0 5 CIITA CIITA NNP 6 15 activates activate VBZ 16 19 the the DT 20 30 expression expression NN 31 33 of of IN 34 37 MHC MHC NNP 38 43 class class NN 44 46 II ii CD 47 52 genes gene NNS 53 55 in in IN 56 61 mouse mouse NN 62 63 T t NN 64 69 cells cell NNS 69 70 . . . 72 74 It it PRP 75 78 has have VBZ 79 83 long long RB 84 88 been be VBN 89 90 a a DT 91 97 puzzle puzzle NN 98 102 that that IN 103 106 MHC MHC NNP 107 112 class class NN 113 115 II ii CD 116 125 molecules molecule NNS 126 129 are be VBP 130 139 expressed express VBN 140 142 in in IN 143 148 human human JJ 149 150 T t NN 151 156 cells cell NNS 157 162 after after IN 163 173 activation activation NN 174 177 but but CC 178 181 not not RB 182 184 in in IN 185 190 mouse mouse NN 191 192 T t NN 193 198 cells cell NNS 198 199 ; ; : 200 204 this this DT 205 215 expression expression NN 216 218 is be VBZ 219 227 believed believe VBN 228 230 to to TO 231 235 play play VB 236 237 a a DT 238 242 role role NN 243 245 in in IN 246 249 the the DT 250 254 cell cell NN 255 263 mediated mediated JJ 264 270 immune immune JJ 271 279 response response NN 279 280 . . . 281 289 Recently recently RB 290 293 the the DT 294 297 MHC MHC NNP 298 303 class class NN 304 306 II ii CD 307 321 transactivator transactivator NN 322 323 ( ( ( 323 328 CIITA CIITA NNP 328 329 ) ) ) 330 333 has have VBZ 334 338 been be VBN 339 347 reported report VBN 348 350 to to TO 351 353 be be VB 354 355 a a DT 356 361 major major JJ 362 372 regulatory regulatory JJ 373 379 factor factor NN 380 383 for for IN 384 388 both both CC 389 392 the the DT 393 405 constitutive constitutive JJ 406 409 and and CC 410 413 IFN ifn NN 414 423 inducible inducible JJ 424 434 expression expression NN 435 437 of of IN 438 441 MHC MHC NNP 442 447 class class NN 448 450 II ii CD 451 456 genes gene NNS 456 457 . . . 458 462 Here here RB 463 465 we we PRP 466 470 show show VBP 471 475 that that IN 476 481 human human JJ 482 483 T t NN 484 489 cells cell NNS 490 500 expressing express VBG 501 504 MHC MHC NNP 505 510 class class NN 511 513 II ii CD 514 518 have have VBP 519 524 CIITA CIITA NNP 525 536 transcripts transcript NNS 537 542 while while IN 543 546 MHC MHC NNP 547 552 class class NN 553 564 II-negative ii-negative JJ 565 570 human human JJ 571 572 T t NN 573 578 cells cell NNS 579 582 and and CC 583 588 mouse mouse NN 589 590 T t NN 591 596 cells cell NNS 597 599 do do VBP 600 603 not not RB 603 604 . . . 605 608 The the DT 609 619 expression expression NN 620 622 of of IN 623 626 MHC MHC NNP 627 632 class class NN 633 635 II ii CD 636 641 genes gene NNS 642 644 in in IN 645 650 mouse mouse NN 651 652 T t NN 653 658 cells cell NNS 659 662 can can MD 663 665 be be VB 666 679 reconstituted reconstitute VBN 680 684 upon upon IN 685 697 transfection transfection NN 698 702 with with IN 703 706 the the DT 707 712 human human JJ 713 718 CIITA CIITA NNP 719 723 cDNA cDNA NNP 723 724 . . . 725 730 These these DT 731 735 data datum NNS 736 744 indicate indicate VBP 745 749 that that IN 750 753 the the DT 754 764 expression expression NN 765 767 of of IN 768 773 CIITA CIITA NNP 774 782 explains explain VBZ 783 786 the the DT 787 797 expression expression NN 798 800 or or CC 801 805 lack lack NN 806 808 of of IN 809 819 expression expression NN 820 822 of of IN 823 826 MHC MHC NNP 827 832 class class NN 833 835 II ii CD 836 838 in in IN 839 844 human human JJ 845 848 and and CC 849 854 mouse mouse NN 855 856 T t NN 857 862 cells cell NNS 863 875 respectively respectively RB 875 876 . . .