (:start . 12) (:id . 43))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 35)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 132) (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-hodgkin") (:form . "non-Hodgkin") (:end . 147)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NHL") (:form . "NHL") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s993.2) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009289@unknown@formal@none@1@S@Constitutive DNA binding activity consisting of p50 homodimers was detected in nuclear extracts from both cell types.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s994.3) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009299@unknown@formal@none@1@S@The development of chronic eosinophilic inflammation is dependent on interleukin-5 (IL-5), a selective eosinophil-activating factor, produced by helper T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 82) (:start . 69) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "eosinophil-activating")\n  (:form . "eosinophil-activating") (:end . 124) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 151)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s995.3) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009309@unknown@formal@none@1@S@In the present study, we investigated the induction mechanism of SAA gene in THP-1 monocyte/macrophage cells which play a critical role in the development of atherosclerotic fatty streak and plaque formation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SAA") (:form . "SAA") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 102) (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 154)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 173) (:start . 158) (:id . 68))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 179)\n  (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "streak") (:form . "streak") (:end . 186)\n  (:start . 180) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 197)\n  (:start . 191) (:id . 72))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 207)\n  (:start . 198) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s996.3) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009319@unknown@formal@none@1@S@Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rbp-jkappa-binding") (:form . "RBP-Jkappa-binding")\n  (:end . 77) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "notch1") (:form . "NOTCH1") (:end . 100)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 122)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 143) (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 150)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s997.5) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009329@unknown@formal@none@1@S@The AP-1 mutant constructs also showed delayed transcriptional activation in PMA-treated fibroblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 38) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pma-treated") (:form . "PMA-treated") (:end . 88)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 100)\n  (:start . 89) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s998.5) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009339@unknown@formal@none@1@S@Oct-2 expressed in this tester strain represses the expression of the reporter gene and changes the phenotype of the cell from Lac+to Lac-.@(((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tester") (:form . "tester") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "change") (:form . "changes") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Lac+to") (:form . "Lac+to") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NNP") (:stem . "Lac-") (:form . "Lac-") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s999.5) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009349@unknown@formal@none@1@S@In this study, we investigated the importance of PI 3-kinase in TCR-directed T-cell activation using activated or inhibitory versions of PI 3-kinase.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tcr-directed") (:form . "TCR-directed") (:end . 76)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "version") (:form . "versions") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1000.6) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009359@unknown@formal@none@1@S@Ascorbate and AZT also had no effect on NF-kappa B activation following TNF-alpha- or PMA-induced stimulation of U1 promonocytic cells.@(((:tag . "NNP") (:stem . "Ascorbate") (:form . "Ascorbate") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "AZT") (:form . "AZT") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "tnf-alpha-") (:form . "TNF-alpha-") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1001.6.1) (:span 27 29)))\n (:nscopes ((:id . :x1001.6.1) (:span 27 134)))\n (:identifiers (:sid . :s1001.6) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009369@unknown@formal@none@1@S@Cell-to-cell contact activates the long terminal repeat of human immunodeficiency virus 1 through its kappaB motif.@(((:tag . "JJ") (:stem . "cell-to-cell") (:form . "Cell-to-cell") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 81) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1003.1) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009379@unknown@formal@none@1@S@Unlike this physiologically relevant stimulation, PHA stimulates productive LAI replication in both naive and memory T cells.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 27) (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1004.4) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009389@unknown@formal@none@1@S@Thus, NF-kappa B, a potent transcriptional activator of HIV expression, is also involved in the expression of RANTES, a chemokine that blocks infection by macrophage-tropic strains of HIV.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 26)\n  (:start . 20) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 42) (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 129)\n  (:start . 120) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "macrophage-tropic") (:form . "macrophage-tropic")\n  (:end . 172) (:start . 155) (:id . 70))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1005.6) (:did . :|9120310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009399@unknown@formal@none@1@S@Finally, we demonstrate that deletion in NFATx1 of the mapped 60 residues leads to its nuclear translocation independent of calcium signaling.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 61) (:start . 55)\n  (:id . 52))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1006.10) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009409@unknown@formal@none@1@S@In astrocytes PDTC also dramatically induces the NF kappaB-dependent enzyme, iNOS, supporting the physiologic relevance of endogenous NO regulation of NF kappaB.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 68) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1007.9) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009419@unknown@formal@none@1@S@Proinflammatory neutrophil stimuli also promoted the accumulation of IkappaB-alpha mRNA transcripts, resulting in the reexpression of the IkappaB-alpha protein.@(((:tag . "JJ") (:stem . "proinflammatory") (:form . "Proinflammatory")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 34)\n  (:start . 27) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 39) (:start . 35)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 65)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 82) (:start . 69) (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 87) (:start . 83)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 99)\n  (:start . 88) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 110)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reexpression") (:form . "reexpression") (:end . 130)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 151) (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 159)\n  (:start . 152) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1008.8) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009429@unknown@formal@none@1@S@BACKGROUND: Retinoic acid (RA) has important immune-modulating effects on both T and B cell function.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "JJ") (:stem . "immune-modulating") (:form . "immune-modulating")\n  (:end . 62) (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1010.2) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009439@unknown@formal@none@1@S@Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.@(((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 22) (:start . 9) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd2-mediated") (:form . "CD2-mediated") (:end . 68)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1011.1) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009449@unknown@formal@none@1@S@CD40 is a receptor that is critical for the survival, growth, differentiation, and isotype switching of B lymphocytes.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 77) (:start . 62) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 117)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1012.2) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009459@unknown@formal@none@1@S@Unexpectedly, the CD8+ T-cell subpopulation failed to respond.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "subpopulation") (:form . "subpopulation")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 50) (:start . 44)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x1013.5.1) (:span 44 50)))\n (:nscopes ((:id . :x1013.5.1) (:span 44 61)))\n (:identifiers (:sid . :s1013.5) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009469@unknown@formal@none@1@S@A 1-kb region of the gene that includes 5' flanking sequence was reported earlier to contain functional promoter activity and was specifically demethylated in expressing cells in contrast to null cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "1-kb") (:form . "1-kb") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 142)\n  (:start . 130) (:id . 64))\n ((:tag . "VBN") (:stem . "demethylate") (:form . "demethylated") (:end . 155)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 169)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 195) (:start . 191)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1014.4) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009479@unknown@formal@none@1@S@Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line.@(((:tag . "NNP") (:stem . "Inhibitor") (:form . "Inhibitor") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 108)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1015.1) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009489@unknown@formal@none@1@S@BEAD-1 blocked the ability of the TCR delta enhancer (Edelta) to activate a promoter when located between the two in a chromatin-integrated construct.@(((:tag . "NNP") (:stem . "BEAD-1") (:form . "BEAD-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Edelta") (:form . "Edelta") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "chromatin-integrated")\n  (:form . "chromatin-integrated") (:end . 139) (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1016.4) (:did . :|9144218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009499@unknown@formal@none@1@S@We conclude that VDR polymorphism does not affect the abundance of the VDR mRNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1017.9.1) (:span 39 42)))\n (:nscopes ((:id . :x1017.9.1) (:span 39 79)))\n (:identifiers (:sid . :s1017.9) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009509@unknown@formal@none@1@S@Together, these studies begin a dissection of the biochemical events that lead to expression of CD95 ligand, a required step for TCR-induced apoptosis.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "begin") (:form . "begin") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dissection") (:form . "dissection") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "required") (:form . "required") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tcr-induced") (:form . "TCR-induced") (:end . 140)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1018.10) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009519@unknown@formal@none@1@S@Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation.@(((:tag . "NN") (:stem . "triggering") (:form . "Triggering") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 44) (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 60) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1020.1) (:did . :|9149909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009529@unknown@formal@none@1@S@The regulation of IL-6 is dependent on various stimuli that include lipopolysaccharide (LPS), viruses, and other cytokines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 86) (:start . 68) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1021.5) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009539@unknown@formal@none@1@S@The ability of CMV IE gene products to enhance IL-6 production may play an important role in immune inflammatory states associated with CMV infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 112)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 130)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1021.15.1) (:span 63 66)))\n (:hscopes ((:id . :x1021.15.1) (:span 63 149)))\n (:identifiers (:sid . :s1021.15) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009549@unknown@formal@none@1@S@The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype switching in human B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "IL)-4") (:form . "IL)-4") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1023.2) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009559@unknown@formal@none@1@S@Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF.@(((:tag . "NNP") (:stem . "Tax1") (:form . "Tax1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 23) (:start . 8) (:id . 45))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 157)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 209) (:start . 196) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 217)\n  (:start . 210) (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 227)\n  (:start . 219) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 238)\n  (:start . 229) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 247) (:start . 244)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1024.2) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009569@unknown@formal@none@1@S@By using several HBD subfragments, the mAb 18C7 epitope was located in the N-terminal region of the HBD from Thr729 to Leu765.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "subfragment") (:form . "subfragments") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hbd") (:form . "HBD") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "thr729") (:form . "Thr729") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "leu765") (:form . "Leu765") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1025.6) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009579@unknown@formal@none@1@S@Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 68) (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1026.1) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009589@unknown@formal@none@1@S@The sequence in which these alterations develop is unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x1027.4.1) (:span 51 58)))\n (:hscopes ((:id . :x1027.4.1) (:span 0 58)))\n (:identifiers (:sid . :s1027.4) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009599@unknown@formal@none@1@S@Alternatively, another factor, distinct from CIITA, might control HLA-DQ expression.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1028.5.1) (:span 52 57)))\n (:hscopes ((:id . :x1028.5.1) (:span 52 83)))\n (:identifiers (:sid . :s1028.5) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009609@unknown@formal@none@1@S@In vitro, thrombin-stimulated fixed platelets bound to neutrophils and monocytes.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "thrombin-stimulated")\n  (:form . "thrombin-stimulated") (:end . 29) (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "fixed") (:form . "fixed") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1029.6) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009619@unknown@formal@none@1@S@Its N-terminal 125 amino acids function as an independent transcriptional activation domain.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "125") (:form . "125") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1030.3) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009629@unknown@formal@none@1@S@Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells.@(((:tag . "NN") (:stem . "tap") (:form . "Tap") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tip") (:form . "Tip") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cos-1") (:form . "COS-1") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "jurkat-t") (:form . "Jurkat-T") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1031.4) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009639@unknown@formal@none@1@S@Transactivation by CIITA was extremely sensitive to a mutation in TBP that in yeast is known to abolish VP16-mediated transcription but leaves basal transcription unaffected.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VB") (:stem . "abolish") (:form . "abolish") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "vp16-mediated") (:form . "VP16-mediated")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "leave") (:form . "leaves") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 162) (:start . 149) (:id . 65))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1032.6) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009649@unknown@formal@none@1@S@However, these plasmids produced transcriptional activity in HeLa cells only in conjunction with interferon gamma stimulation, a condition in which expression of both CIITA and class II major histocompatibility complex surface proteins are induced.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "condition") (:form . "condition") (:end . 138)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 210) (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 218)\n  (:start . 211) (:id . 73))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 226)\n  (:start . 219) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 235)\n  (:start . 227) (:id . 75))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 239) (:start . 236)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 247)\n  (:start . 240) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1033.6) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009659@unknown@formal@none@1@S@This paper reviews the considerable data available relating ROS activity and antioxidant defence to inflammatory diseases and attempts to draw parallels with periodontitis, in an effort to stimulate more periodontal research in this important area.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "review") (:form . "reviews") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "VBG") (:stem . "relate") (:form . "relating") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "ros") (:form . "ROS") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 88)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "defence") (:form . "defence") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 112)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "attempt") (:form . "attempts") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "VB") (:stem . "draw") (:form . "draw") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "parallel") (:form . "parallels") (:end . 152)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "periodontitis") (:form . "periodontitis")\n  (:end . 171) (:start . 158) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "effort") (:form . "effort") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 198)\n  (:start . 189) (:id . 70))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 203) (:start . 199)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "periodontal") (:form . "periodontal") (:end . 215)\n  (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 224)\n  (:start . 216) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 232) (:start . 228)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 242)\n  (:start . 233) (:id . 76))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 247) (:start . 243)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1034.4) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009669@unknown@formal@none@1@S@Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 121)\n  (:start . 110) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1035.7.1) (:span 58 61)))\n (:hscopes ((:id . :x1035.7.1) (:span 58 121)))\n (:identifiers (:sid . :s1035.7) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009679@unknown@formal@none@1@S@Giant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries.@(((:tag . "JJ") (:stem . "giant") (:form . "Giant") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GCA") (:form . "GCA") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "vasculitic") (:form . "vasculitic") (:end . 42)\n  (:start . 32) (:id . 50))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 71) (:start . 57) (:id . 53))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "large-sized") (:form . "large-sized") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "artery") (:form . "arteries") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1037.2) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009689@unknown@formal@none@1@S@The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tgf-beta1-transcribing")\n  (:form . "TGF-beta1-transcribing") (:end . 41) (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 53)\n  (:start . 42) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 47))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "paralysis") (:form . "paralysis") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chronicity") (:form . "chronicity") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 198)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 206) (:start . 202)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 219)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "vasculopathy") (:form . "vasculopathy") (:end . 232)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1037.12.1) (:span 159 162))\n  ((:id . :x1037.12.2) (:span 93 96)))\n (:hscopes ((:id . :x1037.12.1) (:span 159 232))\n  ((:id . :x1037.12.2) (:span 93 153)))\n (:identifiers (:sid . :s1037.12) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009699@unknown@formal@none@1@S@Cells pretreated with dimaprit showed a decrease in the cAMP response to subsequent addition of H2 agonists, whereas the cAMP response to prostaglandin E2 remained unaltered.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dimaprit") (:form . "dimaprit") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 37) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 151) (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1038.10) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009709@unknown@formal@none@1@S@One of the latter elements, the IgH 3' enhancer, is of particular interest: (1) it is B cell-specific and active only in late B cell development; (2) in rodent plasmacytomas and in some human Burkitt's lymphomas it is part of a locus control region (LCR) that is involved in deregulation of the c-myc oncogene as a result of translocation into the IgH locus; and (3) it has been implicated in the mechanisms that control Ig gene class switch recombination.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . 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5009719@unknown@formal@none@1@S@Cis-acting elements with NFkappaB, AP1 and ETS-like binding motifs have been identified in the promoter region of the GM-CSF gene, and are important or essential for transcriptional activity following T cell activation.@(((:tag . "JJ") (:stem . "cis-acting") (:form . "Cis-acting") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ets-like") (:form . "ETS-like") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 161)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 181) (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 190)\n  (:start . 182) (:id . 71))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 200)\n  (:start . 191) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 202) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1041.4) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009729@unknown@formal@none@1@S@This has led to the suggestion that a surrogate gamma'-chain, which can interact with the IL-4R alpha chain to mediate signaling, is expressed on cells lacking gamma(c).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "lead") (:form . "led") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "suggestion") (:form . "suggestion") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "gamma'-chain") (:form . "gamma'-chain") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NNS") (:stem . "gamma(c)") (:form . "gamma(c)") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1042.3.2) (:span 20 30)))\n (:ncues ((:id . :x1042.3.1) (:span 152 159)))\n (:hscopes ((:id . :x1042.3.2) (:span 20 168)))\n (:nscopes ((:id . :x1042.3.1) (:span 152 168)))\n (:identifiers (:sid . :s1042.3) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009739@unknown@formal@none@1@S@Cyclin A transcription is cell cycle regulated and induced by cell proliferative signals.@(((:tag . "NNP") (:stem . "Cyclin") (:form . "Cyclin") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1043.2) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009749@unknown@formal@none@1@S@Interleukin-10 (IL-10) is a potent monocyte regulatory cytokine that inhibits gene expression of proinflammatory mediators.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1044.2) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009759@unknown@formal@none@1@S@These data indicate that IL-10 inhibits IFN-gamma-induced transcription of the ICAM-1 gene by a regulatory mechanism that may involve NF-kappaB.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 57) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1044.12.1) (:span 122 125))\n  ((:id . :x1044.12.2) (:span 11 24)))\n (:hscopes ((:id . :x1044.12.1) (:span 122 143))\n  ((:id . :x1044.12.2) (:span 11 143)))\n (:identifiers (:sid . :s1044.12) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009769@unknown@formal@none@1@S@They are rapidly activated by various cytokines, hormones, and growth factors.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1046.3) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009779@unknown@formal@none@1@S@The glucocorticoid receptor was able to further enhance IL-4-induced gene transcription through the action of Stat6.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1046.13) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009789@unknown@formal@none@1@S@In Jurkat T cells, induction of PIF DNA binding activity was rapidly induced, required de novo protein synthesis, and was sustained at a high level for at least 23 h.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PIF") (:form . "PIF") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 131)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 154) (:start . 152)\n  (:id . 71))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 160)\n  (:start . 155) (:id . 72))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 163) (:start . 161)\n  (:id . 73))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 165) (:start . 164)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1047.6) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009799@unknown@formal@none@1@S@In this study, the effect of anti-E. chaffeensis antibody complexed with E. chaffeensis on the expression of major proinflammatory cytokines in human monocytes was examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "FW") (:stem . "anti-e.") (:form . "anti-E.") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 130) (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 172)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1048.4) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009809@unknown@formal@none@1@S@We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "garlic") (:form . "garlic") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "s-allyl") (:form . "S-allyl") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SAC") (:form . "SAC") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "artery") (:form . "artery") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1049.3) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009819@unknown@formal@none@1@S@No virus replication and no transcription of the Ad2 early genes was observed in either of the cells.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ad2") (:form . "Ad2") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1050.5.1) (:span 25 27)) ((:id . :x1050.5.2) (:span 0 2)))\n (:nscopes ((:id . :x1050.5.1) (:span 25 100))\n  ((:id . :x1050.5.2) (:span 0 100)))\n (:identifiers (:sid . :s1050.5) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009829@unknown@formal@none@1@S@Accordingly, immunoblot experiments showed that amongst NF-kappa B/Rel proteins, RelA and p50 are mobilized to the nucleus following microglial cell stimulation with A beta(25-35) plus IFN gamma.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunoblot") (:form . "immunoblot") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 42) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "IN") (:stem . "amongst") (:form . "amongst") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "mobilize") (:form . "mobilized") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "microglial") (:form . "microglial") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "beta(25-35)") (:form . "beta(25-35)") (:end . 179)\n  (:start . 168) (:id . 67))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1051.6) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009839@unknown@formal@none@1@S@However, a unique DNA-protein complex was detected when the promoter central 21 bp repeat was reacted with nuclear extracts derived from either the U-373 MG glioblastoma cell line or the THP-1 mature monocytic cell line.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "react") (:form . "reacted") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "u-373") (:form . "U-373") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "NNP") (:stem . "MG") (:form . "MG") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 169)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 192)\n  (:start . 187) (:id . 73))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 199)\n  (:start . 193) (:id . 74))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 219) (:start . 215)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1052.5) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009849@unknown@formal@none@1@S@ATL-16T cells express mRNA of three GATA-binding proteins, hGATA-2, hGATA-3 and hGATA-4, and each of them has a potential to bind to the consensus (A/T)GATA(G/ A) motif.@(((:tag . "NNP") (:stem . "ATL-16T") (:form . "ATL-16T") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hgata-2") (:form . "hGATA-2") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hgata-4") (:form . "hGATA-4") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 146)\n  (:start . 137) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "A/T)GATA(G/") (:form . "A/T)GATA(G/") (:end . 159)\n  (:start . 148) (:id . 70))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 72))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 168)\n  (:start . 163) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1053.9) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009859@unknown@formal@none@1@S@Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 38) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 100) (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 114) (:start . 101) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 144) (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 160)\n  (:start . 150) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1054.6) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009869@unknown@formal@none@1@S@The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappab3") (:form . "kappaB3") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 83) (:start . 69) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 101)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 132)\n  (:start . 120) (:id . 61))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 171) (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 182)\n  (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1055.10.1) (:span 138 144)))\n (:nscopes ((:id . :x1055.10.1) (:span 138 182)))\n (:identifiers (:sid . :s1055.10) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009879@unknown@formal@none@1@S@Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific T cell clones.@(((:tag . "NN") (:stem . "rescue") (:form . "Rescue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "antigen-specific") (:form . "antigen-specific")\n  (:end . 97) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1057.1) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009889@unknown@formal@none@1@S@Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells.@(((:tag . "NNP") (:stem . "Association") (:form . "Association") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 83)\n  (:start . 72) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "t-cell-leukemia") (:form . "T-cell-leukemia")\n  (:end . 108) (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 114)\n  (:start . 109) (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 119) (:start . 115)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 121) (:start . 120)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1058.1) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009899@unknown@formal@none@1@S@Here, we show that the DBF site is an interferon-responsive factor (IRF) binding site and that the AP3-L motif binds the T-cell-specific factor NF-AT.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DBF") (:form . "DBF") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "interferon-responsive")\n  (:form . "interferon-responsive") (:end . 59) (:start . 38) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IRF") (:form . "IRF") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "AP3-L") (:form . "AP3-L") (:end . 104)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 110)\n  (:start . 105) (:id . 63))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 116)\n  (:start . 111) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 136) (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1059.4) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009909@unknown@formal@none@1@S@Activation and regulation of NF-kappa B are tightly controlled by a group of inhibitory proteins (I kappa B) that sequester NF-kappa B in the cytoplasm of immune/inflammatory effector cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "sequester") (:form . "sequester") (:end . 123)\n  (:start . 114) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "immune/inflammatory")\n  (:form . "immune/inflammatory") (:end . 174) (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 183)\n  (:start . 175) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1060.4) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009919@unknown@formal@none@1@S@Here we show, by electrophoretic mobility shift assays, that ascorbate increases the binding of NF-kappaB to DNA in TNF-alpha-stimulated Jurkat cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 32) (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "tnf-alpha-stimulated")\n  (:form . "TNF-alpha-stimulated") (:end . 136) (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1061.4) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009929@unknown@formal@none@1@S@These markers will be useful to study the role of genetic variation in these genes in the pathogenesis of type 2 diabetes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 102)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1062.7) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009939@unknown@formal@none@1@S@Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "element/ap-1") (:form . "element/AP-1") (:end . 109)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1064.1) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009949@unknown@formal@none@1@S@These data indicate that functional complexes encompassing both the CD28RE and the AP-1-binding sites influence IL-2 promoter activity in CD28-costimulated T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd28re") (:form . "CD28RE") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "influence") (:form . "influence") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cd28-costimulated") (:form . "CD28-costimulated")\n  (:end . 155) (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1064.11.1) (:span 11 24)))\n (:hscopes ((:id . :x1064.11.1) (:span 11 163)))\n (:identifiers (:sid . :s1064.11) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009959@unknown@formal@none@1@S@We demonstrate that one target of this positive/negative regulation in vivo is the alpha4 integrin, which play a key role in normal hematopoiesis and function of mature leukocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive/negative") (:form . "positive/negative")\n  (:end . 56) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha4") (:form . "alpha4") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 145) (:start . 132) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 168)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1065.10) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009969@unknown@formal@none@1@S@In conjunction with previously published data on c-Raf-induced phosphorylation of GABP factors (E.Flory, A. Hoffmeyer, U.Smola, U.R.Rapp, and J.T.Bruder, J.Virol.70:2260- 2268, 1996), these results indicate a contribution of GABP factors to the Raf-mediated enhancement of IL-2 induction during T-cell activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . 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"during") (:end . 294)\n  (:start . 288) (:id . 88))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 301)\n  (:start . 295) (:id . 89))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 312)\n  (:start . 302) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 313) (:start . 312)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1066.10.1) (:span 198 206)))\n (:hscopes ((:id . :x1066.10.1) (:span 198 312)))\n (:identifiers (:sid . :s1066.10) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009979@unknown@formal@none@1@S@Results of this study suggest that Eed-restricted homeotic gene expression during embryogenesis reflects the action of Eed as a transcriptional repressor.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "eed-restricted") (:form . "Eed-restricted")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "homeotic") (:form . "homeotic") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 95) (:start . 82) (:id . 53))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "eed") (:form . "Eed") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 143) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 153)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1067.10.1) (:span 22 29)))\n (:hscopes ((:id . :x1067.10.1) (:span 22 153)))\n (:identifiers (:sid . :s1067.10) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009989@unknown@formal@none@1@S@Induction of human immunodeficiency virus type 1 expression in monocytic cells by Cryptococcus neoformans and Candida albicans.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 35) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "FW") (:stem . "cryptococcus") (:form . "Cryptococcus") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Candida") (:form . "Candida") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "NNP") (:stem . "albicans") (:form . "albicans") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1069.1) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009999@unknown@formal@none@1@S@It has been proposed that their expression is controlled by the non-clonal, or innate, component of immunity that preceded in evolution the development of an adaptive immune system in vertebrates.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 31)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-clonal") (:form . "non-clonal") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "precede") (:form . "preceded") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 151)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "adaptive") (:form . "adaptive") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 173)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 195)\n  (:start . 184) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1070.4) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010009@unknown@formal@none@1@S@Bufalin treatment activated activator protein-1 transcriptional activity; however, this activation was decreased to 40% in bcl-2-overexpressed U937 cells.@(((:tag . "NNP") (:stem . "Bufalin") (:form . "Bufalin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 63) (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 73) (:start . 72)\n  (:id . 49))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 81)\n  (:start . 74) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 87) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "bcl-2-overexpressed")\n  (:form . "bcl-2-overexpressed") (:end . 142) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1071.6) (:did . :|9242431|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010019@unknown@formal@none@1@S@This indicated that the EKLF-/- erythrocytes in adult animals must be short-lived, apparently due to the imbalance of beta- versus alpha-globin chains, leading to the precipitation of excess alpha-globin chains to form Heinz bodies.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "short-lived") (:form . "short-lived") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "imbalance") (:form . "imbalance") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "beta-") (:form . "beta-") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "alpha-globin") (:form . "alpha-globin") (:end . 143)\n  (:start . 131) (:id . 63))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 150)\n  (:start . 144) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "precipitation") (:form . "precipitation")\n  (:end . 180) (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "excess") (:form . "excess") (:end . 190)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "alpha-globin") (:form . "alpha-globin") (:end . 203)\n  (:start . 191) (:id . 72))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 210)\n  (:start . 204) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 218) (:start . 214)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Heinz") (:form . "Heinz") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 231)\n  (:start . 225) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1072.9.1) (:span 83 93)) ((:id . :x1072.9.2) (:span 62 66))\n  ((:id . :x1072.9.3) (:span 5 19)))\n (:hscopes ((:id . :x1072.9.1) (:span 83 150))\n  ((:id . :x1072.9.2) (:span 62 81)) ((:id . :x1072.9.3) (:span 5 231)))\n (:identifiers (:sid . :s1072.9) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010029@unknown@formal@none@1@S@Inhibition of T cell activation by the immunosuppressants cyclosporin A (CsA) and FK506 exerts a suppressive effect on the induction of these NF-kappa B-controlled cytokine promoters.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 57) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 69)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 150)\n  (:start . 142) (:id . 66))\n ((:tag . "JJ") (:stem . "b-controlled") (:form . "B-controlled") (:end . 163)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1074.3) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010039@unknown@formal@none@1@S@Taken together, these data suggest that EBF and E47 synergize to activate expression of a subset of genes that define an early stage of the B cell lineage.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 154)\n  (:start . 147) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1075.6.1) (:span 27 34)))\n (:hscopes ((:id . :x1075.6.1) (:span 27 154)))\n (:identifiers (:sid . :s1075.6) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010049@unknown@formal@none@1@S@Differential interaction of nuclear factors with the leukocyte-specific pp52 promoter in B and T cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "leukocyte-specific") (:form . "leukocyte-specific")\n  (:end . 71) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1077.1) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010059@unknown@formal@none@1@S@These findings reveal the features controlling the pp52 promoter in B and T cells and provide the foundation for determining the regulation of this promoter in other leukocyte lineages.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "foundation") (:form . "foundation") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 175)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1077.11) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010069@unknown@formal@none@1@S@Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 36) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-tat") (:form . "anti-Tat") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "single-chain") (:form . "single-chain") (:end . 118)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "intrabody") (:form . "intrabodies") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 157)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1079.1) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010079@unknown@formal@none@1@S@Several small molecules, an antisense oligonucleotide, and gene therapeutic agents that inhibit NF-kappa b activation have been described.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1080.3) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010089@unknown@formal@none@1@S@This effect was confirmed in COS-7 cells transfected with the cDNA of CCK(B) receptor cloned from Jurkat T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cos-7") (:form . "COS-7") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "CCK(B)") (:form . "CCK(B)") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1081.6) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010099@unknown@formal@none@1@S@Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 93) (:start . 74) (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 157)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1082.4) (:did . :|9271588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010109@unknown@formal@none@1@S@Because surfactant protein (SP) A is involved in local host defense in the lung and alters immune cell function by modulating the expression of proinflammatory cytokines as well as surface proteins involved in inflammation, we hypothesized that SP-A exerts its action, at least in part, via activation of NF-kappa B.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "surfactant") (:form . "surfactant") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 90)\n  (:start . 84) (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 97)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 111)\n  (:start . 103) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 159) (:start . 144) (:id . 68))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 169)\n  (:start . 160) (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 188)\n  (:start . 181) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 206)\n  (:start . 198) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 76))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 222)\n  (:start . 210) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 226) (:start . 224)\n  (:id . 79))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 239)\n  (:start . 227) (:id . 80))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 244) (:start . 240)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 249) (:start . 245)\n  (:id . 82))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 256)\n  (:start . 250) (:id . 83))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 260) (:start . 257)\n  (:id . 84))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 267)\n  (:start . 261) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 268) (:start . 267)\n  (:id . 