0 10 Functional functional JJ 11 22 interaction interaction NN 23 30 between between IN 31 34 the the DT 35 38 two two CD 39 43 zinc zinc NN 44 50 finger finger NN 51 58 domains domain NNS 59 61 of of IN 62 65 the the DT 66 71 v-erb v-erb NN 72 73 A a NN 74 85 oncoprotein oncoprotein NN 85 86 . . . 88 91 The the DT 92 97 v-erb v-erb NN 98 99 A a NN 100 108 oncogene oncogene NN 109 111 of of IN 112 117 avian avian JJ 118 134 erythroblastosis erythroblastosis NN 135 140 virus virus NN 141 143 is be VBZ 144 145 a a DT 146 153 mutated mutate VBN 154 157 and and CC 158 165 virally virally RB 166 176 transduced transduce VBN 177 181 copy copy NN 182 184 of of IN 185 186 a a DT 187 191 host host NN 192 196 cell cell NN 197 201 gene gene NN 202 210 encoding encode VBG 211 212 a a DT 213 220 thyroid thyroid NN 221 228 hormone hormone NN 229 237 receptor receptor NN 237 238 . . . 239 242 The the DT 243 250 protein protein NN 251 260 expressed express VBN 261 263 by by IN 264 267 the the DT 268 273 v-erb v-erb NN 274 275 A a NN 276 284 oncogene oncogene NN 285 290 binds bind VBZ 291 293 to to TO 294 297 DNA DNA NNP 298 301 and and CC 302 306 acts act VBZ 307 309 as as IN 310 311 a a DT 312 320 dominant dominant JJ 321 329 negative negative JJ 330 339 inhibitor inhibitor NN 340 342 of of IN 343 347 both both CC 348 351 the the DT 352 359 thyroid thyroid NN 360 367 hormone hormone NN 368 376 receptor receptor NN 377 380 and and CC 381 384 the the DT 385 392 closely closely RB 393 400 related related JJ 401 409 retinoic retinoic JJ 410 414 acid acid NN 415 423 receptor receptor NN 423 424 . . . 425 428 The the DT 429 434 v-erb v-erb NN 435 436 A a NN 437 444 protein protein NN 445 448 has have VBZ 449 458 sustained sustain VBN 459 462 two two CD 463 468 amino amino JJ 469 473 acid acid NN 474 485 alterations alteration NNS 486 492 within within IN 493 496 its its PRP$ 497 508 DNA-binding dna-binding JJ 509 515 domain domain NN 516 524 relative relative JJ 525 527 to to TO 528 532 that that DT 533 535 of of IN 536 541 c-erb c-erb NN 542 543 A A NNP 543 544 , , , 545 548 one one CD 549 551 of of IN 552 557 which which WDT 557 558 , , , 559 561 at at IN 562 568 serine serine NN 569 571 61 61 CD 571 572 , , , 573 575 is be VBZ 576 581 known know VBN 582 584 to to TO 585 587 be be VB 588 597 important important JJ 598 601 for for IN 602 607 v-erb v-erb NN 608 609 A a NN 610 618 function function NN 619 621 in in IN 622 625 the the DT 626 636 neoplastic neoplastic JJ 637 641 cell cell NN 641 642 . . . 643 645 We we PRP 646 652 report report VBP 653 657 here here RB 658 662 that that IN 663 666 the the DT 667 673 second second JJ 674 684 alteration alteration NN 684 685 , , , 686 688 at at IN 689 698 threonine threonine NN 699 701 78 78 CD 701 702 , , , 703 707 also also RB 708 713 plays play VBZ 714 716 an an DT 717 726 important important JJ 726 727 , , , 728 736 although although IN 737 741 more more RBR 742 750 indirect indirect JJ 750 751 , , , 752 756 role role NN 756 757 : : : 758 768 alteration alteration NN 769 771 of of IN 772 775 the the DT 776 784 sequence sequence NN 785 787 at at IN 788 797 threonine threonine NN 798 800 78 78 CD 801 805 such such JJ 806 810 that that IN 811 813 it it PRP 814 823 resembles resemble VBZ 824 828 that that DT 829 831 of of IN 832 837 c-erb c-erb NN 838 839 A a NN 840 843 can can MD 844 847 act act VB 848 850 as as IN 851 853 an an DT 854 864 intragenic intragenic JJ 865 875 suppressor suppressor NN 876 879 and and CC 880 883 can can MD 884 893 partially partially RB 894 901 restore restore VB 902 910 function function NN 911 913 to to TO 914 915 a a DT 916 921 v-erb v-erb NN 922 923 A a NN 924 931 protein protein NN 932 940 rendered render VBD 941 950 defective defective JJ 951 954 due due JJ 955 957 to to TO 958 959 a a DT 960 968 mutation mutation NN 969 971 at at IN 972 980 position position NN 981 983 61 61 CD 983 984 . . . 985 994 Threonine Threonine NNP 995 997 78 78 CD 998 1002 lies lie VBZ 1003 1009 within within IN 1010 1013 the the DT 1014 1019 D-box d-box NN 1020 1022 of of IN 1023 1026 the the DT 1027 1032 v-erb v-erb NN 1033 1034 A a NN 1035 1042 protein protein NN 1042 1043 , , , 1044 1045 a a DT 1046 1052 region region NN 1053 1060 thought think VBN 1061 1063 to to TO 1064 1071 mediate mediate VB 1072 1089 receptor-receptor receptor-receptor JJ 1090 1103 dimerizations dimerization NNS 1103 1104 , , , 1105 1108 and and CC 1109 1111 is be VBZ 1112 1115 not not RB 1116 1118 in in IN 1119 1127 physical physical JJ 1128 1137 proximity proximity NN 1138 1140 to to TO 1141 1144 the the DT 1145 1151 serine serine NN 1152 1154 at at IN 1155 1163 position position NN 1164 1166 61 61 CD 1166 1167 . . . 1168 1170 It it PRP 1171 1180 therefore therefore RB 1181 1188 appears appear VBZ 1189 1193 that that IN 1194 1196 an an DT 1197 1205 indirect indirect JJ 1206 1217 interaction interaction NN 1218 1224 occurs occur VBZ 1225 1232 between between IN 1233 1238 these these DT 1239 1242 two two CD 1243 1248 sites site NNS 1249 1252 and and CC 1253 1257 that that IN 1258 1262 this this DT 1263 1274 interaction interaction NN 1275 1277 is be VBZ 1278 1285 crucial crucial JJ 1286 1289 for for IN 1290 1295 v-erb v-erb NN 1296 1297 A a NN 1298 1306 function function NN 1306 1307 . . .