0 7 Genomic genomic JJ 8 20 organization organization NN 20 21 , , , 22 30 sequence sequence NN 30 31 , , , 32 35 and and CC 36 51 transcriptional transcriptional JJ 52 62 regulation regulation NN 63 65 of of IN 66 69 the the DT 70 75 human human JJ 76 83 eotaxin eotaxin NN 84 88 gene gene NN 88 89 . . . 91 98 Eotaxin Eotaxin NNP 99 101 is be VBZ 102 104 an an DT 105 115 eosinophil eosinophil NN 116 124 specific specific JJ 125 139 beta-chemokine beta-chemokine NN 140 147 assumed assume VBN 148 150 to to TO 151 153 be be VB 154 162 involved involve VBN 163 165 in in IN 166 178 eosinophilic eosinophilic JJ 179 191 inflammatory inflammatory JJ 192 200 diseases disease NNS 201 205 such such JJ 206 208 as as IN 209 215 atopic atopic JJ 216 226 dermatitis dermatitis NN 226 227 , , , 228 236 allergic allergic JJ 237 245 rhinitis rhinitis NN 245 246 , , , 247 253 asthma asthma NN 254 257 and and CC 258 267 parasitic parasitic JJ 268 278 infections infection NNS 278 279 . . . 280 283 Its its PRP$ 284 294 expression expression NN 295 297 is be VBZ 298 307 stimulus- stimulus- NN 308 311 and and CC 312 325 cell-specific cell-specific JJ 325 326 . . . 327 329 We we PRP 330 334 here here RB 335 343 describe describe VBP 344 347 the the DT 348 355 genomic genomic JJ 356 368 organisation organisation NN 369 370 ( ( ( 370 371 3 3 CD 372 377 exons exon NNS 378 380 of of IN 381 384 132 132 CD 384 385 , , , 386 389 112 112 CD 390 393 and and CC 394 397 542 542 CD 398 400 bp bp NN 401 404 and and CC 405 406 2 2 CD 407 414 introns intron NNS 415 417 of of IN 418 422 1211 1211 CD 423 426 and and CC 427 430 378 378 CD 431 433 bp bp NN 433 434 ) ) ) 435 438 and and CC 439 447 sequence sequence NN 448 457 including include VBG 458 459 3 3 CD 460 462 kb kb NN 463 465 of of IN 466 469 DNA dna NN 470 474 from from IN 475 478 the the DT 479 488 immediate immediate JJ 489 490 5 5 CD 490 491 ’ ' SYM 492 500 upstream upstream JJ 501 507 region region NN 508 510 of of IN 511 514 the the DT 515 520 human human JJ 521 528 eotaxin eotaxin NN 529 533 gene gene NN 533 534 . . . 535 540 Among among IN 541 544 the the DT 545 555 regulatory regulatory JJ 556 564 promoter promoter NN 565 573 elements element NNS 574 585 potentially potentially RB 586 596 regulating regulate VBG 597 604 eotaxin eotaxin NN 605 609 gene gene NN 610 620 expression expression NN 621 627 and/or and/or CC 628 637 mediating mediate VBG 638 641 the the DT 642 649 effects effect NNS 650 652 of of IN 653 670 anti-inflammatory anti-inflammatory JJ 671 676 drugs drug NNS 677 679 we we PRP 680 690 identified identify VBD 691 700 consensus consensus NN 701 710 sequences sequence NNS 711 716 known know VBN 717 719 to to TO 720 728 interact interact VB 729 733 with with IN 734 741 nuclear nuclear JJ 742 749 factors factor NNS 750 754 like like IN 755 761 NF-IL6 NF-IL6 NNP 761 762 , , , 763 767 AP-1 AP-1 NNP 767 768 , , , 769 770 a a DT 771 781 NF-kappa-B nf-kappa-b NN 782 786 like like IN 787 796 consensus consensus NN 797 805 sequence sequence NN 806 809 and and CC 810 827 gamma-interferon- gamma-interferon- NN 828 830 as as RB 831 835 well well RB 836 838 as as IN 839 853 glucocorticoid glucocorticoid NN 854 862 response response NN 863 871 elements element NNS 871 872 . . .