86))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 271) (:start . 269)\n  (:id . 87))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 277)\n  (:start . 272) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 280) (:start . 278)\n  (:id . 89))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 285) (:start . 281)\n  (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 286) (:start . 285)\n  (:id . 91))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 290) (:start . 287)\n  (:id . 92))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 301)\n  (:start . 291) (:id . 93))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 304) (:start . 302)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 313)\n  (:start . 305) (:id . 95))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 315) (:start . 314)\n  (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 97)))@@@1@56@((:hcues ((:id . :x1084.3.1) (:span 227 239)))\n (:hscopes ((:id . :x1084.3.1) (:span 227 315)))\n (:identifiers (:sid . :s1084.3) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010119@unknown@formal@none@1@S@Cytokine-stimulated cell surface expression of vascular cell adhesion molecule-1 (VCAM-1, CD106) and E-selectin (ELAM-1, CD62E), but not of intercellular adhesion molecule-1 (ICAM-1, CD54), was time- and dose-dependently inhibited by TCP succinate but not by TCP or TCP acetate.@(((:tag . "JJ") (:stem . "cytokine-stimulated")\n  (:form . "Cytokine-stimulated") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 43))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . 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5010129@unknown@formal@none@1@S@Monocytic cell adhesion to EC in response to tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), alpha-thrombin, or phorbol 12-myristate 13-acetate (PMA) was similarly inhibited by NAC.@(((:tag . "JJ") (:stem . "monocytic") (:form . "Monocytic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 72)\n  (:start . 60) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 104) (:start . 86) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha-thrombin") (:form . "alpha-thrombin")\n  (:end . 126) (:start . 112) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 151)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 162)\n  (:start . 152) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 192)\n  (:start . 183) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 195) (:start . 193)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1086.4) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010139@unknown@formal@none@1@S@Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.@(((:tag . "NNP") (:stem . "Leukocyte") (:form . "Leukocyte") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "RB") (:stem . "fundamentally") (:form . "fundamentally")\n  (:end . 37) (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 94)\n  (:start . 88) (:id . 52))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 105)\n  (:start . 95) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1087.2) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010149@unknown@formal@none@1@S@The binding of oxidized low-density lipoprotein (Ox LDL) by monocyte-macrophages causes pleiotropic effects, including changes in gene expression, and is thought to represent an early event in atherogenesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ox") (:form . "Ox") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophages") (:end . 80) (:start . 60) (:id . 53))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 189)\n  (:start . 184) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 206) (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1088.2.1) (:span 154 161)))\n (:hscopes ((:id . :x1088.2.1) (:span 151 206)))\n (:identifiers (:sid . :s1088.2) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010159@unknown@formal@none@1@S@During myelopoiesis, which includes the development of granulocytic and monocytic lineages, transcription factors from several families are active, including AML1/CBF beta, C/EBP, Ets, c-Myb, HOX, and MZF-1.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 67)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 146)\n  (:start . 140) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 157)\n  (:start . 148) (:id . 63))\n ((:tag . "NNP") (:stem . "AML1/CBF") (:form . "AML1/CBF") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 178)\n  (:start . 173) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HOX") (:form . "HOX") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 206)\n  (:start . 201) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1089.4) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010169@unknown@formal@none@1@S@Various extracellular signals, often converging in common intracellular pathways, can induce apoptosis in a cell-type-specific fashion.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "converge") (:form . "converging") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 126) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1091.3) (:did . :|9299589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010179@unknown@formal@none@1@S@2. Our study involved a group of 60 male and female subjects who were exposed to MTBE and benzene-contaminated water concentrations up to 76 PPB for MTBE and 14 PPB for benzene, for a period of 5 to 8 years.@(((:tag . "LS") (:stem . "2.") (:form . "2.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "involve") (:form . "involved") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 51)\n  (:start . 45) (:id . 52))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mtbe") (:form . "MTBE") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "benzene-contaminated")\n  (:form . "benzene-contaminated") (:end . 110) (:start . 90) (:id . 60))\n ((:tag . "NN") (:stem . "water") (:form . "water") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 131) (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "CD") (:stem . "76") (:form . "76") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ppb") (:form . "PPB") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "MTBE") (:form . "MTBE") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ppb") (:form . "PPB") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 168) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 176)\n  (:start . 169) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 76))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 190)\n  (:start . 184) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 78))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 195) (:start . 194)\n  (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 198) (:start . 196)\n  (:id . 80))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 200) (:start . 199)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 206)\n  (:start . 201) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1093.3) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010189@unknown@formal@none@1@S@Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "3q21") (:form . "3q21") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 53) (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "intergenic") (:form . "intergenic") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ecotropic") (:form . "ecotropic") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1094.1) (:did . :|9307271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010199@unknown@formal@none@1@S@Adherence-isolated monocytes showed constitutive DNA binding activity of NF-kappa B.@(((:tag . "JJ") (:stem . "adherence-isolated") (:form . "Adherence-isolated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 28)\n  (:start . 19) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 35) (:start . 29)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 48)\n  (:start . 36) (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1095.5) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010209@unknown@formal@none@1@S@EMSA showed that both constitutive and inducible complexes bound to CLE0, P, P2 and P4, whereas only a constitutive complex bound to P3.@(((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p2") (:form . "P2") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p4") (:form . "P4") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 115)\n  (:start . 103) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "P3") (:form . "P3") (:end . 135) (:start . 133)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1096.6) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010219@unknown@formal@none@1@S@Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "BHRF1") (:form . "BHRF1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MCF-Fas") (:form . "MCF-Fas") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-fas") (:form . "anti-Fas") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tnf-mediated") (:form . "TNF-mediated") (:end . 121)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 131)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1097.4) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010229@unknown@formal@none@1@S@A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virtue") (:form . "virtue") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1098.4) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010239@unknown@formal@none@1@S@The region of A-MYB responsible for the B cell specific activity was defined to be the N-terminal 218 amino acids containing the DNA binding domain.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "CD") (:stem . "218") (:form . "218") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1099.8) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010249@unknown@formal@none@1@S@These data support the conclusion that CN activity is rate-limiting for the activation of primary human T lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rate-limiting") (:form . "rate-limiting")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1100.8) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010259@unknown@formal@none@1@S@The NF kappa B2 effect was dependent on the presence of the STAT6 binding site, demonstrating that the NF kappa B2 motif is necessary but not sufficient for mediating cytokine up-regulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 93)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 133)\n  (:start . 124) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 152)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 166)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 175)\n  (:start . 167) (:id . 72))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 189) (:start . 176) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1101.9.1) (:span 138 141)))\n (:nscopes ((:id . :x1101.9.1) (:span 138 189)))\n (:identifiers (:sid . :s1101.9) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010269@unknown@formal@none@1@S@The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-lps") (:form . "anti-LPS") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mcd14-mediated") (:form . "mCD14-mediated")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 128) (:start . 115) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 154) (:start . 141) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 168)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 178)\n  (:start . 169) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cho-cd14") (:form . "CHO-CD14") (:end . 190)\n  (:start . 182) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 210)\n  (:start . 201) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 71))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 224)\n  (:start . 212) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 73))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 231)\n  (:start . 226) (:id . 74))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 235) (:start . 232)\n  (:id . 75))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 247)\n  (:start . 236) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 250) (:start . 248)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "non-mcd14-mediated") (:form . "non-mCD14-mediated")\n  (:end . 269) (:start . 251) (:id . 78))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 273) (:start . 270)\n  (:id . 79))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 280)\n  (:start . 274) (:id . 80))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 291)\n  (:start . 281) (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 297)\n  (:start . 292) (:id . 82))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 308)\n  (:start . 298) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1102.8) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010279@unknown@formal@none@1@S@Production of IL-2 requires the formation of transcription factors involved in the IL-2-gene regulation.@(((:tag . "NN") (:stem . "production") (:form . "Production") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-2-gene") (:form . "IL-2-gene") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1104.3) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010289@unknown@formal@none@1@S@Messenger RNA (mRNA) levels for the granulocyte-colony stimulating factor (G-CSF) receptor, granulocyte-macrophage (GM)-CSF receptor alpha subunit and tumor necrosis factor (TNF) receptors I (p55) and II (p75) were also detected in this subset in addition to c-kit and flt-3, receptors known to be expressed on progenitor cells.@(((:tag . "NN") (:stem . "messenger") (:form . "Messenger") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . 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"progenitor") (:end . 321)\n  (:start . 311) (:id . 100))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 327)\n  (:start . 322) (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 328) (:start . 327)\n  (:id . 102)))@@@1@61@((:identifiers (:sid . :s1105.4) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010299@unknown@formal@none@1@S@Monochloramine derivatives are long lived physiological oxidants produced by neutrophils during the respiratory burst.@(((:tag . "NNP") (:stem . "Monochloramine") (:form . "Monochloramine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lived") (:form . "lived") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 88)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 95)\n  (:start . 89) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 111)\n  (:start . 100) (:id . 54))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 117)\n  (:start . 112) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1106.2) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010309@unknown@formal@none@1@S@We have investigated the effects of Vpr on host cell activation and confirm that it influences cellular proliferation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "confirm") (:form . "confirm") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 117) (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1107.3) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010319@unknown@formal@none@1@S@We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sp3") (:form . "Sp3") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 45)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TRE1") (:form . "TRE1") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 139) (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1108.4) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010329@unknown@formal@none@1@S@Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ML-1a") (:form . "ML-1a") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dermal") (:form . "dermal") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "microvessel") (:form . "microvessel") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MVEC") (:form . "MVEC") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 136)\n  (:start . 130) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 151)\n  (:start . 141) (:id . 69))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 161)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "co-treatment") (:form . "co-treatment") (:end . 177)\n  (:start . 165) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "phenylarsine") (:form . "phenylarsine") (:end . 195)\n  (:start . 183) (:id . 74))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 201)\n  (:start . 196) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 206) (:start . 203)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 210) (:start . 209)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 219)\n  (:start . 211) (:id . 81))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 229)\n  (:start . 220) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "PTPase") (:form . "PTPase") (:end . 239)\n  (:start . 233) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1109.4) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010339@unknown@formal@none@1@S@The data further show that these overall topographical distributions are independent of gene transcriptional activity and are conserved in different cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "topographical") (:form . "topographical")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 108) (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 135)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 159)\n  (:start . 154) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1110.4) (:did . :|9341877|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010349@unknown@formal@none@1@S@Finally, gel mobility shift assays demonstrated the nuclear translocation of proteins specifically bound to these two NF-kappaB motifs, confirming that VCAM-1 was induced on Tax-expressing cells in a kappaB-dependent manner.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 98)\n  (:start . 86) (:id . 54))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 158)\n  (:start . 152) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 170)\n  (:start . 163) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 188) (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 216) (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 223)\n  (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1111.9) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010359@unknown@formal@none@1@S@We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . 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5010369@unknown@formal@none@1@S@RESULTS: Neutrophil adhesion to cultured corneal endothelial cells increased significantly on exposure to TNFalpha (451.4+/-45.4 cells/mm2, n = 16) compared to control (156.7+/-27.3 cells/mm2, n = 16, P < 0.01).@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "corneal") (:form . "corneal") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 90) (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "CD") (:stem . "451.4+/-45.4") (:form . "451.4+/-45.4") (:end . 128)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "cells/mm2") (:form . "cells/mm2") (:end . 138)\n  (:start . 129) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "CD") (:stem . "156.7+/-27.3") (:form . "156.7+/-27.3") (:end . 181)\n  (:start . 169) (:id . 69))\n ((:tag . "NNS") (:stem . "cells/mm2") (:form . "cells/mm2") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 202) (:start . 201)\n  (:id . 76))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 204) (:start . 203)\n  (:id . 77))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 209) (:start . 205)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1113.9) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010379@unknown@formal@none@1@S@We show here that helenalin, and, to a much lesser degree, 11alpha,13-dihydrohelenalin and chamissonolid, inhibit activation of transcription factor NF-kappaB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "helenalin") (:form . "helenalin") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 43) (:start . 39)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 50) (:start . 44)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 57)\n  (:start . 51) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "11alpha,13-dihydrohelenalin")\n  (:form . "11alpha,13-dihydrohelenalin") (:end . 86) (:start . 59)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chamissonolid") (:form . "chamissonolid")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1114.5) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010389@unknown@formal@none@1@S@Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . 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"TNF-alpha") (:end . 306)\n  (:start . 297) (:id . 88))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 311) (:start . 307)\n  (:id . 89))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 315) (:start . 312)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 91)))@@@1@50@((:ncues ((:id . :x1115.3.1) (:span 312 315)))\n (:nscopes ((:id . :x1115.3.1) (:span 312 315)))\n (:identifiers (:sid . :s1115.3) (:did . :|9350434|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010399@unknown@formal@none@1@S@The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "bi-") (:form . "bi-") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multi-functional") (:form . "multi-functional")\n  (:end . 65) (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1117.2) (:did . :|9352360|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010409@unknown@formal@none@1@S@During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "traf1") (:form . "TRAF1") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 185)\n  (:start . 174) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1118.7) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010419@unknown@formal@none@1@S@Ctx combined with TNFalpha or IL-1beta to produce a synergistic increase in p24 antigen production in U1 promonocytic cells.@(((:tag . "NNP") (:stem . "Ctx") (:form . "Ctx") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 117)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1119.6) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010429@unknown@formal@none@1@S@One transformation effector site (TES1), located within the membrane proximal 45 residues of the cytoplasmic tail, constitutively engages tumor necrosis factor receptor-associated factors.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TES1") (:form . "TES1") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 129) (:start . 115) (:id . 62))\n ((:tag . "VBZ") (:stem . "engage") (:form . "engages") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 159)\n  (:start . 153) (:id . 66))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 179) (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1120.4) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010439@unknown@formal@none@1@S@Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post-stimulation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "much") (:form . "much") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 171)\n  (:start . 166) (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "PRP") (:stem . "'late") (:form . "'late") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 75))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 203) (:start . 199)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 208) (:start . 204)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 80))\n ((:tag . "NN") (:stem . "post-stimulation") (:form . "post-stimulation")\n  (:end . 226) (:start . 210) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1121.2) (:did . :|9357137|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010449@unknown@formal@none@1@S@Paternal expression of WT1 in human fibroblasts and lymphocytes.@(((:tag . "JJ") (:stem . "paternal") (:form . "Paternal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1123.1) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010459@unknown@formal@none@1@S@Many of these events are dependent upon the ability of CD40 to activate the transcription factor NF-kappa B (NF-kappa B).@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1124.4) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010469@unknown@formal@none@1@S@Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner.@(((:tag . "NN") (:stem . "extinction") (:form . "Extinction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 176)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "widespread") (:form . "widespread") (:end . 190)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 203)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 212)\n  (:start . 207) (:id . 72))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 222)\n  (:start . 213) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 225) (:start . 223)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 227) (:start . 226)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 229) (:start . 228)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 243) (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 250)\n  (:start . 244) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1125.1) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010479@unknown@formal@none@1@S@Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "id3") (:form . "Id3") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cdk-2-dependent") (:form . "Cdk-2-dependent")\n  (:end . 56) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1126.1) (:did . :|9372912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010489@unknown@formal@none@1@S@NFAT activation is mediated in part by induced nuclear import.@(((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1127.3) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010499@unknown@formal@none@1@S@Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 102) (:start . 84) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1128.5.1) (:span 67 74)))\n (:nscopes ((:id . :x1128.5.1) (:span 67 108)))\n (:identifiers (:sid . :s1128.5) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010509@unknown@formal@none@1@S@Dose-response studies showed that 10(-7) to 10(-6) mol/L 9-cis RA (12 hours) resulted in peak levels of C/EBP epsilon mRNA; but even 10(-10) mol/L 9-cis RA increased levels of these transcripts.@(((:tag . "JJ") (:stem . "dose-response") (:form . "Dose-response")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "10(-7)") (:form . "10(-7)") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VB") (:stem . "10(-6)") (:form . "10(-6)") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 117)\n  (:start . 110) (:id . 62))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "10(-10)") (:form . "10(-10)") (:end . 140)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 165)\n  (:start . 156) (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 172)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 181)\n  (:start . 176) (:id . 74))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 193)\n  (:start . 182) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1129.5) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010519@unknown@formal@none@1@S@Regulation of nuclear factor-kappa B and its inhibitor I kappa B-alpha/MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-alpha/mad-3") (:form . "B-alpha/MAD-3")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 119)\n  (:start . 107) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 149)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1130.1) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010529@unknown@formal@none@1@S@Further, M. tuberculosis and its tuberculin, purified protein derivative, induced the degradation of I kappa B-alpha and the expression of I kappa B-alpha mRNA, and purified protein derivative induced the activation of NF-kappa B in monocytes.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tuberculin") (:form . "tuberculin") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 173)\n  (:start . 165) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 181)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 192)\n  (:start . 182) (:id . 73))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 200)\n  (:start . 193) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 215)\n  (:start . 205) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 227)\n  (:start . 219) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 229) (:start . 228)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 242)\n  (:start . 233) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1130.11) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010539@unknown@formal@none@1@S@By Northern and in situ hybridization, mNFATc transcript was detected from the early stage of development.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mnfatc") (:form . "mNFATc") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 105)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1132.6) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010549@unknown@formal@none@1@S@Inhibition of PI3K inhibits phosphorylation of Rb, induction of cyclin D3, and degradation of p27kip1.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PI3K") (:form . "PI3K") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 43) (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27kip1") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1133.9) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010559@unknown@formal@none@1@S@The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "buthionine") (:form . "buthionine") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "sulfoximine") (:form . "sulfoximine") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1134.9) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010569@unknown@formal@none@1@S@Site-directed mutational studies demonstrate that Site I and Site IV together support ATF1- and CREB-induced trans-activation of the H4 promoter.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mutational") (:form . "mutational") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Site") (:form . "Site") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Site") (:form . "Site") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "atf1-") (:form . "ATF1-") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "creb-induced") (:form . "CREB-induced") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 125) (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1135.8) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010579@unknown@formal@none@1@S@These data suggest that IL-2 and IL-7 induce assembly of STAT heterodimers in a similar manner and that subsequent cellular responses may be driven by induction of similar sets of genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1136.9.1) (:span 134 137))\n  ((:id . :x1136.9.2) (:span 11 18)))\n (:hscopes ((:id . :x1136.9.1) (:span 104 185))\n  ((:id . :x1136.9.2) (:span 11 185)))\n (:identifiers (:sid . :s1136.9) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010589@unknown@formal@none@1@S@Collectively, these findings indicate that A/R elicits a two-phase neutrophil-endothelial cell adhesion response that involves transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "elicit") (:form . "elicits") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "two-phase") (:form . "two-phase") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "neutrophil-endothelial")\n  (:form . "neutrophil-endothelial") (:end . 89) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 126)\n  (:start . 118) (:id . 57))\n ((:tag . "JJ") (:stem . "transcription-independent")\n  (:form . "transcription-independent") (:end . 152) (:start . 127)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcription-dependent")\n  (:form . "transcription-dependent") (:end . 180) (:start . 157) (:id . 60))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 188)\n  (:start . 181) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 212)\n  (:start . 203) (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 224)\n  (:start . 213) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 229) (:start . 225)\n  (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 238)\n  (:start . 230) (:id . 67))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 248)\n  (:start . 239) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1137.10.1) (:span 29 42)))\n (:hscopes ((:id . :x1137.10.1) (:span 29 248)))\n (:identifiers (:sid . :s1137.10) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010599@unknown@formal@none@1@S@Increased monocyte TF expression in transplant recipients was shown to be adversely affected by treatment with CsA: TF induction was markedly reduced by CsA serum concentrations reaching peak CsA drug levels.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "adversely") (:form . "adversely") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 177) (:start . 163) (:id . 68))\n ((:tag . "VBG") (:stem . "reach") (:form . "reaching") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "JJ") (:stem . "peak") (:form . "peak") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 200) (:start . 196)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 207)\n  (:start . 201) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1139.6) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010609@unknown@formal@none@1@S@G28-5 IgG partially blocked, whereas G28-5 sFv augmented CD40 responses during stimulation with natural ligand (gp39-CD8 fusion protein).@(((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "sFv") (:form . "sFv") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 90)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gp39-cd8") (:form . "gp39-CD8") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1140.6) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010619@unknown@formal@none@1@S@Thus, we conclude that the XP-B and XP-D lymphoblastoid cells do not have impaired RNA transcription activity.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 55) (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1141.9.1) (:span 65 68)))\n (:nscopes ((:id . :x1141.9.1) (:span 65 109)))\n (:identifiers (:sid . :s1141.9) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010629@unknown@formal@none@1@S@In cells that have been preincubated to lower mRNA levels, there is a transient increase in G0S2 mRNA, peaking between 1-2 h, in response to Concanavalin-A (ConA), or to the combination of phorbol ester (TPA), and the calcium ionophore, ionomycin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "lower") (:form . 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"ionomycin") (:end . 246)\n  (:start . 237) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s1142.9) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010639@unknown@formal@none@1@S@This lysate was also necessary for ER to diminish the DNA-binding activity of GATA-1.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "diminish") (:form . "diminish") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1143.7) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010649@unknown@formal@none@1@S@Activation of term infant cord blood mononuclear cells with anti-CD3 monoclonal antibodies resulted in up-regulation of both c-jun and c-fos mRNAs within 15 min of stimulation.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "infant") (:form . "infant") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 116) (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 175)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1144.7) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010659@unknown@formal@none@1@S@Anti-TNF-alpha also prevented nuclear factor-kappa B (NF-kappa B) activation, and a good correlation between this inhibition and inhibition of HIV replication was observed.@(((:tag . "NNP") (:stem . "Anti-TNF-alpha") (:form . "Anti-TNF-alpha")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 50)\n  (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1145.6) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010669@unknown@formal@none@1@S@Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 22) (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-4-driven") (:form . "IL-4-driven") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "decoy") (:form . "decoy") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotide") (:end . 146) (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 160)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1146.7.1) (:span 112 114)))\n (:hscopes ((:id . :x1146.7.1) (:span 105 160)))\n (:identifiers (:sid . :s1146.7) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010679@unknown@formal@none@1@S@Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "proliferate") (:form . "proliferated") (:end . 80)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mite") (:form . "mite") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "allergen") (:form . "allergen") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 146)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mite-specific") (:form . "mite-specific")\n  (:end . 165) (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 172)\n  (:start . 166) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 185) (:start . 181)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 194)\n  (:start . 186) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 214)\n  (:start . 202) (:id . 71))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 227)\n  (:start . 215) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 237)\n  (:start . 231) (:id . 74))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 244)\n  (:start . 238) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1147.6.1) (:span 136 146)))\n (:hscopes ((:id . :x1147.6.1) (:span 136 244)))\n (:identifiers (:sid . :s1147.6) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010689@unknown@formal@none@1@S@We therefore compared the turnover of I kappa B alpha and I kappa B beta in mature B cells and HeLa cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 82)\n  (:start . 76) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 99) (:start . 95)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1148.5) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010699@unknown@formal@none@1@S@A phosphoform of newly synthesized I kappa B alpha is visible when degradation by the proteasome is inhibited and new I kappa B alpha displays the same properties regarding phosphorylation and degradation in response to a second inducer.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphoform") (:form . "phosphoform") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "visible") (:form . "visible") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 78)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 162)\n  (:start . 152) (:id . 69))\n ((:tag . "VBG") (:stem . "regard") (:form . "regarding") (:end . 172)\n  (:start . 163) (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 188) (:start . 173) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 204)\n  (:start . 193) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 216)\n  (:start . 208) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 228)\n  (:start . 222) (:id . 78))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 236)\n  (:start . 229) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1148.15) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010709@unknown@formal@none@1@S@The absence of slow migrating forms of I kappa B beta following stimulation suggests that the phosphorylation does not necessarily constitute the signal-induced event which targets the molecule for proteolysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "migrating") (:form . "migrating") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 109) (:start . 94) (:id . 58))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "signal-induced") (:form . "signal-induced")\n  (:end . 160) (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "VBZ") (:stem . "target") (:form . "targets") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 193)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 209)\n  (:start . 198) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1149.8.1) (:span 76 84)))\n (:ncues ((:id . :x1149.8.2) (:span 4 11)))\n (:hscopes ((:id . :x1149.8.1) (:span 76 209)))\n (:nscopes ((:id . :x1149.8.2) (:span 4 75)))\n (:identifiers (:sid . :s1149.8) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010719@unknown@formal@none@1@S@We argue that in vivo RelA homodimers are likely to play a dominant role in TNF-alpha-induced ICAM-1 transcription in monocytic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "argue") (:form . "argue") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 93) (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1150.10.1) (:span 42 48)))\n (:hscopes ((:id . :x1150.10.1) (:span 22 133)))\n (:identifiers (:sid . :s1150.10) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010729@unknown@formal@none@1@S@These data show that the detection of upregulated p50 homodimers in LPS tolerant cells is dependent on subtle differences in the sequence of the DNA binding motif.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "subtle") (:form . "subtle") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1151.10) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010739@unknown@formal@none@1@S@We identified a cell-type-specific differential response: CREB, CTF, OTF-1, OFT-2, and NF-kappa B genes were strongly induced 1 to 4 hours after influenza A virus infection in the monocytic cell line Mono Mac 6, while in freshly prepared human monocytes no significant changes were detected.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 34) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . 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5010749@unknown@formal@none@1@S@So far, transcriptional analyses of p40 have been carried out only using bacterial constituents such as LPS as stimuli.@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 23) (:start . 8) (:id . 45))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "constituent") (:form . "constituents") (:end . 95)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1155.3) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010759@unknown@formal@none@1@S@For example, certain oxidants are known to activate the nuclear transcription factor kappa B, which regulates the expression of a variety of different adhesion molecules, cytokines, and enzymes.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 169)\n  (:start . 160) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 180)\n  (:start . 171) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 193)\n  (:start . 186) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1156.4) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010769@unknown@formal@none@1@S@In both cell types, the cytokine that inhibits the induction of IkappaBalpha by DEX, also rescues these cells from DEX-induced apoptosis, although the rescue cytokine is different in Th1 and Th2 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 76)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "rescue") (:form . "rescues") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dex-induced") (:form . "DEX-induced") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 179)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 186) (:start . 183)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 194) (:start . 191)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 200)\n  (:start . 195) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1157.6) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010779@unknown@formal@none@1@S@By confocal fluorescence microscopy, we observed a positive staining for NF-kappa B (p65 subunit) in the nuclei of PAEC exposed for 1 hr 30 min to human serum, which indicated NF-kappa B activation in this setting.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "confocal") (:form . "confocal") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PAEC") (:form . "PAEC") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 127)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 152)\n  (:start . 147) (:id . 71))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 158)\n  (:start . 153) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 165)\n  (:start . 160) (:id . 74))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 175)\n  (:start . 166) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 184)\n  (:start . 176) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 197)\n  (:start . 187) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 205) (:start . 201)\n  (:id . 80))\n ((:tag . "NN") (:stem . "setting") (:form . "setting") (:end . 213)\n  (:start . 206) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1158.9) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010789@unknown@formal@none@1@S@Functional studies using human endothelial cells demonstrated that overexpression of CBP rescued cAMP inhibition of NF-kappaB-mediated transcription and transcription mediated by a chimeric protein, GAL4-p65(286-551), which contained the GAL4 DNA binding domain fused to the carboxyl-terminal region of p65 (amino acids 286-551).@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . 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5010799@unknown@formal@none@1@S@Supershift experiments revealed that JunD and c-Fos proteins mediated anti-CD19 induced AP-1-binding activity in 1E8 cells.@(((:tag . "NNP") (:stem . "Supershift") (:form . "Supershift") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "anti-cd19") (:form . "anti-CD19") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 100)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "1e8") (:form . "1E8") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1160.8) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010809@unknown@formal@none@1@S@In particular, naturally occurring sequence variation impacted transcription factor binding to an activating transcription factor/cAMP response element binding (ATF/CREB) binding site (located between the LEF-1 and distal NF-kappaB transcription factor binding sites) that we identified in previous studies of the HIV-1 LTR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "variation") (:form . 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")") (:end . 267) (:start . 266)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 272) (:start . 268)\n  (:id . 79))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 275) (:start . 273)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 286)\n  (:start . 276) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 289) (:start . 287)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 298)\n  (:start . 290) (:id . 83))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 306)\n  (:start . 299) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 309) (:start . 307)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 313) (:start . 310)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 319)\n  (:start . 314) (:id . 87))\n ((:tag . "NNP") (:stem . "LTR") (:form . 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5010819@unknown@formal@none@1@S@IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.@(((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "prolymphocytic") (:form . "prolymphocytic")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1163.1) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010829@unknown@formal@none@1@S@Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R-associated kinase.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "htoll") (:form . "hToll") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "sequential") (:form . "sequential") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adapter") (:form . "adapter") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "il-1r-associated") (:form . "IL-1R-associated")\n  (:end . 122) (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1164.3) (:did . :|9625770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010839@unknown@formal@none@1@S@These results lead to a general model for the synergistic function of activation domains in Oct-1 and OCA-B (mediated by the combined action of the multiple USA components) and, further, suggest a functional redundancy in general coactivators.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 156)\n  (:start . 148) (:id . 68))\n ((:tag . "NNP") (:stem . "USA") (:form . "USA") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 171)\n  (:start . 161) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 185)\n  (:start . 178) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 75))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 194)\n  (:start . 187) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 207)\n  (:start . 197) (:id . 78))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 218)\n  (:start . 208) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 229)\n  (:start . 222) (:id . 81))\n ((:tag . "NNS") (:stem . "coactivator") (:form . "coactivators") (:end . 242)\n  (:start . 230) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1165.8.1) (:span 187 194)))\n (:hscopes ((:id . :x1165.8.1) (:span 187 242)))\n (:identifiers (:sid . :s1165.8) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010849@unknown@formal@none@1@S@Tuberculosis has emerged as an epidemic, extended by the large number of individuals infected with human immunodeficiency virus type 1 (HIV-1).@(((:tag . "NNP") (:stem . "Tuberculosis") (:form . "Tuberculosis") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epidemic") (:form . "epidemic") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "extend") (:form . "extended") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 121) (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1167.2) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010859@unknown@formal@none@1@S@Effects of oxidative stress on stimulation-dependent signal transduction, leading to IL-2 expression, were studied.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stimulation-dependent")\n  (:form . "stimulation-dependent") (:end . 52) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 72)\n  (:start . 60) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1168.2) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010869@unknown@formal@none@1@S@We report that activation of the two transcription factors NF-kappa B and AP-1 is crucially involved in FasL expression induced by etoposide, teniposide, and UV irradiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "crucially") (:form . "crucially") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "teniposide") (:form . "teniposide") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 172)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1169.3) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010879@unknown@formal@none@1@S@More than 50% of TPO-treated UT-7/GMT cells positively stained for Hb.@(((:tag . "JJR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tpo-treated") (:form . "TPO-treated") (:end . 28)\n  (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "ut-7/gmt") (:form . "UT-7/GMT") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hb") (:form . "Hb") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1170.5) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010889@unknown@formal@none@1@S@Diminished NF-kappaB activity has been shown to occur in T cells with aging, suggesting that impaired activation of NF-kappaB might occur during cellular senescence.@(((:tag . "VBN") (:stem . "diminish") (:form . "Diminished") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 164)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1171.4.1) (:span 126 131))\n  ((:id . :x1171.4.2) (:span 77 87)))\n (:hscopes ((:id . :x1171.4.1) (:span 126 164))\n  ((:id . :x1171.4.2) (:span 77 164)))\n (:identifiers (:sid . :s1171.4) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010899@unknown@formal@none@1@S@Mononuclear phagocytes are exposed to fibrinous provisional matrix throughout migration into inflammatory foci, so this study was undertaken to determine whether fibrinogen triggers activation of NF-kappa B transcription factors.@(((:tag . "JJ") (:stem . "mononuclear") (:form . "Mononuclear") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "fibrinous") (:form . "fibrinous") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "provisional") (:form . "provisional") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 92) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 105)\n  (:start . 93) (:id . 53))\n ((:tag . "NNS") (:stem . "focus") (:form . "foci") (:end . 110)\n  (:start . 106) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 55))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "undertake") (:form . "undertaken") (:end . 140)\n  (:start . 130) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 153)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 161)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "fibrinogen") (:form . "fibrinogen") (:end . 172)\n  (:start . 162) (:id . 64))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 181)\n  (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 204)\n  (:start . 196) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 220) (:start . 207) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 228)\n  (:start . 221) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1172.3.1) (:span 154 161)))\n (:hscopes ((:id . :x1172.3.1) (:span 154 228)))\n (:identifiers (:sid . :s1172.3) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010909@unknown@formal@none@1@S@The adoptive transfer of tumor-draining lymph node (LN) T cells activated ex vivo with anti-CD3 and interleukin 2 (IL-2) mediates the regression of the poorly immunogenic murine melanoma D5.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adoptive") (:form . "adoptive") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 39) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 111)\n  (:start . 100) (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regression") (:form . "regression") (:end . 144)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 158)\n  (:start . 152) (:id . 70))\n ((:tag . "JJ") (:stem . "immunogenic") (:form . "immunogenic") (:end . 170)\n  (:start . 159) (:id . 71))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 177)\n  (:start . 171) (:id . 72))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 186)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "d5") (:form . "D5") (:end . 189) (:start . 187)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1173.2) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010919@unknown@formal@none@1@S@Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1-") (:form . "IL-1-") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-18-mediated") (:form . "IL-18-mediated")\n  (:end . 81) (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1174.1) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010929@unknown@formal@none@1@S@TNFRI has been recently shown to activate NF-kappaB through association with TRADD, RIP, and TRAF2; activation of the NF-kappaB-inducing kinase (NIK); activation of the IkappaB alpha kinases (IKKalpha and IKKbeta); and phosphorylation of IkappaB alpha.@(((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB-inducing") (:form . "NF-kappaB-inducing")\n  (:end . 136) (:start . 118) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 161)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 176)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 182)\n  (:start . 177) (:id . 73))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 190)\n  (:start . 183) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 200)\n  (:start . 192) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 212)\n  (:start . 205) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 214) (:start . 213)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 81))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 234) (:start . 219) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 245)\n  (:start . 238) (:id . 84))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 251)\n  (:start . 246) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1175.4) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010939@unknown@formal@none@1@S@The inhibition of NF-kappaB is apparently permanent as DMDTC-treated T cells did not regain normal TNF-alpha activation, even after 72 h in culture.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dmdtc-treated") (:form . "DMDTC-treated")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VB") (:stem . "regain") (:form . "regain") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1176.7.1) (:span 81 84)))\n (:nscopes ((:id . :x1176.7.1) (:span 81 147)))\n (:identifiers (:sid . :s1176.7) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010949@unknown@formal@none@1@S@Evidence for a role for PKCalpha as an effector of Rho was obtained by the observation that coexpression of the N-terminal domain of PKCalpha blocked the effects of activated Rho plus PMA on AP-1 transcriptional activity.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PKCalpha") (:form . "PKCalpha") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 104)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PKCalpha") (:form . "PKCalpha") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 183) (:start . 179)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 190) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 195) (:start . 191)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 211) (:start . 196) (:id . 76))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 220)\n  (:start . 212) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1177.7) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010959@unknown@formal@none@1@S@However, plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF2 and TRAF6 adaptors, which effectively block signaling through the cytoplasmic tails of the TNF-alpha and IL-1 receptors, respectively, do not inhibit Tax induction of NF-kappaB.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "membrane-proximal") (:form . "membrane-proximal")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . 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5010969@unknown@formal@none@1@S@In contrast to the differential signaling of BW 828 and 9.3 in resting T cells, the two mAbs exhibited a similar pattern of early signaling events in activated T cells and Jurkat cells (p56(lck) activation, association of phosphatidylinositol 3-kinase with CD28), indicating that the signaling capacity of CD28 changes with activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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(:end . 335) (:start . 334)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x1179.8.1) (:span 264 279)))\n (:hscopes ((:id . :x1179.8.1) (:span 264 334)))\n (:identifiers (:sid . :s1179.8) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010979@unknown@formal@none@1@S@In this study, we show that a novel function of iNO is to terminate inflammatory processes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 44)\n  (:start . 36) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 55))\n ((:tag . "VB") (:stem . "terminate") (:form . "terminate") (:end . 67)\n  (:start . 58) (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 80)\n  (:start . 68) (:id . 57))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1181.3) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010989@unknown@formal@none@1@S@We analyzed the activation of STATs in primary human T and NK cells by a variety of specific cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 92)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 102)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1182.4) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010999@unknown@formal@none@1@S@S9a at 10 to 100 nM inhibited HIV production as potently as 3'-azido-3'-deoxythymidine (AZT), an inhibitor of viral reverse transcriptase.@(((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 19) (:start . 17)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 29)\n  (:start . 20) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 44)\n  (:start . 34) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "3'-azido-3'-deoxythymidine")\n  (:form . "3'-azido-3'-deoxythymidine") (:end . 86) (:start . 60) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AZT") (:form . "AZT") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 137) (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1183.3) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011009@unknown@formal@none@1@S@Maximal inhibition of IgE production for B cells was at 10(-8) mol/L for all-trans RA (94% ± 1.8%) and 96% ± 3.2% for 13-cis RA.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "10(-8)") (:form . "10(-8)") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "CD") (:stem . "94") (:form . "94") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1.8") (:form . "1.8") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 97) (:start . 96)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 64))\n ((:tag . "CD") (:stem . "96") (:form . "96") (:end . 105) (:start . 103)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 106) (:start . 105)\n  (:id . 66))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 108) (:start . 107)\n  (:id . 67))\n ((:tag . "CD") (:stem . "3.2") (:form . "3.2") (:end . 112) (:start . 109)\n  (:id . 68))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 113) (:start . 112)\n  (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "13-cis") (:form . "13-cis") (:end . 124)\n  (:start . 118) (:id . 71))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 127) (:start . 125)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1184.5) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011019@unknown@formal@none@1@S@Our analyses of the induction of nuclear factor-kappaB (NFkappaB) in activated memory (CD45RO+) and naive (CD45RA+) T cell subsets from young and elderly donors has demonstrated that, regardless of donor age, memory T cells are not significantly altered in their responsiveness to TNF-alpha-mediated induction of NFkappaB.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . 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"their") (:end . 262)\n  (:start . 257) (:id . 89))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 277) (:start . 263) (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 280) (:start . 278)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "tnf-alpha-mediated") (:form . "TNF-alpha-mediated")\n  (:end . 299) (:start . 281) (:id . 92))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 309)\n  (:start . 300) (:id . 93))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 312) (:start . 310)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 321)\n  (:start . 313) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 322) (:start . 321)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s1185.3) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011029@unknown@formal@none@1@S@In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "JJ") (:stem . "e2f-mediated") (:form . "E2F-mediated") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 97) (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "CD") (:stem . "p16(INK4A)") (:form . "p16(INK4A)") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1186.6) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011039@unknown@formal@none@1@S@As described in other systems, fragmentation required ongoing protein synthesis.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1187.6) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011049@unknown@formal@none@1@S@T lymphocytes from 6 of the 14 patients also exhibited an increased expression of the dual specificity phosphatase, map kinase phosphatase-1 (MKP-1).@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "phosphatase-1") (:form . "phosphatase-1")\n  (:end . 140) (:start . 127) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mkp-1") (:form . "MKP-1") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1188.6) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011059@unknown@formal@none@1@S@We have identified a 104-bp minimal promoter region of the NF-IL6 gene that is sufficient for basal and activation-dependent induction of transcription in U937 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "104-bp") (:form . "104-bp") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 124) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 151) (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1189.4) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011069@unknown@formal@none@1@S@Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Mn") (:form . "Mn") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SOD") (:form . "SOD") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1191.1.1) (:span 39 46)))\n (:nscopes ((:id . :x1191.1.1) (:span 39 101)))\n (:identifiers (:sid . :s1191.1) (:did . :|9730957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011079@unknown@formal@none@1@S@Minimizing energy studies of BMT structure reveal that a trans-disulfide of thiamine (holo drug) disulfide (TDS, protodrug) is allosterically transited to the reactive twisted disulfide of BMT (allo drug) by o,o'-bismyristoyl esterification of TDS.@(((:tag . "VBG") (:stem . "minimize") (:form . "Minimizing") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "energy") (:form . "energy") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BMT") (:form . "BMT") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "trans-disulfide") (:form . "trans-disulfide")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thiamine") (:form . "thiamine") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "holo") (:form . "holo") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TDS") (:form . "TDS") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protodrug") (:form . "protodrug") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "RB") (:stem . "allosterically") (:form . "allosterically")\n  (:end . 141) (:start . 127) (:id . 65))\n ((:tag . "VBN") (:stem . "transit") (:form . "transited") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "JJ") (:stem . "twisted") (:form . "twisted") (:end . 175)\n  (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "BMT") (:form . "BMT") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . "NN") (:stem . "allo") (:form . "allo") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 203) (:start . 199)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "o,o'-bismyristoyl") (:form . "o,o'-bismyristoyl")\n  (:end . 225) (:start . 208) (:id . 79))\n ((:tag . "NN") (:stem . "esterification") (:form . "esterification")\n  (:end . 240) (:start . 226) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "TDS") (:form . "TDS") (:end . 247) (:start . 244)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1192.5) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011089@unknown@formal@none@1@S@In marked contrast, expression of the dominant interfering deltaDNA-binding domain RXR, containing a deletion of the entire DNA-binding domain, was incompatible with erythroid cell growth in vitro, suggesting a pivotal role of RXR for erythroid cell development.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "deltadna-binding") (:form . "deltaDNA-binding")\n  (:end . 75) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "rxr") (:form . "RXR") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "incompatible") (:form . "incompatible") (:end . 160)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 175)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 180) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 187)\n  (:start . 181) (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 208)\n  (:start . 198) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 218)\n  (:start . 211) (:id . 75))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 223) (:start . 219)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "NN") (:stem . "rxr") (:form . "RXR") (:end . 230) (:start . 227)\n  (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 234) (:start . 231)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 244)\n  (:start . 235) (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 249) (:start . 245)\n  (:id . 81))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 261)\n  (:start . 250) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1193.9.1) (:span 198 208)))\n (:hscopes ((:id . :x1193.9.1) (:span 198 261)))\n (:identifiers (:sid . :s1193.9) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011099@unknown@formal@none@1@S@We have pursued our investigation of the role of the CD4 transduction pathway in HIV-induced apoptosis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "pursue") (:form . "pursued") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-induced") (:form . "HIV-induced") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1195.3) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011109@unknown@formal@none@1@S@We analysed IL-2 production in purified neonatal and adult T cells using polyclonal activator phorbol ester + calcium ionophore (PDBu + iono) or receptor-mediated anti-CD3/anti-CD3+ anti-CD28 stimulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyse") (:form . "analysed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pdbu") (:form . "PDBu") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "iono") (:form . "iono") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "receptor-mediated") (:form . "receptor-mediated")\n  (:end . 162) (:start . 145) (:id . 67))\n ((:tag . "JJ") (:stem . "anti-cd3/anti-cd3+") (:form . "anti-CD3/anti-CD3+")\n  (:end . 181) (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 191)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 203)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1196.3) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011119@unknown@formal@none@1@S@METHODS AND RESULTS: Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monolayer") (:form . "Monolayers") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nonstimulated") (:form . "nonstimulated")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adp-activated") (:form . "ADP-activated")\n  (:end . 124) (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 203)\n  (:start . 197) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 208) (:start . 204)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 219)\n  (:start . 209) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 222) (:start . 220)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 228)\n  (:start . 223) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 232) (:start . 229)\n  (:id . 77))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 247)\n  (:start . 238) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 80))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 261)\n  (:start . 249) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1197.4) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011129@unknown@formal@none@1@S@Members of a protein family, characterized by three zinc fingers highly homologous to those found in transcription factor Sp1, interact with these motifs.@(((:tag . "NNS") (:stem . "member") (:form . "Members") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 42) (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1198.4) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011139@unknown@formal@none@1@S@ICAM-1 and CD71 are nevertheless up-regulated by LMP1 in primary B cells and cell lines expressing the dominant IkappaB.@(((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD71") (:form . "CD71") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "ikappab") (:form . "IkappaB") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1199.7) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011149@unknown@formal@none@1@S@Collectively, the current findings open new perspectives about mechanisms that are likely to regulate gene transcription in neutrophils.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "open") (:form . "open") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "perspective") (:form . "perspectives") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 135)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1200.8.1) (:span 83 89)))\n (:hscopes ((:id . :x1200.8.1) (:span 74 135)))\n (:identifiers (:sid . :s1200.8) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011159@unknown@formal@none@1@S@These results show that PEBP2betaMYH11 can impair neutrophil development and provide evidence that alterations of Pebp2 can contribute to the genesis of myelodysplasia.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pebp2betamyh11") (:form . "PEBP2betaMYH11")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "impair") (:form . "impair") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 110)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pebp2") (:form . "Pebp2") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "genesis") (:form . "genesis") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "myelodysplasia") (:form . "myelodysplasia")\n  (:end . 167) (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1201.9) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011169@unknown@formal@none@1@S@These data provide further information on the molecular events occurring in immune cells generated through in vivo and in vitro administration of IL-2, and further document that there is not a precise congruence between PBMC activated in vivo and in vitro by IL-2.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "administration") (:form . "administration")\n  (:end . 142) (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "document") (:form . "document") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 192) (:start . 191)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 200)\n  (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "congruence") (:form . "congruence") (:end . 211)\n  (:start . 201) (:id . 75))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 219)\n  (:start . 212) (:id . 76))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 234)\n  (:start . 225) (:id . 78))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 79))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 242) (:start . 238)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 246) (:start . 243)\n  (:id . 81))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 249) (:start . 247)\n  (:id . 82))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 255)\n  (:start . 250) (:id . 83))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 258) (:start . 256)\n  (:id . 84))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 263) (:start . 259)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x1202.10.1) (:span 187 190)))\n (:nscopes ((:id . :x1202.10.1) (:span 187 263)))\n (:identifiers (:sid . :s1202.10) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011179@unknown@formal@none@1@S@HIV-1 replication was determined by p24 antigen level.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1204.5) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011189@unknown@formal@none@1@S@In 1G5, a Jurkat-derived T cell line stably transfected with a luciferase gene driven by HIV-1 long terminal repeat (LTR), we found that PGE2 markedly enhanced HIV-1 LTR-mediated reporter gene activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "1g5") (:form . "1G5") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "jurkat-derived") (:form . "Jurkat-derived")\n  (:end . 24) (:start . 10) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 131)\n  (:start . 126) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 141) (:start . 137)\n  (:id . 69))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 150)\n  (:start . 142) (:id . 70))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 159)\n  (:start . 151) (:id . 71))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 165)\n  (:start . 160) (:id . 72))\n ((:tag . "JJ") (:stem . "ltr-mediated") (:form . "LTR-mediated") (:end . 178)\n  (:start . 166) (:id . 73))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 187)\n  (:start . 179) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 201)\n  (:start . 193) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1205.4) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011199@unknown@formal@none@1@S@The molecular events that follow and that transduce signals from these receptors to the nucleus are still poorly defined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "transduce") (:form . "transduce") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1206.4) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011209@unknown@formal@none@1@S@In this study we have analyzed changes in gene expression associated with this variable VDR expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1207.3) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011219@unknown@formal@none@1@S@In vitro studies identify three essential elements of the TATA-less blr1 core promoter that confer cell type- and differentiation-specific expression in the B cells of both humans and mice, a functional promoter region (-36 with respect to the transcription start site), a NF-kappaB motif (+44), and a noncanonical octamer motif (+157).@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . 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"motif") (:end . 328)\n  (:start . 323) (:id . 98))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 330) (:start . 329)\n  (:id . 99))\n ((:tag . "CD") (:stem . "+157") (:form . "+157") (:end . 334) (:start . 330)\n  (:id . 100))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 335) (:start . 334)\n  (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 336) (:start . 335)\n  (:id . 102)))@@@1@61@((:identifiers (:sid . :s1208.3) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011229@unknown@formal@none@1@S@When used in combination, the polyamides inhibit virus replication by >99% in isolated human peripheral blood lymphocytes, with no detectable cell toxicity.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "polyamide") (:form . "polyamides") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "CD") (:stem . ">99") (:form . ">99") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1209.6.1) (:span 128 130)))\n (:nscopes ((:id . :x1209.6.1) (:span 128 155)))\n (:identifiers (:sid . :s1209.6) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011239@unknown@formal@none@1@S@Furthermore, 30% of IkappaBalpha transfected cells were apoptotic after 8 h of TNFalpha treatment.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 32)\n  (:start . 20) (:id . 47))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1210.9) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011249@unknown@formal@none@1@S@Additionally, no tyrosine phosphorylation of HS1 was induced by mitogenic pairs of anti-CD2 mAbs capable of activating the transcription factor NFAT (nuclear factor of activated T cells).@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS1") (:form . "HS1") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 177)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1211.7.1) (:span 14 16)))\n (:nscopes ((:id . :x1211.7.1) (:span 14 186)))\n (:identifiers (:sid . :s1211.7) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011259@unknown@formal@none@1@S@IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity.@(((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "delay") (:form . "delayed") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-Myc") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Bcl-xL") (:form . "Bcl-xL") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 103) (:start . 98)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 110)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1212.6) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011269@unknown@formal@none@1@S@We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Akt/PKB") (:form . "Akt/PKB") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1213.8.1) (:span 21 32)))\n (:hscopes ((:id . :x1213.8.1) (:span 21 101)))\n (:identifiers (:sid . :s1213.8) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011279@unknown@formal@none@1@S@Diminished expression of TCRzeta and p56(lck) that are associated with the TCR and reduced nuclear localization of RelA containing nuclear factor kappaB (NFkappaB) complexes have been noted.@(((:tag . "VBN") (:stem . "diminish") (:form . "Diminished") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 111)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 152)\n  (:start . 146) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 189)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1214.3) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011289@unknown@formal@none@1@S@In patients treated with IL-2/IFN alpha-based therapy, relative levels of TCRzeta increased significantly (P = 0.002) on day 15 of cycle one compared with the baseline.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2/ifn") (:form . "IL-2/IFN") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "alpha-based") (:form . "alpha-based") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.002") (:form . "0.002") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 167)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1214.13) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011299@unknown@formal@none@1@S@Human lysosomal acid lipase (LAL) is a hydrolase required for the cleavage of cholesteryl esters and triglycerides derived from plasma lipoproteins.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipase") (:form . "lipase") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LAL") (:form . "LAL") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hydrolase") (:form . "hydrolase") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cholesteryl") (:form . "cholesteryl") (:end . 89)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "triglyceride") (:form . "triglycerides")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1215.2) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011309@unknown@formal@none@1@S@A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nongenomic") (:form . "nongenomic") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "progesterone-mediated")\n  (:form . "progesterone-mediated") (:end . 48) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 66) (:start . 49) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 78)\n  (:start . 68) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 50))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 93)\n  (:start . 85) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 147)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1216.1) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011319@unknown@formal@none@1@S@Mononuclear phagocytes play a major role in immune and inflammatory responses.@(((:tag . "JJ") (:stem . "mononuclear") (:form . "Mononuclear") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1217.2) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011329@unknown@formal@none@1@S@Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 53) (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 60)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stress-activated") (:form . "stress-activated")\n  (:end . 121) (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 57))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 137)\n  (:start . 130) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 151)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 158) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1218.1) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011339@unknown@formal@none@1@S@This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 21) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1219.3) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011349@unknown@formal@none@1@S@The purpose of this study was to examine the effects of bis[4-[2,4-dioxo-5-thiazolidinyl)methyl]phenyl]methane (YM-268), a thiazolidinedione derivative, on glucose uptake, adipocyte differentiation through peroxisome proliferator-activated receptor gamma(PPARgamma), and phosphatidylinositol 3-kinase (PI 3-kinase) activity in cultured cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN")\n  (:stem . "bis[4-[2,4-dioxo-5-thiazolidinyl)methyl]phenyl]methane")\n  (:form . "bis[4-[2,4-dioxo-5-thiazolidinyl)methyl]phenyl]methane")\n  (:end . 110) (:start . 56) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ym-268") (:form . "YM-268") (:end . 118)\n  (:start . 112) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thiazolidinedione") (:form . "thiazolidinedione")\n  (:end . 140) (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 151)\n  (:start . 141) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 155) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 163)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 170)\n  (:start . 164) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "adipocyte") (:form . "adipocyte") (:end . 181)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 197) (:start . 182) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 205)\n  (:start . 198) (:id . 68))\n ((:tag . "NN") (:stem . "peroxisome") (:form . "peroxisome") (:end . 216)\n  (:start . 206) (:id . 69))\n ((:tag . "JJ") (:stem . "proliferator-activated")\n  (:form . "proliferator-activated") (:end . 239) (:start . 217) (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 248)\n  (:start . 240) (:id . 71))\n ((:tag . "NN") (:stem . "gamma(PPARgamma)") (:form . "gamma(PPARgamma)")\n  (:end . 265) (:start . 249) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 266) (:start . 265)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 270) (:start . 267)\n  (:id . 74))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 291) (:start . 271) (:id . 75))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 300)\n  (:start . 292) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 302) (:start . 301)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 304) (:start . 302)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 313)\n  (:start . 305) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 314) (:start . 313)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 323)\n  (:start . 315) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 326) (:start . 324)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 335)\n  (:start . 327) (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 341)\n  (:start . 336) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 342) (:start . 341)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1220.2) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011359@unknown@formal@none@1@S@We determined whether the interaction of SS RBC with cultured endothelial cells induced cellular oxidant stress that would culminate in expression of cell adhesion molecules (CAMs) involved in the adhesion and diapedesis of monocytes and the adherence of SS reticulocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "VB") (:stem . "culminate") (:form . "culminate") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 173)\n  (:start . 164) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CAM") (:form . "CAMs") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 205)\n  (:start . 197) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "diapedesis") (:form . "diapedesis") (:end . 220)\n  (:start . 210) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 233)\n  (:start . 224) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 79))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 251)\n  (:start . 242) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 254) (:start . 252)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 257) (:start . 255)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "reticulocyte") (:form . "reticulocytes")\n  (:end . 271) (:start . 258) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1221.3.1) (:span 117 122))\n  ((:id . :x1221.3.2) (:span 14 21)))\n (:hscopes ((:id . :x1221.3.1) (:span 117 271))\n  ((:id . :x1221.3.2) (:span 14 271)))\n (:identifiers (:sid . :s1221.3) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011369@unknown@formal@none@1@S@TS induces the synthesis of heat shock (HS)/stress proteins (HSP), and, in particular, of Hsp70.@(((:tag . "NNP") (:stem . "TS") (:form . "TS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HS)/stress") (:form . "HS)/stress") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HSP") (:form . "HSP") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 85)\n  (:start . 75) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Hsp70") (:form . "Hsp70") (:end . 95) (:start . 90)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1222.3) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011379@unknown@formal@none@1@S@However, not only is expression of the beta-casein gene regulated by STAT5 but it is also affected by other molecules such as glucocorticoid and Ras.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 50)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 117)\n  (:start . 108) (:id . 62))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 140) (:start . 126) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1223.3) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011389@unknown@formal@none@1@S@Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstruction.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "JJ") (:stem . "ureteral") (:form . "ureteral") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "obstruction") (:form . "obstruction") (:end . 87)\n  (:start . 76) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1224.1) (:did . :|9819151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011399@unknown@formal@none@1@S@Exogenously transfected TAL1 and LMO, but not either alone, induced RALDH2 expression in a T-ALL cell line, HPB-ALL, not expressing endogeneous TAL1 or LMO.@(((:tag . "RB") (:stem . "exogenously") (:form . "Exogenously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HPB-ALL") (:form . "HPB-ALL") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 131)\n  (:start . 121) (:id . 65))\n ((:tag . "JJ") (:stem . "endogeneous") (:form . "endogeneous") (:end . 143)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "tal1") (:form . "TAL1") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1225.6.1) (:span 117 120))\n  ((:id . :x1225.6.2) (:span 42 45)))\n (:nscopes ((:id . :x1225.6.1) (:span 117 155))\n  ((:id . :x1225.6.2) (:span 42 58)))\n (:identifiers (:sid . :s1225.6) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011409@unknown@formal@none@1@S@StatG in normal immature human myeloid cells, i.e. adult CD34+ bone marrow cells, was composed of Stat3beta.@(((:tag . "NNP") (:stem . "StatG") (:form . "StatG") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Stat3beta") (:form . "Stat3beta") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1226.4) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011419@unknown@formal@none@1@S@Immunoprecipitation analysis revealed that under these circumstances, Calphostin C inhibited the production of IL-1beta protein, whereas Staurosporine allowed protein production, but inhibited its secretion.@(((:tag . "NNP") (:stem . "Immunoprecipitation")\n  (:form . "Immunoprecipitation") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 37)\n  (:start . 29) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 45))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 48) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 68) (:start . 55) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Calphostin") (:form . "Calphostin") (:end . 80)\n  (:start . 70) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 92)\n  (:start . 83) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 107)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 127)\n  (:start . 120) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 136)\n  (:start . 129) (:id . 59))\n ((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 150) (:start . 137) (:id . 60))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 158)\n  (:start . 151) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 166)\n  (:start . 159) (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 177)\n  (:start . 167) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 182) (:start . 179)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 192)\n  (:start . 183) (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 196) (:start . 193)\n  (:id . 67))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 206)\n  (:start . 197) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1227.6) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011429@unknown@formal@none@1@S@We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion molecule expression and cytokine secretion.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "porcine") (:form . "porcine") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1228.3) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011439@unknown@formal@none@1@S@The same pattern of inhibition was observed using anti-human LT sera.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-human") (:form . "anti-human") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "lt") (:form . "LT") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1228.13) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011449@unknown@formal@none@1@S@These data demonstrate the efficiency of the system and support the notion that numerous genes falling into those categories remain unidentified and that they can be cloned by this method.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "fall") (:form . "falling") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "category") (:form . "categories") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 144)\n  (:start . 132) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1229.8.1) (:span 68 74)))\n (:hscopes ((:id . :x1229.8.1) (:span 68 187)))\n (:identifiers (:sid . :s1229.8) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011459@unknown@formal@none@1@S@Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 187)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 198) (:start . 197)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 203) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 214)\n  (:start . 204) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1230.9.1) (:span 162 165))\n  ((:id . :x1230.9.2) (:span 123 129)))\n (:hscopes ((:id . :x1230.9.1) (:span 162 214))\n  ((:id . :x1230.9.2) (:span 123 214)))\n (:identifiers (:sid . :s1230.9) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011469@unknown@formal@none@1@S@BACKGROUND & AIMS: Entamoeba histolytica infection of the intestine can induce severe gut inflammation.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "&") (:form . "&") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "AIMS") (:form . "AIMS") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Entamoeba") (:form . "Entamoeba") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "histolytica") (:form . "histolytica") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "intestine") (:form . "intestine") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1232.2) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011479@unknown@formal@none@1@S@Results indicate that TIMP-1-positive BL lines show resistance to cold-shock-induced apoptosis.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "timp-1-positive") (:form . "TIMP-1-positive")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "BL") (:form . "BL") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cold-shock-induced") (:form . "cold-shock-induced")\n  (:end . 84) (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1233.4.1) (:span 8 21)))\n (:hscopes ((:id . :x1233.4.1) (:span 8 94)))\n (:identifiers (:sid . :s1233.4) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011489@unknown@formal@none@1@S@Human peripheral B cells became capable of constitutively producing p40 by in vitro transformation with EBV, coincident with the expression of latent membrane protein 1 (LMP1) of EBV.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 57) (:start . 43) (:id . 49))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 98) (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "coincident") (:form . "coincident") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 182) (:start . 179)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1234.4) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011499@unknown@formal@none@1@S@C5a induced kappaB binding activity was detected 15 min after agonist stimulation, peaked at 30-40 min, and remained detectable at 2 h.@(((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 89) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "30-40") (:form . "30-40") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1235.6) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011509@unknown@formal@none@1@S@However, it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "MEK1S218/222A") (:form . "MEK1S218/222A")\n  (:end . 128) (:start . 115) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mek1/mek2") (:form . "MEK1/MEK2") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "pd098059") (:form . "PD098059") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1236.6) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011519@unknown@formal@none@1@S@The lung macrophage was identified as the main cellular source for critical inflammatory mediators such as tumor necrosis factor-alpha, the chemokines interleukin (IL)-8 and -6, and matrix metalloproteinase-9 in this model system of mechanical ventilation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 88)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 134)\n  (:start . 122) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "CD") (:stem . "IL)-8") (:form . "IL)-8") (:end . 169)\n  (:start . 164) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-6") (:form . "-6") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 188)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "metalloproteinase-9")\n  (:form . "metalloproteinase-9") (:end . 208) (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 216) (:start . 212)\n  (:id . 74))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 222)\n  (:start . 217) (:id . 75))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 229)\n  (:start . 223) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 243)\n  (:start . 233) (:id . 78))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 255)\n  (:start . 244) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1237.5) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011529@unknown@formal@none@1@S@Interleukin-4 (IL-4) plays a major role in this process by promoting the differentiation of IL-4-secreting Th2 cells.@(((:tag . "NN") (:stem . "interleukin-4") (:form . "Interleukin-4")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 88) (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-4-secreting") (:form . "IL-4-secreting")\n  (:end . 106) (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1238.3) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011539@unknown@formal@none@1@S@Interleukin-10 (IL-10) and transforming growth factor beta (TGF-beta) are inhibitory for B and T cells, IgE production, and mast cell proliferation, and they induce apoptosis in eosinophils.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 118)\n  (:start . 108) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 147) (:start . 134) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 164)\n  (:start . 158) (:id . 72))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 174)\n  (:start . 165) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 189)\n  (:start . 178) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1239.2) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011549@unknown@formal@none@1@S@Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells.@(((:tag . "NN") (:stem . "receptor") (:form . "Receptor") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RANK") (:form . "RANK") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1240.2) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011559@unknown@formal@none@1@S@Uncontrolled replication of a virus, which is harmful to the host is also disadvantageous to the virus.@(((:tag . "JJ") (:stem . "uncontrolled") (:form . "Uncontrolled") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "harmful") (:form . "harmful") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "disadvantageous") (:form . "disadvantageous")\n  (:end . 89) (:start . 74) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1241.2) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011569@unknown@formal@none@1@S@Disturbance of both the immune surveillance as well as viral gene regulation may result in EBV-associated disease.@(((:tag . "NN") (:stem . "disturbance") (:form . "Disturbance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "surveillance") (:form . "surveillance") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ebv-associated") (:form . "EBV-associated")\n  (:end . 105) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1241.12.1) (:span 77 80)))\n (:hscopes ((:id . :x1241.12.1) (:span 77 113)))\n (:identifiers (:sid . :s1241.12) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011579@unknown@formal@none@1@S@In this review, we describe the host-cell transcription factors that interact with the 5'-UTR and discuss their role in the transcriptional regulation of HIV-1 gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "host-cell") (:form . "host-cell") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 139) (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1242.10) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011589@unknown@formal@none@1@S@Further characterization of FKHRL1 and its related family members should shed light on the transcriptional mechanisms of this fork head gene subfamily and their role in T helper cell differentiation and regulation of cell growth.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 24) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FKHRL1") (:form . "FKHRL1") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "VB") (:stem . "shed") (:form . "shed") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fork") (:form . "fork") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 177)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 198) (:start . 183) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 213)\n  (:start . 203) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 221) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 228)\n  (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1243.10.1) (:span 66 72)))\n (:hscopes ((:id . :x1243.10.1) (:span 66 228)))\n (:identifiers (:sid . :s1243.10) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011599@unknown@formal@none@1@S@Not only functional but also specific binding interactions between CIITA and CBP were demonstrated.@(((:tag . "RB") (:stem . "not") (:form . "Not") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1245.5) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011609@unknown@formal@none@1@S@In contrast, an RE/AP reporter was blocked by CTLA4Ig by >90%.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RE/AP") (:form . "RE/AP") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ctla4ig") (:form . "CTLA4Ig") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "CD") (:stem . ">90") (:form . ">90") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1246.7) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011619@unknown@formal@none@1@S@Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 101) (:start . 88) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1248.4.1) (:span 125 132))\n  ((:id . :x1248.4.2) (:span 29 32)) ((:id . :x1248.4.3) (:span 9 17)))\n (:hscopes ((:id . :x1248.4.1) (:span 125 142))\n  ((:id . :x1248.4.2) (:span 29 142)) ((:id . :x1248.4.3) (:span 9 142)))\n (:identifiers (:sid . :s1248.4) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011629@unknown@formal@none@1@S@IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 50)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 67) (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 82)\n  (:start . 76) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 97)\n  (:start . 87) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 107)\n  (:start . 98) (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1248.14) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011639@unknown@formal@none@1@S@These results define a role for NF-kappaB in mediating FasL expression during T cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "fasl") (:form . "FasL") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1249.9) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011649@unknown@formal@none@1@S@Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), or human herpesvirus 8, is a lymphotropic virus strongly linked to several AIDS-related neoplasms.@(((:tag . "NNP") (:stem . "Kaposi") (:form . "Kaposi") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sarcoma") (:form . "sarcoma") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "KS)-associated") (:form . "KS)-associated")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "KSHV") (:form . "KSHV") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 73)\n  (:start . 62) (:id . 54))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 94)\n  (:start . 82) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 127)\n  (:start . 120) (:id . 64))\n ((:tag . "JJ") (:stem . "aids-related") (:form . "AIDS-related") (:end . 140)\n  (:start . 128) (:id . 65))\n ((:tag . "NNS") (:stem . "neoplasm") (:form . "neoplasms") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1251.2) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011659@unknown@formal@none@1@S@The up-regulation of IL-1beta message could be mediated by the latent membrane protein-1, EBV nuclear proteins 2, 3, 4, and 6 genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1252.5) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011669@unknown@formal@none@1@S@A TATA-like motif was identified immediately upstream of the transcriptional start site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tata-like") (:form . "TATA-like") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 76) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1253.4) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011679@unknown@formal@none@1@S@We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 73) (:start . 60) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2)-dependent") (:form . "IL-2)-dependent")\n  (:end . 90) (:start . 75) (:id . 56))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1254.4) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011689@unknown@formal@none@1@S@Mildly oxLDLs (50 and 100 microgram/ml) decreased the number of lymphoblasts and the level of IL-2 concentration in the culture supernatants after activation of lymphocytes by phytohaemagglutinin and PMA+ionomycin.@(((:tag . "RB") (:stem . "mildly") (:form . "Mildly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "microgram/ml") (:form . "microgram/ml") (:end . 38)\n  (:start . 26) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 76)\n  (:start . 64) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 140)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 172)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "phytohaemagglutinin")\n  (:form . "phytohaemagglutinin") (:end . 195) (:start . 176) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA+ionomycin") (:form . "PMA+ionomycin")\n  (:end . 213) (:start . 200) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1255.5) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011699@unknown@formal@none@1@S@These cDNAs correspond to HMG-I and HMG-Y, isoforms regarded as architectural proteins.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HMG-Y") (:form . "HMG-Y") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "regard") (:form . "regarded") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "architectural") (:form . "architectural")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1256.6) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011709@unknown@formal@none@1@S@However, when PBMC were stimulated with LPS or IL-1beta, both C3a and C3a(desArg) were found to enhance IL-6 release by PBMC in a dose-dependent manner.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 144) (:start . 130) (:id . 67))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1257.5) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011719@unknown@formal@none@1@S@TNF and LPS stimulated vascular cell adhesion molecule (VCAM)-1 surface expression and adhesion of U-937 monocyte-like cells to HUVECs but not to HUAECs.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "VCAM)-1") (:form . "VCAM)-1") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocyte-like") (:form . "monocyte-like")\n  (:end . 118) (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "huaec") (:form . "HUAECs") (:end . 152)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1258.3.1) (:span 139 142)))\n (:nscopes ((:id . :x1258.3.1) (:span 139 152)))\n (:identifiers (:sid . :s1258.3) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011729@unknown@formal@none@1@S@Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lysophosphatidylcholine")\n  (:form . "lysophosphatidylcholine") (:end . 84) (:start . 61) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1259.1) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011739@unknown@formal@none@1@S@Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "tend") (:form . "tended") (:end . 45) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lysophospholipid") (:form . "lysophospholipid")\n  (:end . 93) (:start . 77) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1259.11) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011749@unknown@formal@none@1@S@We therefore propose that Hsp70 can be used as a vehicle for intracytoplasmic and intranuclear delivery of proteins or DNA to modulate gene expression and thereby control immune responses.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hsp70") (:form . "Hsp70") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "vehicle") (:form . "vehicle") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intracytoplasmic") (:form . "intracytoplasmic")\n  (:end . 77) (:start . 61) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intranuclear") (:form . "intranuclear") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 170)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 177)\n  (:start . 171) (:id . 69))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 187)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1260.6.1) (:span 13 20)))\n (:hscopes ((:id . :x1260.6.1) (:span 13 187)))\n (:identifiers (:sid . :s1260.6) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011759@unknown@formal@none@1@S@Phosphorylation of CREB occurred through a herbimycin A and Rp-cAMP-sensitive pathway, suggesting phosphorylation required antecedent activation of both protein tyrosine kinases (PTK) and protein kinase A (PKA).@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rp-camp-sensitive") (:form . "Rp-cAMP-sensitive")\n  (:end . 77) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 113) (:start . 98) (:id . 55))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 56))\n ((:tag . "JJ") (:stem . "antecedent") (:form . "antecedent") (:end . 133)\n  (:start . 123) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 152) (:start . 148)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 160)\n  (:start . 153) (:id . 61))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 169)\n  (:start . 161) (:id . 62))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 177)\n  (:start . 170) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 182) (:start . 179)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 195)\n  (:start . 188) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 202)\n  (:start . 196) (:id . 69))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 204) (:start . 203)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1261.10.1) (:span 87 97)))\n (:hscopes ((:id . :x1261.10.1) (:span 87 210)))\n (:identifiers (:sid . :s1261.10) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011769@unknown@formal@none@1@S@NO production by HUVECs is increased after the second A/R challenge, but not after the first A/R challenge.@(((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1262.8.1) (:span 73 76)))\n (:nscopes ((:id . :x1262.8.1) (:span 73 106)))\n (:identifiers (:sid . :s1262.8) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011779@unknown@formal@none@1@S@We previously identified a Fas ligand regulatory element (FLRE) in the Fas ligand (fasL) promoter that binds Egr family proteins and demonstrated that Egr-3 (PILOT) but not Egr-1 (NGFI-A, Krox-24, Tis-8, and Zif-268) induces transcription of fasL.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FLRE") (:form . "FLRE") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fasl") (:form . "fasL") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 108)\n  (:start . 103) (:id . 62))\n ((:tag . "NNP") (:stem . "Egr") (:form . "Egr") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 119)\n  (:start . 113) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 145)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Egr-3") (:form . "Egr-3") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PILOT") (:form . "PILOT") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 168) (:start . 165)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 172) (:start . 169)\n  (:id . 74))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 178)\n  (:start . 173) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NGFI-A") (:form . "NGFI-A") (:end . 186)\n  (:start . 180) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Krox-24") (:form . "Krox-24") (:end . 195)\n  (:start . 188) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 80))\n ((:tag . "NN") (:stem . "tis-8") (:form . "Tis-8") (:end . 202)\n  (:start . 197) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 83))\n ((:tag . "NN") (:stem . "zif-268") (:form . "Zif-268") (:end . 215)\n  (:start . 208) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 85))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 224)\n  (:start . 217) (:id . 86))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 238) (:start . 225) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 88))\n ((:tag . "NN") (:stem . "fasl") (:form . "fasL") (:end . 246) (:start . 242)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 90)))@@@1@49@((:ncues ((:id . :x1263.2.1) (:span 169 172)))\n (:nscopes ((:id . :x1263.2.1) (:span 169 216)))\n (:identifiers (:sid . :s1263.2) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011789@unknown@formal@none@1@S@Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN).@(((:tag . "NNP") (:stem . "Interleukin-8") (:form . "Interleukin-8")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha-chemokine") (:form . "alpha-chemokine")\n  (:end . 71) (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CXC") (:form . "CXC") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 148)\n  (:start . 139) (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 158)\n  (:start . 149) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 180) (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1264.2) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011799@unknown@formal@none@1@S@Moreover, each proximal P element is essential for optimal IL-4 promoter activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1265.6) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011809@unknown@formal@none@1@S@HTLV-I is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with tropical spastic paraparesis/HTLV-I-associated myelopathy.@(((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia/lymphoma") (:form . "leukemia/lymphoma")\n  (:end . 63) (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tropical") (:form . "tropical") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "spastic") (:form . "spastic") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "JJ") (:stem . "paraparesis/htlv-i-associated")\n  (:form . "paraparesis/HTLV-I-associated") (:end . 133) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "myelopathy") (:form . "myelopathy") (:end . 144)\n  (:start . 134) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1267.2) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011819@unknown@formal@none@1@S@We demonstrate the utility of using primary lymphocyte models to study HTLV-I transcription in the context of cell signaling and suggest that activated PBMC maintain elevated levels of P-CREB, which promote basal HTLV-I transcription and enhance viral persistence in vivo.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "utility") (:form . "utility") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "maintain") (:form . "maintain") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 181)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "P-CREB") (:form . "P-CREB") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 198)\n  (:start . 193) (:id . 72))\n ((:tag . "VBP") (:stem . "promote") (:form . "promote") (:end . 206)\n  (:start . 199) (:id . 73))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 212)\n  (:start . 207) (:id . 74))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 219)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 233) (:start . 220) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 245)\n  (:start . 238) (:id . 78))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 251)\n  (:start . 246) (:id . 79))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 263)\n  (:start . 252) (:id . 80))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 81))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 271) (:start . 267)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1267.12.1) (:span 129 136)))\n (:hscopes ((:id . :x1267.12.1) (:span 129 271)))\n (:identifiers (:sid . :s1267.12) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011829@unknown@formal@none@1@S@Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines.@(((:tag . "NNP") (:stem . "Lactobacilli") (:form . "Lactobacilli") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "vaginal") (:form . "vaginal") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "flora") (:form . "flora") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 94) (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "HIV)-1") (:form . "HIV)-1") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 149)\n  (:start . 143) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 162)\n  (:start . 152) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 172)\n  (:start . 167) (:id . 72))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 183)\n  (:start . 173) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 194)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1269.2) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011839@unknown@formal@none@1@S@We first demonstrate that an HIV-1 provirus (SF-2 strain) very effectively replicates in thymocytes cocultured with TEC whereas this provirus, with kappaB sites deleted, fails to replicate.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sf-2") (:form . "SF-2") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "VBZ") (:stem . "replicate") (:form . "replicates") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "VBN") (:stem . "coculture") (:form . "cocultured") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 168)\n  (:start . 161) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 188)\n  (:start . 179) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1270.4.1) (:span 170 175)))\n (:nscopes ((:id . :x1270.4.1) (:span 170 188)))\n (:identifiers (:sid . :s1270.4) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011849@unknown@formal@none@1@S@However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "synovitis") (:form . "synovitis") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1271.3.1) (:span 111 118)))\n (:hscopes ((:id . :x1271.3.1) (:span 9 118)))\n (:identifiers (:sid . :s1271.3) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011859@unknown@formal@none@1@S@At 10 to 100 micromol/L for >24 hours, oleate inhibited the expression of all adhesion molecules tested.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "micromol/l") (:form . "micromol/L") (:end . 23)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . ">24") (:form . ">24") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oleate") (:form . "oleate") (:end . 45)\n  (:start . 39) (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1272.5) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011869@unknown@formal@none@1@S@Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cbp/p300") (:form . "CBP/p300") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Stat1") (:form . "Stat1") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CBP/p300") (:form . "CBP/p300") (:end . 192)\n  (:start . 184) (:id . 70))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 204)\n  (:start . 197) (:id . 72))\n ((:tag . "NN") (:stem . "il-2-") (:form . "IL-2-") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "ifngamma-dependent") (:form . "IFNgamma-dependent")\n  (:end . 233) (:start . 215) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 247) (:start . 234) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1273.5.1) (:span 19 24)))\n (:nscopes ((:id . :x1273.5.1) (:span 19 71)))\n (:identifiers (:sid . :s1273.5) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5100009@unknown@formal@none@1@S@Assuming that the 23rd amino acid is also encoded by a stop codon, we systematically predicted proteins that contain stop-codon-encoded amino acids from 191 prokaryotic genomes.@(((:tag . "VBG") (:stem . "assume") (:form . "Assuming") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "RB") (:stem . "systematically") (:form . "systematically")\n  (:end . 84) (:start . 70) (:id . 57))\n ((:tag . "VBD") (:stem . "predict") (:form . "predicted") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 135) (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1.10.1) (:span 0 8)))\n (:hscopes ((:id . :x1.10.1) (:span 0 65)))\n (:identifiers (:sid . :s1.10) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100019@unknown@formal@none@1@S@Two such amino acids have been discovered to date: selenocysteine 34 and pyrrolysine 56.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 65) (:start . 51) (:id . 52))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "CD") (:stem . "56") (:form . "56") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.20) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100029@unknown@formal@none@1@S@Because genome sequences of various prokaryotes are available today, there will be a chance to discover the novel amino acid via analysis of these genomes.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "today") (:form . "today") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "discover") (:form . "discover") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1.30) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100039@unknown@formal@none@1@S@By enumerating ORFs that have an inframe stop codon from genomes and examining their evolutionary conservation, candidate proteins can be predicted.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "enumerate") (:form . "enumerating") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 84)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.40) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100049@unknown@formal@none@1@S@If we enumerate all iORFs from microbial genomes, most of the readthrough genes will be included in them.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "enumerate") (:form . "enumerate") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 73)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "include") (:form . "included") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.50) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100059@unknown@formal@none@1@S@(a) Schematic illustration of an interrupted ORF (iORF).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "schematic") (:form . "Schematic") (:end . 13)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "illustration") (:form . "illustration") (:end . 26)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "interrupted") (:form . "interrupted") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORF") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "iORF") (:form . "iORF") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.60) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100069@unknown@formal@none@1@S@In this way, they can be eliminated as candidates.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "eliminate") (:form . "eliminated") (:end . 35)\n  (:start . 25) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 49)\n  (:start . 39) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.70) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100079@unknown@formal@none@1@S@The prediction schema is shown in Figure 2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "schema") (:form . "schema") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.80) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100089@unknown@formal@none@1@S@A flowchart of the prediction procedure@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "flowchart") (:form . "flowchart") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 39)\n  (:start . 30) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.90) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100099@unknown@formal@none@1@S@There were 94,690 iORFs that have interspecific hits.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "94,690") (:form . "94,690") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "interspecific") (:form . "interspecific")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.100) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100109@unknown@formal@none@1@S@Hence, three-step filtering procedures were applied to remove the false positives.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "three-step") (:form . "three-step") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "filtering") (:form . "filtering") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "procedure") (:form . "procedures") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "remove") (:form . "remove") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.110) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100119@unknown@formal@none@1@S@Of the 14 families, 11 were found in our prediction result.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 51)\n  (:start . 41) (:id . 52))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.120) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100129@unknown@formal@none@1@S@For example, "GSU2293 + downstream" means that the iORF consists of the gene GSU2293 and its downstream sequence.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GSU2293") (:form . "GSU2293") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "downstream") (:form . "downstream") (:end . 34)\n  (:start . 24) (:id . 48))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gsu2293") (:form . "GSU2293") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 103)\n  (:start . 93) (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.130) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100139@unknown@formal@none@1@S@The rest is a cluster of TetR-like transcriptional regulators from Methanosarcina acetivorans and M. barkeri.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rest") (:form . "rest") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tetr-like") (:form . "TetR-like") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Methanosarcina") (:form . "Methanosarcina")\n  (:end . 81) (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "acetivorans") (:form . "acetivorans") (:end . 93)\n  (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "barkeri") (:form . "barkeri") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.140) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100149@unknown@formal@none@1@S@There were two such clusters (Table 1).@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.150) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100159@unknown@formal@none@1@S@A protein Dpro_2 contains yet another inframe stop codon (TAG) at the column 189.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "dpro_2") (:form . "Dpro_2") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 76)\n  (:start . 70) (:id . 56))\n ((:tag . "CD") (:stem . "189") (:form . "189") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.160) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100169@unknown@formal@none@1@S@However, computational analysis of sequences immediately downstream of the inframe stop codons failed to identify SECIS elements, which is a hallmark of selenocysteine-containing genes.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "secis") (:form . "SECIS") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hallmark") (:form . "hallmark") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "selenocysteine-containing")\n  (:form . "selenocysteine-containing") (:end . 178) (:start . 153)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 184)\n  (:start . 179) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1.170.1) (:span 95 101)))\n (:nscopes ((:id . :x1.170.1) (:span 95 128)))\n (:identifiers (:sid . :s1.170) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100179@unknown@formal@none@1@S@Stop codon usage in the pre-filtering clusters@(((:tag . "NNP") (:stem . "Stop") (:form . "Stop") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 46)\n  (:start . 38) (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.180) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100189@unknown@formal@none@1@S@Discrepancies of stop codon usages between the inframe and C-terminal stop codons@(((:tag . "NNS") (:stem . "discrepancy") (:form . "Discrepancies") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "usage") (:form . "usages") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 81)\n  (:start . 75) (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.190) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100199@unknown@formal@none@1@S@Sensitivity of this test is not high because many organisms that utilize selenocysteine were below the defined threshold.@(((:tag . "NN") (:stem . "sensitivity") (:form . "Sensitivity") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "utilize") (:form . "utilize") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 87) (:start . 73) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.200) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100209@unknown@formal@none@1@S@Perrodou et al. 19 constructed a database of predicted recoding events in microbes.@(((:tag . "NNP") (:stem . "Perrodou") (:form . "Perrodou") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "VBG") (:stem . "recode") (:form . "recoding") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "microbe") (:form . "microbes") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.210) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100219@unknown@formal@none@1@S@Dimethylamine methyltransferases also lack non-readthrough homologs.@(((:tag . "NNP") (:stem . "Dimethylamine") (:form . "Dimethylamine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "methyltransferas") (:form . "methyltransferases")\n  (:end . 32) (:start . 14) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 42) (:start . 38)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 58) (:start . 43) (:id . 46))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 67)\n  (:start . 59) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 48)))@@@1@7@((:ncues ((:id . :x1.220.1) (:span 38 42)))\n (:nscopes ((:id . :x1.220.1) (:span 38 67)))\n (:identifiers (:sid . :s1.220) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100229@unknown@formal@none@1@S@However, almost no novel candidates for readthrough genes were predicted.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.230) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100239@unknown@formal@none@1@S@Yet another possibility is that the 23rd amino acid exists but is not encoded by stop codons.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1.240.2) (:span 12 23)))\n (:ncues ((:id . :x1.240.1) (:span 66 69)))\n (:hscopes ((:id . :x1.240.2) (:span 12 92)))\n (:nscopes ((:id . :x1.240.1) (:span 66 92)))\n (:identifiers (:sid . :s1.240) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100249@unknown@formal@none@1@S@Such selenoproteins identified through our screening of nearly 200 microbial genomes were selenoprotein A and only one uncertain candidate.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 103) (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "uncertain") (:form . "uncertain") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.250) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100259@unknown@formal@none@1@S@Although many of the currently known selenoproteins and pyrrolysine proteins were successfully detected, no candidate for the 23rd amino acid was discovered.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 51) (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 67)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1.260.1) (:span 105 107)))\n (:nscopes ((:id . :x1.260.1) (:span 105 156)))\n (:identifiers (:sid . :s1.260) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100269@unknown@formal@none@1@S@A total of 328 complete genome sequences of prokaryotes were downloaded from the KEGG FTP site 25 in April 2006.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "328") (:form . "328") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "KEGG") (:form . "KEGG") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "FTP") (:form . "FTP") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "April") (:form . "April") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.270) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100279@unknown@formal@none@1@S@Similarly, iORFs were compared with RNA genes using BLASTN, and those matched with the RNAs were removed.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BLASTN") (:form . "BLASTN") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "match") (:form . "matched") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.280) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100289@unknown@formal@none@1@S@Subsequently, conservation of the inframe stop codons in each cluster was examined.@(((:tag . "RB") (:stem . "subsequently") (:form . "Subsequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.290) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100299@unknown@formal@none@1@S@Then, 2Δl = 2(lfree – lfix) approximately follows the χ2 distribution with one degree of freedom.@(((:tag . "RB") (:stem . "then") (:form . "Then") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "2δl") (:form . "2Δl") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "FW") (:stem . "2(lfree") (:form . "2(lfree") (:end . 19)\n  (:start . 12) (:id . 46))\n ((:tag . "NN") (:stem . "–") (:form . "–") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lfix") (:form . "lfix") (:end . 26) (:start . 22)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 41) (:start . 28) (:id . 50))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "χ2") (:form . "χ2") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 69)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "freedom") (:form . "freedom") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.300) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100309@unknown@formal@none@1@S@If the N- and C-terminal parts of an iORF have distinct but closely arranged BLAST hits in other genomes, it strongly suggests the iORF is actually two adjacent genes.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "N-") (:form . "N-") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 24)\n  (:start . 14) (:id . 46))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "VBN") (:stem . "arrange") (:form . "arranged") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "RB") (:stem . "actually") (:form . "actually") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 160)\n  (:start . 152) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1.310.1) (:span 118 126)))\n (:hscopes ((:id . :x1.310.1) (:span 118 166)))\n (:identifiers (:sid . :s1.310) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100319@unknown@formal@none@1@S@The matrix elements were subsequently normalized to the number of alignments N.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "normalize") (:form . "normalized") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.320) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100329@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.3) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100339@unknown@formal@none@1@S@Comparison of the prediction dataset to other available human interaction datasets estimates the false positive rate of the new method to be below 80% which is competitive with other methods.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "VBZ") (:stem . "estimate") (:form . "estimates") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 171)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 190)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x2.13.1) (:span 83 92)))\n (:hscopes ((:id . :x2.13.1) (:span 83 190)))\n (:identifiers (:sid . :s2.13) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100349@unknown@formal@none@1@S@Interactions determined by high-throughput methods are generally considered to be less reliable than those obtained by low-throughput studies 1314 and as a consequence efforts are also underway to extract evidence for interactions from the literature 151617.@(((:tag . "NNS") (:stem . "interaction") (:form . "Interactions") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 42) (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 50)\n  (:start . 43) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 64)\n  (:start . 55) (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "reliable") (:form . "reliable") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "low-throughput") (:form . "low-throughput")\n  (:end . 133) (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . "CD") (:stem . "1314") (:form . "1314") (:end . 146) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 167)\n  (:start . 156) (:id . 64))\n ((:tag . "NNS") (:stem . "effort") (:form . "efforts") (:end . 175)\n  (:start . 168) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 179) (:start . 176)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "underway") (:form . "underway") (:end . 193)\n  (:start . 185) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "VB") (:stem . "extract") (:form . "extract") (:end . 204)\n  (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 213)\n  (:start . 205) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 217) (:start . 214)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 230)\n  (:start . 218) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 235) (:start . 231)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 75))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 250)\n  (:start . 240) (:id . 76))\n ((:tag . "CD") (:stem . "151617") (:form . "151617") (:end . 257)\n  (:start . 251) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x2.23.1) (:span 65 75)))\n (:hscopes ((:id . :x2.23.1) (:span 0 141)))\n (:identifiers (:sid . :s2.23) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100359@unknown@formal@none@1@S@For example, the major complexes in yeast have been predicted by this strategy 25.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.33) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100369@unknown@formal@none@1@S@4) Predictors based on functional features exploit non-sequence information to infer interactions.@(((:tag . "LS") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 2) (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "predictor") (:form . "Predictors") (:end . 13)\n  (:start . 3) (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "exploit") (:form . "exploit") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "non-sequence") (:form . "non-sequence") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "VB") (:stem . "infer") (:form . "infer") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 97)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.43) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100379@unknown@formal@none@1@S@Although, many computational methods have investigated the prediction of protein-protein interactions, few have so far been applied to the human proteome.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 88) (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 101)\n  (:start . 89) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.53) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100389@unknown@formal@none@1@S@Results and discussion@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "discussion") (:form . "discussion") (:end . 22)\n  (:start . 12) (:id . 44)))@@@1@3@((:identifiers (:sid . :s2.63) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100399@unknown@formal@none@1@S@In the absence of the Transitive module, the Preliminary Score is used as the final likelihood ratio output by the predictor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "Preliminary") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "score") (:form . "Score") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x2.73.1) (:span 7 14)))\n (:nscopes ((:id . :x2.73.1) (:span 7 39)))\n (:identifiers (:sid . :s2.73) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100409@unknown@formal@none@1@S@The final likelihood ratio is then the product of the preliminary score calculated in panel A and the likelihood ratio output by the transitive module in panel B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 150)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.83) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100419@unknown@formal@none@1@S@The evaluation of this ratio is difficult because not all true interactions are known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 75)\n  (:start . 63) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.93) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100429@unknown@formal@none@1@S@However, since the highest likelihood ratio for the expression datasets that we consider is 33, they are not sufficient on their own to predict interacting protein pairs with a posterior odds ratio above 1.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "dataset") (:form . "datasets") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 155)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 69))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 169)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 176) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 186)\n  (:start . 177) (:id . 73))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 191) (:start . 187)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 197)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 205) (:start . 204)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x2.103.1) (:span 105 108)))\n (:nscopes ((:id . :x2.103.1) (:span 105 205)))\n (:identifiers (:sid . :s2.103) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100439@unknown@formal@none@1@S@Additionally, this combination circumvents possible problems of dependence between these features.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "circumvent") (:form . "circumvents") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "problem") (:form . "problems") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x2.113.1) (:span 43 51)))\n (:hscopes ((:id . :x2.113.1) (:span 43 97)))\n (:identifiers (:sid . :s2.113) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100449@unknown@formal@none@1@S@When investigated as a separate feature, the chi-square score of co-occurrence of domain pairs correlates well with the likelihood of interaction of protein pairs that contain these domains, with the highest chi-square score bin obtaining a likelihood ratio of 14, as shown in Figure 3A.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "chi-square") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 175)\n  (:start . 168) (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 189)\n  (:start . 182) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 195) (:start . 191)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 207)\n  (:start . 200) (:id . 74))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "chi-square") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 228) (:start . 225)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "obtain") (:form . "obtaining") (:end . 238)\n  (:start . 229) (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 240) (:start . 239)\n  (:id . 79))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 251)\n  (:start . 241) (:id . 80))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 257)\n  (:start . 252) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 260) (:start . 258)\n  (:id . 82))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 263) (:start . 261)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 264) (:start . 263)\n  (:id . 84))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 267) (:start . 265)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 273)\n  (:start . 268) (:id . 86))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 276) (:start . 274)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 283)\n  (:start . 277) (:id . 88))\n ((:tag . "NN") (:stem . "3a") (:form . "3A") (:end . 286) (:start . 284)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 287) (:start . 