0	5	Human	human	JJ
6	16	interferon	interferon	NN
17	27	regulatory	regulatory	JJ
28	34	factor	factor	NN
35	36	2	2	CD
37	41	gene	gene	NN
41	42	.	.	.

43	54	Intron-exon	intron-exon	JJ
55	67	organization	organization	NN
68	71	and	and	CC
72	82	functional	functional	JJ
83	91	analysis	analysis	NN
92	94	of	of	IN
95	106	5’-flanking	5'-flanking	JJ
107	113	region	region	NN
113	114	.	.	.

116	126	Interferon	Interferon	NNP
127	137	regulatory	regulatory	JJ
138	144	factor	factor	NN
145	146	2	2	CD
147	148	(	(	(
148	153	IRF-2	irf-2	NN
153	154	)	)	)
155	157	is	be	VBZ
158	159	a	a	DT
160	175	transcriptional	transcriptional	JJ
176	186	regulatory	regulatory	JJ
187	194	protein	protein	NN
195	199	that	that	WDT
200	210	terminates	terminate	VBZ
211	221	interferon	interferon	NN
222	226	beta	beta	NN
227	237	expression	expression	NN
238	247	initiated	initiate	VBN
248	250	by	by	IN
251	261	interferon	interferon	NN
262	272	regulatory	regulatory	JJ
273	279	factor	factor	NN
280	281	1	1	CD
281	282	.	.	.

283	285	In	in	IN
286	290	this	this	DT
291	296	study	study	NN
296	297	,	,	,
298	300	we	we	PRP
301	309	isolated	isolate	VBD
310	313	the	the	DT
314	321	genomic	genomic	JJ
322	325	DNA	dna	NN
326	329	for	for	IN
330	335	human	human	JJ
336	341	IRF-2	irf-2	NN
342	346	gene	gene	NN
346	347	,	,	,
348	358	determined	determine	VBD
359	362	the	the	DT
363	374	intron-exon	intron-exon	JJ
375	384	structure	structure	NN
385	387	of	of	IN
388	391	the	the	DT
392	397	human	human	JJ
398	403	IRF-2	irf-2	NN
404	408	gene	gene	NN
408	409	,	,	,
410	416	mapped	map	VBD
417	420	the	the	DT
421	426	major	major	JJ
427	440	transcription	transcription	NN
441	451	initiation	initiation	NN
452	456	site	site	NN
456	457	,	,	,
458	468	identified	identify	VBD
469	470	a	a	DT
471	477	number	number	NN
478	480	of	of	IN
481	490	potential	potential	JJ
491	501	regulatory	regulatory	JJ
502	510	elements	element	NNS
511	513	in	in	IN
514	517	the	the	DT
518	529	5’-flanking	5'-flanking	JJ
530	536	region	region	NN
536	537	,	,	,
538	541	and	and	CC
542	551	localized	localize	VBD
552	555	the	the	DT
556	561	IRF-2	irf-2	NN
562	566	gene	gene	NN
567	569	on	on	IN
570	575	human	human	JJ
576	586	chromosome	chromosome	NN
587	588	4	4	CD
588	589	.	.	.

590	593	The	the	DT
594	599	IRF-2	irf-2	NN
600	608	promoter	promoter	NN
609	615	region	region	NN
616	624	contains	contain	VBZ
625	626	a	a	DT
627	630	CpG	CpG	NNP
631	637	island	island	NN
637	638	,	,	,
639	643	with	with	IN
644	651	several	several	JJ
652	654	GC	GC	NNP
655	660	boxes	box	NNS
660	661	,	,	,
662	663	a	a	DT
664	672	putative	putative	JJ
673	681	NF-kappa	NF-kappa	NNP
682	691	B-binding	b-binding	JJ
692	696	site	site	NN
696	697	,	,	,
698	701	and	and	CC
702	703	a	a	DT
704	708	CAAT	CAAT	NNP
709	712	box	box	NN
712	713	,	,	,
714	717	but	but	CC
718	720	no	no	DT
721	725	TATA	TATA	NNP
726	729	box	box	NN
729	730	.	.	.

