0	8	Abnormal	abnormal	JJ
9	19	regulation	regulation	NN
20	22	of	of	IN
23	26	the	the	DT
27	31	IL-2	il-2	NN
32	40	promoter	promoter	NN
41	43	in	in	IN
44	47	lpr	lpr	NN
48	56	CD4-CD8-	cd4-cd8-	JJ
57	58	T	t	NN
59	70	lymphocytes	lymphocyte	NNS
71	78	results	result	VBZ
79	81	in	in	IN
82	94	constitutive	constitutive	JJ
95	105	expression	expression	NN
106	108	of	of	IN
109	110	a	a	DT
111	116	novel	novel	JJ
117	124	nuclear	nuclear	JJ
125	131	factor	factor	NN
132	134	of	of	IN
135	144	activated	activate	VBN
145	146	T	t	NN
147	160	cells-binding	cells-binding	JJ
161	167	factor	factor	NN
167	168	.	.	.

170	173	The	the	DT
174	179	inert	inert	JJ
180	187	quality	quality	NN
188	190	of	of	IN
191	202	MRL-Ipr/Ipr	MRL-Ipr/Ipr	NNP
203	204	(	(	(
204	207	Ipr	Ipr	NNP
207	208	)	)	)
209	219	peripheral	peripheral	JJ
220	228	CD4-CD8-	cd4-cd8-	CD4-CD8-
229	230	(	(	(
230	236	CD4-8-	cd4-8-	JJ
236	237	)	)	)
238	239	T	t	NN
240	245	cells	cell	NNS
246	255	manifests	manifest	VBZ
256	265	primarily	primarily	RB
266	268	as	as	IN
269	271	an	an	DT
272	281	inability	inability	NN
282	284	to	to	TO
285	296	proliferate	proliferate	VB
297	299	or	or	CC
300	307	produce	produce	VB
308	312	IL-2	il-2	NN
313	315	in	in	IN
316	324	response	response	NN
325	327	to	to	TO
328	331	TCR	TCR	NNP
332	334	or	or	CC
335	344	mitogenic	mitogenic	JJ
345	356	stimulation	stimulation	NN
356	357	.	.	.

358	361	Yet	yet	RB
362	367	these	these	DT
368	372	same	same	JJ
373	378	cells	cell	NNS
379	381	do	do	VBP
382	390	initiate	initiate	VB
391	396	early	early	JJ
397	409	TCR-mediated	tcr-mediated	JJ
410	419	signaling	signaling	NN
420	426	events	event	NNS
426	427	,	,	,
428	432	such	such	JJ
433	435	as	as	IN
436	446	generation	generation	NN
447	449	of	of	IN
450	458	inositol	inositol	NN
459	469	phosphates	phosphate	NNS
470	473	and	and	CC
474	483	increased	increase	VBN
484	497	intracellular	intracellular	JJ
498	505	calcium	calcium	NN
505	506	.	.	.

507	511	They	they	PRP
512	516	also	also	RB
517	524	display	display	VBP
525	539	constitutively	constitutively	RB
540	544	high	high	JJ
545	551	levels	level	NNS
552	554	of	of	IN
555	561	p59fyn	p59fyn	NN
562	565	and	and	CC
566	569	CD3	cd3	NN
570	574	zeta	zeta	NN
575	583	tyrosine	tyrosine	NN
584	599	phosphorylation	phosphorylation	NN
599	600	.	.	.

601	604	The	the	DT
605	615	generation	generation	NN
616	618	of	of	IN
619	625	second	second	JJ
626	636	messengers	messenger	NNS
637	639	in	in	IN
640	641	T	t	NN
642	647	cells	cell	NNS
648	656	normally	normally	RB
657	662	leads	lead	VBZ
663	665	to	to	TO
666	676	downstream	downstream	JJ
677	686	signaling	signaling	NN
687	691	that	that	WDT
692	699	results	result	VBZ
700	702	in	in	IN
703	718	transcriptional	transcriptional	JJ
719	729	activation	activation	NN
730	732	of	of	IN
733	736	the	the	DT
737	741	IL-2	il-2	NN
742	746	gene	gene	NN
746	747	.	.	.