286)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s2.123) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100459@unknown@formal@none@1@S@The transitive module enhances the preliminary likelihood score (PS) (calculated using the group A modules) by considering the local topology of the resulting network which is assessed using the neighborhood topology score as detailed in the Methods section.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PS") (:form . "PS") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 184)\n  (:start . 176) (:id . 72))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 190) (:start . 185)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "NN") (:stem . "neighborhood") (:form . "neighborhood") (:end . 207)\n  (:start . 195) (:id . 75))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 225) (:start . 223)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "detail") (:form . "detailed") (:end . 234)\n  (:start . 226) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Methods") (:form . "Methods") (:end . 249)\n  (:start . 242) (:id . 82))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 257)\n  (:start . 250) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s2.133) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100469@unknown@formal@none@1@S@Independence of all modules used in our predictor was verified by calculating Pearson correlation coefficients for all pairs of modules.@(((:tag . "NN") (:stem . "independence") (:form . "Independence") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "verify") (:form . "verified") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "calculate") (:form . "calculating") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "coefficient") (:form . "coefficients") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.143) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100479@unknown@formal@none@1@S@Table 3 summarizes the characteristics of 19 different predictors and shows accuracy measures.@(((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "summarize") (:form . "summarizes") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.153) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100489@unknown@formal@none@1@S@As the scores of the predictors increase, so do the number of interactions predicted above different posterior odds ratio thresholds (see lower portion of Table 3).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 74)\n  (:start . 62) (:id . 55))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "threshold") (:form . "thresholds") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 143) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.163) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100499@unknown@formal@none@1@S@It is this predictor that is further analyzed in the next sections.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.173) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100509@unknown@formal@none@1@S@As shown in Table 4, the predictors trained on datasets containing 100 times more negatives than positives perform significantly better than those trained on datasets containing equal numbers of positives and negatives.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 35)\n  (:start . 25) (:id . 49))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "VBP") (:stem . "perform") (:form . "perform") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 166)\n  (:start . 158) (:id . 67))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 177)\n  (:start . 167) (:id . 68))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 183)\n  (:start . 178) (:id . 69))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 191)\n  (:start . 184) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 204)\n  (:start . 195) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 218)\n  (:start . 209) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.183) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100519@unknown@formal@none@1@S@A criticism of randomly chosen negatives is that they will contain some true interactors.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "criticism") (:form . "criticism") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.193) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100529@unknown@formal@none@1@S@The localization-derived negative trained predictor tested on sets containing localization-derived negatives achieves a lower accuracy than that of the random negative trained predictor tested on a test set containing randomly-generated negatives (0.0686 +/- 0.0010 vs 0.0747 +/- 0.0022).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 24) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 33)\n  (:start . 25) (:id . 44))\n ((:tag . "JJ") (:stem . "trained") (:form . "trained") (:end . 41)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 51)\n  (:start . 42) (:id . 46))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 58) (:start . 52)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 98) (:start . 78) (:id . 51))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 108)\n  (:start . 99) (:id . 52))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 117)\n  (:start . 109) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 125) (:start . 120)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 134)\n  (:start . 126) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 139) (:start . 135)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 158)\n  (:start . 152) (:id . 61))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 167)\n  (:start . 159) (:id . 62))\n ((:tag . "JJ") (:stem . "trained") (:form . "trained") (:end . 175)\n  (:start . 168) (:id . 63))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 185)\n  (:start . 176) (:id . 64))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 192)\n  (:start . 186) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 195) (:start . 193)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 67))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 202) (:start . 198)\n  (:id . 68))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 206) (:start . 203)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 217)\n  (:start . 207) (:id . 70))\n ((:tag . "JJ") (:stem . "randomly-generated") (:form . "randomly-generated")\n  (:end . 236) (:start . 218) (:id . 71))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 246)\n  (:start . 237) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 248) (:start . 247)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0.0686") (:form . "0.0686") (:end . 254)\n  (:start . 248) (:id . 74))\n ((:tag . "SYM") (:stem . "+/-") (:form . "+/-") (:end . 258) (:start . 255)\n  (:id . 75))\n ((:tag . "CD") (:stem . "0.0010") (:form . "0.0010") (:end . 265)\n  (:start . 259) (:id . 76))\n ((:tag . "IN") (:stem . "vs") (:form . "vs") (:end . 268) (:start . 266)\n  (:id . 77))\n ((:tag . "CD") (:stem . "0.0747") (:form . "0.0747") (:end . 275)\n  (:start . 269) (:id . 78))\n ((:tag . "SYM") (:stem . "+/-") (:form . "+/-") (:end . 279) (:start . 276)\n  (:id . 79))\n ((:tag . "CD") (:stem . "0.0022") (:form . "0.0022") (:end . 286)\n  (:start . 280) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 287) (:start . 286)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s2.203) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100539@unknown@formal@none@1@S@As shown in Figure 4A, all modules contribute positively (i.e. contribute a likelihood ratio greater than 1.0) to the prediction of a certain proportion of the interactions in the LR400 dataset.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "4a") (:form . "4A") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 128)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 152)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 172)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 185)\n  (:start . 180) (:id . 74))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 193)\n  (:start . 186) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.213) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100549@unknown@formal@none@1@S@Few interactions in the LR400 dataset are predicted on the basis of having interacting orthologs in worm or fly alone.@(((:tag . "JJ") (:stem . "few") (:form . "Few") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 74) (:start . 68)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "worm") (:form . "worm") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.223) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100559@unknown@formal@none@1@S@The Combined and Transitive modules contribute the most to the prediction of interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "combined") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.233) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100569@unknown@formal@none@1@S@The right side of the curve illustrates the number of interactions that are predicted above likelihood ratios of 400 and more.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "right") (:form . "right") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "curve") (:form . "curve") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "illustrate") (:form . "illustrates") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.243) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100579@unknown@formal@none@1@S@As the posterior odds ratio increases, the false positive rate decreases and the ratio of the true positive rate divided by the false positive ratio increases.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.253) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100589@unknown@formal@none@1@S@We estimated false positive rates for each of the datasets by comparing them two by two to one of the reference datasets, thus generating 4 to 6 different estimates of false positive rates for each computational dataset, as shown in Figure 6A (the two Lehner datasets were not compared to each other, which is why they have fewer FPR estimates).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "estimate") (:form . "estimated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 111)\n  (:start . 102) (:id . 62))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 120)\n  (:start . 112) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "generate") (:form . "generating") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 154)\n  (:start . 145) (:id . 70))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 164)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 173)\n  (:start . 168) (:id . 73))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 192) (:start . 189)\n  (:id . 76))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 197) (:start . 193)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 211) (:start . 198) (:id . 78))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 219)\n  (:start . 212) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 223) (:start . 221)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 229)\n  (:start . 224) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 239)\n  (:start . 233) (:id . 84))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 242) (:start . 240)\n  (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 244) (:start . 243)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 87))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 251) (:start . 248)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 258)\n  (:start . 252) (:id . 89))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 267)\n  (:start . 259) (:id . 90))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 272) (:start . 268)\n  (:id . 91))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 276) (:start . 273)\n  (:id . 92))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 285)\n  (:start . 277) (:id . 93))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 288) (:start . 286)\n  (:id . 94))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 293) (:start . 289)\n  (:id . 95))\n ((:tag . "NN") (:stem . "other") (:form . "other") (:end . 299)\n  (:start . 294) (:id . 96))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 300) (:start . 299)\n  (:id . 97))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 306)\n  (:start . 301) (:id . 98))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 309) (:start . 307)\n  (:id . 99))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 313) (:start . 310)\n  (:id . 100))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 318) (:start . 314)\n  (:id . 101))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 323) (:start . 319)\n  (:id . 102))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 329) (:start . 324)\n  (:id . 103))\n ((:tag . "NN") (:stem . "fpr") (:form . "FPR") (:end . 333) (:start . 330)\n  (:id . 104))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 343)\n  (:start . 334) (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 344) (:start . 343)\n  (:id . 106))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 345) (:start . 344)\n  (:id . 107)))@@@1@66@((:ncues ((:id . :x2.263.1) (:span 273 276)))\n (:nscopes ((:id . :x2.263.1) (:span 243 299)))\n (:identifiers (:sid . :s2.263) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100599@unknown@formal@none@1@S@The number and overlap of distinct proteins (shown in B) and distinct interactions (shown in C) are shown for the LR400 dataset, the Rhodes prediction dataset and the June 2006 version of the HPRD.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 82)\n  (:start . 70) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 105)\n  (:start . 100) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 119)\n  (:start . 114) (:id . 66))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 127)\n  (:start . 120) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 139)\n  (:start . 133) (:id . 70))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 150)\n  (:start . 140) (:id . 71))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 158)\n  (:start . 151) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 171) (:start . 167)\n  (:id . 75))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 176) (:start . 172)\n  (:id . 76))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 184)\n  (:start . 177) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 196) (:start . 192)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s2.273) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100609@unknown@formal@none@1@S@Using such a threshold, the authors claim to predict 180 010 human interactions.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "VBP") (:stem . "claim") (:form . "claim") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "CD") (:stem . "180") (:form . "180") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "CD") (:stem . "010") (:form . "010") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.283) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100619@unknown@formal@none@1@S@Such examples include interactions that allow the formation of well-known protein complexes such as the proteasome, the MCM protein complex involved in the initiation of genome replication, replication factor C, the TBP/TAF complex (TBP-associated factors) and the EIF complex (eukaryotic translation initiation factors).@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "allow") (:form . "allow") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MCM") (:form . "MCM") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 176)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 188)\n  (:start . 177) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 201)\n  (:start . 190) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 208)\n  (:start . 202) (:id . 72))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TBP/TAF") (:form . "TBP/TAF") (:end . 223)\n  (:start . 216) (:id . 76))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 231)\n  (:start . 224) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "tbp-associated") (:form . "TBP-associated")\n  (:end . 247) (:start . 233) (:id . 79))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 255)\n  (:start . 248) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 256) (:start . 255)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 260) (:start . 257)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 264) (:start . 261)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "EIF") (:form . "EIF") (:end . 268) (:start . 265)\n  (:id . 84))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 276)\n  (:start . 269) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 278) (:start . 277)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 288)\n  (:start . 278) (:id . 87))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 300)\n  (:start . 289) (:id . 88))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 311)\n  (:start . 301) (:id . 89))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 319)\n  (:start . 312) (:id . 90))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 320) (:start . 319)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 321) (:start . 320)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s2.293) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100629@unknown@formal@none@1@S@-TCPTP was predicted to interact with STAT6 at a posterior odds ratio of 4300.@(((:tag . "NNP") (:stem . "-TCPTP") (:form . "-TCPTP") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4300") (:form . "4300") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.303) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100639@unknown@formal@none@1@S@-Sam68 and Smad2 achieve a predicted posterior odds ratio of 32.@(((:tag . "NNP") (:stem . "-Sam68") (:form . "-Sam68") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Smad2") (:form . "Smad2") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.313) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100649@unknown@formal@none@1@S@A subset of our novel predictions have been independently validated by identifying recent reports that experimentally investigated and confirmed that these protein pairs do interact.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "validate") (:form . "validated") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 117) (:start . 103) (:id . 57))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 130)\n  (:start . 118) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 144)\n  (:start . 135) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 169)\n  (:start . 164) (:id . 64))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.323) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100659@unknown@formal@none@1@S@Additionally, some proteins were not recovered in the conversion between different identifiers.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "identifier") (:form . "identifiers") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x2.333.1) (:span 33 36)))\n (:nscopes ((:id . :x2.333.1) (:span 14 94)))\n (:identifiers (:sid . :s2.333) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100669@unknown@formal@none@1@S@In addition, positive to negative ratios of 1:1 and 1:100 were considered.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1:1") (:form . "1:1") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1:100") (:form . "1:100") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.343) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100679@unknown@formal@none@1@S@The transparency of the method allows the straightforward determination of which features are most predictive of interaction at the level of the whole proteome as well as for individual protein pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transparency") (:form . "transparency") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "straightforward") (:form . "straightforward")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 185)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 71))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.353) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100689@unknown@formal@none@1@S@When a particular state of a feature occurs only in positive examples (known interacting proteins), the likelihoods are set to the highest non-infinite value of any state for that feature (to avoid infinite values).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . "JJ") (:stem . "non-infinite") (:form . "non-infinite") (:end . 151)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 187)\n  (:start . 180) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 76))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 197)\n  (:start . 192) (:id . 77))\n ((:tag . "JJ") (:stem . "infinite") (:form . "infinite") (:end . 206)\n  (:start . 198) (:id . 78))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 213)\n  (:start . 207) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s2.363) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100699@unknown@formal@none@1@S@Thus, between the two releases of the HPRD, there was a large increase in the number of interactions for this subset of proteins and this is likely to continue for at least the next few releases.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "release") (:form . "releases") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 49) (:start . 44)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 61) (:start . 56)\n  (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 84)\n  (:start . 78) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 100)\n  (:start . 88) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 116)\n  (:start . 110) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 137) (:start . 133)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 147)\n  (:start . 141) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "VB") (:stem . "continue") (:form . "continue") (:end . 159)\n  (:start . 151) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 172)\n  (:start . 167) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 181) (:start . 177)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 185) (:start . 182)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "release") (:form . "releases") (:end . 194)\n  (:start . 186) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x2.373.1) (:span 141 147)))\n (:hscopes ((:id . :x2.373.1) (:span 133 194)))\n (:identifiers (:sid . :s2.373) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100709@unknown@formal@none@1@S@Pearson correlations were calculated for all 56620761 transcript pairs and correlation values were grouped into 20 bins of increasing co-expression.@(((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "correlation") (:form . "correlations") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "CD") (:stem . "56620761") (:form . "56620761") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 106)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 147) (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.383) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100719@unknown@formal@none@1@S@The orthology module has four additional bins: two bin for human pairs that have interacting paralogs in human (a medium and a low confidence bin which use the same definition as above for the model organisms), one bin for human pairs that have interacting homologs in more than one organism (these can be orthologs in yeast, worm or fly, or paralogs in human) and one bin for human pairs that have only non-interacting orthologs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "orthology") (:form . "orthology") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "NNS") (:stem . "paralog") (:form . "paralogs") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 175)\n  (:start . 165) (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 178) (:start . 176)\n  (:id . 74))\n ((:tag . "RB") (:stem . "above") (:form . "above") (:end . 184)\n  (:start . 179) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 77))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 198)\n  (:start . 193) (:id . 78))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 208)\n  (:start . 199) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 81))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 214) (:start . 211)\n  (:id . 82))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 218) (:start . 215)\n  (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 222) (:start . 219)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 228)\n  (:start . 223) (:id . 85))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 234)\n  (:start . 229) (:id . 86))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 239) (:start . 235)\n  (:id . 87))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 244) (:start . 240)\n  (:id . 88))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 256)\n  (:start . 245) (:id . 89))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 265)\n  (:start . 257) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 268) (:start . 266)\n  (:id . 91))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 273) (:start . 269)\n  (:id . 92))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 278) (:start . 274)\n  (:id . 93))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 282) (:start . 279)\n  (:id . 94))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 291)\n  (:start . 283) (:id . 95))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 293) (:start . 292)\n  (:id . 96))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 298)\n  (:start . 293) (:id . 97))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 302) (:start . 299)\n  (:id . 98))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 305) (:start . 303)\n  (:id . 99))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 315)\n  (:start . 306) (:id . 100))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 318) (:start . 316)\n  (:id . 101))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 324)\n  (:start . 319) (:id . 102))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 325) (:start . 324)\n  (:id . 103))\n ((:tag . "NN") (:stem . "worm") (:form . "worm") (:end . 330) (:start . 326)\n  (:id . 104))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 333) (:start . 331)\n  (:id . 105))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 337) (:start . 334)\n  (:id . 106))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 338) (:start . 337)\n  (:id . 107))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 341) (:start . 339)\n  (:id . 108))\n ((:tag . "NNS") (:stem . "paralog") (:form . "paralogs") (:end . 350)\n  (:start . 342) (:id . 109))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 353) (:start . 351)\n  (:id . 110))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 359)\n  (:start . 354) (:id . 111))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 360) (:start . 359)\n  (:id . 112))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 364) (:start . 361)\n  (:id . 113))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 368) (:start . 365)\n  (:id . 114))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 372) (:start . 369)\n  (:id . 115))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 376) (:start . 373)\n  (:id . 116))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 382)\n  (:start . 377) (:id . 117))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 388)\n  (:start . 383) (:id . 118))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 393) (:start . 389)\n  (:id . 119))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 398) (:start . 394)\n  (:id . 120))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 403) (:start . 399)\n  (:id . 121))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 419) (:start . 404) (:id . 122))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 429)\n  (:start . 420) (:id . 123))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 430) (:start . 429)\n  (:id . 124)))@@@1@83@((:identifiers (:sid . :s2.393) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100729@unknown@formal@none@1@S@Additionally, Pfam 74 domain pairs known to interact from three-dimensional structures 75 were included in the highest Chi-square score bin.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "74") (:form . "74") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "three-dimensional") (:form . "three-dimensional")\n  (:end . 75) (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "include") (:form . "included") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "Chi-square") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.403) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100739@unknown@formal@none@1@S@Disorder module@(((:tag . "NN") (:stem . "disorder") (:form . "Disorder") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 15) (:start . 9)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.413) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100749@unknown@formal@none@1@S@It does this by considering the local topology of the network predicted by the integration of the Group A modules as depicted in Figure 2.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "depict") (:form . "depicted") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.423) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100759@unknown@formal@none@1@S@For a given set of neighbors, T increases as the interactions with these neighbors become more likely (as the sum of se increases).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "neighbor") (:form . "neighbors") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 41)\n  (:start . 32) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 61)\n  (:start . 49) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "neighbor") (:form . "neighbors") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sum") (:form . "sum") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "se") (:form . "se") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 129)\n  (:start . 120) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.433) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100769@unknown@formal@none@1@S@Accuracy measurements@(((:tag . "NN") (:stem . "accuracy") (:form . "Accuracy") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "measurement") (:form . "measurements") (:end . 21)\n  (:start . 9) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.443) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100779@unknown@formal@none@1@S@The area under ROC curves is often used as a summary measure of accuracy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ROC") (:form . "ROC") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "summary") (:form . "summary") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.453) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100789@unknown@formal@none@1@S@SCOPE outperformed a broad range of existing motif discovery algorithms on the same dataset by a statistically significant margin.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "outperforme") (:form . "outperformed") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 110) (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s3.9) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100799@unknown@formal@none@1@S@Motif finding programs rely on a search algorithm to optimize a motif model (an abstract representation of a set of transcription factor binding sites).@(((:tag . "NN") (:stem . "motif") (:form . "Motif") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "rely") (:form . "rely") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "optimize") (:form . "optimize") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "abstract") (:form . "abstract") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "representation") (:form . "representation")\n  (:end . 103) (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s3.19) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100809@unknown@formal@none@1@S@Even assuming that optimal parameter settings exist for a motif finding program for each specific situation, for the typical biologist looking to identify motifs in a set of uncharacterized sequences, acquiring such expertise is an onerous task.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "assume") (:form . "assuming") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "situation") (:form . "situation") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "biologist") (:form . "biologist") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "VBG") (:stem . "look") (:form . "looking") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 161)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "uncharacterized") (:form . "uncharacterized")\n  (:end . 189) (:start . 174) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 199)\n  (:start . 190) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "acquire") (:form . "acquiring") (:end . 210)\n  (:start . 201) (:id . 74))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expertise") (:form . "expertise") (:end . 225)\n  (:start . 216) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "onerous") (:form . "onerous") (:end . 239)\n  (:start . 232) (:id . 79))\n ((:tag . "NN") (:stem . "task") (:form . "task") (:end . 244) (:start . 240)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x3.29.1) (:span 5 13)))\n (:hscopes ((:id . :x3.29.1) (:span 5 107)))\n (:identifiers (:sid . :s3.29) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100819@unknown@formal@none@1@S@Ensemble methods, well known in the machine learning community 9, are typically composed of multiple methods comprising different search strategies (or the same search strategies with different initiation settings or random restarts) with a unified objective function.@(((:tag . "JJ") (:stem . "ensemble") (:form . "Ensemble") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "machine") (:form . "machine") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "VBG") (:stem . "learn") (:form . "learning") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "community") (:form . "community") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 193)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 204)\n  (:start . 194) (:id . 72))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 213)\n  (:start . 205) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 223)\n  (:start . 217) (:id . 75))\n ((:tag . "NNS") (:stem . "restart") (:form . "restarts") (:end . 232)\n  (:start . 224) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 238) (:start . 234)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 240) (:start . 239)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "unified") (:form . "unified") (:end . 248)\n  (:start . 241) (:id . 80))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 258)\n  (:start . 249) (:id . 81))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 267)\n  (:start . 259) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s3.39) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100829@unknown@formal@none@1@S@Rather than randomly restarting the same search algorithm or comparing multiple search strategies that all search for the same global optimum (and are potentially vulnerable to the same local optima), our algorithm assumes that the ""biological significance surface"" primarily consists of three local optima, and that one of these peaks represents the global optimum.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "restart") (:form . "restarting") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . 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"of") (:end . 289) (:start . 287)\n  (:id . 88))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 295)\n  (:start . 290) (:id . 89))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 301)\n  (:start . 296) (:id . 90))\n ((:tag . "NNS") (:stem . "optimum") (:form . "optima") (:end . 308)\n  (:start . 302) (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 309) (:start . 308)\n  (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 313) (:start . 310)\n  (:id . 93))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 318) (:start . 314)\n  (:id . 94))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 322) (:start . 319)\n  (:id . 95))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 325) (:start . 323)\n  (:id . 96))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 331)\n  (:start . 326) (:id . 97))\n ((:tag . "NNS") (:stem . "peak") (:form . "peaks") (:end . 337)\n  (:start . 332) (:id . 98))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 348)\n  (:start . 338) (:id . 99))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 352) (:start . 349)\n  (:id . 100))\n ((:tag . "JJ") (:stem . "global") (:form . "global") (:end . 359)\n  (:start . 353) (:id . 101))\n ((:tag . "NN") (:stem . "optimum") (:form . "optimum") (:end . 367)\n  (:start . 360) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 368) (:start . 367)\n  (:id . 103)))@@@1@62@((:hcues ((:id . :x3.49.1) (:span 215 222)) ((:id . :x3.49.2) (:span 151 162))\n  ((:id . :x3.49.3) (:span 58 60)))\n (:ncues ((:id . :x3.49.4) (:span 0 11)))\n (:hscopes ((:id . :x3.49.1) (:span 215 367))\n  ((:id . :x3.49.2) (:span 151 173)) ((:id . :x3.49.3) (:span 12 199)))\n (:nscopes ((:id . :x3.49.4) (:span 0 199)))\n (:identifiers (:sid . :s3.49) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100839@unknown@formal@none@1@S@The ultimate goal of a motif finder is to identify the specific subsequences Û in U that act as binding sites for the transcription factor(s) that regulate G.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ultimate") (:form . "ultimate") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "goal") (:form . "goal") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "NNS") (:stem . "subsequence") (:form . "subsequences") (:end . 76)\n  (:start . 64) (:id . 54))\n ((:tag . "VBP") (:stem . "û") (:form . "Û") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "factor(s)") (:form . "factor(s)") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s3.59) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100849@unknown@formal@none@1@S@BEAM and SPACER are run independently; PRISM runs on the top 100 motifs output by BEAM.@(((:tag . "NN") (:stem . "beam") (:form . "BEAM") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 15)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "run") (:form . "run") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "run") (:form . "runs") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.69) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100859@unknown@formal@none@1@S@In general, we seek to maximize -log(p(M = m)).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "seek") (:form . "seek") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "maximize") (:form . "maximize") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "JJ") (:stem . "-log(p(M") (:form . "-log(p(M") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.79) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100869@unknown@formal@none@1@S@In contrast, we have proposed that all characters should not be treated equally, but should be penalized in proportion to the information provided by them 1112.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "character") (:form . "characters") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "penalize") (:form . "penalized") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 118)\n  (:start . 108) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 137)\n  (:start . 126) (:id . 65))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1112") (:form . "1112") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.89.1) (:span 85 91)) ((:id . :x3.89.2) (:span 50 56))\n  ((:id . :x3.89.4) (:span 21 29)))\n (:ncues ((:id . :x3.89.3) (:span 57 60)))\n (:hscopes ((:id . :x3.89.1) (:span 85 154)) ((:id . :x3.89.2) (:span 35 79))\n  ((:id . :x3.89.4) (:span 21 154)))\n (:nscopes ((:id . :x3.89.3) (:span 35 79)))\n (:identifiers (:sid . :s3.89) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100879@unknown@formal@none@1@S@These objective functions were as follows: position bias (based on the Kolmogorov-Smirnov, or KS, statistic), overrepresentation (a Poisson-based measure based on how often a motif occurs in U) and coverage (a Poisson-based measure based on how many upstream sequences contain the motif).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Kolmogorov-Smirnov") (:form . "Kolmogorov-Smirnov")\n  (:end . 89) (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "statistic") (:form . "statistic") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 128) (:start . 110) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "poisson-based") (:form . "Poisson-based")\n  (:end . 145) (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 187)\n  (:start . 181) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 192) (:start . 191)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 78))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 206)\n  (:start . 198) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "poisson-based") (:form . "Poisson-based")\n  (:end . 223) (:start . 210) (:id . 82))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 231)\n  (:start . 224) (:id . 83))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 237)\n  (:start . 232) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 240) (:start . 238)\n  (:id . 85))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 244) (:start . 241)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 249) (:start . 245)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 258)\n  (:start . 250) (:id . 88))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 268)\n  (:start . 259) (:id . 89))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 276)\n  (:start . 269) (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 280) (:start . 277)\n  (:id . 91))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 286)\n  (:start . 281) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 287) (:start . 286)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s3.99) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100889@unknown@formal@none@1@S@Non-degenerate 6-mers from S. cerevisiae were scored according to Sig scores based on (a) Overrepresentation, (b) Overrepresentation-KS, (c) Coverage and (d) KS metrics of statistical significance.@(((:tag . "JJ") (:stem . "non-degenerate") (:form . "Non-degenerate")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "6-mer") (:form . "6-mers") (:end . 21)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "score") (:form . "scored") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Overrepresentation") (:form . "Overrepresentation")\n  (:end . 108) (:start . 90) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "overrepresentation-ks")\n  (:form . "Overrepresentation-KS") (:end . 135) (:start . 114) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Coverage") (:form . "Coverage") (:end . 149)\n  (:start . 141) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 70))\n ((:tag . "LS") (:stem . "d") (:form . "d") (:end . 156) (:start . 155)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ks") (:form . "KS") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "metric") (:form . "metrics") (:end . 168)\n  (:start . 161) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 183)\n  (:start . 172) (:id . 76))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 196)\n  (:start . 184) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.109) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100899@unknown@formal@none@1@S@We used the overrepresentation objective function for the other species, as our upstream definitions for those species were of variable length due to the available annotations.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 30) (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "definition") (:form . "definitions") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 175)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.119) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100909@unknown@formal@none@1@S@Performance at different overrepresentation Sig values on synthetic data.@(((:tag . "NNP") (:stem . "Performance") (:form . "Performance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 43) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "sig") (:form . "Sig") (:end . 47) (:start . 44)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s3.129) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100919@unknown@formal@none@1@S@SCOPE's reported accuracy was significantly higher than any of its component algorithms (Table 1).@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 50) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.139) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100929@unknown@formal@none@1@S@Average and standard error of sensitivity and PPV for the component algorithms of SCOPE on all 78 regulons@(((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 106)\n  (:start . 98) (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.149) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100939@unknown@formal@none@1@S@One rule that may prove effective is to weight the output of each algorithm according to (for example) the frequency of occurrence of each class of motif (non-degenerate, short degenerate or long degenerate) in the species or by learning the appropriate weights on a representative training set, creating, in effect, a Naïve Bayesian Network.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . 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"on") (:end . 264) (:start . 262)\n  (:id . 89))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 266) (:start . 265)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 281) (:start . 267) (:id . 91))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 290)\n  (:start . 282) (:id . 92))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 294) (:start . 291)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 295) (:start . 294)\n  (:id . 94))\n ((:tag . "VBG") (:stem . "create") (:form . "creating") (:end . 304)\n  (:start . 296) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 305) (:start . 304)\n  (:id . 96))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 308) (:start . 306)\n  (:id . 97))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 315)\n  (:start . 309) (:id . 98))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 316) (:start . 315)\n  (:id . 99))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 318) (:start . 317)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "Naïve") (:form . "Naïve") (:end . 324)\n  (:start . 319) (:id . 101))\n ((:tag . "NNP") (:stem . "Bayesian") (:form . "Bayesian") (:end . 333)\n  (:start . 325) (:id . 102))\n ((:tag . "NNP") (:stem . "Network") (:form . "Network") (:end . 341)\n  (:start . 334) (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 342) (:start . 341)\n  (:id . 104)))@@@1@63@((:hcues ((:id . :x3.159.1) (:span 14 17)))\n (:hscopes ((:id . :x3.159.1) (:span 14 33)))\n (:identifiers (:sid . :s3.159) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100949@unknown@formal@none@1@S@Motif model abbreviations: cons = consensus; PWM = position weight matrix; mis = consensus with predefined number of allowed non-position-specific mismatches.@(((:tag . "NN") (:stem . "motif") (:form . "Motif") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "con") (:form . "cons") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mis") (:form . "mis") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "predefine") (:form . "predefined") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "JJ") (:stem . "non-position-specific")\n  (:form . "non-position-specific") (:end . 146) (:start . 125) (:id . 64))\n ((:tag . "NNS") (:stem . "mismatch") (:form . "mismatches") (:end . 157)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.169) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100959@unknown@formal@none@1@S@Performance comparisons@(((:tag . "NNP") (:stem . "Performance") (:form . "Performance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 23)\n  (:start . 12) (:id . 43)))@@@1@2@((:identifiers (:sid . :s3.179) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100969@unknown@formal@none@1@S@By these measures, SCOPE was the only program that scored highly in both sensitivity and PPV (ranking first and second respectively).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "score") (:form . "scored") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "rank") (:form . "ranking") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 118)\n  (:start . 112) (:id . 63))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 131)\n  (:start . 119) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.189) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100979@unknown@formal@none@1@S@Therefore, sets of genes identified from co-expression data may often contain multiple extraneous upstream sequences.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x3.199.1) (:span 60 63)))\n (:hscopes ((:id . :x3.199.1) (:span 60 116)))\n (:identifiers (:sid . :s3.199) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100989@unknown@formal@none@1@S@Increasing quantities of randomly selected upstream regions were added to each regulon.@(((:tag . "VBG") (:stem . "increase") (:form . "Increasing") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "quantity") (:form . "quantities") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.209) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100999@unknown@formal@none@1@S@Conversely, the PWM-based methods have an apparently more powerful motif model 17, but their search strategies cannot guarantee optimality and often terminate at local optima.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pwm-based") (:form . "PWM-based") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 92)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "VB") (:stem . "guarantee") (:form . "guarantee") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "optimality") (:form . "optimality") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "VBP") (:stem . "terminate") (:form . "terminate") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "optimum") (:form . "optima") (:end . 174)\n  (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x3.219.1) (:span 111 117)))\n (:nscopes ((:id . :x3.219.1) (:span 111 138)))\n (:identifiers (:sid . :s3.219) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101009@unknown@formal@none@1@S@In this light, SCOPE can be seen as leveraging the second key observation by embracing the No Free Lunch Theorem:: rather than boost average performance by taking the average results of three general purpose algorithms, SCOPE uses highly specialized algorithms and assumes each will perform strongly on some regulons and weakly on others (and that the unified scoring metric can tell the difference).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "leverage") (:form . "leveraging") (:end . 46)\n  (:start . 36) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 73)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "embrace") (:form . "embracing") (:end . 86)\n  (:start . 77) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "No") (:form . "No") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Free") (:form . "Free") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Lunch") (:form . "Lunch") (:end . 104)\n  (:start . 99) (:id . 61))\n ((:tag . "NNP") (:stem . "Theorem") (:form . "Theorem") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 114) (:start . 113)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 121)\n  (:start . 115) (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 66))\n ((:tag . "VB") (:stem . "boost") (:form . "boost") (:end . 132)\n  (:start . 127) (:id . 67))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 140)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 152)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 174)\n  (:start . 167) (:id . 73))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 182)\n  (:start . 175) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 191)\n  (:start . 186) (:id . 76))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 199)\n  (:start . 192) (:id . 77))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 207)\n  (:start . 200) (:id . 78))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 218)\n  (:start . 208) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 225)\n  (:start . 220) (:id . 81))\n ((:tag . "NNS") (:stem . "use") (:form . "uses") (:end . 230) (:start . 226)\n  (:id . 82))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 237)\n  (:start . 231) (:id . 83))\n ((:tag . "VBN") (:stem . "specialize") (:form . "specialized") (:end . 249)\n  (:start . 238) (:id . 84))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 260)\n  (:start . 250) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 264) (:start . 261)\n  (:id . 86))\n ((:tag . "VBZ") (:stem . "assume") (:form . "assumes") (:end . 272)\n  (:start . 265) (:id . 87))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 277) (:start . 273)\n  (:id . 88))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 282) (:start . 278)\n  (:id . 89))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 290)\n  (:start . 283) (:id . 90))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 299)\n  (:start . 291) (:id . 91))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 302) (:start . 300)\n  (:id . 92))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 307) (:start . 303)\n  (:id . 93))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 316)\n  (:start . 308) (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 320) (:start . 317)\n  (:id . 95))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 327)\n  (:start . 321) (:id . 96))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 330) (:start . 328)\n  (:id . 97))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 337)\n  (:start . 331) (:id . 98))\n ((:tag . "(") (:stem . "(") (:form . 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"difference") (:end . 398)\n  (:start . 388) (:id . 109))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 399) (:start . 398)\n  (:id . 110))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 400) (:start . 399)\n  (:id . 111)))@@@1@70@((:hcues ((:id . :x3.229.1) (:span 265 272))\n  ((:id . :x3.229.3) (:span 21 24)))\n (:ncues ((:id . :x3.229.2) (:span 115 126)))\n (:hscopes ((:id . :x3.229.1) (:span 265 399))\n  ((:id . :x3.229.3) (:span 15 112)))\n (:nscopes ((:id . :x3.229.2) (:span 115 218)))\n (:identifiers (:sid . :s3.229) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101019@unknown@formal@none@1@S@This observation could be leveraged by a search algorithm that explicitly searches for motifs matching this unique structure.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "leverage") (:form . "leveraged") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "explicitly") (:form . "explicitly") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "search") (:form . "searches") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x3.239.1) (:span 17 22)))\n (:hscopes ((:id . :x3.239.1) (:span 17 124)))\n (:identifiers (:sid . :s3.239) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101029@unknown@formal@none@1@S@An important factor to consider when taking the best of multiple runs is the relative size of the search space.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "consider") (:form . "consider") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 43) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "run") (:form . "runs") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.249) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101039@unknown@formal@none@1@S@Whereas previous performance comparisons attempt to optimize the parameters of the programs in question 467 or allow expert users to tune their own programs and manually filter both the input and output 5 we intentionally made our comparisons between programs without manually optimizing any parameters for any species so as to emulate typical use conditions.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "VBP") (:stem . "attempt") (:form . "attempt") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . 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"any") (:end . 310) (:start . 307)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 318)\n  (:start . 311) (:id . 89))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 321) (:start . 319)\n  (:id . 90))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 324) (:start . 322)\n  (:id . 91))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 327) (:start . 325)\n  (:id . 92))\n ((:tag . "VB") (:stem . "emulate") (:form . "emulate") (:end . 335)\n  (:start . 328) (:id . 93))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 343)\n  (:start . 336) (:id . 94))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 347) (:start . 344)\n  (:id . 95))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 358)\n  (:start . 348) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 359) (:start . 358)\n  (:id . 97)))@@@1@56@((:ncues ((:id . :x3.259.1) (:span 260 267)))\n (:nscopes ((:id . :x3.259.1) (:span 260 358)))\n (:identifiers (:sid . :s3.259) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101049@unknown@formal@none@1@S@Whereas a background set of promoter regions is easy to identify, it is not clear how to define a reasonable genomic sample of enhancers.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "easy") (:form . "easy") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 95)\n  (:start . 89) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "reasonable") (:form . "reasonable") (:end . 108)\n  (:start . 98) (:id . 62))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 116)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x3.269.1) (:span 72 81)))\n (:hscopes ((:id . :x3.269.1) (:span 72 136)))\n (:identifiers (:sid . :s3.269) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101059@unknown@formal@none@1@S@By dividing the search space into tractable domains, SCOPE mitigates the potential liabilities associated with ensemble methods, resulting in a program that is capable of finding cis-regulatory elements of arbitrary length, degree of degeneracy, motif orientation and frequency of occurrence.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "divide") (:form . "dividing") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tractable") (:form . "tractable") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "mitigate") (:form . "mitigates") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "liability") (:form . "liabilities") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 138)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 193) (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 202)\n  (:start . 194) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "arbitrary") (:form . "arbitrary") (:end . 215)\n  (:start . 206) (:id . 73))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 222)\n  (:start . 216) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 75))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 230)\n  (:start . 224) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 77))\n ((:tag . "NN") (:stem . "degeneracy") (:form . "degeneracy") (:end . 244)\n  (:start . 234) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 79))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 251)\n  (:start . 246) (:id . 80))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 263)\n  (:start . 252) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 267) (:start . 264)\n  (:id . 82))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 277)\n  (:start . 268) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 280) (:start . 278)\n  (:id . 84))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 291)\n  (:start . 281) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s3.279) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101069@unknown@formal@none@1@S@As in Hu et al. 4, we define accuracy to be the Phi score between the known and predicted binding sites.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Hu") (:form . "Hu") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 28)\n  (:start . 22) (:id . 50))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 37)\n  (:start . 29) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 51) (:start . 48)\n  (:id . 55))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 57) (:start . 52)\n  (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 65)\n  (:start . 58) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 75) (:start . 70)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 89)\n  (:start . 80) (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 103) (:start . 98)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.289) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101079@unknown@formal@none@1@S@The most common statistical test in motif finding is based on overrepresentation, which can be roughly defined as the probability that a motif m that is observed C(m) times in the regulon would occur at least C(m) times in a random collection of the same number of genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 80) (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 129)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "JJ") (:stem . "C(m)") (:form . "C(m)") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 187)\n  (:start . 180) (:id . 74))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 193)\n  (:start . 188) (:id . 75))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 199)\n  (:start . 194) (:id . 76))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 202) (:start . 200)\n  (:id . 77))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "CD") (:stem . "C(m)") (:form . "C(m)") (:end . 213) (:start . 209)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 219)\n  (:start . 214) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 224) (:start . 223)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 231)\n  (:start . 225) (:id . 83))\n ((:tag . "NN") (:stem . "collection") (:form . "collection") (:end . 242)\n  (:start . 232) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 254) (:start . 250)\n  (:id . 87))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 261)\n  (:start . 255) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 270)\n  (:start . 265) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s3.299) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101089@unknown@formal@none@1@S@Transcription factors often require their binding sites to be located in a restricted range relative to the start of transcription.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 41)\n  (:start . 36) (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.309) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101099@unknown@formal@none@1@S@The reference sample Y is defined as the set of starting positions of m in all upstream regions in the genome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 109)\n  (:start . 103) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.319) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101109@unknown@formal@none@1@S@Such an assumption may be overly generous – as the TBP example above makes clear, the transcriptional machinery of a cell is clearly able to differentiate between the two strands.@(((:tag . "PDT") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "overly") (:form . "overly") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "generous") (:form . "generous") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "–") (:form . "–") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "make") (:form . "makes") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 154) (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "strand") (:form . "strands") (:end . 178)\n  (:start . 171) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x3.329.1) (:span 19 22)))\n (:hscopes ((:id . :x3.329.1) (:span 19 41)))\n (:identifiers (:sid . :s3.329) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101119@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.7) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101129@unknown@formal@none@1@S@One way to understand a protein's function is to look at its composition of conserved domains.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "VB") (:stem . "look") (:form . "look") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.17) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101139@unknown@formal@none@1@S@The structural evidence lends strong support to the inferred domain pair, resulting in a high confidence set of domain pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "lend") (:form . "lends") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inferred") (:form . "inferred") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x4.27.1) (:span 52 60)) ((:id . :x4.27.2) (:span 24 44)))\n (:hscopes ((:id . :x4.27.1) (:span 52 72)) ((:id . :x4.27.2) (:span 24 72)))\n (:identifiers (:sid . :s4.27) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101149@unknown@formal@none@1@S@How conserved are domain–domain pairs between species, and how many interacting domain pairs are still unknown?@(((:tag . "WRB") (:stem . "how") (:form . "How") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x4.37.1) (:span 103 110)))\n (:hscopes ((:id . :x4.37.1) (:span 59 110)))\n (:identifiers (:sid . :s4.37) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101159@unknown@formal@none@1@S@Given that 74% of all UniProt proteins contain at least one Pfam match, this is not by itself surprising.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "74") (:form . "74") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "UniProt") (:form . "UniProt") (:end . 29)\n  (:start . 22) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 93)\n  (:start . 87) (:id . 61))\n ((:tag . "JJ") (:stem . "surprising") (:form . "surprising") (:end . 104)\n  (:start . 94) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x4.47.1) (:span 80 83)))\n (:nscopes ((:id . :x4.47.1) (:span 80 104)))\n (:identifiers (:sid . :s4.47) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101169@unknown@formal@none@1@S@The relatively low iPfam coverage is by itself a disappointing finding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "disappointing") (:form . "disappointing")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.57) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101179@unknown@formal@none@1@S@In the following paragraph, we will call the experimental interactions that contain an iPfam domain pair the covered experimental interactions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "paragraph") (:form . "paragraph") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "call") (:form . "call") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 57)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 129)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 142)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.67) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101189@unknown@formal@none@1@S@In both H. sapiens (blue) and S. cerevisiae (green) a small number of iPfam domain pairs covers a large fraction of the interactome, whereas in E. coli, no iPfam domain occurs in more than 4 experimental interactions at a time.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 32) (:start . 30)\n  (:id . 50))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 43)\n  (:start . 33) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 50) (:start . 45)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 59) (:start . 54)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 66)\n  (:start . 60) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 75) (:start . 70)\n  (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 82)\n  (:start . 76) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 88) (:start . 83)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "cover") (:form . "covers") (:end . 95)\n  (:start . 89) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 103) (:start . 98)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 112)\n  (:start . 104) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 131)\n  (:start . 120) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 69))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 140)\n  (:start . 133) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 146) (:start . 144)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 151) (:start . 147)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 74))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 155) (:start . 153)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 161)\n  (:start . 156) (:id . 76))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 168)\n  (:start . 162) (:id . 77))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 175)\n  (:start . 169) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 79))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 183) (:start . 179)\n  (:id . 80))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 188) (:start . 184)\n  (:id . 81))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 190) (:start . 189)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 203)\n  (:start . 191) (:id . 83))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 216)\n  (:start . 204) (:id . 84))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 219) (:start . 217)\n  (:id . 85))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 221) (:start . 220)\n  (:id . 86))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 226) (:start . 222)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 88)))@@@1@47@((:ncues ((:id . :x4.77.1) (:span 153 155)))\n (:nscopes ((:id . :x4.77.1) (:span 153 226)))\n (:identifiers (:sid . :s4.77) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101199@unknown@formal@none@1@S@We reasoned that if there are iPfam domain pairs that act as reusable modules in protein interactions, then highly connected proteins should also be more likely to contain promiscuous iPfam domain pairs and vice-versa.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "reason") (:form . "reasoned") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 101)\n  (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "connected") (:form . "connected") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "JJ") (:stem . "promiscuous") (:form . "promiscuous") (:end . 183)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 202)\n  (:start . 197) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "vice-versa") (:form . "vice-versa") (:end . 217)\n  (:start . 207) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x4.87.1) (:span 134 140 154 160))\n  ((:id . :x4.87.3) (:span 3 11)))\n (:hscopes ((:id . :x4.87.1) (:span 108 217))\n  ((:id . :x4.87.3) (:span 3 217)))\n (:identifiers (:sid . :s4.87) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101209@unknown@formal@none@1@S@The correlation is outlined by dotted lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "outline") (:form . "outlined") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "dot") (:form . "dotted") (:end . 37) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.97) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101219@unknown@formal@none@1@S@Looking for example at the covered experimental interactions in H. sapiens(Additional file 1), only 8 out of the 100 most frequent iPfam domain pairs are seen in intrachain interactions exclusively, while 61 are exclusive to interchain interactions and 31 are seen in both.@(((:tag . "VBG") (:stem . "look") (:form . "Looking") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sapiens(Additional") (:form . "sapiens(Additional")\n  (:end . 85) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 172)\n  (:start . 162) (:id . 71))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 185)\n  (:start . 173) (:id . 72))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 197)\n  (:start . 186) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 74))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 211) (:start . 208)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 221)\n  (:start . 212) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 224) (:start . 222)\n  (:id . 79))\n ((:tag . "VB") (:stem . "interchain") (:form . "interchain") (:end . 235)\n  (:start . 225) (:id . 80))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 248)\n  (:start . 236) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 255) (:start . 253)\n  (:id . 83))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 259) (:start . 256)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 264) (:start . 260)\n  (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 267) (:start . 265)\n  (:id . 86))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 272) (:start . 268)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s4.107) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101229@unknown@formal@none@1@S@3671 out of a total of 5380 interacting protein pairs from the PDB contain an iPfam domain pair that does not interact in one complex structure but does so in another.@(((:tag . "CD") (:stem . "3671") (:form . "3671") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5380") (:form . "5380") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 39)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 166)\n  (:start . 159) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x4.117.1) (:span 106 109)))\n (:nscopes ((:id . :x4.117.1) (:span 106 143)))\n (:identifiers (:sid . :s4.117) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101239@unknown@formal@none@1@S@We also analysed the full dataset of protein complexes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "analyse") (:form . "analysed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.127) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101249@unknown@formal@none@1@S@Within the 3 to 19% of experimental interactions covered by iPfam, we analysed the conservation of iPfam domain pairs between species.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 35)\n  (:start . 23) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 48)\n  (:start . 36) (:id . 50))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "analyse") (:form . "analysed") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 95)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.137) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101259@unknown@formal@none@1@S@The iPfam domains in these pairs are related to housekeeping activities such as translation, replication or ATP synthesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "housekeeping") (:form . "housekeeping") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ATP") (:form . "ATP") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s4.147) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101269@unknown@formal@none@1@S@From these random results, we derive a P value of 3.6 · 10-30 that the observed correlation is random.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "derive") (:form . "derive") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "CD") (:stem . "3.6") (:form . "3.6") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "·") (:form . "·") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10-30") (:form . "10-30") (:end . 61) (:start . 56)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 58))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 91)\n  (:start . 80) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.157) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101279@unknown@formal@none@1@S@ΨS The proteome size for species S@(((:tag . "VBZ") (:stem . "ψs") (:form . "ΨS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 34) (:start . 33)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.167) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101289@unknown@formal@none@1@S@The estimates for the total number of iPfam domain pairs ranges from 33813 to 120511, with an average of 76918.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "range") (:form . "ranges") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "33813") (:form . "33813") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "120511") (:form . "120511") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "CD") (:stem . "76918") (:form . "76918") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.177) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101299@unknown@formal@none@1@S@The estimated total number of iPfam domains in all species@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 58)\n  (:start . 51) (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.187) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101309@unknown@formal@none@1@S@This in turn creates new targets for future structural genomics projects 30.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "create") (:form . "creates") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "genomic") (:form . "genomics") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "project") (:form . "projects") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.197) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101319@unknown@formal@none@1@S@In fact, we find the most frequent iPfam domain pairs to be recognition domains in signal transduction.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 16) (:start . 12)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 25) (:start . 21)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 34)\n  (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 47)\n  (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 71)\n  (:start . 60) (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 89)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 102)\n  (:start . 90) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.207) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101329@unknown@formal@none@1@S@While all such estimates should be taken with caution, our results show that at best 10% of all structural domain pairs are represented in iPfam.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "caution") (:form . "caution") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 106)\n  (:start . 96) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 113)\n  (:start . 107) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 119)\n  (:start . 114) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 135)\n  (:start . 124) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.217) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101339@unknown@formal@none@1@S@They found only 16 orthologous interacting protein pairs that were conserved in S. cerevisiae, C. elegans, D. melanogaster and H. sapiens.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "orthologous") (:form . "orthologous") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 122) (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.227) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101349@unknown@formal@none@1@S@In this study, we addressed the utility of current knowledge about structural domain interactions in order to interpret experimental protein interactions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "address") (:form . "addressed") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "utility") (:form . "utility") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VB") (:stem . "interpret") (:form . "interpret") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 132)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 153)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s4.237) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101359@unknown@formal@none@1@S@A wide range of databases were used to cover as many distinct experimental data sets as possible.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.247) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101369@unknown@formal@none@1@S@Species@(((:tag . "NNP") (:stem . "Specie") (:form . "Species") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.257) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101379@unknown@formal@none@1@S@All such interacting domain pairs are stored in a database together with detailed information on the residues involved 13.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "store") (:form . "stored") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "involve") (:form . "involved") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s4.267) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101389@unknown@formal@none@1@S@Species distribution of iPfam domain pairs@(((:tag . "NNP") (:stem . "Species") (:form . "Species") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 42) (:start . 37)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s4.277) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101399@unknown@formal@none@1@S@Random networks@(((:tag . "NNP") (:stem . "Random") (:form . "Random") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 15)\n  (:start . 7) (:id . 43)))@@@1@2@((:identifiers (:sid . :s4.287) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101409@unknown@formal@none@1@S@Where appropriate, the inverse probability P(X > x) = 1 - f(x; μ, σ) was applied.@(((:tag . "WRB") (:stem . "where") (:form . "Where") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "P(X") (:form . "P(X") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "x") (:form . "x") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "f(x") (:form . "f(x") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "μ") (:form . "μ") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "σ") (:form . "σ") (:end . 67) (:start . 66)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 80)\n  (:start . 73) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.297) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101419@unknown@formal@none@1@S@Finally, ectopic expression of neur in D-mib mutant larvae rescues the wing D-mib phenotype, indicating that Neur can compensate for the lack of D-mib activity.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "rescue") (:form . "rescues") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VB") (:stem . "compensate") (:form . "compensate") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x5.10.2) (:span 93 108)))\n (:ncues ((:id . :x5.10.1) (:span 137 141)))\n (:hscopes ((:id . :x5.10.2) (:span 93 159)))\n (:nscopes ((:id . :x5.10.1) (:span 137 159)))\n (:identifiers (:sid . :s5.10) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101429@unknown@formal@none@1@S@Conversely, Ser (but not Dl) is specifically required for segmental patterning [5].@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 50))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 44)\n  (:start . 32) (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "segmental") (:form . "segmental") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "patterning") (:form . "patterning") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x5.20.1) (:span 21 24)))\n (:nscopes ((:id . :x5.20.1) (:span 21 28)))\n (:identifiers (:sid . :s5.20) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101439@unknown@formal@none@1@S@Third, two distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), have recently been shown to regulate Dl endocytosis and N activation in Drosophila and Danio rerio, respectively [18,19,20,21,22,23,24,25].@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "ligas") (:form . "ligases") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Neuralized") (:form . "Neuralized") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mind") (:form . "Mind") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bomb") (:form . "bomb") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 85) (:start . 81)\n  (:id . 61))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 94)\n  (:start . 86) (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 99) (:start . 95)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 105)\n  (:start . 100) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 65))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 117)\n  (:start . 109) (:id . 66))\n ((:tag . "NN") (:stem . "dl") (:form . "Dl") (:end . 120) (:start . 118)\n  (:id . 67))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 132)\n  (:start . 121) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 138) (:start . 137)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 163)\n  (:start . 153) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Danio") (:form . "Danio") (:end . 173)\n  (:start . 168) (:id . 75))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 179)\n  (:start . 174) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 77))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 193)\n  (:start . 181) (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 195) (:start . 194)\n  (:id . 79))\n ((:tag . "CD") (:stem . "18,19,20,21,22,23,24,25")\n  (:form . "18,19,20,21,22,23,24,25") (:end . 218) (:start . 195) (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 219) (:start . 218)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s5.30) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101449@unknown@formal@none@1@S@How endocytosis of Dl leads to the activation of N remains to be elucidated.@(((:tag . "WRB") (:stem . "how") (:form . "How") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x5.40.1) (:span 51 75)))\n (:hscopes ((:id . :x5.40.1) (:span 0 75)))\n (:identifiers (:sid . :s5.40) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101459@unknown@formal@none@1@S@We report here that D-mib, like D. rerio Mib, appears to regulate Dl signaling during leg segmentation, wing vein formation, and lateral inhibition in the adult notum.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 53)\n  (:start . 46) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 65)\n  (:start . 57) (:id . 55))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 78)\n  (:start . 69) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "leg") (:form . "leg") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "segmentation") (:form . "segmentation") (:end . 102)\n  (:start . 90) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 123)\n  (:start . 114) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 136)\n  (:start . 129) (:id . 67))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 147)\n  (:start . 137) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x5.50.1) (:span 46 53)))\n (:hscopes ((:id . :x5.50.1) (:span 20 166)))\n (:identifiers (:sid . :s5.50) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101469@unknown@formal@none@1@S@Insertion of this P-element confers late pupal lethality.@(((:tag . "NNP") (:stem . "Insertion") (:form . "Insertion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.60) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101479@unknown@formal@none@1@S@First, lethality of homozygous D-mib1 pupae is associated with the insertion of a P-element into the 5? UTR of the D-mib gene.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "pupae") (:form . "pupae") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p-element") (:form . "P-element") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "utr") (:form . "UTR") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.70) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101489@unknown@formal@none@1@S@Open reading frames are shown in black.@(((:tag . "JJ") (:stem . "open") (:form . "Open") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "black") (:form . "black") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s5.80) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101499@unknown@formal@none@1@S@D-mib (E) and Ser (F) mutant flies showed similar wing loss phenotypes.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 9) (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 17) (:start . 14)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 48))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 20) (:start . 19)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 28)\n  (:start . 22) (:id . 51))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 34) (:start . 29)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 41) (:start . 35)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 49)\n  (:start . 42) (:id . 54))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 54) (:start . 50)\n  (:id . 55))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 59) (:start . 55)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 70)\n  (:start . 60) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.90) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101509@unknown@formal@none@1@S@D-mib Regulates Dl Signaling@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "Regulates") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 28)\n  (:start . 19) (:id . 45)))@@@1@4@((:identifiers (:sid . :s5.100) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101519@unknown@formal@none@1@S@Finally, the vein phenotype seen in D-mib hypomorphic flies is similar to the one seen in Dlts mutant flies [39].@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hypomorphic") (:form . "hypomorphic") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Dlt") (:form . "Dlts") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 107) (:start . 102)\n  (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "CD") (:stem . "39") (:form . "39") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s5.110) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101529@unknown@formal@none@1@S@We then studied in more detail the function of D-mib during wing development.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.120) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101539@unknown@formal@none@1@S@Thus, the D-mib wing phenotype may result from defective N inductive signaling at the D-V boundary.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inductive") (:form . "inductive") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x5.130.1) (:span 31 34)))\n (:hscopes ((:id . :x5.130.1) (:span 31 98)))\n (:identifiers (:sid . :s5.130) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101549@unknown@formal@none@1@S@D-mib co-localized with Ser, Dl, and N at the apical cortex (Figure 3B–3D???).@(((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "co-localized") (:form . "co-localized") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 59)\n  (:start . 53) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 67)\n  (:start . 61) (:id . 56))\n ((:tag . "NNP") (:stem . "3B–3D") (:form . "3B–3D") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 75) (:start . 74)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 76) (:start . 75)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.140) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101559@unknown@formal@none@1@S@(E–E??) D-mib (green in [E and E?]) co-localized with Dl (red in [E and E??]) at the apical cortex of wing pouch cells.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E–E") (:form . "E–E") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 13) (:start . 8)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 20) (:start . 15)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 25) (:start . 24)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 26) (:start . 25)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 32) (:start . 31)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 33) (:start . 32)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 34) (:start . 33)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "co-localize") (:form . "co-localized") (:end . 48)\n  (:start . 36) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 56) (:start . 54)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 61) (:start . 58)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 66) (:start . 65)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 67) (:start . 66)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 73) (:start . 72)\n  (:id . 67))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 74) (:start . 73)\n  (:id . 68))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 75) (:start . 74)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 76) (:start . 75)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 91)\n  (:start . 85) (:id . 74))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 98)\n  (:start . 92) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 106) (:start . 102)\n  (:id . 77))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 112)\n  (:start . 107) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s5.150) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101569@unknown@formal@none@1@S@(B) and (D) show high-magnification views of the areas boxed in (A) and (C), respectively.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 11) (:start . 10)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high-magnification") (:form . "high-magnification")\n  (:end . 35) (:start . 17) (:id . 50))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 41) (:start . 36)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 54) (:start . 49)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "box") (:form . "boxed") (:end . 60) (:start . 55)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 66) (:start . 65)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 74) (:start . 73)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 64))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 89)\n  (:start . 77) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.160) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101579@unknown@formal@none@1@S@We therefore conclude that the D-mib gene is required to regulate the level of Ser at the apical cortex of wing disc cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s5.170) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101589@unknown@formal@none@1@S@Clone boundaries are outlined in (H and H?) and (J and J?).@(((:tag . "NNP") (:stem . "Clone") (:form . "Clone") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "boundary") (:form . "boundaries") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "outline") (:form . "outlined") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 50) (:start . 49)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 56) (:start . 55)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 57) (:start . 56)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.180) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101599@unknown@formal@none@1@S@The uptake of anti-Ser and anti-Dl antibodies was then assessed using secondary antibodies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.190) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101609@unknown@formal@none@1@S@(C–C??) and (F–F??) show confocal z-sections.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C–C") (:form . "C–C") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "F–F") (:form . "F–F") (:end . 16) (:start . 13)\n  (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 17) (:start . 16)\n  (:id . 50))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 18) (:start . 17)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 24) (:start . 20)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "confocal") (:form . "confocal") (:end . 33)\n  (:start . 25) (:id . 54))\n ((:tag . "NNS") (:stem . "z-section") (:form . "z-sections") (:end . 44)\n  (:start . 34) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.200) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101619@unknown@formal@none@1@S@Loss of D-mib activity in large dorsal clones of D-mib2 mutant cells resulted in a loss of Cut expression at the D-V interface (Figure 6A and 6B).@(((:tag . "NN") (:stem . "loss") (:form . "Loss") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interface") (:form . "interface") (:end . 126)\n  (:start . 117) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 134)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "6b") (:form . "6B") (:end . 144) (:start . 142)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.210) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101629@unknown@formal@none@1@S@A similar rescue was observed with a YFP::D-mib protein (Figure 7B–7B?)”, indicating that YFP::D-mib is functional.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "7B–7B?)”") (:form . "7B–7B?)”") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x5.220.1) (:span 76 91)))\n (:hscopes ((:id . :x5.220.1) (:span 76 116)))\n (:identifiers (:sid . :s5.220) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101639@unknown@formal@none@1@S@D-mib Acts Downstream of Ser and Upstream of Activated N@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "Acts") (:form . "Acts") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Downstream") (:form . "Downstream") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Upstream") (:form . "Upstream") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Activated") (:form . "Activated") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 56) (:start . 55)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.230) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101649@unknown@formal@none@1@S@Expression of Neur in dorsal cells was sufficient to compensate for the loss of D-mib activity (D).