0 10 Regulatory regulatory JJ 11 18 effects effect NNS 19 21 of of IN 22 36 interleukin-11 interleukin-11 NN 37 43 during during IN 44 49 acute acute JJ 50 54 lung lung NN 55 67 inflammatory inflammatory JJ 68 74 injury injury NN 74 75 . . . 77 80 The the DT 81 85 role role NN 86 88 of of IN 89 103 interleukin-11 interleukin-11 NN 104 105 ( ( ( 105 110 IL-11 IL-11 NNP 110 111 ) ) ) 112 115 was be VBD 116 125 evaluated evaluate VBN 126 128 in in IN 129 132 the the DT 133 136 IgG IgG NNP 137 143 immune immune JJ 144 151 complex complex NN 152 157 model model NN 158 160 of of IN 161 166 acute acute JJ 167 171 lung lung NN 172 178 injury injury NN 179 181 in in IN 182 186 rats rat NNS 186 187 . . . 188 193 IL-11 IL-11 NNP 194 198 mRNA mRNA NNP 199 202 and and CC 203 210 protein protein NN 211 215 were be VBD 216 220 both both DT 221 233 up-regulated up-regulate VBN 234 240 during during IN 241 244 the the DT 245 251 course course NN 252 254 of of IN 255 259 this this DT 260 272 inflammatory inflammatory JJ 273 281 response response NN 281 282 . . . 283 294 Exogenously exogenously RB 295 307 administered administer VBN 308 313 IL-11 il-11 NN 314 327 substantially substantially RB 328 335 reduced reduce VBD 335 336 , , , 337 339 in in IN 340 341 a a DT 342 356 dose-dependent dose-dependent JJ 357 363 manner manner NN 363 364 , , , 365 368 the the DT 369 383 intrapulmonary intrapulmonary JJ 384 396 accumulation accumulation NN 397 399 of of IN 400 411 neutrophils neutrophil NNS 412 415 and and CC 416 419 the the DT 420 424 lung lung NN 425 433 vascular vascular JJ 434 438 leak leak NN 439 441 of of IN 442 449 albumin albumin NN 449 450 . . . 451 456 These these DT 457 459 in in FW 460 464 vivo vivo FW 465 482 anti-inflammatory anti-inflammatory JJ 483 490 effects effect NNS 491 493 of of IN 494 499 IL-11 IL-11 NNP 500 504 were be VBD 505 515 associated associate VBN 516 520 with with IN 521 528 reduced reduce VBN 529 538 NF-kappaB NF-kappaB NNP 539 549 activation activation NN 550 552 in in IN 553 557 lung lung NN 557 558 , , , 559 566 reduced reduce VBD 567 573 levels level NNS 574 576 of of IN 577 582 tumor tumor NN 583 591 necrosis necrosis NN 592 598 factor factor NN 599 604 alpha alpha NN 605 606 ( ( ( 606 615 TNF-alpha TNF-alpha NNP 615 616 ) ) ) 617 619 in in IN 620 635 bronchoalveolar bronchoalveolar JJ 636 642 lavage lavage NN 643 644 ( ( ( 644 647 BAL BAL NNP 647 648 ) ) ) 649 655 fluids fluid NNS 655 656 , , , 657 660 and and CC 661 671 diminished diminish VBN 672 685 up-regulation up-regulation NN 686 688 of of IN 689 693 lung lung NN 694 702 vascular vascular JJ 703 709 ICAM-1 icam-1 NN 709 710 . . . 711 713 It it PRP 714 716 is be VBZ 717 728 interesting interesting JJ 729 733 that that IN 734 739 IL-11 IL-11 NNP 740 743 did do VBD 744 747 not not RB 748 754 affect affect VB 755 758 BAL bal NN 759 764 fluid fluid NN 765 772 content content NN 773 775 of of IN 776 779 the the DT 780 783 CXC CXC NNP 784 794 chemokines chemokine NNS 794 795 , , , 796 806 macrophage macrophage NN 807 819 inflammatory inflammatory JJ 820 829 protein-2 protein-2 NN 830 831 ( ( ( 831 836 MIP-2 mip-2 NN 836 837 ) ) ) 838 841 and and CC 842 860 cytokine-inducible cytokine-inducible JJ 861 871 neutrophil neutrophil NN 872 887 chemoattractant chemoattractant NN 888 889 ( ( ( 889 893 CINC CINC NNP 893 894 ) ) ) 894 895 ; ; : 896 899 the the DT 900 908 presence presence NN 909 911 of of IN 912 917 IL-11 IL-11 NNP 918 921 did do VBD 922 925 not not RB 926 932 affect affect VB 933 938 these these DT 939 949 chemokines chemokine NNS 949 950 . . . 951 958 However however RB 958 959 , , , 960 963 BAL bal NN 964 971 content content NN 972 974 of of IN 975 978 C5a C5a NNP 979 982 was be VBD 983 990 reduced reduce VBN 991 993 by by IN 994 999 IL-11 IL-11 NNP 999 1000 . . . 1001 1006 These these DT 1007 1011 data datum NNS 1012 1020 indicate indicate VBP 1021 1025 that that IN 1026 1031 IL-11 il-11 NN 1032 1034 is be VBZ 1035 1036 a a DT 1037 1047 regulatory regulatory JJ 1048 1056 cytokine cytokine NN 1057 1059 in in IN 1060 1063 the the DT 1064 1068 lung lung NN 1069 1072 and and CC 1073 1077 that that IN 1077 1078 , , , 1079 1083 like like IN 1084 1089 other other JJ 1090 1097 members member NNS 1098 1100 of of IN 1101 1105 this this DT 1106 1112 family family NN 1112 1113 , , , 1114 1117 its its PRP$ 1118 1135 anti-inflammatory anti-inflammatory JJ 1136 1146 properties property NNS 1147 1153 appear appear VBP 1154 1156 to to TO 1157 1159 be be VB 1160 1166 linked link VBN 1167 1169 to to TO 1170 1173 its its PRP$ 1174 1185 suppression suppression NN 1186 1188 of of IN 1189 1198 NF-kappaB NF-kappaB NNP 1199 1209 activation activation NN 1209 1210 , , , 1211 1221 diminished diminish VBD 1222 1232 production production NN 1233 1235 of of IN 1236 1245 TNF-alpha TNF-alpha NNP 1245 1246 , , , 1247 1250 and and CC 1251 1258 reduced reduce VBN 1259 1272 up-regulation up-regulation NN 1273 1275 of of IN 1276 1280 lung lung NN 1281 1289 vascular vascular JJ 1290 1296 ICAM-1 icam-1 NN 1296 1297 . . .