0 9 Induction Induction NNP 10 12 of of IN 13 22 monocytic monocytic JJ 23 38 differentiation differentiation NN 39 42 and and CC 43 51 NF-kappa NF-kappa NNP 52 58 B-like b-like JJ 59 69 activities activity NNS 70 72 by by IN 73 78 human human JJ 79 95 immunodeficiency immunodeficiency NN 96 101 virus virus NN 102 103 1 1 CD 104 113 infection infection NN 114 116 of of IN 117 133 myelomonoblastic myelomonoblastic JJ 134 139 cells cell NNS 139 140 . . . 142 145 The the DT 146 153 effects effect NNS 154 156 of of IN 157 162 human human JJ 163 179 immunodeficiency immunodeficiency NN 180 185 virus virus NN 186 187 1 1 CD 188 189 ( ( ( 189 194 HIV-1 HIV-1 NNP 194 195 ) ) ) 196 205 infection infection NN 206 208 on on IN 209 217 cellular cellular JJ 218 233 differentiation differentiation NN 234 237 and and CC 238 246 NF-kappa NF-kappa NNP 247 248 B B NNP 249 252 DNA DNA NNP 253 260 binding binding NN 261 269 activity activity NN 270 274 have have VBP 275 279 been be VBN 280 292 investigated investigate VBN 293 295 in in IN 296 297 a a DT 298 301 new new JJ 302 307 model model NN 308 310 of of IN 311 318 myeloid myeloid JJ 319 334 differentiation differentiation NN 334 335 . . . 336 343 PLB-985 PLB-985 NNP 344 349 cells cell NNS 350 359 represent represent VBP 360 361 a a DT 362 373 bipotential bipotential JJ 374 390 myelomonoblastic myelomonoblastic JJ 391 395 cell cell NN 396 406 population population NN 407 414 capable capable JJ 415 417 of of IN 418 424 either either CC 425 437 granulocytic granulocytic JJ 438 440 or or CC 441 450 monocytic monocytic JJ 451 466 differentiation differentiation NN 467 472 after after IN 473 482 induction induction NN 483 487 with with IN 488 499 appropriate appropriate JJ 500 508 inducers inducer NNS 508 509 . . . 510 512 By by IN 513 519 virtue virtue NN 520 522 of of IN 523 526 the the DT 527 535 presence presence NN 536 538 of of IN 539 542 CD4 cd4 NN 543 545 on on IN 546 549 the the DT 550 554 cell cell NN 555 562 surface surface NN 562 563 , , , 564 571 PLB-985 PLB-985 NNP 572 577 cells cell NNS 578 582 were be VBD 583 594 chronically chronically RB 595 603 infected infect VBN 604 608 with with IN 609 614 HIV-1 HIV-1 NNP 615 621 strain strain NN 622 626 IIIB IIIB NNP 626 627 . . . 628 636 PLB-IIIB PLB-IIIB NNP 637 642 cells cell NNS 643 650 clearly clearly RB 651 660 possessed possess VBD 661 662 a a DT 663 667 more more RBR 668 677 monocytic monocytic JJ 678 687 phenotype phenotype NN 688 692 than than IN 693 696 the the DT 697 705 parental parental JJ 706 717 myeloblasts myeloblast NNS 717 718 , , , 719 721 as as IN 722 732 determined determine VBN 733 735 by by IN 736 748 differential differential JJ 749 757 staining staining NN 757 758 , , , 759 768 increased increase VBN 769 779 expression expression NN 780 782 of of IN 783 786 the the DT 787 803 myeloid-specific myeloid-specific JJ 804 811 surface surface NN 812 819 markers marker NNS 819 820 , , , 821 824 and and CC 825 838 transcription transcription NN 839 841 of of IN 842 845 the the DT 846 851 c-fms c-fms NN 852 866 proto-oncogene proto-oncogene NN 866 867 . . . 