748	750	We	we	PRP
750	751	,	,	,
752	761	therefore	therefore	RB
761	762	,	,	,
763	771	compared	compare	VBD
772	775	the	the	DT
776	786	activation	activation	NN
787	792	state	state	NN
793	795	of	of	IN
796	799	the	the	DT
800	804	IL-2	il-2	NN
805	809	gene	gene	NN
810	818	promoter	promoter	NN
819	825	region	region	NN
826	828	in	in	IN
829	836	freshly	freshly	RB
837	845	isolated	isolate	VBN
846	849	and	and	CC
850	860	stimulated	stimulate	VBN
861	864	Ipr	Ipr	NNP
865	871	CD4-8-	cd4-8-	NN
872	873	T	t	NN
874	879	cells	cell	NNS
880	884	with	with	IN
885	889	that	that	DT
890	892	of	of	IN
893	899	normal	normal	JJ
900	901	T	t	NN
902	913	lymphocytes	lymphocyte	NNS
913	914	.	.	.

915	921	Levels	level	NNS
922	924	of	of	IN
925	928	the	the	DT
929	936	octamer	octamer	NN
936	937	,	,	,
938	946	NF-kappa	NF-kappa	NNP
947	948	B	B	NNP
949	950	(	(	(
950	957	p50-p65	p50-p65	NN
958	969	heterodimer	heterodimer	NN
969	970	)	)	)
970	971	,	,	,
972	975	and	and	CC
976	980	AP-1	ap-1	NN
981	996	transcriptional	transcriptional	JJ
997	1004	factors	factor	NNS
1005	1008	are	be	VBP
1009	1023	constitutively	constitutively	RB
1024	1032	elevated	elevate	VBN
1033	1035	in	in	IN
1036	1043	freshly	freshly	RB
1044	1052	isolated	isolate	VBN
1053	1056	Ipr	Ipr	NNP
1057	1063	CD4-8-	cd4-8-	NN
1064	1065	T	t	NN
1066	1071	cells	cell	NNS
1071	1072	,	,	,
1073	1083	consistent	consistent	JJ
1084	1088	with	with	IN
1089	1092	the	the	DT
1093	1102	activated	activate	VBN
1103	1112	phenotype	phenotype	NN
1113	1115	of	of	IN
1116	1121	these	these	DT
1122	1127	cells	cell	NNS
1127	1128	.	.	.

1129	1133	Upon	upon	IN
1134	1145	stimulation	stimulation	NN
1146	1150	with	with	IN
1151	1159	mitogens	mitogen	NNS
1159	1160	,	,	,
1161	1170	formation	formation	NN
1171	1173	of	of	IN
1174	1177	the	the	DT
1178	1193	transactivating	transactivate	VBG
1194	1201	complex	complex	NN
1201	1202	,	,	,
1203	1210	nuclear	nuclear	JJ
1211	1217	factor	factor	NN
1218	1220	of	of	IN
1221	1230	activated	activate	VBN
1231	1232	T	t	NN
1233	1238	cells	cell	NNS
1239	1240	(	(	(
1240	1245	NF-AT	NF-AT	NNP
1245	1246	)	)	)
1246	1247	,	,	,
1248	1254	occurs	occur	VBZ
1255	1259	with	with	IN
1260	1266	normal	normal	JJ
1267	1275	kinetics	kinetic	NNS
1276	1278	in	in	IN
1279	1282	Ipr	Ipr	NNP
1283	1289	CD4-8-	CD4-8-	NNP
1290	1291	T	t	NN
1292	1297	cells	cell	NNS
1297	1298	.	.	.

