0	6	Active	active	JJ
7	18	suppression	suppression	NN
19	21	of	of	IN
22	25	the	the	DT
26	31	class	class	NN
32	34	II	ii	CD
35	58	transactivator-encoding	transactivator-encoding	JJ
59	64	AIR-1	air-1	NN
65	70	locus	locus	NN
71	73	is	be	VBZ
74	85	responsible	responsible	JJ
86	89	for	for	IN
90	93	the	the	DT
94	98	lack	lack	NN
99	101	of	of	IN
102	107	major	major	JJ
108	126	histocompatibility	histocompatibility	NN
127	134	complex	complex	NN
135	140	class	class	NN
141	143	II	ii	CD
144	148	gene	gene	NN
149	159	expression	expression	NN
160	168	observed	observe	VBN
169	175	during	during	IN
176	191	differentiation	differentiation	NN
192	196	from	from	IN
197	198	B	B	NNP
199	204	cells	cell	NNS
205	207	to	to	TO
208	214	plasma	plasma	NN
215	220	cells	cell	NNS
220	221	.	.	.

223	225	In	in	IN
226	230	this	this	DT
231	236	study	study	NN
237	240	the	the	DT
241	248	genetic	genetic	JJ
249	256	control	control	NN
257	259	of	of	IN
260	265	major	major	JJ
266	284	histocompatibility	histocompatibility	NN
285	292	complex	complex	NN
293	294	(	(	(
294	297	MHC	MHC	NNP
297	298	)	)	)
299	304	class	class	NN
305	307	II	ii	CD
308	312	gene	gene	NN
313	323	expression	expression	NN
324	330	during	during	IN
331	334	the	the	DT
335	345	transition	transition	NN
346	350	from	from	IN
351	352	B	B	NNP
353	357	cell	cell	NN
358	360	to	to	TO
361	367	plasma	plasma	NN
368	372	cell	cell	NN
373	376	has	have	VBZ
377	381	been	be	VBN
382	390	analyzed	analyze	VBN
390	391	.	.	.

392	397	Class	Class	NNP
398	400	II	ii	CD
401	410	molecules	molecule	NNS
411	414	are	be	VBP
415	418	not	not	RB
419	428	expressed	express	VBN
429	431	in	in	IN
432	438	plasma	plasma	NN
439	444	cells	cell	NNS
445	452	because	because	IN
453	455	of	of	IN
456	458	an	an	DT
459	465	active	active	JJ
466	477	suppression	suppression	NN
478	487	resulting	result	VBG
488	490	in	in	IN
491	494	the	the	DT
495	505	abrogation	abrogation	NN
506	508	of	of	IN
509	514	class	class	NN
515	517	II	ii	CD
518	522	gene	gene	NN
523	536	transcription	transcription	NN
536	537	.	.	.

538	540	We	we	PRP
541	545	show	show	VBP
546	550	here	here	RB
551	555	that	that	IN
556	559	the	the	DT
560	566	plasma	plasma	NN
567	580	cell-specific	cell-specific	JJ
581	590	repressor	repressor	NN
591	599	function	function	NN
599	600	,	,	,
601	611	designated	designate	VBN
612	615	SIR	SIR	NNP
616	617	(	(	(
617	627	suppressor	suppressor	NN
628	630	of	of	IN
631	637	immune	immune	JJ
638	646	response	response	NN
647	652	genes	gene	NNS
652	653	)	)	)
653	654	,	,	,
655	659	does	do	VBZ
660	663	not	not	RB
664	667	act	act	VB
668	676	directly	directly	RB
677	679	on	on	IN
680	683	the	the	DT
684	697	transcription	transcription	NN
698	700	of	of	IN
701	706	class	class	NN
707	709	II	ii	CD
710	715	genes	gene	NNS
715	716	,	,	,
717	720	but	but	CC
721	728	instead	instead	RB
729	731	on	on	IN
732	735	the	the	DT
736	749	transcription	transcription	NN
750	752	of	of	IN
753	756	the	the	DT
757	762	AIR-1	air-1	NN
763	767	gene	gene	NN
767	768	,	,	,
769	774	whose	whose	WP$
775	782	product	product	NN
782	783	,	,	,
784	787	the	the	DT
788	793	class	class	NN
794	796	II	ii	CD
797	811	transactivator	transactivator	NN
812	813	(	(	(
813	818	CIITA	CIITA	NNP
818	819	)	)	)
819	820	,	,	,
821	823	is	be	VBZ
824	835	fundamental	fundamental	JJ
836	839	for	for	IN
840	843	the	the	DT
844	854	regulation	regulation	NN
855	857	of	of	IN
858	861	the	the	DT
862	874	constitutive	constitutive	JJ
875	878	and	and	CC
879	888	inducible	inducible	JJ
889	899	expression	expression	NN
900	902	of	of	IN
903	906	MHC	MHC	NNP
907	912	class	class	NN
913	915	II	ii	CD
916	921	genes	gene	NNS
921	922	.	.	.

