0	5	HMG-I	HMG-I	NNP
6	11	binds	bind	VBZ
12	14	to	to	TO
15	19	GATA	GATA	NNP
20	26	motifs	motif	NNS
26	27	:	:	:
28	40	implications	implication	NNS
41	44	for	for	IN
45	47	an	an	DT
48	52	HPFH	HPFH	NNP
53	61	syndrome	syndrome	NN
61	62	.	.	.

64	66	We	we	PRP
67	71	have	have	VBP
72	80	examined	examine	VBN
81	88	binding	binding	NN
89	91	of	of	IN
92	95	the	the	DT
96	103	nuclear	nuclear	JJ
104	111	protein	protein	NN
112	117	HMG-I	HMG-I	NNP
118	120	to	to	TO
121	124	the	the	DT
125	130	human	human	JJ
131	143	gamma-globin	gamma-globin	NN
144	152	promoter	promoter	NN
152	153	.	.	.

154	156	We	we	PRP
157	161	find	find	VBP
162	166	that	that	IN
167	172	HMG-I	HMG-I	NNP
173	178	binds	bind	VBZ
179	193	preferentially	preferentially	RB
194	196	to	to	TO
197	200	the	the	DT
201	205	more	more	JJR
206	207	3	3	CD
207	208	’	'	SYM
209	211	of	of	IN
212	213	a	a	DT
214	218	pair	pair	NN
219	221	of	of	IN
222	226	GATA	GATA	NNP
227	233	motifs	motif	NNS
234	236	in	in	IN
237	240	the	the	DT
241	253	gamma-globin	gamma-globin	NN
254	262	promoter	promoter	NN
262	263	;	;	:
264	268	this	this	DT
269	275	paired	paired	JJ
276	281	motif	motif	NN
282	284	is	be	VBZ
285	290	bound	bind	VBN
291	293	by	by	IN
294	297	the	the	DT
298	307	erythroid	erythroid	JJ
308	314	factor	factor	NN
315	321	GATA-1	gata-1	NN
321	322	.	.	.

323	324	A	a	DT
325	334	naturally	naturally	RB
335	344	occurring	occur	VBG
345	353	mutation	mutation	NN
354	355	(	(	(
355	359	-175	-175	CD
360	363	T-C	T-C	NNP
363	364	)	)	)
365	367	in	in	IN
368	371	the	the	DT
372	376	area	area	NN
377	382	bound	bind	VBN
383	385	by	by	IN
386	391	HMG-I	HMG-I	NNP
392	399	results	result	VBZ
400	402	in	in	IN
403	417	overexpression	overexpression	NN
418	420	of	of	IN
421	433	gamma-globin	gamma-globin	NN
434	436	in	in	IN
437	442	adult	adult	JJ
443	446	red	red	JJ
447	452	blood	blood	NN
453	458	cells	cell	NNS
459	460	(	(	(
460	464	HPFH	HPFH	NNP
464	465	)	)	)
466	469	and	and	CC
470	483	up-regulation	up-regulation	NN
484	486	of	of	IN
487	490	the	the	DT
491	503	gamma-globin	gamma-globin	NN
504	512	promoter	promoter	NN
513	515	in	in	IN
516	518	in	in	FW
519	524	vitro	vitro	FW
525	535	expression	expression	NN
536	542	assays	assay	NNS
542	543	;	;	:
544	549	HMG-I	HMG-I	NNP
550	554	does	do	VBZ
555	558	not	not	RB
559	563	bind	bind	VB
564	566	to	to	TO
567	571	this	this	DT
572	578	mutant	mutant	JJ
579	587	sequence	sequence	NN
587	588	.	.	.

589	590	A	a	DT
591	597	survey	survey	NN
598	600	of	of	IN
601	605	GATA	GATA	NNP
606	612	motifs	motif	NNS
613	617	from	from	IN
618	623	other	other	JJ
624	630	globin	globin	NN
631	643	cis-elements	cis-element	NNS
644	656	demonstrates	demonstrate	VBZ
657	662	HMG-I	HMG-I	NNP
663	670	binding	bind	VBG
671	673	to	to	TO
674	678	most	most	JJS
679	681	of	of	IN
682	686	them	them	PRP
686	687	.	.	.

688	693	These	these	DT
694	702	findings	finding	NNS
703	712	implicate	implicate	VBP
713	718	HMG-I	HMG-I	NNP
719	721	in	in	IN
722	725	the	the	DT
726	730	HPFH	HPFH	NNP
731	740	phenotype	phenotype	NN
740	741	;	;	:
742	744	we	we	PRP
745	754	speculate	speculate	VBP
755	759	that	that	IN
760	762	it	it	PRP
763	766	may	may	MD
767	778	participate	participate	VB
779	781	in	in	IN
782	785	the	the	DT
786	795	formation	formation	NN
796	798	of	of	IN
799	811	multiprotein	multiprotein	NN
812	821	complexes	complex	NNS
822	826	that	that	WDT
827	835	regulate	regulate	VBP
836	842	globin	globin	NN
843	847	gene	gene	NN
848	858	expression	expression	NN
858	859	.	.	.