1299	1302	Yet	yet	RB
1302	1303	,	,	,
1304	1307	the	the	DT
1308	1314	levels	level	NNS
1315	1317	of	of	IN
1318	1321	the	the	DT
1322	1332	activating	activate	VBG
1333	1338	NF-AT	nf-at	NN
1339	1346	complex	complex	NN
1347	1352	never	never	RB
1353	1358	reach	reach	VBP
1359	1364	those	those	DT
1365	1373	observed	observe	VBN
1374	1376	in	in	IN
1377	1386	similarly	similarly	RB
1387	1397	stimulated	stimulate	VBN
1398	1404	normal	normal	JJ
1405	1406	T	t	NN
1407	1412	cells	cell	NNS
1412	1413	.	.	.

1414	1425	Furthermore	furthermore	RB
1425	1426	,	,	,
1427	1434	nuclear	nuclear	JJ
1435	1443	extracts	extract	NNS
1444	1448	from	from	IN
1449	1452	Ipr	Ipr	NNP
1453	1459	CD4-8-	CD4-8-	NNP
1460	1461	T	t	NN
1462	1467	cells	cell	NNS
1468	1475	display	display	VBP
1476	1480	high	high	JJ
1481	1487	levels	level	NNS
1488	1490	of	of	IN
1491	1492	a	a	DT
1493	1498	novel	novel	JJ
1499	1507	specific	specific	JJ
1508	1515	binding	binding	NN
1516	1524	activity	activity	NN
1525	1527	at	at	IN
1528	1531	the	the	DT
1532	1537	NF-AT	NF-AT	NNP
1538	1542	site	site	NN
1542	1543	,	,	,
1544	1549	which	which	WDT
1550	1552	is	be	VBZ
1553	1560	present	present	JJ
1561	1563	at	at	IN
1564	1568	much	much	RB
1569	1574	lower	low	JJR
1575	1581	levels	level	NNS
1582	1584	in	in	IN
1585	1592	freshly	freshly	RB
1593	1601	isolated	isolate	VBN
1602	1608	normal	normal	JJ
1609	1610	T	t	NN
1611	1622	lymphocytes	lymphocyte	NNS
1622	1623	.	.	.

1624	1628	Upon	upon	IN
1629	1638	mitogenic	mitogenic	JJ
1639	1650	stimulation	stimulation	NN
1650	1651	,	,	,
1652	1655	the	the	DT
1656	1663	binding	binding	NN
1664	1672	activity	activity	NN
1673	1675	of	of	IN
1676	1679	the	the	DT
1680	1685	novel	novel	JJ
1686	1699	NF-AT-binding	nf-at-binding	JJ
1700	1706	factor	factor	NN
1707	1709	is	be	VBZ
1710	1717	rapidly	rapidly	RB
1718	1732	down-regulated	down-regulate	VBN
1733	1735	in	in	IN
1736	1742	normal	normal	JJ
1743	1744	T	t	NN
1745	1750	cells	cell	NNS
1750	1751	,	,	,
1752	1755	but	but	CC
1756	1764	persists	persist	VBZ
1765	1767	at	at	IN
1768	1772	high	high	JJ
1773	1779	levels	level	NNS
1780	1782	in	in	IN
1783	1786	Ipr	Ipr	NNP
1787	1793	CD4-8-	CD4-8-	NNP
1794	1795	T	t	NN
1796	1801	cells	cell	NNS
1801	1802	.	.	.

1803	1808	These	these	DT
1809	1812	two	two	CD
1813	1826	abnormalities	abnormality	NNS
1827	1829	at	at	IN
1830	1833	the	the	DT
1834	1839	NF-AT	NF-AT	NNP
1840	1844	site	site	NN
1845	1852	provide	provide	VBP
1853	1854	a	a	DT
1855	1864	potential	potential	JJ
1865	1874	mechanism	mechanism	NN
1875	1877	to	to	TO
1878	1885	account	account	VB
1886	1889	for	for	IN
1890	1893	the	the	DT
1894	1900	defect	defect	NN
1901	1903	in	in	IN
1904	1908	IL-2	il-2	NN
1909	1919	production	production	NN
1920	1924	from	from	IN
1925	1928	Ipr	Ipr	NNP
1929	1935	CD4-8-	CD4-8-	NNP
1936	1937	T	t	NN
1938	1943	cells	cell	NNS
1943	1944	.	.	.