0 14 CD30-dependent cd30-dependent JJ 15 26 degradation degradation NN 27 29 of of IN 30 35 TRAF2 traf2 NN 35 36 : : : 37 49 implications implication NNS 50 53 for for IN 54 62 negative negative JJ 63 73 regulation regulation NN 74 76 of of IN 77 81 TRAF TRAF NNP 82 91 signaling signaling NN 92 95 and and CC 96 99 the the DT 100 107 control control NN 108 110 of of IN 111 115 cell cell NN 116 124 survival survival NN 124 125 . . . 127 131 CD30 CD30 NNP 132 134 is be VBZ 135 136 a a DT 137 149 cell-surface cell-surface JJ 150 158 receptor receptor NN 159 163 that that WDT 164 167 can can MD 168 175 augment augment VB 176 186 lymphocyte lymphocyte NN 187 197 activation activation NN 198 201 and and CC 202 210 survival survival NN 211 218 through through IN 219 222 its its PRP$ 223 230 ability ability NN 231 233 to to TO 234 240 induce induce VB 241 244 the the DT 245 258 transcription transcription NN 259 265 factor factor NN 266 275 NF-kappaB nf-kappab NN 275 276 . . . 277 281 CD30 CD30 NNP 281 282 , , , 283 290 however however RB 290 291 , , , 292 295 has have VBZ 296 300 also also RB 301 305 been be VBN 306 316 implicated implicate VBN 317 319 in in IN 320 323 the the DT 324 333 induction induction NN 334 336 of of IN 337 346 apoptotic apoptotic JJ 347 351 cell cell NN 352 357 death death NN 358 360 of of IN 361 372 lymphocytes lymphocyte NNS 372 373 . . . 374 378 Here here RB 379 381 we we PRP 382 386 show show VBP 387 391 that that IN 392 395 one one CD 396 398 of of IN 399 402 the the DT 403 410 effects effect NNS 411 413 of of IN 414 418 CD30 CD30 NNP 419 425 signal signal NN 426 438 transduction transduction NN 439 441 is be VBZ 442 444 to to TO 445 451 render render VB 452 457 cells cell NNS 458 467 sensitive sensitive JJ 468 470 to to TO 471 480 apoptosis apoptosis NN 481 488 induced induce VBN 489 491 by by IN 492 495 the the DT 496 500 type type NN 501 502 1 1 CD 503 508 tumor tumor NN 509 517 necrosis necrosis NN 518 524 factor factor NN 525 533 receptor receptor NN 534 535 ( ( ( 535 540 TNFR1 TNFR1 NNP 540 541 ) ) ) 541 542 . . . 543 547 This this DT 548 561 sensitization sensitization NN 562 564 is be VBZ 565 574 dependent dependent JJ 575 577 on on IN 578 581 the the DT 582 594 TRAF-binding traf-binding JJ 595 600 sites site NNS 601 607 within within IN 608 611 the the DT 612 616 CD30 cd30 NN 617 628 cytoplasmic cytoplasmic JJ 629 635 domain domain NN 635 636 . . . 637 640 One one CD 641 643 of of IN 644 647 the the DT 648 656 proteins protein NNS 657 661 that that WDT 662 667 binds bind VBZ 668 670 to to TO 671 676 these these DT 677 682 sites site NNS 683 685 is be VBZ 686 691 TRAF2 traf2 NN 691 692 , , , 693 694 a a DT 695 701 signal signal NN 702 714 transduction transduction NN 715 723 molecule molecule NN 724 728 that that WDT 729 731 is be VBZ 732 736 also also RB 737 745 utilized utilize VBN 746 748 by by IN 749 754 TNFR1 tnfr1 NN 755 757 to to TO 758 765 mediate mediate VB 766 769 the the DT 770 780 activation activation NN 781 783 of of IN 784 791 several several JJ 792 802 downstream downstream JJ 803 810 kinases kinase NNS 811 814 and and CC 815 828 transcription transcription NN 829 836 factors factor NNS 836 837 . . . 