0	4	MIP1	mip1	NN
5	10	alpha	alpha	NN
11	18	nuclear	nuclear	JJ
19	26	protein	protein	NN
27	28	(	(	(
28	31	MNP	MNP	NNP
31	32	)	)	)
32	33	,	,	,
34	35	a	a	DT
36	41	novel	novel	JJ
42	55	transcription	transcription	NN
56	62	factor	factor	NN
63	72	expressed	express	VBN
73	75	in	in	IN
76	89	hematopoietic	hematopoietic	JJ
90	95	cells	cell	NNS
96	100	that	that	WDT
101	103	is	be	VBZ
104	111	crucial	crucial	JJ
112	115	for	for	IN
116	129	transcription	transcription	NN
130	132	of	of	IN
133	136	the	the	DT
137	142	human	human	JJ
143	148	MIP-1	mip-1	NN
149	154	alpha	alpha	NN
155	159	gene	gene	NN
159	160	.	.	.

162	168	Murine	murine	JJ
169	179	macrophage	macrophage	NN
180	192	inflammatory	inflammatory	JJ
193	200	protein	protein	NN
201	202	1	1	CD
203	208	alpha	alpha	NN
209	210	(	(	(
210	215	MIP-1	mip-1	NN
216	221	alpha	alpha	NN
221	222	)	)	)
223	226	and	and	CC
227	230	its	its	PRP$
231	236	human	human	JJ
237	247	equivalent	equivalent	NN
248	249	(	(	(
249	254	GOS19	GOS19	NNP
254	255	,	,	,
256	260	LD78	LD78	NNP
260	261	,	,	,
262	264	or	or	CC
265	270	AT464	AT464	NNP
270	271	)	)	)
272	275	are	be	VBP
276	283	members	member	NNS
284	286	of	of	IN
287	290	the	the	DT
291	295	-C-C	-C-C	NNP
296	302	family	family	NN
303	305	of	of	IN
306	326	low-molecular-weight	low-molecular-weight	JJ
327	337	chemokines	chemokine	NNS
337	338	.	.	.

339	347	Secreted	secrete	VBN
348	352	from	from	IN
353	362	activated	activate	VBN
363	364	T	t	NN
365	370	cells	cell	NNS
371	374	and	and	CC
375	386	macrophages	macrophage	NNS
386	387	,	,	,
388	392	bone	bone	NN
393	407	marrow-derived	marrow-derived	JJ
408	413	MIP-1	mip-1	NN
414	425	alpha/GOS19	alpha/gos19	NN
426	434	inhibits	inhibit	VBZ
435	444	primitive	primitive	JJ
445	458	hematopoietic	hematopoietic	JJ
459	463	stem	stem	NN
464	469	cells	cell	NNS
470	473	and	and	CC
474	481	appears	appear	VBZ
482	484	to	to	TO
485	487	be	be	VB
488	496	involved	involve	VBN
497	499	in	in	IN
500	503	the	the	DT
504	515	homeostatic	homeostatic	JJ
516	523	control	control	NN
524	526	of	of	IN
527	531	stem	stem	NN
532	536	cell	cell	NN
537	550	proliferation	proliferation	NN
550	551	.	.	.

552	554	It	it	PRP
555	559	also	also	RB
560	567	induces	induce	VBZ
568	578	chemotaxis	chemotaxis	NN
579	582	and	and	CC
583	595	inflammatory	inflammatory	JJ
596	605	responses	response	NNS
606	608	in	in	IN
609	615	mature	mature	JJ
616	620	cell	cell	NN
621	626	types	type	NNS
626	627	.	.	.

628	637	Therefore	therefore	RB
637	638	,	,	,
639	641	it	it	PRP
642	644	is	be	VBZ
645	654	important	important	JJ
655	657	to	to	TO
658	668	understand	understand	VB
669	672	the	the	DT
673	683	mechanisms	mechanism	NNS
684	689	which	which	WDT
690	697	control	control	VBP
698	701	the	the	DT
702	712	expression	expression	NN
713	715	of	of	IN
716	721	MIP-1	MIP-1	NNP
722	733	alpha/GOS19	alpha/gos19	NN
733	734	.	.	.

735	743	Previous	previous	JJ
744	748	work	work	NN
749	752	has	have	VBZ
753	758	shown	show	VBN
759	763	that	that	IN
764	766	in	in	IN
767	773	Jurkat	Jurkat	NNP
774	775	T	t	NN
776	781	cells	cell	NNS
781	782	,	,	,
783	784	a	a	DT
785	788	set	set	NN
789	791	of	of	IN
792	798	widely	widely	RB
799	808	expressed	express	VBN
809	822	transcription	transcription	NN
823	830	factors	factor	NNS
831	832	(	(	(
832	835	the	the	DT
836	841	ICK-1	ick-1	NN
842	848	family	family	NN
848	849	)	)	)
850	856	affect	affect	VBP
857	860	the	the	DT
861	866	GOS19	gos19	NN
867	875	promoter	promoter	NN
875	876	.	.	.

877	880	One	one	CD
881	887	member	member	NN
887	888	,	,	,
889	895	ICK-1A	ICK-1A	NNP
895	896	,	,	,
897	904	behaves	behave	VBZ
905	907	as	as	IN
908	909	a	a	DT
910	916	strong	strong	JJ
917	925	negative	negative	JJ
926	935	regulator	regulator	NN
935	936	.	.	.

