0 4 Role role NN 5 7 of of IN 8 16 cellular cellular JJ 17 22 tumor tumor NN 23 31 necrosis necrosis NN 32 38 factor factor NN 39 58 receptor-associated receptor-associated JJ 59 66 factors factor NNS 67 69 in in IN 70 79 NF-kappaB NF-kappaB NNP 80 90 activation activation NN 91 94 and and CC 95 105 lymphocyte lymphocyte NN 106 120 transformation transformation NN 121 123 by by IN 124 135 herpesvirus herpesvirus NN 136 143 Saimiri Saimiri NNP 144 147 STP STP NNP 147 148 . . . 150 153 The the DT 154 157 STP STP NNP 158 170 oncoproteins oncoprotein NNS 171 173 of of IN 174 177 the the DT 178 189 herpesvirus herpesvirus NN 190 197 saimiri saimiri NN 198 199 ( ( ( 199 202 HVS HVS NNP 202 203 ) ) ) 204 212 subgroup subgroup NN 213 214 A a NN 215 221 strain strain NN 222 224 11 11 CD 225 228 and and CC 229 237 subgroup subgroup NN 238 239 C C NNP 240 246 strain strain NN 247 250 488 488 CD 251 254 are be VBP 255 258 now now RB 259 264 found find VBN 265 267 to to TO 268 270 be be VB 271 277 stably stably RB 278 288 associated associate VBN 289 293 with with IN 294 299 tumor tumor NN 300 308 necrosis necrosis NN 309 315 factor factor NN 316 335 receptor-associated receptor-associated JJ 336 342 factor factor NN 343 344 ( ( ( 344 348 TRAF TRAF NNP 348 349 ) ) ) 350 351 1 1 CD 351 352 , , , 353 354 2 2 CD 354 355 , , , 356 358 or or CC 359 360 3 3 CD 360 361 . . . 362 372 Mutational mutational JJ 373 381 analyses analysis NNS 382 392 identified identify VBD 393 401 residues residue NNS 402 404 of of IN 405 412 PXQXT/S pxqxt/s NN 413 415 in in IN 416 423 STP-A11 stp-a11 NN 424 426 as as IN 427 435 critical critical JJ 436 439 for for IN 440 444 TRAF TRAF NNP 445 456 association association NN 456 457 . . . 458 460 In in IN 461 469 addition addition NN 469 470 , , , 471 472 a a DT 473 481 somewhat somewhat RB 482 491 divergent divergent JJ 492 498 region region NN 499 501 of of IN 502 510 STP-C488 stp-c488 NN 511 513 is be VBZ 514 522 critical critical JJ 523 526 for for IN 527 531 TRAF TRAF NNP 532 543 association association NN 543 544 . . . 545 555 Mutational mutational JJ 556 564 analysis analysis NN 565 569 also also RB 570 578 revealed reveal VBD 579 583 that that IN 584 592 STP-C488 stp-c488 NN 593 600 induced induce VBD 601 610 NF-kappaB NF-kappaB NNP 611 621 activation activation NN 622 626 that that WDT 627 630 was be VBD 631 641 correlated correlate VBN 642 646 with with IN 647 650 its its PRP$ 651 658 ability ability NN 659 661 to to TO 662 671 associate associate VB 672 676 with with IN 677 682 TRAFs TRAF NNP 682 683 . . . 684 687 The the DT 688 691 HVS HVS NNP 692 700 STP-C488 STP-C488 NNP 701 708 P10–>R P10–>R NNP 709 715 mutant mutant NN 716 719 was be VBD 720 729 deficient deficient JJ 730 732 in in IN 733 738 human human JJ 739 751 T-lymphocyte T-lymphocyte NNP 752 766 transformation transformation NN 767 769 to to TO 770 795 interleukin-2-independent interleukin-2-independent JJ 796 802 growth growth NN 803 806 but but CC 807 813 showed show VBD 814 823 wild-type wild-type JJ 824 833 phenotype phenotype NN 834 837 for for IN 838 846 marmoset marmoset NN 847 859 T-lymphocyte T-lymphocyte NNP 860 874 transformation transformation NN 875 877 in in FW 878 883 vitro vitro FW 884 887 and and CC 888 890 in in FW 891 895 vivo vivo FW 895 896 . . . 897 900 The the DT 901 909 STP-C488 stp-c488 NN 910 917 P10–>R p10–>r NN 918 924 mutant mutant NN 925 928 was be VBD 929 933 also also RB 934 943 defective defective JJ 944 946 in in IN 947 952 Rat-1 rat-1 NN 953 963 fibroblast fibroblast NN 964 978 transformation transformation NN 978 979 , , , 980 983 and and CC 984 994 fibroblast fibroblast NN 995 999 cell cell NN 1000 1014 transformation transformation NN 1015 1018 was be VBD 1019 1026 blocked block VBN 1027 1029 by by IN 1030 1031 a a DT 1032 1037 TRAF2 traf2 NN 1038 1055 dominant-negative dominant-negative JJ 1056 1062 mutant mutant NN 1062 1063 . . . 1064 1069 These these DT 1070 1074 data datum NNS 1075 1084 implicate implicate VBP 1085 1090 TRAFs traf NNS 1091 1093 in in IN 1094 1111 STP-C488-mediated stp-c488-mediated JJ 1112 1126 transformation transformation NN 1127 1129 of of IN 1130 1135 human human JJ 1136 1147 lymphocytes lymphocyte NNS 1148 1151 and and CC 1152 1158 rodent rodent JJ 1159 1170 fibroblasts fibroblast NNS 1170 1171 . . . 1172 1177 Other other JJ 1178 1185 factors factor NNS 1186 1189 are be VBP 1190 1200 implicated implicate VBN 1201 1203 in in IN 1204 1219 immortalization immortalization NN 1220 1222 of of IN 1223 1229 common common JJ 1230 1238 marmoset marmoset NN 1239 1240 T t NN 1241 1252 lymphocytes lymphocyte NNS 1253 1256 and and CC 1257 1260 may may MD 1261 1265 also also RB 1266 1268 be be VB 1269 1277 critical critical JJ 1278 1280 in in IN 1281 1284 the the DT 1285 1299 transformation transformation NN 1300 1302 of of IN 1303 1308 human human JJ 1309 1320 lymphocytes lymphocyte NNS 1321 1324 and and CC 1325 1331 rodent rodent JJ 1332 1343 fibroblasts fibroblast NNS 1343 1344 . . .