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "compensate") (:form . "compensate") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.240) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101659@unknown@formal@none@1@S@We conclude that ectopic expression of Neur compensates for the loss of D-mib activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "compensate") (:form . "compensates") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.250) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101669@unknown@formal@none@1@S@Second, expression of D-mib in the dorsal Ser-signaling cells was sufficient to rescue the D-mib mutant wing phenotype.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "ser-signaling") (:form . "Ser-signaling")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.260) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101679@unknown@formal@none@1@S@Interestingly, the strong requirement for Dl and Ser endocytosis seen in Drosophila is not conserved in Caenorhabditis elegans, in which secreted ligands have been shown to be functional [58,59].@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 118) (:start . 104) (:id . 59))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 186)\n  (:start . 176) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "CD") (:stem . "58,59") (:form . "58,59") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x5.270.1) (:span 87 90)))\n (:nscopes ((:id . :x5.270.1) (:span 15 186)))\n (:identifiers (:sid . :s5.270) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101689@unknown@formal@none@1@S@The functional differences observed between D-mib and neur cannot be simply explained by obvious differences in molecular activity and/or substrate specificity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 147)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 159)\n  (:start . 148) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x5.280.1) (:span 59 65)))\n (:nscopes ((:id . :x5.280.1) (:span 0 159)))\n (:identifiers (:sid . :s5.280) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101699@unknown@formal@none@1@S@Whether endogenous Neur binds and activates Ser remains to be tested.@(((:tag . "IN") (:stem . "whether") (:form . "Whether") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 68) (:start . 62)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x5.290.1) (:span 0 7)))\n (:hscopes ((:id . :x5.290.1) (:span 0 47)))\n (:identifiers (:sid . :s5.290) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101709@unknown@formal@none@1@S@In conclusion, Neur and D-mib appear to have similar molecular activities in the regulation of Dl and Ser endocytosis but distinct developmental functions in Drosophila.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x5.300.1) (:span 30 36)))\n (:hscopes ((:id . :x5.300.1) (:span 15 168)))\n (:identifiers (:sid . :s5.300) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101719@unknown@formal@none@1@S@Sequence analysis of the D-mib3 and D-mib4 alleles was carried on PCR products prepared from genomic DNA prepared from D-mib3/D-mib2 and D-mib4/D-mib2 mutant pupae.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "d-mib3/d-mib2") (:form . "D-mib3/D-mib2")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "d-mib4/d-mib2") (:form . "D-mib4/D-mib2")\n  (:end . 150) (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.310) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101729@unknown@formal@none@1@S@Rabbit polyclonal anti-D-mib antibodies were raised against the CYNERKTDDSELPGN peptide (CovalAb, Lyon, France).@(((:tag . "NN") (:stem . "rabbit") (:form . "Rabbit") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "anti-d-mib") (:form . "anti-D-mib") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cynerktddselpgn") (:form . "CYNERKTDDSELPGN")\n  (:end . 79) (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CovalAb") (:form . "CovalAb") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Lyon") (:form . "Lyon") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "France") (:form . "France") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.320) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101739@unknown@formal@none@1@S@Following three medium changes and a 45-min chase period, wing discs were fixed and incubated with secondary antibodies.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "45-min") (:form . "45-min") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "chase") (:form . "chase") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.330) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101749@unknown@formal@none@1@S@We also studied several divergent proteins encoded by the sea urchin and lancelet genomes that are 25%-30% identical to the RAG1 N-terminal domain and the RAG1 core.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "CD") (:stem . "25%-30") (:form . "25%-30") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.10) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101759@unknown@formal@none@1@S@In addition to this combinatorial diversity, further diversity is generated by small insertions and deletions at junctions between the joined segments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "insertion") (:form . "insertions") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "junction") (:form . "junctions") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "joined") (:form . "joined") (:end . 141)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.20) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101769@unknown@formal@none@1@S@In vertebrates, in vivo RAG-mediated transpositions are strongly suppressed, probably to minimize potential harm to genome function.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "rag-mediated") (:form . "RAG-mediated") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 51) (:start . 37) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VB") (:stem . "minimize") (:form . "minimize") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "harm") (:form . "harm") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x6.30.1) (:span 77 85)))\n (:hscopes ((:id . :x6.30.1) (:span 77 131)))\n (:identifiers (:sid . :s6.30) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101779@unknown@formal@none@1@S@Genomes of plants and vertebrates seem to be free of any recognizable Transib transposons (Figure 1).@(((:tag . "NNS") (:stem . "genome") (:form . "Genomes") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "plant") (:form . "plants") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "seem") (:form . "seem") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "recognizable") (:form . "recognizable") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x6.40.1) (:span 34 38)))\n (:hscopes ((:id . :x6.40.1) (:span 0 89)))\n (:identifiers (:sid . :s6.40) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101789@unknown@formal@none@1@S@In fungi, the Transib TPase was detected in soybean rust only.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fungus") (:form . "fungi") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "soybean") (:form . "soybean") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "rust") (:form . "rust") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.50) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101799@unknown@formal@none@1@S@To achieve that, we combined protein sequences of the seven known Transib TPases with the set of all GenBank proteins.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "combine") (:form . "combined") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 80) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.60) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101809@unknown@formal@none@1@S@The more diverse the TPases used in determining the PSSM, the more accurate is the approximation; some of the insect Transib TPases are less than 30% identical to each other, as shown in Figure 2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 27) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "approximation") (:form . "approximation")\n  (:end . 96) (:start . 83) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 124)\n  (:start . 117) (:id . 64))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 131)\n  (:start . 125) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 159)\n  (:start . 150) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 72))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 167) (:start . 163)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 173)\n  (:start . 168) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 183)\n  (:start . 178) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 193)\n  (:start . 187) (:id . 79))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 195) (:start . 194)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s6.70) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101819@unknown@formal@none@1@S@At the same time, recently sequenced genomes of honeybee, roundworms, fish, frog, mammals, sea squirts, plants, and fungi (except soybean rust) do not contain any detectable Transib transposons (see Figure 1).@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "honeybee") (:form . "honeybee") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "roundworm") (:form . "roundworms") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "frog") (:form . "frog") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 89)\n  (:start . 82) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "squirt") (:form . "squirts") (:end . 102)\n  (:start . 95) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "plant") (:form . "plants") (:end . 110)\n  (:start . 104) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "fungus") (:form . "fungi") (:end . 121)\n  (:start . 116) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 68))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 129)\n  (:start . 123) (:id . 69))\n ((:tag . "NN") (:stem . "soybean") (:form . "soybean") (:end . 137)\n  (:start . 130) (:id . 70))\n ((:tag . "NN") (:stem . "rust") (:form . "rust") (:end . 142) (:start . 138)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 146) (:start . 144)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 150) (:start . 147)\n  (:id . 74))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 158)\n  (:start . 151) (:id . 75))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 162) (:start . 159)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 173)\n  (:start . 163) (:id . 77))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 181)\n  (:start . 174) (:id . 78))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 193)\n  (:start . 182) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 80))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 198) (:start . 195)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 205)\n  (:start . 199) (:id . 82))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 207) (:start . 206)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x6.80.1) (:span 147 150)))\n (:nscopes ((:id . :x6.80.1) (:span 147 193)))\n (:identifiers (:sid . :s6.80) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101829@unknown@formal@none@1@S@Each empty cell indicates that the corresponding TPase query was not used at the particular stage of PSI-BLAST analysis.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "empty") (:form . "empty") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 48)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x6.90.1) (:span 65 68)))\n (:nscopes ((:id . :x6.90.1) (:span 31 119)))\n (:identifiers (:sid . :s6.90) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101839@unknown@formal@none@1@S@This includes the distances between the second D and E residues, which are much longer in Transib transposons (206–214 aa) and RAG1 (253 aa) than in DDE TPases from other studied superfamilies (e.g., approximately 35-aa in Mariner/Tc1 [23], 2-aa in P [23], approximately 35-aa in Harbinger [24], with hAT as an exception (325-aa, [25]).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "distance") (:form . "distances") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "RBR") (:stem . "longer") (:form . "longer") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 109)\n  (:start . 98) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "CD") (:stem . "206–214") (:form . "206–214") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "CD") (:stem . "253") (:form . "253") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 139) (:start . 137)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 70))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 145) (:start . 141)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "DDE") (:form . "DDE") (:end . 152) (:start . 149)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 159)\n  (:start . 153) (:id . 74))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 164) (:start . 160)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 170)\n  (:start . 165) (:id . 76))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 178)\n  (:start . 171) (:id . 77))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies")\n  (:end . 192) (:start . 179) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 79))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 198) (:start . 194)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 81))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 213) (:start . 200) (:id . 82))\n ((:tag . "JJ") (:stem . "35-aa") (:form . "35-aa") (:end . 219)\n  (:start . 214) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 84))\n ((:tag . "NN") (:stem . "mariner/tc1") (:form . "Mariner/Tc1") (:end . 234)\n  (:start . 223) (:id . 85))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 236) (:start . 235)\n  (:id . 86))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 238) (:start . 236)\n  (:id . 87))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 239) (:start . 238)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 240) (:start . 239)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "2-aa") (:form . "2-aa") (:end . 245) (:start . 241)\n  (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 91))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 250) (:start . 249)\n  (:id . 92))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 252) (:start . 251)\n  (:id . 93))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 254) (:start . 252)\n  (:id . 94))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 255) (:start . 254)\n  (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 256) (:start . 255)\n  (:id . 96))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 270) (:start . 257) (:id . 97))\n ((:tag . "JJ") (:stem . "35-aa") (:form . "35-aa") (:end . 276)\n  (:start . 271) (:id . 98))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 279) (:start . 277)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "Harbinger") (:form . "Harbinger") (:end . 289)\n  (:start . 280) (:id . 100))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 291) (:start . 290)\n  (:id . 101))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 293) (:start . 291)\n  (:id . 102))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 294) (:start . 293)\n  (:id . 103))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 295) (:start . 294)\n  (:id . 104))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 300) (:start . 296)\n  (:id . 105))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 304) (:start . 301)\n  (:id . 106))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 307) (:start . 305)\n  (:id . 107))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 310) (:start . 308)\n  (:id . 108))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 320)\n  (:start . 311) (:id . 109))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 322) (:start . 321)\n  (:id . 110))\n ((:tag . "JJ") (:stem . "325-aa") (:form . "325-aa") (:end . 328)\n  (:start . 322) (:id . 111))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 329) (:start . 328)\n  (:id . 112))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 331) (:start . 330)\n  (:id . 113))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 333) (:start . 331)\n  (:id . 114))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 334) (:start . 333)\n  (:id . 115))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 335) (:start . 334)\n  (:id . 116))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 336) (:start . 335)\n  (:id . 117)))@@@1@76@((:identifiers (:sid . :s6.100) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101849@unknown@formal@none@1@S@Based on this information, the function of these motifs in Transib TPases is expected to be similar to that in RAG1.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "TPases") (:form . "TPases") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x6.110.1) (:span 77 85)))\n (:hscopes ((:id . :x6.110.1) (:span 27 115)))\n (:identifiers (:sid . :s6.110) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101859@unknown@formal@none@1@S@Starting positions of the motifs immediately follow the corresponding protein names.@(((:tag . "VBG") (:stem . "start") (:form . "Starting") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 69)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "name") (:form . "names") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.120) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101869@unknown@formal@none@1@S@(A) Frequencies of the most frequent nucleotides at each position of the consensus sequence of the 5? TIRs of transposons that belong to 20 families of Transib transposons identified in fruit flies and mosquitoes.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNS") (:stem . "frequency") (:form . "Frequencies") (:end . 15)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 121)\n  (:start . 110) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 148)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 159)\n  (:start . 152) (:id . 71))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 171)\n  (:start . 160) (:id . 72))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 182)\n  (:start . 172) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 191)\n  (:start . 186) (:id . 75))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 197) (:start . 192)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "mosquito") (:form . "mosquitoes") (:end . 212)\n  (:start . 202) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.130) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101879@unknown@formal@none@1@S@In one study [12], 35 of 38 (92%) TSDs generated during RAG-mediated intermolecular transposition were 5 bp long, and the remaining 8% were either 4 or 3 bp long.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 48))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 21) (:start . 19)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 50))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 27) (:start . 25)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 52))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 31) (:start . 29)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 32) (:start . 31)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 38) (:start . 34)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 48)\n  (:start . 39) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 55)\n  (:start . 49) (:id . 58))\n ((:tag . "JJ") (:stem . "rag-mediated") (:form . "RAG-mediated") (:end . 68)\n  (:start . 56) (:id . 59))\n ((:tag . "JJ") (:stem . "intermolecular") (:form . "intermolecular")\n  (:end . 83) (:start . 69) (:id . 60))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 97) (:start . 84) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 107) (:start . 105)\n  (:id . 64))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 112) (:start . 108)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 131)\n  (:start . 122) (:id . 69))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 133) (:start . 132)\n  (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 134) (:start . 133)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 139) (:start . 135)\n  (:id . 72))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 146)\n  (:start . 140) (:id . 73))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 148) (:start . 147)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 75))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 153) (:start . 152)\n  (:id . 76))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 156) (:start . 154)\n  (:id . 77))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 161) (:start . 157)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.140) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101889@unknown@formal@none@1@S@Both RAG1/2-mediated and Transib transpositions show strong preference for GC-rich target sites [12–14,32], even though genomes hosting Transib transposons are AT-rich (Figure S4; Table 2).@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rag1/2-mediated") (:form . "RAG1/2-mediated")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 47) (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "preference") (:form . "preference") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gc-rich") (:form . "GC-rich") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "CD") (:stem . "12–14,32") (:form . "12–14,32") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "VBG") (:stem . "host") (:form . "hosting") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 155)\n  (:start . 144) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "at-rich") (:form . "AT-rich") (:end . 167)\n  (:start . 160) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "NNP") (:stem . "S4") (:form . "S4") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s6.150) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101899@unknown@formal@none@1@S@RAG1 Core–Like Sequences in the Sea Urchin, Lancelet, Starlet Sea Anemone, and Hydra Genomes@(((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Core–Like") (:form . "Core–Like") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Sequence") (:form . "Sequences") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Lancelet") (:form . "Lancelet") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Starlet") (:form . "Starlet") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Anemone") (:form . "Anemone") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Hydra") (:form . "Hydra") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NNPS") (:stem . "Genome") (:form . "Genomes") (:end . 92)\n  (:start . 85) (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.160) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101909@unknown@formal@none@1@S@Although the two proteins are only 38% identical to each other, they share common features: (1) their N-terminal portions are missing and the RAG1-like sequences start at positions 17 or 18; (2) in both proteins the first aa residue overlaps with the acceptor splice site; and (3) their similarity to RAG1 starts at positions corresponding to position 470 of the human RAG1.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 101)\n  (:start . 96) (:id . 63))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 112)\n  (:start . 102) (:id . 64))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 121)\n  (:start . 113) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 133)\n  (:start . 126) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 151)\n  (:start . 142) (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 161)\n  (:start . 152) (:id . 71))\n ((:tag . "VBP") (:stem . "start") (:form . "start") (:end . 167)\n  (:start . 162) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 170) (:start . 168)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 180)\n  (:start . 171) (:id . 74))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 183) (:start . 181)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 186) (:start . 184)\n  (:id . 76))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 189) (:start . 187)\n  (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 190) (:start . 189)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 79))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 193) (:start . 192)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 82))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 202) (:start . 198)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 211)\n  (:start . 203) (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 221)\n  (:start . 216) (:id . 86))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 224) (:start . 222)\n  (:id . 87))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 232)\n  (:start . 225) (:id . 88))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 241)\n  (:start . 233) (:id . 89))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 246) (:start . 242)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 91))\n ((:tag . "NN") (:stem . "acceptor") (:form . "acceptor") (:end . 259)\n  (:start . 251) (:id . 92))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 266)\n  (:start . 260) (:id . 93))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 271) (:start . 267)\n  (:id . 94))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 272) (:start . 271)\n  (:id . 95))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 276) (:start . 273)\n  (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 278) (:start . 277)\n  (:id . 97))\n ((:tag . "LS") (:stem . "3") (:form . "3") (:end . 279) (:start . 278)\n  (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 280) (:start . 279)\n  (:id . 99))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 286)\n  (:start . 281) (:id . 100))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 297)\n  (:start . 287) (:id . 101))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 300) (:start . 298)\n  (:id . 102))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 305) (:start . 301)\n  (:id . 103))\n ((:tag . "VBZ") (:stem . "start") (:form . "starts") (:end . 312)\n  (:start . 306) (:id . 104))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 315) (:start . 313)\n  (:id . 105))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 325)\n  (:start . 316) (:id . 106))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 339)\n  (:start . 326) (:id . 107))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 342) (:start . 340)\n  (:id . 108))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 351)\n  (:start . 343) (:id . 109))\n ((:tag . "CD") (:stem . "470") (:form . "470") (:end . 355) (:start . 352)\n  (:id . 110))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 358) (:start . 356)\n  (:id . 111))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 362) (:start . 359)\n  (:id . 112))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 368)\n  (:start . 363) (:id . 113))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 373) (:start . 369)\n  (:id . 114))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 374) (:start . 373)\n  (:id . 115)))@@@1@74@((:ncues ((:id . :x6.170.1) (:span 126 133)))\n (:nscopes ((:id . :x6.170.1) (:span 96 133)))\n (:identifiers (:sid . :s6.170) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101919@unknown@formal@none@1@S@Using these trace sequences, we partially assembled a hydra gene, called RAG1L_NM, which encodes the RAG1 core–like protein.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "assemble") (:form . "assembled") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 72) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RAG1L_NM") (:form . "RAG1L_NM") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 115)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.180) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101929@unknown@formal@none@1@S@Names of these elements are shown above the rectangles.@(((:tag . "NNS") (:stem . "name") (:form . "Names") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.190) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101939@unknown@formal@none@1@S@Furthermore, we found that unassembled WGS trace sequences encode two other proteins, P4_SP and P5_SP, similar to the N-terminal RAG1 domain (Figure 6).@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unassembled") (:form . "unassembled") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "P4_SP") (:form . "P4_SP") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "P5_SP") (:form . "P5_SP") (:end . 101)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.200) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101949@unknown@formal@none@1@S@To test whether the reported sea urchin sequences represent a true RAG1-like match, we cut off the ring finger motif and repeated the BLASTP search against all GenBank proteins.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "cut") (:form . "cut") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "RP") (:stem . "off") (:form . "off") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "repeat") (:form . "repeated") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 147)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 155)\n  (:start . 148) (:id . 68))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 176)\n  (:start . 168) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x6.210.1) (:span 8 15)))\n (:hscopes ((:id . :x6.210.1) (:span 8 82)))\n (:identifiers (:sid . :s6.210) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101959@unknown@formal@none@1@S@The sea urchin and lancelet proteins are marked by “_SP” and “_BF” following the identification numbers of the corresponding contigs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 47) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "_SP") (:form . "_SP") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "_BF") (:form . "_BF") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 76)\n  (:start . 67) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 95) (:start . 81) (:id . 60))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 124)\n  (:start . 111) (:id . 64))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s6.220) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101969@unknown@formal@none@1@S@As shown in this paper, the RAG1 core was derived from a Transib TPase, but given the low identity between the Transib TPase and the RAG1 core (14%–17%) it is not clear whether the ancestral transposon was a member of the group of canonical Transib transposons preserved in modern genomes of insects, hydra, and sea urchin (see Figure 1), or a member of an unknown group of Transib transposons that encoded a TPase that was more similar to RAG1 core than to the canonical TPase from the currently known Transib transposons.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 37) (:start . 33)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 49)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 64)\n  (:start . 57) (:id . 55))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 70) (:start . 65)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 81) (:start . 76)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 89) (:start . 86)\n  (:id . 61))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 98)\n  (:start . 90) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 106)\n  (:start . 99) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 118)\n  (:start . 111) (:id . 65))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 124)\n  (:start . 119) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 137) (:start . 133)\n  (:id . 69))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 142) (:start . 138)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 71))\n ((:tag . "CD") (:stem . "14%–17") (:form . "14%–17") (:end . 150)\n  (:start . 144) (:id . 72))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 151) (:start . 150)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 74))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 155) (:start . 153)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 76))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 162) (:start . 159)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 168)\n  (:start . 163) (:id . 78))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 176)\n  (:start . 169) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "ancestral") (:form . "ancestral") (:end . 190)\n  (:start . 181) (:id . 81))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 201)\n  (:start . 191) (:id . 82))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 205) (:start . 202)\n  (:id . 83))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 207) (:start . 206)\n  (:id . 84))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 214)\n  (:start . 208) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 87))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 227)\n  (:start . 222) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 240)\n  (:start . 231) (:id . 90))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 248)\n  (:start . 241) (:id . 91))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 260)\n  (:start . 249) (:id . 92))\n ((:tag . "VBN") (:stem . "preserve") (:form . "preserved") (:end . 270)\n  (:start . 261) (:id . 93))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 273) (:start . 271)\n  (:id . 94))\n ((:tag . "JJ") (:stem . "modern") (:form . "modern") (:end . 280)\n  (:start . 274) (:id . 95))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 288)\n  (:start . 281) (:id . 96))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 291) (:start . 289)\n  (:id . 97))\n ((:tag . "NNS") (:stem . "insect") (:form . "insects") (:end . 299)\n  (:start . 292) (:id . 98))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 300) (:start . 299)\n  (:id . 99))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 306)\n  (:start . 301) (:id . 100))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 307) (:start . 306)\n  (:id . 101))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 311) (:start . 308)\n  (:id . 102))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 315) (:start . 312)\n  (:id . 103))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 322)\n  (:start . 316) (:id . 104))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 324) (:start . 323)\n  (:id . 105))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 327) (:start . 324)\n  (:id . 106))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 334)\n  (:start . 328) (:id . 107))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 336) (:start . 335)\n  (:id . 108))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 337) (:start . 336)\n  (:id . 109))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 338) (:start . 337)\n  (:id . 110))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 341) (:start . 339)\n  (:id . 111))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 343) (:start . 342)\n  (:id . 112))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 350)\n  (:start . 344) (:id . 113))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 353) (:start . 351)\n  (:id . 114))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 356) (:start . 354)\n  (:id . 115))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 364)\n  (:start . 357) (:id . 116))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 370)\n  (:start . 365) (:id . 117))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 373) (:start . 371)\n  (:id . 118))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 381)\n  (:start . 374) (:id . 119))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 393)\n  (:start . 382) (:id . 120))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 398) (:start . 394)\n  (:id . 121))\n ((:tag . "VBD") (:stem . "encode") (:form . "encoded") (:end . 406)\n  (:start . 399) (:id . 122))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 408) (:start . 407)\n  (:id . 123))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 414)\n  (:start . 409) (:id . 124))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 419) (:start . 415)\n  (:id . 125))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 423) (:start . 420)\n  (:id . 126))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 428) (:start . 424)\n  (:id . 127))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 436)\n  (:start . 429) (:id . 128))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 439) (:start . 437)\n  (:id . 129))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 444) (:start . 440)\n  (:id . 130))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 449) (:start . 445)\n  (:id . 131))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 454) (:start . 450)\n  (:id . 132))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 457) (:start . 455)\n  (:id . 133))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 461) (:start . 458)\n  (:id . 134))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 471)\n  (:start . 462) (:id . 135))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 477)\n  (:start . 472) (:id . 136))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 482) (:start . 478)\n  (:id . 137))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 486) (:start . 483)\n  (:id . 138))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 496)\n  (:start . 487) (:id . 139))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 502)\n  (:start . 497) (:id . 140))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 510)\n  (:start . 503) (:id . 141))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 522)\n  (:start . 511) (:id . 142))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 523) (:start . 522)\n  (:id . 143)))@@@1@102@((:hcues ((:id . :x6.230.1) (:span 339 341))\n  ((:id . :x6.230.2) (:span 169 176)) ((:id . :x6.230.3) (:span 159 168)))\n (:hscopes ((:id . :x6.230.1) (:span 206 522))\n  ((:id . :x6.230.2) (:span 169 522)) ((:id . :x6.230.3) (:span 159 522)))\n (:identifiers (:sid . :s6.230) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101979@unknown@formal@none@1@S@Nevertheless, based on the orientations and relative positions of these transposons, none of them appears to be associated with the RAG1-like sequences (see Figure 5).@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "orientation") (:form . "orientations") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 163)\n  (:start . 157) (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x6.240.2) (:span 98 105)))\n (:ncues ((:id . :x6.240.1) (:span 85 89)))\n (:hscopes ((:id . :x6.240.2) (:span 85 151)))\n (:nscopes ((:id . :x6.240.1) (:span 85 151)))\n (:identifiers (:sid . :s6.240) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101989@unknown@formal@none@1@S@In the sea urchin, lancelet, hydra, and starlet sea anemone genomes, the RAG1 core–like sequences and the N-terminal domain–like sequences do not appear to be linked to each other or to any other proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 47)\n  (:start . 40) (:id . 52))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 59)\n  (:start . 52) (:id . 54))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 67)\n  (:start . 60) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 77) (:start . 73)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 87)\n  (:start . 78) (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 97)\n  (:start . 88) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 116)\n  (:start . 106) (:id . 63))\n ((:tag . "JJ") (:stem . "domain–like") (:form . "domain–like") (:end . 128)\n  (:start . 117) (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 76))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 195)\n  (:start . 190) (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 204)\n  (:start . 196) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x6.250.2) (:span 146 152)))\n (:ncues ((:id . :x6.250.1) (:span 142 145)))\n (:hscopes ((:id . :x6.250.2) (:span 69 204)))\n (:nscopes ((:id . :x6.250.1) (:span 69 204)))\n (:identifiers (:sid . :s6.250) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101999@unknown@formal@none@1@S@Again, it is unclear if this part is not present in sea urchins or simply undetectable due to its small size and the high sequence divergence.@(((:tag . "RB") (:stem . "again") (:form . "Again") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 20)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 48)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "urchin") (:form . "urchins") (:end . 63)\n  (:start . 56) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 73)\n  (:start . 67) (:id . 57))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 86)\n  (:start . 74) (:id . 58))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 103) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 108) (:start . 104)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 121) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 130)\n  (:start . 122) (:id . 67))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 141)\n  (:start . 131) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x6.260.2) (:span 64 66)) ((:id . :x6.260.3) (:span 21 23))\n  ((:id . :x6.260.4) (:span 13 20)))\n (:ncues ((:id . :x6.260.1) (:span 37 40)))\n (:hscopes ((:id . :x6.260.2) (:span 37 63))\n  ((:id . :x6.260.3) (:span 21 141)) ((:id . :x6.260.4) (:span 13 141)))\n (:nscopes ((:id . :x6.260.1) (:span 37 86)))\n (:identifiers (:sid . :s6.260) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102009@unknown@formal@none@1@S@The observed sequence similarity between the RAG1 and Transib TPase protein can help to identify aa residues in the TPase that are crucial for transposition of Transib transposons.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "JJ") (:stem . "aa") (:form . "aa") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 156) (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x6.270.1) (:span 76 79)))\n (:hscopes ((:id . :x6.270.1) (:span 76 179)))\n (:identifiers (:sid . :s6.270) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102019@unknown@formal@none@1@S@Second, although RAG1/2-mediated transpositions are characterized by 5-bp (sometimes 4-bp) TSDs, all known hAT transposons are characterized by 8-bp TSDs.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "rag1/2-mediated") (:form . "RAG1/2-mediated")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 47) (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 65) (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "RB") (:stem . "sometimes") (:form . "sometimes") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "JJ") (:stem . "4-bp") (:form . "4-bp") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TSD") (:form . "TSDs") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "8-bp") (:form . "8-bp") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s6.280) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102029@unknown@formal@none@1@S@Partially assembled S. purpuratus contig sequences were downloaded on 12 August 2004 from the Baylor College of Medicine through the Web site at ftp://ftp.hgsc.bcm.tmc.edu/pub/data/Spurpuratus/blast/Spur20030922-genome.@(((:tag . "RB") (:stem . "partially") (:form . "Partially") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "assemble") (:form . "assembled") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "purpuratus") (:form . "purpuratus") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "August") (:form . "August") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Baylor") (:form . "Baylor") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "College") (:form . "College") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Medicine") (:form . "Medicine") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Web") (:form . "Web") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NN")\n  (:stem\n   . "ftp://ftp.hgsc.bcm.tmc.edu/pub/data/Spurpuratus/blast/Spur20030922-genome")\n  (:form\n   . "ftp://ftp.hgsc.bcm.tmc.edu/pub/data/Spurpuratus/blast/Spur20030922-genome")\n  (:end . 218) (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s6.290) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102039@unknown@formal@none@1@S@To avoid background noise introduced by mutations, Transib relics, whose TPase-coding regions contained numerous stop codons and indels, were ignored unless several copies were available.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "noise") (:form . "noise") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "relic") (:form . "relics") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tpase-coding") (:form . "TPase-coding") (:end . 85)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "indel") (:form . "indels") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "ignore") (:form . "ignored") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 171)\n  (:start . 165) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 186)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.300) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102049@unknown@formal@none@1@S@A standalone 2001 version of PSI (Position-Specific Iterating)-BLAST [18,45] was used for detection of proteins that were significantly similar to TPases encoded by Transib and other superfamilies of DNA transposons.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "standalone") (:form . "standalone") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "CD") (:stem . "2001") (:form . "2001") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PSI") (:form . "PSI") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "position-specific") (:form . "Position-Specific")\n  (:end . 51) (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "Iterating)-BLAST") (:form . "Iterating)-BLAST")\n  (:end . 68) (:start . 52) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "CD") (:stem . "18,45") (:form . "18,45") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 135) (:start . 122) (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies")\n  (:end . 196) (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 215)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s6.310) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102059@unknown@formal@none@1@S@The following protocol describes the procedure: (1) Use a GenBank set combined with N number of Transib TPases (in our studies, N was equal to 7, 13, and 18), (2) run PSI-BLAST against GenBank combined with TPases using each TPase as a query or seed, (3) select only Transib TPase sequences with E-values less than 10-5 to define the PSSM, (4) take the best E-value (Ei) obtained by PSI-BLAST for RAG1s when PSSM is constructed without RAG1, then (5) repeat these operations for different numbers (N) of TPases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "protocol") (:form . "protocol") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "use") (:form . "Use") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 126)\n  (:start . 119) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 129) (:start . 128)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 139)\n  (:start . 134) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 71))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 144) (:start . 143)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 73))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 148) (:start . 146)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 76))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 156) (:start . 154)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 80))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 161) (:start . 160)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 82))\n ((:tag . "VB") (:stem . "run") (:form . "run") (:end . 166) (:start . 163)\n  (:id . 83))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 176)\n  (:start . 167) (:id . 84))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 184)\n  (:start . 177) (:id . 85))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 192)\n  (:start . 185) (:id . 86))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 201)\n  (:start . 193) (:id . 87))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 206) (:start . 202)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 213)\n  (:start . 207) (:id . 89))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 219) (:start . 214)\n  (:id . 90))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 224) (:start . 220)\n  (:id . 91))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 230)\n  (:start . 225) (:id . 92))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 233) (:start . 231)\n  (:id . 93))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 235) (:start . 234)\n  (:id . 94))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 241)\n  (:start . 236) (:id . 95))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 244) (:start . 242)\n  (:id . 