0 11 Suppression suppression NN 12 14 of of IN 15 18 MHC MHC NNP 19 24 class class NN 25 27 II ii CD 28 38 expression expression NN 39 41 by by IN 42 47 human human JJ 48 53 class class NN 54 56 II ii CD 57 72 trans-activator trans-activator NN 73 83 constructs construct NNS 84 91 lacking lack VBG 92 95 the the DT 96 106 N-terminal n-terminal JJ 107 113 domain domain NN 113 114 . . . 116 119 The the DT 120 125 class class NN 126 128 II ii CD 129 144 trans-activator trans-activator NN 145 146 ( ( ( 146 151 CIITA CIITA NNP 151 152 ) ) ) 153 155 is be VBZ 156 157 a a DT 158 161 bi- bi- JJ 162 164 or or CC 165 181 multi-functional multi-functional JJ 182 188 domain domain NN 189 196 protein protein NN 197 202 which which WDT 203 208 plays play VBZ 209 210 a a DT 211 219 critical critical JJ 220 224 role role NN 225 227 in in IN 228 231 the the DT 232 242 expression expression NN 243 245 of of IN 246 249 MHC MHC NNP 250 255 class class NN 256 258 II ii CD 259 264 genes gene NNS 264 265 . . . 266 268 We we PRP 269 275 report report VBP 276 280 that that IN 281 288 removal removal NN 289 291 of of IN 292 295 the the DT 296 306 N-terminal n-terminal JJ 307 310 151 151 CD 311 316 amino amino NN 317 322 acids acid NNS 322 323 , , , 324 336 encompassing encompass VBG 337 340 all all DT 341 343 of of IN 344 347 the the DT 348 354 acidic acidic JJ 355 361 domain domain NN 362 365 but but CC 366 373 leaving leave VBG 374 380 intact intact JJ 381 384 the the DT 385 414 proline/serine/threonine-rich proline/serine/threonine-rich JJ 415 421 domain domain NN 421 422 , , , 423 430 results result VBZ 431 433 in in IN 434 435 a a DT 436 442 mutant mutant JJ 443 450 protein protein NN 451 455 with with IN 456 462 potent potent JJ 463 474 suppressive suppressive JJ 475 485 properties property NNS 486 489 for for IN 490 493 MHC MHC NNP 494 499 class class NN 500 502 II ii CD 503 513 expression expression NN 513 514 . . . 515 519 HeLa HeLa NNP 520 525 cells cell NNS 526 532 stably stably RB 533 535 or or CC 536 547 transiently transiently RB 548 559 transfected transfecte VBN 560 564 with with IN 565 571 mutant mutant JJ 572 577 CIITA CIITA NNP 578 588 constructs construct NNS 589 595 showed show VBD 596 598 up up RB 599 601 to to TO 602 604 99 99 CD 604 605 % % NN 606 617 suppression suppression NN 618 620 of of IN 621 624 MHC MHC NNP 625 630 class class NN 631 633 II ii CD 634 641 antigen antigen NN 642 651 induction induction NN 652 654 by by IN 655 664 IFN-gamma IFN-gamma NNP 665 668 and and CC 669 675 marked marked JJ 676 687 suppression suppression NN 688 690 of of IN 691 698 HLA-DRA HLA-DRA NNP 699 703 mRNA mRNA NNP 704 714 expression expression NN 714 715 . . . 716 725 Transient transient JJ 726 738 transfection transfection NN 739 741 of of IN 742 743 a a DT 744 745 B B NNP 746 754 lymphoma lymphoma NN 755 759 line line NN 760 768 resulted result VBD 769 771 in in IN 772 774 up up RB 775 777 to to TO 778 780 89 89 CD 780 781 % % NN 782 791 reduction reduction NN 792 794 of of IN 795 807 constitutive constitutive JJ 808 811 MHC MHC NNP 812 817 class class NN 818 820 II ii CD 821 831 expression expression NN 832 838 within within IN 839 840 5 5 CD 841 845 days day NNS 846 849 and and CC 850 861 suppression suppression NN 862 864 of of IN 865 872 HLA-DRA HLA-DRA NNP 873 877 mRNA mRNA NNP 878 887 synthesis synthesis NN 887 888 . . .