0 6 Cupric cupric JJ 7 10 ion ion NN 11 17 blocks block VBZ 18 20 NF nf NN 21 26 kappa kappa NN 27 28 B B NNP 29 39 activation activation NN 40 47 through through IN 48 58 inhibiting inhibit VBG 59 62 the the DT 63 77 signal-induced signal-induced JJ 78 93 phosphorylation phosphorylation NN 94 96 of of IN 97 98 I i NN 99 104 kappa kappa NN 105 106 B B NNP 107 112 alpha alpha NN 112 113 . . . 115 116 A a DT 117 130 transcription transcription NN 131 137 factor factor NN 138 140 NF NF NNP 141 146 kappa kappa NN 147 148 B B NNP 148 149 , , , 150 155 which which WDT 156 165 regulates regulate VBZ 166 176 expression expression NN 177 179 of of IN 180 187 various various JJ 188 196 cellular cellular JJ 197 202 genes gene NNS 203 211 involved involve VBN 212 214 in in IN 215 221 immune immune JJ 222 231 responses response NNS 232 235 and and CC 236 241 viral viral JJ 242 247 genes gene NNS 248 257 including include VBG 258 261 HIV HIV NNP 261 262 , , , 263 265 is be VBZ 266 277 sequestered sequester VBN 278 280 in in IN 281 284 the the DT 285 294 cytoplasm cytoplasm NN 295 297 as as IN 298 299 a a DT 300 307 complex complex NN 308 312 with with IN 313 315 an an DT 316 326 inhibitory inhibitory JJ 327 334 protein protein NN 335 336 I i NN 337 342 kappa kappa NN 343 345 B. B. NNP 346 353 Various various JJ 354 367 extracellular extracellular JJ 368 375 signals signal NNS 376 382 induce induce VBP 383 398 phosphorylation phosphorylation NN 399 402 and and CC 403 408 rapid rapid JJ 409 420 degradation degradation NN 421 423 of of IN 424 425 I i NN 426 431 kappa kappa NN 432 433 B B NNP 434 439 alpha alpha NN 440 442 to to TO 443 450 release release VB 451 453 NF NF NNP 454 459 kappa kappa NN 460 462 B. B. NNP 463 467 Cu2+ Cu2+ NNP 468 471 was be VBD 472 477 found find VBN 478 480 to to TO 481 488 inhibit inhibit VB 489 492 the the DT 493 503 activation activation NN 504 506 of of IN 507 509 NF NF NNP 510 515 kappa kappa NN 516 517 B B NNP 518 525 induced induce VBN 526 528 by by IN 529 538 TNF-alpha TNF-alpha NNP 538 539 , , , 540 543 TPA TPA NNP 543 544 , , , 545 547 or or CC 548 552 H2O2 h2o2 NN 552 553 . . . 554 566 Deoxycholate Deoxycholate NNP 567 576 treatment treatment NN 577 579 of of IN 580 583 the the DT 584 595 cytoplasmic cytoplasmic JJ 596 603 extract extract NN 604 612 prepared prepare VBN 613 617 from from IN 618 623 cells cell NNS 624 634 stimulated stimulate VBN 635 637 by by IN 638 647 TNF-alpha TNF-alpha NNP 648 650 in in IN 651 654 the the DT 655 663 presence presence NN 664 666 of of IN 667 671 Cu2+ Cu2+ NNP 672 680 resulted result VBD 681 683 in in IN 684 687 the the DT 688 695 release release NN 696 698 of of IN 699 701 NF NF NNP 702 707 kappa kappa NN 708 709 B B NNP 710 714 from from IN 715 716 I i NN 717 722 kappa kappa NN 723 724 B B NNP 725 730 alpha alpha NN 730 731 , , , 732 742 indicating indicate VBG 743 747 that that IN 748 752 Cu2+ cu2+ NN 753 763 interferes interfere VBZ 764 768 with with IN 769 772 the the DT 773 785 dissociation dissociation NN 786 788 of of IN 789 792 the the DT 793 795 NF NF NNP 796 801 kappa kappa NN 802 805 B-I B-I NNP 806 811 kappa kappa NN 812 813 B B NNP 814 821 complex complex NN 821 822 . . . 823 830 Neither neither CC 831 846 phosphorylation phosphorylation NN 847 850 nor nor CC 851 862 degradation degradation NN 863 865 of of IN 866 867 I i NN 868 873 kappa kappa NN 874 875 B B NNP 876 881 alpha alpha NN 882 885 was be VBD 886 894 observed observe VBN 895 899 upon upon IN 900 909 TNF-alpha TNF-alpha NNP 910 921 stimulation stimulation NN 922 924 in in IN 925 928 the the DT 929 937 presence presence NN 938 940 of of IN 941 945 Cu2+ Cu2+ NNP 945 946 . . . 947 952 These these DT 953 960 results result NNS 961 969 indicate indicate VBP 970 974 that that IN 975 979 Cu2+ cu2+ NN 980 988 inhibits inhibit VBZ 989 992 the the DT 993 1000 release release NN 1001 1003 of of IN 1004 1006 NF NF NNP 1007 1012 kappa kappa NN 1013 1014 B B NNP 1015 1017 by by IN 1018 1026 blockade blockade NN 1027 1029 of of IN 1030 1031 a a DT 1032 1038 signal signal NN 1039 1046 leading lead VBG 1047 1049 to to TO 1050 1053 the the DT 1054 1069 phosphorylation phosphorylation NN 1070 1072 of of IN 1073 1074 I i NN 1075 1080 kappa kappa NN 1081 1082 B B NNP 1083 1088 alpha alpha NN 1088 1089 . . .