838 844 During during IN 845 849 CD30 CD30 NNP 850 856 signal signal NN 857 869 transduction transduction NN 869 870 , , , 871 873 we we PRP 874 879 found find VBD 880 884 that that IN 885 892 binding binding NN 893 895 of of IN 896 901 TRAF2 traf2 NN 902 904 to to TO 905 908 the the DT 909 920 cytoplasmic cytoplasmic JJ 921 927 domain domain NN 928 930 of of IN 931 935 CD30 cd30 NN 936 943 results result VBZ 944 946 in in IN 947 950 the the DT 951 956 rapid rapid JJ 957 966 depletion depletion NN 967 969 of of IN 970 975 TRAF2 traf2 NN 976 979 and and CC 980 983 the the DT 984 994 associated associate VBN 995 1002 protein protein NN 1003 1008 TRAF1 traf1 NN 1009 1011 by by IN 1012 1023 proteolysis proteolysis NN 1023 1024 . . . 1025 1030 These these DT 1031 1035 data datum NNS 1036 1043 suggest suggest VBP 1044 1045 a a DT 1046 1051 model model NN 1052 1054 in in IN 1055 1060 which which WDT 1061 1065 CD30 CD30 NNP 1066 1072 limits limit VBZ 1073 1076 its its PRP$ 1077 1080 own own JJ 1081 1088 ability ability NN 1089 1091 to to TO 1092 1101 transduce transduce VB 1102 1106 cell cell NN 1107 1115 survival survival NN 1116 1123 signals signal NNS 1124 1131 through through IN 1132 1146 signal-coupled signal-coupled JJ 1147 1156 depletion depletion NN 1157 1159 of of IN 1160 1165 TRAF2 traf2 NN 1165 1166 . . . 1167 1176 Depletion depletion NN 1177 1179 of of IN 1180 1193 intracellular intracellular JJ 1194 1199 TRAF2 traf2 NN 1200 1203 and and CC 1204 1207 its its PRP$ 1208 1220 coassociated coassociate VBN 1221 1229 proteins protein NNS 1230 1234 also also RB 1235 1244 increased increase VBD 1245 1248 the the DT 1249 1260 sensitivity sensitivity NN 1261 1263 of of IN 1264 1267 the the DT 1268 1272 cell cell NN 1273 1275 to to TO 1276 1286 undergoing undergo VBG 1287 1296 apoptosis apoptosis NN 1297 1303 during during IN 1304 1314 activation activation NN 1315 1317 of of IN 1318 1332 death-inducing death-inducing JJ 1333 1342 receptors receptor NNS 1343 1347 such such JJ 1348 1350 as as IN 1351 1356 TNFR1 TNFR1 NNP 1356 1357 . . . 1358 1368 Consistent consistent JJ 1369 1373 with with IN 1374 1378 this this DT 1379 1389 hypothesis hypothesis NN 1389 1390 , , , 1391 1401 expression expression NN 1402 1404 of of IN 1405 1406 a a DT 1407 1424 dominant-negative dominant-negative JJ 1425 1429 form form NN 1430 1432 of of IN 1433 1438 TRAF2 traf2 NN 1439 1442 was be VBD 1443 1448 found find VBN 1449 1451 to to TO 1452 1462 potentiate potentiate VB 1463 1477 TNFR1-mediated tnfr1-mediated JJ 1478 1483 death death NN 1483 1484 . . . 1485 1490 These these DT 1491 1498 studies study NNS 1499 1506 provide provide VBP 1507 1508 a a DT 1509 1518 potential potential JJ 1519 1528 mechanism mechanism NN 1529 1536 through through IN 1537 1542 which which WDT 1543 1547 CD30 cd30 NN 1547 1548 , , , 1549 1551 as as RB 1552 1556 well well RB 1557 1559 as as IN 1560 1565 other other JJ 1566 1578 TRAF-binding traf-binding JJ 1579 1586 members member NNS 1587 1589 of of IN 1590 1593 the the DT 1594 1598 TNFR TNFR NNP 1599 1610 superfamily superfamily NN 1610 1611 , , , 1612 1615 can can MD 1616 1626 negatively negatively RB 1627 1635 regulate regulate VB 1636 1640 cell cell NN 1641 1649 survival survival NN 1649 1650 . . .