937	939	In	in	IN
940	944	this	this	DT
945	958	communication	communication	NN
958	959	,	,	,
960	962	we	we	PRP
963	970	provide	provide	VBP
971	979	evidence	evidence	NN
980	984	that	that	IN
985	988	the	the	DT
989	996	pathway	pathway	NN
997	999	of	of	IN
1000	1009	induction	induction	NN
1010	1012	in	in	IN
1013	1016	the	the	DT
1017	1027	macrophage	macrophage	NN
1028	1032	cell	cell	NN
1033	1037	line	line	NN
1038	1042	U937	u937	NN
1043	1045	is	be	VBZ
1046	1055	different	different	JJ
1056	1060	from	from	IN
1061	1065	that	that	DT
1066	1068	in	in	IN
1069	1075	Jurkat	Jurkat	NNP
1076	1081	cells	cell	NNS
1081	1082	.	.	.

1083	1094	Furthermore	furthermore	RB
1094	1095	,	,	,
1096	1098	we	we	PRP
1099	1103	show	show	VBP
1104	1108	that	that	IN
1109	1112	the	the	DT
1113	1118	ICK-1	ick-1	NN
1119	1126	binding	binding	NN
1127	1131	site	site	NN
1132	1136	does	do	VBZ
1137	1140	not	not	RB
1141	1147	confer	confer	VB
1148	1156	negative	negative	JJ
1157	1167	regulation	regulation	NN
1168	1170	in	in	IN
1171	1175	U937	u937	NN
1176	1181	cells	cell	NNS
1181	1182	.	.	.

1183	1185	We	we	PRP
1186	1193	provide	provide	VBP
1194	1202	evidence	evidence	NN
1203	1206	for	for	IN
1207	1209	an	an	DT
1210	1220	additional	additional	JJ
1221	1228	binding	bind	VBG
1229	1233	site	site	NN
1233	1234	,	,	,
1235	1238	the	the	DT
1239	1244	MIP-1	mip-1	NN
1245	1250	alpha	alpha	NN
1251	1258	nuclear	nuclear	JJ
1259	1266	protein	protein	NN
1267	1268	(	(	(
1268	1271	MNP	MNP	NNP
1271	1272	)	)	)
1273	1277	site	site	NN
1277	1278	,	,	,
1279	1284	which	which	WDT
1285	1293	overlaps	overlap	VBZ
1294	1297	the	the	DT
1298	1303	ICK-1	ick-1	NN
1304	1308	site	site	NN
1308	1309	.	.	.

1310	1321	Interaction	interaction	NN
1322	1324	of	of	IN
1325	1332	nuclear	nuclear	JJ
1333	1341	extracts	extract	NNS
1342	1346	from	from	IN
1347	1354	various	various	JJ
1355	1359	cell	cell	NN
1360	1365	lines	line	NNS
1366	1369	and	and	CC
1370	1376	tissue	tissue	NN
1377	1381	with	with	IN
1382	1385	the	the	DT
1386	1389	MNP	MNP	NNP
1390	1394	site	site	NN
1395	1400	leads	lead	VBZ
1401	1403	to	to	TO
1404	1407	the	the	DT
1408	1417	formation	formation	NN
1418	1420	of	of	IN
1421	1435	fast-migrating	fast-migrating	JJ
1436	1447	protein-DNA	protein-dna	JJ
1448	1457	complexes	complex	NNS
1458	1462	with	with	IN
1463	1470	similar	similar	JJ
1471	1474	but	but	CC
1475	1483	distinct	distinct	JJ
1484	1499	electrophoretic	electrophoretic	JJ
1500	1510	mobilities	mobility	NNS
1510	1511	.	.	.

1512	1513	A	a	DT
1514	1522	mutation	mutation	NN
1523	1525	of	of	IN
1526	1529	the	the	DT
1530	1533	MNP	MNP	NNP
1534	1538	site	site	NN
1539	1544	which	which	WDT
1545	1549	does	do	VBZ
1550	1553	not	not	RB
1554	1562	abrogate	abrogate	VB
1563	1568	ICK-1	ick-1	NN
1569	1576	binding	binding	NN
1577	1588	inactivates	inactivate	VBZ
1589	1592	the	the	DT
1593	1600	GOS19.1	gos19.1	NN
1601	1609	promoter	promoter	NN
1610	1612	in	in	IN
1613	1617	U937	u937	NN
1618	1623	cells	cell	NNS
1624	1627	and	and	CC
1628	1635	reduces	reduce	VBZ
1636	1639	its	its	PRP$
1640	1648	activity	activity	NN
1649	1651	by	by	IN
1652	1660	fourfold	fourfold	RB
1661	1663	in	in	IN
1664	1670	Jurkat	Jurkat	NNP
1671	1676	cells	cell	NNS
1676	1677	.	.	.

1678	1680	We	we	PRP
1681	1688	propose	propose	VBP
1689	1693	that	that	IN
1694	1697	the	the	DT
1698	1701	MNP	MNP	NNP
1702	1712	protein(s)	protein(s)	NNP
1713	1720	binding	binding	NN
1721	1723	at	at	IN
1724	1727	the	the	DT
1728	1731	MNP	MNP	NNP
1732	1736	site	site	NN
1737	1748	constitutes	constitute	VBZ
1749	1750	a	a	DT
1751	1756	novel	novel	JJ
1757	1770	transcription	transcription	NN
1771	1780	factor(s)	factor(s)	NN
1781	1790	expressed	express	VBN
1791	1793	in	in	IN
1794	1807	hematopoietic	hematopoietic	JJ
1808	1813	cells	cell	NNS
1813	1814	.	.	.