923	927	This	this	DT
928	931	was	be	VBD
932	945	unambiguously	unambiguously	RB
946	958	demonstrated	demonstrate	VBN
959	961	by	by	IN
962	965	the	the	DT
966	970	fact	fact	NN
971	975	that	that	IN
976	988	plasmacytoma	plasmacytoma	NN
989	990	x	x	NN
991	992	B	B	NNP
993	997	cell	cell	NN
998	1005	hybrids	hybrid	NNS
1006	1014	carrying	carry	VBG
1015	1017	an	an	DT
1018	1023	AIR-1	air-1	NN
1024	1029	locus	locus	NN
1030	1037	derived	derive	VBN
1038	1042	from	from	IN
1043	1059	CIITA-expressing	ciita-expressing	JJ
1060	1065	cells	cell	NNS
1066	1068	do	do	VBP
1069	1072	not	not	RB
1073	1080	express	express	VB
1081	1095	CIITA-specific	ciita-specific	JJ
1096	1107	transcripts	transcript	NNS
1107	1108	.	.	.

1109	1121	Transfection	transfection	NN
1122	1124	of	of	IN
1125	1126	a	a	DT
1127	1131	cDNA	cdna	NN
1132	1142	containing	contain	VBG
1143	1146	the	the	DT
1147	1152	human	human	JJ
1153	1158	CIITA	CIITA	NNP
1159	1165	coding	coding	NN
1166	1174	sequence	sequence	NN
1175	1180	under	under	IN
1181	1184	the	the	DT
1185	1192	control	control	NN
1193	1195	of	of	IN
1196	1198	an	an	DT
1199	1211	heterologous	heterologous	JJ
1212	1220	promoter	promoter	NN
1221	1229	restores	restore	VBZ
1230	1240	expression	expression	NN
1241	1243	of	of	IN
1244	1249	human	human	JJ
1250	1253	MHC	MHC	NNP
1254	1259	class	class	NN
1260	1262	II	ii	CD
1263	1268	genes	gene	NNS
1269	1271	in	in	IN
1272	1275	the	the	DT
1276	1283	hybrids	hybrid	NNS
1284	1287	and	and	CC
1288	1290	is	be	VBZ
1291	1302	responsible	responsible	JJ
1303	1306	for	for	IN
1307	1309	de	de	FW
1310	1314	novo	novo	FW
1315	1325	expression	expression	NN
1326	1328	of	of	IN
1329	1334	mouse	mouse	NN
1335	1338	MHC	MHC	NNP
1339	1344	class	class	NN
1345	1347	II	ii	CD
1348	1353	genes	gene	NNS
1354	1356	in	in	IN
1357	1361	both	both	CC
1362	1365	the	the	DT
1366	1371	mouse	mouse	NN
1372	1384	plasmacytoma	plasmacytoma	NN
1385	1389	cell	cell	NN
1390	1394	line	line	NN
1395	1398	and	and	CC
1399	1402	the	the	DT
1403	1410	hybrids	hybrid	NNS
1410	1411	.	.	.