868 876 NF-kappa NF-kappa NNP 877 878 B B NNP 879 886 binding binding NN 887 895 activity activity NN 896 899 was be VBD 900 909 inducible inducible JJ 910 912 by by IN 913 918 tumor tumor NN 919 927 necrosis necrosis NN 928 934 factor factor NN 935 938 and and CC 939 946 phorbol phorbol NN 947 956 myristate myristate NN 957 964 acetate acetate NN 965 967 in in IN 968 975 PLB-985 PLB-985 NNP 975 976 . . . 977 984 However however RB 984 985 , , , 986 988 in in IN 989 997 PLB-IIIB PLB-IIIB NNP 998 1003 cells cell NNS 1003 1004 , , , 1005 1017 constitutive constitutive JJ 1018 1028 expression expression NN 1029 1031 of of IN 1032 1033 a a DT 1034 1039 novel novel JJ 1040 1048 NF-kappa NF-kappa NNP 1049 1050 B B NNP 1051 1058 complex complex NN 1059 1062 was be VBD 1063 1071 detected detect VBN 1071 1072 , , , 1073 1081 composed compose VBN 1082 1084 of of IN 1085 1093 proteins protein NNS 1094 1101 ranging range VBG 1102 1109 between between IN 1110 1112 70 70 CD 1113 1116 and and CC 1117 1120 110 110 CD 1121 1123 kD kd NN 1123 1124 . . . 1125 1130 These these DT 1131 1139 proteins protein NNS 1140 1150 interacted interact VBD 1151 1163 specifically specifically RB 1164 1168 with with IN 1169 1172 the the DT 1173 1182 symmetric symmetric JJ 1183 1191 NF-kappa NF-kappa NNP 1192 1193 B B NNP 1194 1198 site site NN 1199 1203 from from IN 1204 1207 the the DT 1208 1218 interferon interferon NN 1219 1223 beta beta NN 1224 1225 ( ( ( 1225 1233 IFN-beta IFN-beta NNP 1233 1234 ) ) ) 1235 1243 promoter promoter NN 1243 1244 . . . 1245 1254 Mutations mutation NNS 1255 1264 affecting affect VBG 1265 1268 the the DT 1269 1270 5 5 CD 1270 1271 ’ ' SYM 1272 1279 guanine guanine NN 1280 1288 residues residue NNS 1289 1291 of of IN 1292 1295 the the DT 1296 1301 kappa kappa NN 1302 1303 B B NNP 1304 1308 site site NN 1309 1313 were be VBD 1314 1320 unable unable JJ 1321 1323 to to TO 1324 1331 compete compete VB 1332 1335 for for IN 1336 1341 these these DT 1342 1350 NF-kappa NF-kappa NNP 1351 1360 B-related b-related JJ 1361 1369 proteins protein NNS 1369 1370 . . . 1371 1383 Inducibility inducibility NN 1384 1386 of of IN 1387 1397 endogenous endogenous JJ 1398 1406 IFN-beta IFN-beta NNP 1407 1410 and and CC 1411 1420 IFN-alpha IFN-alpha NNP 1421 1424 RNA RNA NNP 1425 1428 was be VBD 1429 1433 also also RB 1434 1443 increased increase VBN 1444 1446 in in IN 1447 1455 PLB-IIIB PLB-IIIB NNP 1456 1461 cells cell NNS 1461 1462 . . . 1463 1468 These these DT 1469 1476 studies study NNS 1477 1485 indicate indicate VBP 1486 1490 that that IN 1491 1496 HIV-1 HIV-1 NNP 1497 1506 infection infection NN 1507 1509 of of IN 1510 1526 myelomonoblastic myelomonoblastic JJ 1527 1532 cells cell NNS 1533 1536 may may MD 1537 1543 select select VB 1544 1547 for for IN 1548 1549 a a DT 1550 1554 more more RBR 1555 1561 mature mature JJ 1562 1571 monocytic monocytic JJ 1572 1581 phenotype phenotype NN 1582 1585 and and CC 1586 1590 that that IN 1591 1597 unique unique JJ 1598 1605 subunit subunit NN 1606 1618 associations association NNS 1619 1621 of of IN 1622 1630 NF-kappa NF-kappa NNP 1631 1632 B B NNP 1633 1636 DNA DNA NNP 1637 1644 binding binding NN 1645 1653 proteins protein NNS 1654 1657 may may MD 1658 1668 contribute contribute VB 1669 1671 to to TO 1672 1684 differential differential JJ 1685 1693 NF-kappa NF-kappa NNP 1694 1704 B-mediated b-mediated JJ 1705 1709 gene gene NN 1710 1720 expression expression NN 1720 1721 . . .