0 1 A a DT 2 13 hydrophobic hydrophobic JJ 14 20 domain domain NN 21 23 of of IN 24 39 Ca2+-modulating ca2+-modulating JJ 40 51 cyclophilin cyclophilin NN 52 58 ligand ligand NN 59 68 modulates modulate VBZ 69 76 calcium calcium NN 77 83 influx influx NN 84 93 signaling signaling NN 94 96 in in IN 97 98 T t NN 99 110 lymphocytes lymphocyte NNS 110 111 . . . 113 128 Ca2+-modulating ca2+-modulating JJ 129 140 cyclophilin cyclophilin NN 141 147 ligand ligand NN 148 149 ( ( ( 149 153 CAML CAML NNP 153 154 ) ) ) 155 158 was be VBD 159 169 originally originally RB 170 179 described describe VBN 180 182 as as IN 183 184 a a DT 185 196 cyclophilin cyclophilin NN 197 206 B-binding b-binding JJ 207 214 protein protein NN 215 220 whose whose WP$ 221 235 overexpression overexpression NN 236 238 in in IN 239 240 T t NN 241 246 cells cell NNS 247 253 causes cause VBZ 254 255 a a DT 256 260 rise rise NN 261 263 in in IN 264 277 intracellular intracellular JJ 278 285 calcium calcium NN 285 286 , , , 287 291 thus thus RB 292 302 activating activate VBG 303 316 transcription transcription NN 317 324 factors factor NNS 325 336 responsible responsible JJ 337 340 for for IN 341 344 the the DT 345 350 early early JJ 351 357 immune immune JJ 358 366 response response NN 366 367 . . . 368 370 As as IN 371 379 reported report VBN 380 384 here here RB 384 385 , , , 386 404 structure-function structure-function JJ 405 413 analysis analysis NN 414 416 of of IN 417 420 the the DT 421 425 CAML CAML NNP 426 430 gene gene NN 431 433 in in IN 434 440 Jurkat Jurkat NNP 441 442 T t NN 443 448 cells cell NNS 449 458 indicates indicate VBZ 459 463 that that IN 464 467 two two CD 468 470 of of IN 471 475 CAML CAML NNP 475 477 ’s 's POS 478 486 putative putative JJ 487 504 membrane-spanning membrane-spanning JJ 505 512 domains domain NNS 513 516 are be VBP 517 526 necessary necessary JJ 527 530 and and CC 531 541 sufficient sufficient JJ 542 545 for for IN 546 549 the the DT 550 560 modulation modulation NN 561 563 of of IN 564 577 intracellular intracellular JJ 578 585 calcium calcium NN 585 586 . . . 587 589 We we PRP 590 597 propose propose VBP 598 602 that that IN 603 606 the the DT 607 618 hydrophobic hydrophobic JJ 619 629 C-terminal c-terminal JJ 630 634 tail tail NN 635 637 of of IN 638 642 CAML CAML NNP 643 648 forms form VBZ 649 652 its its PRP$ 653 661 effector effector NN 662 668 domain domain NN 668 669 , , , 670 674 thus thus RB 675 686 implicating implicate VBG 687 690 the the DT 691 701 N-terminal n-terminal JJ 702 713 hydrophilic hydrophilic JJ 714 720 domain domain NN 721 723 in in IN 724 725 a a DT 726 736 regulatory regulatory JJ 737 741 role role NN 741 742 . . . 743 748 These these DT 749 757 findings finding NNS 758 764 define define VBP 765 766 a a DT 767 772 novel novel JJ 773 780 protein protein NN 781 786 motif motif NN 787 791 that that WDT 792 801 functions function VBZ 802 804 in in IN 805 818 intracellular intracellular JJ 819 826 calcium calcium NN 827 836 signaling signaling NN 836 837 . . .