0	2	An	an	DT
3	7	IL-2	il-2	NN
8	16	response	response	NN
17	24	element	element	NN
25	27	in	in	IN
28	31	the	the	DT
32	37	human	human	JJ
38	42	IL-2	il-2	NN
43	51	receptor	receptor	NN
52	57	alpha	alpha	NN
58	63	chain	chain	NN
64	72	promoter	promoter	NN
73	75	is	be	VBZ
76	77	a	a	DT
78	87	composite	composite	JJ
88	95	element	element	NN
96	100	that	that	WDT
101	106	binds	bind	VBZ
107	112	Stat5	Stat5	NNP
112	113	,	,	,
114	119	Elf-1	Elf-1	NNP
119	120	,	,	,
121	129	HMG-I(Y)	HMG-I(Y)	NNP
130	133	and	and	CC
134	135	a	a	DT
136	140	GATA	GATA	NNP
141	147	family	family	NN
148	155	protein	protein	NN
155	156	.	.	.

158	168	Expression	expression	NN
169	171	of	of	IN
172	175	the	the	DT
176	181	human	human	JJ
182	195	interleukin-2	interleukin-2	NN
196	197	(	(	(
197	201	IL-2	il-2	NN
201	202	)	)	)
203	211	receptor	receptor	NN
212	217	alpha	alpha	NN
218	223	chain	chain	NN
224	228	gene	gene	NN
229	231	is	be	VBZ
232	240	potently	potently	RB
241	252	upregulated	upregulate	VBN
253	255	by	by	IN
256	259	its	its	PRP$
260	263	own	own	JJ
264	270	ligand	ligand	NN
270	271	,	,	,
272	276	IL-2	il-2	NN
276	277	.	.	.

278	280	In	in	IN
281	285	this	this	DT
286	291	study	study	NN
291	292	,	,	,
293	295	we	we	PRP
296	308	characterize	characterize	VBP
309	311	an	an	DT
312	321	essential	essential	JJ
322	330	upstream	upstream	JJ
331	335	IL-2	il-2	NN
336	344	response	response	NN
345	352	element	element	NN
353	357	that	that	WDT
358	366	contains	contain	VBZ
367	371	both	both	CC
372	381	consensus	consensus	NN
382	385	and	and	CC
386	399	non-consensus	non-consensus	JJ
400	403	GAS	GAS	NNP
404	410	motifs	motif	NNS
410	411	,	,	,
412	415	two	two	CD
416	424	putative	putative	JJ
425	428	Ets	ets	NN
429	436	binding	binding	NN
437	442	sites	site	NNS
443	444	(	(	(
444	447	EBS	EBS	NNP
447	448	)	)	)
448	449	,	,	,
450	453	one	one	CD
454	456	of	of	IN
457	462	which	which	WDT
463	471	overlaps	overlap	VBZ
472	475	the	the	DT
476	485	consensus	consensus	NN
486	489	GAS	GAS	NNP
490	495	motif	motif	NN
495	496	,	,	,
497	500	and	and	CC
501	502	a	a	DT
503	507	GATA	GATA	NNP
508	513	motif	motif	NN
513	514	,	,	,
515	520	which	which	WDT
521	529	overlaps	overlap	VBZ
530	533	the	the	DT
534	547	non-consensus	non-consensus	JJ
548	551	GAS	GAS	NNP
552	557	motif	motif	NN
557	558	.	.	.

559	561	We	we	PRP
562	573	demonstrate	demonstrate	VBP
574	578	that	that	IN
579	587	although	although	IN
588	591	the	the	DT
592	602	individual	individual	JJ
603	613	components	component	NNS
614	616	of	of	IN
617	621	this	this	DT
622	629	element	element	NN
630	632	do	do	VBP
633	636	not	not	RB
637	644	respond	respond	VB
645	647	to	to	TO
648	652	IL-2	il-2	NN
652	653	,	,	,
654	662	together	together	RB
663	667	they	they	PRP
668	672	form	form	VBP
673	674	a	a	DT
675	684	composite	composite	JJ
685	692	element	element	NN
693	700	capable	capable	JJ
701	703	of	of	IN
704	714	conferring	confer	VBG
715	719	IL-2	il-2	NN
720	734	responsiveness	responsiveness	NN
735	737	to	to	TO
738	739	a	a	DT
740	752	heterologous	heterologous	JJ
753	761	promoter	promoter	NN
761	762	.	.	.

763	771	Multiple	multiple	JJ
772	779	factors	factor	NNS
780	789	including	include	VBG
790	795	Stat5	Stat5	NNP
795	796	,	,	,
797	802	Elf-1	Elf-1	NNP
802	803	,	,	,
804	812	HMG-I(Y)	HMG-I(Y)	NNP
813	816	and	and	CC
817	821	GATA	GATA	NNP
822	828	family	family	NN
829	837	proteins	protein	NNS
838	842	bind	bind	VBP
843	845	to	to	TO
846	849	the	the	DT
850	854	IL-2	il-2	NN
855	863	response	response	NN
864	871	element	element	NN
872	875	and	and	CC
876	884	mutation	mutation	NN
885	887	of	of	IN
888	891	any	any	DT
892	895	one	one	CD
896	898	of	of	IN
899	904	these	these	DT
905	912	binding	bind	VBG
913	918	sites	site	NNS
919	929	diminishes	diminish	VBZ
930	933	the	the	DT
934	942	activity	activity	NN
943	945	of	of	IN
946	950	this	this	DT
951	958	element	element	NN
958	959	.	.	.

960	962	An	an	DT
963	975	unidentified	unidentified	JJ
976	979	Ets	Ets	NNP
980	986	family	family	NN
987	994	protein	protein	NN
995	1000	binds	bind	VBZ
1001	1003	to	to	TO
1004	1007	the	the	DT
1008	1011	EBS	ebs	NN
1012	1023	overlapping	overlap	VBG
1024	1027	the	the	DT
1028	1037	consensus	consensus	NN
1038	1041	GAS	GAS	NNP
1042	1047	motif	motif	NN
1048	1051	and	and	CC
1052	1059	appears	appear	VBZ
1060	1062	to	to	TO
1063	1073	negatively	negatively	RB
1074	1082	regulate	regulate	VB
1083	1086	the	the	DT
1087	1092	human	human	JJ
1093	1098	IL-2R	il-2r	NN
1099	1104	alpha	alpha	NN
1105	1113	promoter	promoter	NN
1113	1114	.	.	.

1115	1119	Thus	thus	RB
1119	1120	,	,	,
1121	1133	IL-2-induced	il-2-induced	JJ
1134	1139	IL-2R	IL-2R	NNP
1140	1145	alpha	alpha	NN
1146	1154	promoter	promoter	NN
1155	1163	activity	activity	NN
1164	1172	requires	require	VBZ
1173	1174	a	a	DT
1175	1182	complex	complex	JJ
1183	1191	upstream	upstream	JJ
1192	1199	element	element	NN
1199	1200	,	,	,
1201	1206	which	which	WDT
1207	1214	appears	appear	VBZ
1215	1217	to	to	TO
1218	1225	contain	contain	VB
1226	1233	binding	bind	VBG
1234	1239	sites	site	NNS
1240	1243	for	for	IN
1244	1248	both	both	CC
1249	1257	positive	positive	JJ
1258	1261	and	and	CC
1262	1270	negative	negative	JJ
1271	1281	regulatory	regulatory	JJ
1282	1289	factors	factor	NNS
1289	1290	.	.	.