731	735	When	when	WRB
736	739	the	the	DT
740	748	promoter	promoter	NN
749	755	region	region	NN
756	759	was	be	VBD
760	766	linked	link	VBN
767	771	with	with	IN
772	773	a	a	DT
774	786	heterologous	heterologous	JJ
787	795	reporter	reporter	NN
796	800	gene	gene	NN
800	801	,	,	,
802	804	we	we	PRP
805	810	found	find	VBD
811	815	that	that	IN
816	819	the	the	DT
820	828	promoter	promoter	NN
829	835	region	region	NN
836	838	is	be	VBZ
839	848	inducible	inducible	JJ
849	851	by	by	IN
852	856	both	both	DT
857	868	interferons	interferon	NNS
869	870	(	(	(
870	886	interferon-alpha	interferon-alpha	NN
887	890	and	and	CC
891	897	-gamma	-gamma	NN
897	898	)	)	)
899	902	and	and	CC
903	913	interferon	interferon	NN
914	924	regulatory	regulatory	JJ
925	931	factor	factor	NN
932	933	1	1	CD
933	934	.	.	.

935	938	The	the	DT
939	945	region	region	NN
946	951	which	which	WDT
952	959	induced	induce	VBD
960	965	these	these	DT
966	976	inductions	induction	NNS
977	980	was	be	VBD
981	991	identified	identify	VBN
992	994	as	as	IN
995	1000	being	be	VBG
1001	1009	confined	confine	VBN
1010	1012	to	to	TO
1013	1015	40	40	CD
1016	1027	nucleotides	nucleotide	NNS
1028	1029	5	5	CD
1029	1030	’	'	SYM
1031	1033	to	to	TO
1034	1037	the	the	DT
1038	1043	major	major	JJ
1044	1059	transcriptional	transcriptional	JJ
1060	1070	initiation	initiation	NN
1071	1075	site	site	NN
1076	1078	by	by	IN
1079	1086	testing	test	VBG
1087	1088	a	a	DT
1089	1095	series	series	NN
1096	1098	of	of	IN
1099	1105	clones	clone	NNS
1106	1110	with	with	IN
1111	1120	truncated	truncate	VBN
1121	1129	promoter	promoter	NN
1130	1132	of	of	IN
1133	1138	IRF-2	irf-2	NN
1138	1139	.	.	.

1140	1144	This	this	DT
1145	1151	region	region	NN
1152	1160	contains	contain	VBZ
1161	1169	elements	element	NNS
1170	1175	which	which	WDT
1176	1179	are	be	VBP
1180	1186	shared	share	VBN
1187	1191	with	with	IN
1192	1195	the	the	DT
1196	1211	transcriptional	transcriptional	JJ
1212	1221	enhancers	enhancer	NNS
1222	1224	of	of	IN
1225	1230	other	other	JJ
1231	1236	genes	gene	NNS
1237	1246	including	include	VBG
1247	1257	interferon	interferon	NN
1258	1268	regulatory	regulatory	JJ
1269	1275	factor	factor	NN
1276	1277	1	1	CD
1277	1278	,	,	,
1279	1289	interferon	interferon	NN
1290	1294	beta	beta	NN
1294	1295	,	,	,
1296	1299	and	and	CC
1300	1320	interferon-inducible	interferon-inducible	JJ
1321	1326	genes	gene	NNS
1326	1327	.	.	.

1328	1333	These	these	DT
1334	1338	data	datum	NNS
1339	1346	suggest	suggest	VBP
1347	1351	that	that	IN
1352	1362	interferon	interferon	NN
1363	1373	regulatory	regulatory	JJ
1374	1380	factor	factor	NN
1381	1382	1	1	CD
1383	1386	not	not	RB
1387	1391	only	only	RB
1392	1400	triggers	trigger	VBZ
1401	1404	the	the	DT
1405	1415	activation	activation	NN
1416	1418	of	of	IN
1419	1422	the	the	DT
1423	1433	interferon	interferon	NN
1434	1440	signal	signal	NN
1441	1453	transduction	transduction	NN
1454	1461	pathway	pathway	NN
1461	1462	,	,	,
1463	1466	but	but	CC
1467	1471	also	also	RB
1472	1475	may	may	MD
1476	1480	play	play	VB
1481	1482	a	a	DT
1483	1487	role	role	NN
1488	1490	in	in	IN
1491	1499	limiting	limit	VBG
1500	1503	the	the	DT
1504	1512	duration	duration	NN
1513	1515	of	of	IN
1516	1520	this	this	DT
1521	1529	response	response	NN
1530	1532	by	by	IN
1533	1543	activating	activate	VBG
1544	1547	the	the	DT
1548	1561	transcription	transcription	NN
1562	1564	of	of	IN
1565	1570	IRF-2	irf-2	NN
1570	1571	.	.	.