96))\n ((:tag . "NN") (:stem . "seed") (:form . "seed") (:end . 249) (:start . 245)\n  (:id . 97))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 250) (:start . 249)\n  (:id . 98))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 252) (:start . 251)\n  (:id . 99))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 253) (:start . 252)\n  (:id . 100))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 254) (:start . 253)\n  (:id . 101))\n ((:tag . "VBP") (:stem . "select") (:form . "select") (:end . 261)\n  (:start . 255) (:id . 102))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 266) (:start . 262)\n  (:id . 103))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 274)\n  (:start . 267) (:id . 104))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 280)\n  (:start . 275) (:id . 105))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 290)\n  (:start . 281) (:id . 106))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 295) (:start . 291)\n  (:id . 107))\n ((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 304)\n  (:start . 296) (:id . 108))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 309) (:start . 305)\n  (:id . 109))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 314) (:start . 310)\n  (:id . 110))\n ((:tag . "CD") (:stem . "10-5") (:form . "10-5") (:end . 319) (:start . 315)\n  (:id . 111))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 322) (:start . 320)\n  (:id . 112))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 329)\n  (:start . 323) (:id . 113))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 333) (:start . 330)\n  (:id . 114))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 338) (:start . 334)\n  (:id . 115))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 339) (:start . 338)\n  (:id . 116))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 341) (:start . 340)\n  (:id . 117))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 342) (:start . 341)\n  (:id . 118))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 343) (:start . 342)\n  (:id . 119))\n ((:tag . "VBP") (:stem . "take") (:form . "take") (:end . 348) (:start . 344)\n  (:id . 120))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 352) (:start . 349)\n  (:id . 121))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 357) (:start . 353)\n  (:id . 122))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 365)\n  (:start . 358) (:id . 123))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 367) (:start . 366)\n  (:id . 124))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 369) (:start . 367)\n  (:id . 125))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 370) (:start . 369)\n  (:id . 126))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 379)\n  (:start . 371) (:id . 127))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 382) (:start . 380)\n  (:id . 128))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 392)\n  (:start . 383) (:id . 129))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 396) (:start . 393)\n  (:id . 130))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 402)\n  (:start . 397) (:id . 131))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 407) (:start . 403)\n  (:id . 132))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 412) (:start . 408)\n  (:id . 133))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 415) (:start . 413)\n  (:id . 134))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 427)\n  (:start . 416) (:id . 135))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 435)\n  (:start . 428) (:id . 136))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 440) (:start . 436)\n  (:id . 137))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 441) (:start . 440)\n  (:id . 138))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 446) (:start . 442)\n  (:id . 139))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 448) (:start . 447)\n  (:id . 140))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 449) (:start . 448)\n  (:id . 141))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 450) (:start . 449)\n  (:id . 142))\n ((:tag . "VBP") (:stem . "repeat") (:form . "repeat") (:end . 457)\n  (:start . 451) (:id . 143))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 463)\n  (:start . 458) (:id . 144))\n ((:tag . "NNS") (:stem . "operation") (:form . "operations") (:end . 474)\n  (:start . 464) (:id . 145))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 478) (:start . 475)\n  (:id . 146))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 488)\n  (:start . 479) (:id . 147))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 496)\n  (:start . 489) (:id . 148))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 498) (:start . 497)\n  (:id . 149))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 499) (:start . 498)\n  (:id . 150))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 500) (:start . 499)\n  (:id . 151))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 503) (:start . 501)\n  (:id . 152))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 510)\n  (:start . 504) (:id . 153))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 511) (:start . 510)\n  (:id . 154)))@@@1@113@((:ncues ((:id . :x6.320.1) (:span 428 435)))\n (:nscopes ((:id . :x6.320.1) (:span 428 440)))\n (:identifiers (:sid . :s6.320) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102069@unknown@formal@none@1@S@One of the 5-bp TSDs flanking the 3? terminus of a Transib was excluded in each case.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 45)\n  (:start . 37) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 58)\n  (:start . 51) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 71)\n  (:start . 63) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.330) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102079@unknown@formal@none@1@S@Multiple Alignment of the RAG1 Core and Transib TPase Proteins@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "Alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 62)\n  (:start . 54) (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.340) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102089@unknown@formal@none@1@S@Dots indicate nucleotide identity with the consensus sequence; hyphens represent alignment gaps.@(((:tag . "NNS") (:stem . "dot") (:form . "Dots") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hyphen") (:form . "hyphens") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "NNS") (:stem . "gap") (:form . "gaps") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.350) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102099@unknown@formal@none@1@S@(G) TransibN1_SP family from sea urchin.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN1_SP") (:form . "TransibN1_SP") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 40) (:start . 39)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.360) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102109@unknown@formal@none@1@S@Structure of hAT 5? Termini@(((:tag . "NN") (:stem . "structure") (:form . "Structure") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Termini") (:form . "Termini") (:end . 27)\n  (:start . 20) (:id . 47)))@@@1@6@((:identifiers (:sid . :s6.370) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102119@unknown@formal@none@1@S@Columns 1 and 2 list common and Latin names of species whose genomes contain Transib TPase sequences.@(((:tag . "NNS") (:stem . "column") (:form . "Columns") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "latin") (:form . "Latin") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "name") (:form . "names") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.380) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102129@unknown@formal@none@1@S@A Role for Adenosine Deaminase in Drosophila Larval Development@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Role") (:form . "Role") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "NNP") (:stem . "Deaminase") (:form . "Deaminase") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "Larval") (:form . "Larval") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 63)\n  (:start . 52) (:id . 50)))@@@1@9@((:identifiers (:sid . :s7.1) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5102139@unknown@formal@none@1@S@Adenosine deaminase (ADA) is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine.@(((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "deaminase") (:form . "deaminase") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "catalyze") (:form . "catalyzes") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 95)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "deamination") (:form . "deamination") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 139) (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inosine") (:form . "inosine") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "deoxyinosine") (:form . "deoxyinosine") (:end . 167)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s7.11) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102149@unknown@formal@none@1@S@The predominant source of extracellular adenosine during systemic activation of the stress system is the sympathetic nervous system [7].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sympathetic") (:form . "sympathetic") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.21) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102159@unknown@formal@none@1@S@We also demonstrated that adenosine functions as a negative signal for cell proliferation and concluded that ADGFs stimulate cell growth in vitro by depletion of extracellular adenosine [16].@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "conclude") (:form . "concluded") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ADGF") (:form . "ADGFs") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 175) (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.31) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102169@unknown@formal@none@1@S@Some homozygous third-instar larvae can be found alive in the vial even after 10 d of development.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "alive") (:form . "alive") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "vial") (:form . "vial") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.41) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102179@unknown@formal@none@1@S@This result confirms that the mutant phenotype is caused by the mutation in the ADGF-A gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "confirm") (:form . "confirms") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s7.51) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102189@unknown@formal@none@1@S@Each experiment was repeated at least four times (with 20–30 animals in each vial) and the standard error is shown.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20–30") (:form . "20–30") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "vial") (:form . "vial") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.61) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102199@unknown@formal@none@1@S@However, neither of the two lines carrying the mutated version of the UAS-ADGF-A (producing full-length protein detected by anti-myc antibody; see Materials and Methods) showed any rescue of the mutant phenotype.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "UAS-ADGF-A") (:form . "UAS-ADGF-A") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-myc") (:form . "anti-myc") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 168)\n  (:start . 161) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 187)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 201)\n  (:start . 195) (:id . 75))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x7.71.1) (:span 9 16)))\n (:nscopes ((:id . :x7.71.1) (:span 9 211)))\n (:identifiers (:sid . :s7.71) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102209@unknown@formal@none@1@S@This process is similar to normal metamorphic changes, in which the hemocytes are first released from the front lobes, and the posterior lobes disperse later.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "front") (:form . "front") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "lobe") (:form . "lobes") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 136)\n  (:start . 127) (:id . 65))\n ((:tag . "NNS") (:stem . "lobe") (:form . "lobes") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "VBP") (:stem . "disperse") (:form . "disperse") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "RB") (:stem . "later") (:form . "later") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.81) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102219@unknown@formal@none@1@S@Hemocyte Abnormalities in adgf-a Mutant Larvae@(((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 22)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "Larvae") (:form . "Larvae") (:end . 46)\n  (:start . 40) (:id . 47)))@@@1@6@((:identifiers (:sid . :s7.91) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102229@unknown@formal@none@1@S@Crystal Cells in Late Third Instar Larvae@(((:tag . "JJ") (:stem . "crystal") (:form . "Crystal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Cell") (:form . "Cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Late") (:form . "Late") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Third") (:form . "Third") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Instar") (:form . "Instar") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "Larvae") (:form . "Larvae") (:end . 41)\n  (:start . 35) (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.101) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102239@unknown@formal@none@1@S@The number of hemocytes is also reduced, but to a lesser extent in larvae rescued by Cg-Gal4/UAS-ADGF-A.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 56) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Cg-Gal4/UAS-ADGF-A") (:form . "Cg-Gal4/UAS-ADGF-A")\n  (:end . 103) (:start . 85) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.111) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102249@unknown@formal@none@1@S@No rescue of the phenotype, including body shape of escaping pupae, was observed.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "shape") (:form . "shape") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "escape") (:form . "escaping") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "pupae") (:form . "pupae") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x7.121.1) (:span 0 2)))\n (:nscopes ((:id . :x7.121.1) (:span 0 80)))\n (:identifiers (:sid . :s7.121) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102259@unknown@formal@none@1@S@However, the delay in development and block of pupariation (Figure 6B), as well as the pupal body shape, were not influenced by this mutation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "delay") (:form . "delay") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "6b") (:form . "6B") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 92) (:start . 87)\n  (:id . 61))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 97) (:start . 93)\n  (:id . 62))\n ((:tag . "NN") (:stem . "shape") (:form . "shape") (:end . 103) (:start . 98)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 109) (:start . 105)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 124)\n  (:start . 114) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 132) (:start . 128)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 141)\n  (:start . 133) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x7.131.1) (:span 110 113)))\n (:nscopes ((:id . :x7.131.1) (:span 9 141)))\n (:identifiers (:sid . :s7.131) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102269@unknown@formal@none@1@S@Previous results suggest that fat body disintegration might be caused by the action of hemocytes.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 53) (:start . 39) (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x7.141.1) (:span 54 59)) ((:id . :x7.141.2) (:span 17 24)))\n (:hscopes ((:id . :x7.141.1) (:span 30 96))\n  ((:id . :x7.141.2) (:span 17 96)))\n (:identifiers (:sid . :s7.141) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102279@unknown@formal@none@1@S@Mutation in a Putative Adenosine Receptor Suppresses the Block of Pupariation in adgf-a@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "putative") (:form . "Putative") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "Receptor") (:form . "Receptor") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "Suppresses") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Block") (:form . "Block") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Pupariation") (:form . "Pupariation") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 87)\n  (:start . 81) (:id . 54)))@@@1@13@((:hcues ((:id . :x7.151.1) (:span 14 22)))\n (:hscopes ((:id . :x7.151.1) (:span 14 41)))\n (:identifiers (:sid . :s7.151) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102289@unknown@formal@none@1@S@Ecdysone Regulation of Development in adgf-a@(((:tag . "NNP") (:stem . "Ecdysone") (:form . "Ecdysone") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 44)\n  (:start . 38) (:id . 47)))@@@1@6@((:identifiers (:sid . :s7.161) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102299@unknown@formal@none@1@S@The delayed development and low pupariation rate in the adgf-a mutant larvae (see Figures 2A and 7A) could be caused by an effect on hormonal regulation of development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 129)\n  (:start . 123) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 141)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 152)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 167)\n  (:start . 156) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x7.171.1) (:span 101 106)))\n (:hscopes ((:id . :x7.171.1) (:span 0 167)))\n (:identifiers (:sid . :s7.171) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102309@unknown@formal@none@1@S@All analyzed adgf-a mutant larvae carrying the Sgs?3-GFP construct showed normal expression of Sgs-GFP in salivary glands (Figure 7D).@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Sgs?3-GFP") (:form . "Sgs?3-GFP") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 73) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Sgs-GFP") (:form . "Sgs-GFP") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "7d") (:form . "7D") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.181) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102319@unknown@formal@none@1@S@Overexpression of ADGF-A in animals with a hypomorphic cact combination (cactE8/cactIIIG) increased the adult survival rate almost 4-fold (Figure 8A).@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hypomorphic") (:form . "hypomorphic") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "cact") (:form . "cact") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "cactE8/cactIIIG") (:form . "cactE8/cactIIIG")\n  (:end . 88) (:start . 73) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "RB") (:stem . "4-fold") (:form . "4-fold") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "8a") (:form . "8A") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.191) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102329@unknown@formal@none@1@S@(B) Percentage of late third instar larvae presenting melanotic tumor formation.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "percentage") (:form . "Percentage") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "VBG") (:stem . "present") (:form . "presenting") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.201) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102339@unknown@formal@none@1@S@This suggests a function for ADGF-A within the lymph gland.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x7.211.1) (:span 5 13)))\n (:hscopes ((:id . :x7.211.1) (:span 5 58)))\n (:identifiers (:sid . :s7.211) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102349@unknown@formal@none@1@S@Constitutive activation of Toll signaling leads to developmental arrest and hematopoietic defects associated with melanotic tumor formation [35], similar to the phenotype of the adgf-a mutant.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 89) (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 97)\n  (:start . 90) (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 123)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 141) (:start . 140)\n  (:id . 59))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 144) (:start . 143)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.221) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102359@unknown@formal@none@1@S@One of the most remarkable features of the adgf-a mutant phenotype is the disintegration of the fat body in third-instar larvae, another indication of precocious metamorphic changes since the disintegration normally occurs much later, during pupal life.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "remarkable") (:form . "remarkable") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 88) (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 120)\n  (:start . 108) (:id . 61))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "indication") (:form . "indication") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 161)\n  (:start . 151) (:id . 67))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 173)\n  (:start . 162) (:id . 68))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 187)\n  (:start . 182) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 206) (:start . 192) (:id . 72))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 215)\n  (:start . 207) (:id . 73))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 222)\n  (:start . 216) (:id . 74))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 227) (:start . 223)\n  (:id . 75))\n ((:tag . "RB") (:stem . "later") (:form . "later") (:end . 233)\n  (:start . 228) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 234) (:start . 233)\n  (:id . 77))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 241)\n  (:start . 235) (:id . 78))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 247)\n  (:start . 242) (:id . 79))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 252) (:start . 248)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x7.231.1) (:span 137 147)))\n (:hscopes ((:id . :x7.231.1) (:span 137 181)))\n (:identifiers (:sid . :s7.231) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102369@unknown@formal@none@1@S@Possible Signaling Role for Adenosine@(((:tag . "JJ") (:stem . "possible") (:form . "Possible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "Role") (:form . "Role") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 37)\n  (:start . 28) (:id . 46)))@@@1@5@((:hcues ((:id . :x7.241.1) (:span 0 8)))\n (:hscopes ((:id . :x7.241.1) (:span 0 37)))\n (:identifiers (:sid . :s7.241) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102379@unknown@formal@none@1@S@One possible explanation for the developmental delay and failure to pupariate is that the adgf-a mutation affects the production or release of ecdysteroid hormones from the major endocrine organ of the Drosophila larva—the ring gland.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "delay") (:form . "delay") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VB") (:stem . "pupariate") (:form . "pupariate") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ecdysteroid") (:form . "ecdysteroid") (:end . 154)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 212)\n  (:start . 202) (:id . 73))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 218)\n  (:start . 213) (:id . 74))\n ((:tag . "NN") (:stem . "—") (:form . "—") (:end . 219) (:start . 218)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 227) (:start . 223)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 233)\n  (:start . 228) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x7.251.2) (:span 4 12)))\n (:ncues ((:id . :x7.251.1) (:span 57 64)))\n (:hscopes ((:id . :x7.251.2) (:span 4 77)))\n (:nscopes ((:id . :x7.251.1) (:span 57 77)))\n (:identifiers (:sid . :s7.251) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102389@unknown@formal@none@1@S@Work using adenosine-receptor deficient mammalian cells also suggested the existence of a novel, undefined adenosine signaling mechanism [44].@(((:tag . "NNP") (:stem . "Work") (:form . "Work") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adenosine-receptor") (:form . "adenosine-receptor")\n  (:end . 29) (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 49)\n  (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 136)\n  (:start . 127) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x7.261.1) (:span 61 70)))\n (:hscopes ((:id . :x7.261.1) (:span 61 136)))\n (:identifiers (:sid . :s7.261) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102399@unknown@formal@none@1@S@This would be consistent with the role of adenosine as a “stress hormone” in mammals [6].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 72)\n  (:start . 65) (:id . 55))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x7.271.1) (:span 5 10)))\n (:hscopes ((:id . :x7.271.1) (:span 5 84)))\n (:identifiers (:sid . :s7.271) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102409@unknown@formal@none@1@S@A mutation in the adenosine receptor gene on Chromosome III was produced by the ends-out targeting method (ED, unpublished data) and is referred to here as adoR.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ends-out") (:form . "ends-out") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ED") (:form . "ED") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 127)\n  (:start . 123) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 160) (:start . 156)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.281) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102419@unknown@formal@none@1@S@To recognize homozygous larvae, balancer chromosomes with the GFP marker were used: CyO Pw+mW.hs=Ubi-GFP.S65TPAD1 (BL-4559) and TM3 Pw+mC=ActGFPJMR2 Ser (BL-4888).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "balancer") (:form . "balancer") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CyO") (:form . "CyO") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Pw+mW.hs=Ubi-GFP.S65TPAD1")\n  (:form . "Pw+mW.hs=Ubi-GFP.S65TPAD1") (:end . 113) (:start . 88) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "BL-4559") (:form . "BL-4559") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TM3") (:form . "TM3") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Pw+mC=ActGFPJMR2") (:form . "Pw+mC=ActGFPJMR2")\n  (:end . 148) (:start . 132) (:id . 63))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "bl-4888") (:form . "BL-4888") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.291) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102429@unknown@formal@none@1@S@Fat body observation@(((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 20)\n  (:start . 9) (:id . 44)))@@@1@3@((:identifiers (:sid . :s7.301) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102439@unknown@formal@none@1@S@To observe hemocyte morphology, samples were analyzed at least 10 min after the deposition of solution with hemocytes, in order to allow the cells to adhere to the surface of the slide.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "observe") (:form . "observe") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "deposition") (:form . "deposition") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "VB") (:stem . "adhere") (:form . "adhere") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 171)\n  (:start . 164) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "slide") (:form . "slide") (:end . 184)\n  (:start . 179) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s7.311) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102449@unknown@formal@none@1@S@The sequence encoding the myc-tag 5?- GAGCAAAAGCTCATTTCTGAAGAGGACTTG-3? plus a stop codon was inserted into XbaI site of pUAST (using the XbaI site on the 5? end and the NheI site on the 3? end) cut by XhoI/XbaI.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "myc-tag") (:form . "myc-tag") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gagcaaaagctcatttctgaagaggacttg-3")\n  (:form . "GAGCAAAAGCTCATTTCTGAAGAGGACTTG-3") (:end . 70) (:start . 38)\n  (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 71) (:start . 70)\n  (:id . 49))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "XbaI") (:form . "XbaI") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "puast") (:form . "pUAST") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 133) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "XbaI") (:form . "XbaI") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NheI") (:form . "NheI") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 179) (:start . 175)\n  (:id . 74))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 76))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 188) (:start . 187)\n  (:id . 77))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 189) (:start . 188)\n  (:id . 78))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 193) (:start . 190)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "cut") (:form . "cut") (:end . 198) (:start . 195)\n  (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 201) (:start . 199)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "XhoI/XbaI") (:form . "XhoI/XbaI") (:end . 211)\n  (:start . 202) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s7.321) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102459@unknown@formal@none@1@S@A comparison of programmed cell death between species@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 53)\n  (:start . 46) (:id . 49)))@@@1@8@((:identifiers (:sid . :s8.1) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5102469@unknown@formal@none@1@S@Programmed cell death has long been known to be a part of normal development, but it was not until the discovery of the first genes essential for the phenomenon that our understanding of the events leading up to the deliberate elimination of a cell began to take shape.@(((:tag . "VBN") (:stem . "program") (:form . "Programmed") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 98) (:start . 93)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 112)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 125)\n  (:start . 120) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 67))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 141)\n  (:start . 132) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 160)\n  (:start . 150) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 183) (:start . 170) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 197)\n  (:start . 191) (:id . 77))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 205)\n  (:start . 198) (:id . 78))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 208) (:start . 206)\n  (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "deliberate") (:form . "deliberate") (:end . 226)\n  (:start . 216) (:id . 82))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 238)\n  (:start . 227) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 243) (:start . 242)\n  (:id . 85))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 248) (:start . 244)\n  (:id . 86))\n ((:tag . "VBD") (:stem . "begin") (:form . "began") (:end . 254)\n  (:start . 249) (:id . 87))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 257) (:start . 255)\n  (:id . 88))\n ((:tag . "VB") (:stem . "take") (:form . "take") (:end . 262) (:start . 258)\n  (:id . 89))\n ((:tag . "NN") (:stem . "shape") (:form . "shape") (:end . 268)\n  (:start . 263) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s8.11) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102479@unknown@formal@none@1@S@Drosophila has at least eight caspases, five of which have been at least partially characterized (Dcp-1, Dcp-2/Dredd, drICE, Dronc, and Decay) and three uncharacterized ones found encoded in the genome sequence [7].@(((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "eight") (:form . "eight") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Dcp-1") (:form . "Dcp-1") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Dcp-2/Dredd") (:form . "Dcp-2/Dredd") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "drICE") (:form . "drICE") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Dronc") (:form . "Dronc") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Decay") (:form . "Decay") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 70))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 152)\n  (:start . 147) (:id . 71))\n ((:tag . "JJ") (:stem . "uncharacterized") (:form . "uncharacterized")\n  (:end . 168) (:start . 153) (:id . 72))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 187)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 77))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 201)\n  (:start . 195) (:id . 78))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 210)\n  (:start . 202) (:id . 79))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 212) (:start . 211)\n  (:id . 80))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 213) (:start . 212)\n  (:id . 81))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 214) (:start . 213)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s8.21) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102489@unknown@formal@none@1@S@Like CED-4, Apaf-1 requires dATP for caspase activation, but Apaf-1 requires cytochrome c in addition [14].@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "datp") (:form . "dATP") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s8.31) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102499@unknown@formal@none@1@S@The rate of mitochondrial release of cytochrome c in mammalian cells undergoing apoptosis was recently measured and found to be rapid [18].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitochondrial") (:form . "mitochondrial")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s8.41) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102509@unknown@formal@none@1@S@A third group shows that peptide caspase inhibitors can block Drosophila Bok-mediated apoptosis in cell culture, lending support to a model in which expression of Bok protein leads to caspase activation [24].@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "bok-mediated") (:form . "Bok-mediated") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "lend") (:form . "lending") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 202)\n  (:start . 192) (:id . 73))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 204) (:start . 203)\n  (:id . 74))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 207) (:start . 206)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s8.51) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102519@unknown@formal@none@1@S@One notable exception is that the C.elegans homologs of IAPs do not appear to function in programmed cell death.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "notable") (:form . "notable") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNPS") (:stem . "C.elegans") (:form . "C.elegans") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x8.61.2) (:span 68 74)))\n (:ncues ((:id . :x8.61.1) (:span 64 67)))\n (:hscopes ((:id . :x8.61.2) (:span 30 111)))\n (:nscopes ((:id . :x8.61.1) (:span 30 111)))\n (:identifiers (:sid . :s8.61) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102529@unknown@formal@none@1@S@Also, Hid has been shown to be negatively regulated by survival signals mediated by receptor tyrosine kinases through the Ras and mitogen-activated protein (MAP) kinase pathway, which is also well conserved in mammals [28,29].@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 41)\n  (:start . 31) (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NNPS") (:stem . "Ras") (:form . "Ras") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 147) (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 168)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 176)\n  (:start . 169) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 191) (:start . 187)\n  (:id . 74))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 206)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 217)\n  (:start . 210) (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 219) (:start . 218)\n  (:id . 79))\n ((:tag . "CD") (:stem . "28,29") (:form . "28,29") (:end . 224)\n  (:start . 219) (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 225) (:start . 224)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s8.71) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102539@unknown@formal@none@1@S@The observation that transcription of both reaper and dark/hac-1/dapaf-1 can be induced by ionizing radiation suggests that these death-inducing signals can feed into the cell death pathway at multiple points.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dark/hac-1/dapaf-1") (:form . "dark/hac-1/dapaf-1")\n  (:end . 72) (:start . 54) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "death-inducing") (:form . "death-inducing")\n  (:end . 144) (:start . 130) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 152)\n  (:start . 145) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "VB") (:stem . "feed") (:form . "feed") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 181)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 189)\n  (:start . 182) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 192) (:start . 190)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 201)\n  (:start . 193) (:id . 70))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 208)\n  (:start . 202) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x8.81.1) (:span 153 156))\n  ((:id . :x8.81.2) (:span 110 118)))\n (:hscopes ((:id . :x8.81.1) (:span 153 208))\n  ((:id . :x8.81.2) (:span 110 208)))\n (:identifiers (:sid . :s8.81) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102549@unknown@formal@none@1@S@Loss-of-function mutants in diap1 have a very striking early embryonic phenotype: virtually all cells display an apoptotic morphology, as well as displaying DNA fragmentation seen by TUNEL labeling, four to five hours into development [47,49,50].@(((:tag . "JJ") (:stem . "loss-of-function") (:form . "Loss-of-function")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 24)\n  (:start . 17) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "diap1") (:form . "diap1") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "display") (:form . "displaying") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 174) (:start . 161) (:id . 67))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TUNEL") (:form . "TUNEL") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 197)\n  (:start . 189) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 72))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 203) (:start . 199)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 211) (:start . 207)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 217)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 234)\n  (:start . 223) (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 236) (:start . 235)\n  (:id . 79))\n ((:tag . "CD") (:stem . "47,49,50") (:form . "47,49,50") (:end . 244)\n  (:start . 236) (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 245) (:start . 244)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s8.91) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102559@unknown@formal@none@1@S@Conservation of key regulators of programmed cell death between species@(((:tag . "NNP") (:stem . "Conservation") (:form . "Conservation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 71)\n  (:start . 64) (:id . 51)))@@@1@10@((:identifiers (:sid . :s8.101) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5102569@unknown@formal@none@1@S@While it is clear that the search for homologs of known cell death genes has been greatly facilitated by the availability of the entire genome sequence for C. elegans, Drosophila, and humans, there are limitations to this strategy.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "VBN") (:stem . "facilitate") (:form . "facilitated") (:end . 101)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 121)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 166)\n  (:start . 159) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 190)\n  (:start . 184) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 197)\n  (:start . 192) (:id . 77))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "limitation") (:form . "limitations") (:end . 213)\n  (:start . 202) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 216) (:start . 214)\n  (:id . 80))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 221) (:start . 217)\n  (:id . 81))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 230)\n  (:start . 222) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s8.111) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102579@unknown@formal@none@1@S@Because sex chromosomes appeared relatively late in evolution, dosage compensation evolved independently in different organisms and is accomplished by distinct mechanisms.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 82)\n  (:start . 70) (:id . 52))\n ((:tag . "VBD") (:stem . "evolve") (:form . "evolved") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 104) (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 127)\n  (:start . 118) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "accomplish") (:form . "accomplished") (:end . 147)\n  (:start . 135) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 159)\n  (:start . 151) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 170)\n  (:start . 160) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s9.7) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102589@unknown@formal@none@1@S@It is assumed that Xist RNA provides a mark for specific histones (for example, histone macroH2A1.2), as well as proteins deacetylating histones and methylating many of the X-linked genes at GpC dinucleotides [9,10,11]; all these events are important for maintaining the silenced state of the inactivated X.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Xist") (:form . "Xist") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . 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5102599@unknown@formal@none@1@S@The three recent papers [1,2,3] have now started to address the role of the roX genes in this process and investigated which MSL proteins interact with the roX RNAs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "paper") (:form . "papers") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1,2,3") (:form . "1,2,3") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "start") (:form . "started") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 93) (:start . 89)\n  (:id . 61))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 101)\n  (:start . 94) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 118)\n  (:start . 106) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "msl") (:form . "MSL") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s9.27) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102609@unknown@formal@none@1@S@They found that roX1 and roX2 RNAs are associated with the X chromosome at different stages and sites during the assembly of the DCC.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s9.37) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102619@unknown@formal@none@1@S@The HAT domain of MOF is responsible for histone H4 acetylation, both in vivo and in vitro, as shown by Smith et al. [3].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HAT") (:form . "HAT") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "acetylation") (:form . "acetylation") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 100) (:start . 95)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Smith") (:form . "Smith") (:end . 109)\n  (:start . 104) (:id . 64))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 112) (:start . 110)\n  (:id . 65))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 116) (:start . 113)\n  (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 118) (:start . 117)\n  (:id . 67))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 119) (:start . 118)\n  (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 120) (:start . 119)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s9.47) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102629@unknown@formal@none@1@S@It is intriguing to speculate that the chromodomain of other remodeling proteins also exert their activity through RNA interactions and that RNAs might be more common than generally appreciated in transcriptional regulation.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "intrigue") (:form . "intriguing") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "speculate") (:form . "speculate") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "remodel") (:form . "remodeling") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 97)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 131)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "VBN") (:stem . "appreciate") (:form . "appreciated") (:end . 193)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 212) (:start . 197) (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 223)\n  (:start . 213) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x9.57.1) (:span 146 151)) ((:id . :x9.57.2) (:span 20 29)))\n (:hscopes ((:id . :x9.57.1) (:span 146 223))\n  ((:id . :x9.57.2) (:span 20 223)))\n (:identifiers (:sid . :s9.57) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102639@unknown@formal@none@1@S@Multiple RNA-protein interactions within the DCC@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "rna-protein") (:form . "RNA-protein") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 48) (:start . 45)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s9.67) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102649@unknown@formal@none@1@S@Evidence from co-immunoprecipitation experiments indicates that MSL1 and MSL2 interact directly with each other, a notion supported by the MSL1-MSL2 association at the 35 chromosomal entry sites in the absence of any other MSLs (the preDCC; Figure 1).@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "co-immunoprecipitation")\n  (:form . "co-immunoprecipitation") (:end . 36) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 48)\n  (:start . 37) (:id . 45))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 58)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MSL1") (:form . "MSL1") (:end . 68) (:start . 64)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MSL2") (:form . "MSL2") (:end . 77) (:start . 73)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "msl1-msl2") (:form . "MSL1-MSL2") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 160)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 182)\n  (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 188)\n  (:start . 183) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 209)\n  (:start . 202) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 73))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 222)\n  (:start . 217) (:id . 75))\n ((:tag . "NNS") (:stem . "msl") (:form . "MSLs") (:end . 227) (:start . 223)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "predcc") (:form . "preDCC") (:end . 239)\n  (:start . 233) (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 240) (:start . 239)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 247)\n  (:start . 241) (:id . 81))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 249) (:start . 248)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x9.77.1) (:span 49 63)))\n (:hscopes ((:id . :x9.77.1) (:span 49 111)))\n (:identifiers (:sid . :s9.77) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102659@unknown@formal@none@1@S@Although roX1 mutant males are fully viable [7], it was suggested that roX1 mutant males lacking a large number of additional genes, including roX2, have a lethal dosage-compensation phenotype because the DCC fails to assemble on the X chromosome [19].@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "(") (:stem . "[") (:form . 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5102669@unknown@formal@none@1@S@Not unlike in Drosophila, the DCC complex of C. elegans is also assembled in an ordered sequence, but no RNAs have been identified that might be involved in this assembly process [20]; either there will be yet another surprising turn in this multifaceted process or the CroX (C. elegans roX) RNAs wait to be discovered.@(((:tag . "RB") (:stem . "not") (:form . "Not") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unlike") (:form . "unlike") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DCC") (:form . 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