1412	1417	These	these	DT
1418	1425	results	result	NNS
1426	1433	confirm	confirm	VBP
1434	1437	and	and	CC
1438	1444	extend	extend	VBP
1445	1448	the	the	DT
1449	1455	notion	notion	NN
1456	1458	of	of	IN
1459	1462	the	the	DT
1463	1473	functional	functional	JJ
1474	1486	conservation	conservation	NN
1487	1489	of	of	IN
1490	1493	the	the	DT
1494	1499	AIR-1	air-1	NN
1500	1504	gene	gene	NN
1505	1512	product	product	NN
1513	1519	across	across	IN
1520	1527	species	specie	NNS
1528	1536	barriers	barrier	NNS
1536	1537	.	.	.

1538	1551	Interestingly	interestingly	RB
1551	1552	,	,	,
1553	1555	in	in	IN
1556	1573	CIITA-transfected	ciita-transfected	JJ
1574	1578	cell	cell	NN
1579	1586	hybrids	hybrid	NNS
1586	1587	,	,	,
1588	1592	cell	cell	NN
1593	1600	surface	surface	NN
1601	1611	expression	expression	NN
1612	1614	of	of	IN
1615	1618	the	the	DT
1619	1624	human	human	JJ
1625	1631	HLA-DQ	HLA-DQ	NNP
1632	1643	heterodimer	heterodimer	NN
1644	1647	was	be	VBD
1648	1651	not	not	RB
1652	1660	observed	observe	VBN
1660	1661	.	.	.

1662	1666	This	this	DT
1667	1673	result	result	NN
1674	1677	was	be	VBD
1678	1681	not	not	RB
1682	1694	attributable	attributable	JJ
1695	1697	to	to	TO
1698	1702	lack	lack	NN
1703	1705	of	of	IN
1706	1712	HLA-DQ	HLA-DQ	NNP
1713	1718	alpha	alpha	NN
1719	1721	or	or	CC
1722	1725	-DQ	-DQ	NNP
1726	1730	beta	beta	NN
1731	1744	transcription	transcription	NN
1744	1745	,	,	,
1746	1753	because	because	IN
1754	1758	both	both	DT
1759	1770	transcripts	transcript	NNS
1771	1775	were	be	VBD
1776	1783	present	present	JJ
1784	1786	in	in	IN
1787	1790	the	the	DT
1791	1808	CIITA-transfected	ciita-transfected	JJ
1809	1816	hybrids	hybrid	NNS
1816	1817	,	,	,
1818	1826	although	although	IN
1827	1829	at	at	IN
1830	1837	reduced	reduce	VBN
1838	1844	levels	level	NNS
1844	1845	.	.	.

1846	1851	These	these	DT
1852	1860	findings	finding	NNS
1861	1868	further	further	RB
1869	1876	support	support	VBP
1877	1880	our	our	PRP$
1881	1889	previous	previous	JJ
1890	1902	observations	observation	NNS
1903	1905	on	on	IN
1906	1909	the	the	DT
1910	1918	distinct	distinct	JJ
1919	1929	regulation	regulation	NN
1930	1932	of	of	IN
1933	1943	expression	expression	NN
1944	1946	of	of	IN
1947	1950	the	the	DT
1951	1956	human	human	JJ
1957	1963	HLA-DQ	HLA-DQ	NNP
1964	1969	class	class	NN
1970	1972	II	ii	CD
1973	1979	subset	subset	NN
1979	1980	,	,	,
1981	1986	which	which	WDT
1987	1990	may	may	MD
1991	1993	be	be	VB
1994	1998	thus	thus	RB
1999	2009	controlled	control	VBN
2010	2012	at	at	IN
2013	2016	the	the	DT
2017	2036	posttranscriptional	posttranscriptional	JJ
2037	2042	level	level	NN
2043	2045	by	by	IN
2046	2047	a	a	DT
2048	2065	CIITA-independent	ciita-independent	JJ
2066	2075	mechanism	mechanism	NN
2075	2076	.	.	.