0 9 Apoptosis Apoptosis NNP 10 19 signaling signaling NN 20 28 pathways pathway NNS 29 31 in in IN 32 38 normal normal JJ 39 40 T t NN 41 46 cells cell NNS 46 47 : : : 48 60 differential differential JJ 61 69 activity activity NN 70 72 of of IN 73 78 Bcl-2 bcl-2 NN 79 82 and and CC 83 102 IL-1beta-converting il-1beta-converting NN 103 109 enzyme enzyme NN 110 116 family family NN 117 125 protease protease NN 126 136 inhibitors inhibitor NNS 137 139 on on IN 140 155 glucocorticoid- glucocorticoid- NN 156 159 and and CC 160 172 Fas-mediated fas-mediated JJ 173 185 cytotoxicity cytotoxicity NN 185 186 . . . 188 200 Fas-mediated fas-mediated JJ 201 210 apoptosis apoptosis NN 211 216 plays play VBZ 217 219 an an DT 220 229 important important JJ 230 234 role role NN 235 237 in in IN 238 248 regulating regulate VBG 249 252 the the DT 253 259 immune immune JJ 260 268 response response NN 269 271 in in IN 272 282 peripheral peripheral JJ 283 284 T t NN 285 290 cells cell NNS 290 291 . . . 292 305 Restimulation restimulation NN 306 308 of of IN 309 310 T t NN 311 315 cell cell NN 316 322 blasts blast NNS 323 335 up-regulates up-regulate VBZ 336 339 Fas Fas NNP 340 343 and and CC 344 347 Fas Fas NNP 348 354 ligand ligand NN 355 365 expression expression NN 365 366 , , , 367 371 with with IN 372 382 subsequent subsequent JJ 383 394 interaction interaction NN 395 402 leading lead VBG 403 405 to to TO 406 410 cell cell NN 411 416 death death NN 416 417 . . . 418 432 Overexpression overexpression NN 433 435 of of IN 436 441 Bcl-2 bcl-2 NN 442 444 in in IN 445 450 tumor tumor NN 451 456 cells cell NNS 457 463 blocks block VBZ 464 473 apoptosis apoptosis NN 474 481 induced induce VBN 482 484 by by IN 485 489 many many JJ 490 497 stimuli stimulus NNS 497 498 , , , 499 502 but but CC 503 513 inhibition inhibition NN 514 516 of of IN 517 529 Fas-mediated fas-mediated JJ 530 537 killing killing NN 538 541 has have VBZ 542 545 not not RB 546 550 been be VBN 551 563 consistently consistently RB 564 572 observed observe VBN 572 573 . . . 574 576 To to TO 577 584 examine examine VB 585 588 the the DT 589 597 behavior behavior NN 598 600 of of IN 601 606 Bcl-2 bcl-2 NN 607 609 in in IN 610 616 normal normal JJ 617 622 cells cell NNS 622 623 , , , 624 625 T t NN 626 630 cell cell NN 631 637 blasts blast NNS 638 642 were be VBD 643 654 transiently transiently RB 655 666 transfected transfecte VBN 667 671 with with IN 672 677 Bcl-2 bcl-2 NN 678 681 and and CC 682 689 related related JJ 690 694 gene gene NN 695 703 products product NNS 704 706 to to TO 707 716 determine determine VB 717 720 the the DT 721 727 effect effect NN 728 730 on on IN 731 740 apoptotic apoptotic JJ 741 750 signaling signaling NN 750 751 . . . 752 761 Transient transient JJ 762 776 overexpression overexpression NN 777 779 of of IN 780 785 Bcl-2 bcl-2 NN 786 788 in in IN 789 794 mouse mouse NN 795 798 and and CC 799 804 human human JJ 805 806 T t NN 807 811 cell cell NN 812 818 blasts blast NNS 819 822 did do VBD 823 826 not not RB 827 832 block block VB 833 845 Fas-mediated fas-mediated JJ 846 855 apoptosis apoptosis NN 855 856 , , , 857 864 whereas whereas IN 865 875 etoposide- etoposide- NN 876 879 and and CC 880 902 glucocorticoid-induced glucocorticoid-induced JJ 903 915 cytotoxicity cytotoxicity NN 916 919 was be VBD 920 928 potently potently RB 929 938 inhibited inhibit VBN 938 939 . . . 940 950 Expression expression NN 951 953 of of IN 954 960 Bcl-xL Bcl-xL NNP 961 964 and and CC 965 975 adenovirus adenovirus NN 976 979 E1B E1B NNP 980 983 19K 19k NN 984 987 did do VBD 988 991 not not RB 992 1001 interfere interfere VB 1002 1006 with with IN 1007 1015 anti-Fas anti-fas JJ 1016 1023 killing killing NN 1023 1024 . . . 1025 1027 In in IN 1028 1036 contrast contrast NN 1036 1037 , , , 1038 1066 interleukin-1beta-converting interleukin-1beta-converting JJ 1067 1073 enzyme enzyme NN 1074 1080 family family NN 1081 1089 protease protease NN 1090 1100 inhibitors inhibitor NNS 1101 1112 Ac-DEVD-CHO Ac-DEVD-CHO NNP 1113 1116 and and CC 1117 1121 CrmA CrmA NNP 1122 1129 blocked block VBD 1130 1142 Fas-mediated fas-mediated JJ 1143 1152 apoptosis apoptosis NN 1152 1153 . . . 1154 1159 These these DT 1160 1167 results result NNS 1168 1175 suggest suggest VBP 1176 1180 that that IN 1181 1191 peripheral peripheral JJ 1192 1193 T t NN 1194 1199 cells cell NNS 1200 1203 use use VBP 1204 1212 distinct distinct JJ 1213 1222 apoptosis apoptosis NN 1223 1232 signaling signaling NN 1233 1241 pathways pathway NNS 1242 1246 with with IN 1247 1259 differential differential JJ 1260 1271 sensitivity sensitivity NN 1272 1274 to to TO 1275 1280 Bcl-2 bcl-2 NN 1281 1284 and and CC 1285 1313 interleukin-1beta-converting interleukin-1beta-converting JJ 1314 1320 enzyme enzyme NN 1321 1327 family family NN 1328 1336 protease protease NN 1337 1347 inhibitors inhibitor NNS 1347 1348 . . . 1349 1354 Since since IN 1355 1356 T t NN 1357 1362 cells cell NNS 1363 1371 normally normally RB 1372 1379 express express VBP 1380 1385 Bcl-2 bcl-2 NN 1386 1389 and and CC 1390 1396 Bcl-xL bcl-xl NN 1397 1406 following follow VBG 1407 1417 activation activation NN 1417 1418 , , , 1419 1424 their their PRP$ 1425 1434 inability inability NN 1435 1437 to to TO 1438 1443 block block VB 1444 1456 Fas-mediated fas-mediated JJ 1457 1466 apoptosis apoptosis NN 1467 1470 may may MD 1471 1476 allow allow VB 1477 1480 for for IN 1481 1484 the the DT 1485 1496 elimination elimination NN 1497 1499 of of IN 1500 1513 self-reactive self-reactive JJ 1514 1519 cells cell NNS 1520 1523 and and CC 1524 1527 the the DT 1528 1539 appropriate appropriate JJ 1540 1550 regulation regulation NN 1551 1553 of of IN 1554 1560 immune immune JJ 1561 1570 responses response NNS 1570 1571 . . .