0 13 Transcription Transcription NNP 14 20 factor factor NN 21 30 NF-kappaB NF-kappaB NNP 31 40 regulates regulate VBZ 41 50 inducible inducible JJ 51 56 Oct-2 oct-2 NN 57 61 gene gene NN 62 72 expression expression NN 73 75 in in IN 76 85 precursor precursor NN 86 87 B B NNP 88 99 lymphocytes lymphocyte NNS 99 100 . . . 102 105 The the DT 106 109 POU POU NNP 110 123 transcription transcription NN 124 131 factors factor NNS 132 137 Oct-1 oct-1 NN 138 141 and and CC 142 147 Oct-2 oct-2 NN 148 156 regulate regulate VBP 157 160 the the DT 161 169 activity activity NN 170 172 of of IN 173 190 octamer-dependent octamer-dependent JJ 191 200 promoters promoter NNS 200 201 , , , 202 211 including include VBG 212 217 those those DT 218 222 that that WDT 223 229 direct direct VBP 230 243 transcription transcription NN 244 248 from from IN 249 259 rearranged rearrange VBN 260 274 immunoglobulin immunoglobulin NN 275 280 genes gene NNS 280 281 . . . 282 288 Unlike unlike IN 289 294 Oct-1 Oct-1 NNP 294 295 , , , 296 301 which which WDT 302 304 is be VBZ 305 319 constitutively constitutively RB 320 329 expressed express VBN 330 332 in in IN 333 337 many many JJ 338 342 cell cell NN 343 348 types type NNS 348 349 , , , 350 355 Oct-2 oct-2 NN 356 366 expression expression NN 367 369 is be VBZ 370 380 restricted restrict VBN 381 390 primarily primarily RB 391 393 to to TO 394 395 B B NNP 396 407 lymphocytes lymphocyte NNS 408 411 and and CC 412 415 can can MD 416 418 be be VB 419 426 induced induce VBN 427 429 in in IN 430 439 precursor precursor NN 440 441 B b NN 442 447 cells cell NNS 448 450 by by IN 451 462 stimulation stimulation NN 463 467 with with IN 468 477 bacterial bacterial JJ 478 496 lipopolysaccharide lipopolysaccharide NN 497 498 ( ( ( 498 501 LPS LPS NNP 501 502 ) ) ) 502 503 . . . 504 511 However however RB 511 512 , , , 513 516 the the DT 517 524 precise precise JJ 525 532 factors factor NNS 533 537 that that WDT 538 545 mediate mediate VBP 546 550 this this DT 551 560 induction induction NN 561 570 mechanism mechanism NN 571 577 remain remain VBP 578 585 unknown unknown JJ 585 586 . . . 587 589 In in IN 590 593 the the DT 594 601 present present JJ 602 607 study study NN 607 608 , , , 609 611 we we PRP 612 621 monitored monitor VBD 622 627 Oct-2 oct-2 NN 628 638 expression expression NN 639 641 in in IN 642 647 cells cell NNS 648 656 arrested arrest VBN 657 660 for for IN 661 664 the the DT 665 675 activation activation NN 676 678 of of IN 679 688 NF-kappaB NF-kappaB NNP 688 689 , , , 690 692 an an DT 693 707 LPS-responsive lps-responsive JJ 708 714 member member NN 715 717 of of IN 718 721 the the DT 722 725 Rel Rel NNP 726 739 transcription transcription NN 740 746 factor factor NN 747 753 family family NN 753 754 . . . 755 762 Despite despite IN 763 774 stimulation stimulation NN 775 779 with with IN 780 783 LPS LPS NNP 783 784 , , , 785 795 disruption disruption NN 796 798 of of IN 799 802 the the DT 803 812 NF-kappaB nf-kappab NN 813 822 signaling signaling NN 823 830 pathway pathway NN 831 833 in in IN 834 843 precursor precursor NN 844 845 B b NN 846 851 cells cell NNS 852 855 led lead VBD 856 858 to to TO 859 862 the the DT 863 867 loss loss NN 868 870 of of IN 871 880 inducible inducible JJ 881 886 Oct-2 oct-2 NN 887 890 DNA dna NN 891 898 binding binding NN 899 907 activity activity NN 908 910 in in FW 911 916 vitro vitro FW 917 920 and and CC 921 924 the the DT 925 936 suppression suppression NN 937 939 of of IN 940 954 Oct-2-directed oct-2-directed JJ 955 968 transcription transcription NN 969 971 in in FW 972 976 vivo vivo FW 976 977 . . . 978 982 This this DT 983 994 biochemical biochemical JJ 995 1001 defect defect NN 1002 1012 correlated correlate VBD 1013 1017 with with IN 1018 1019 a a DT 1020 1028 specific specific JJ 1029 1034 block block NN 1035 1037 to to TO 1038 1043 Oct-2 oct-2 NN 1044 1048 gene gene NN 1049 1059 expression expression NN 1060 1062 at at IN 1063 1066 the the DT 1067 1072 level level NN 1073 1075 of of IN 1076 1089 transcription transcription NN 1089 1090 , , , 1091 1098 whereas whereas IN 1099 1102 the the DT 1103 1113 expression expression NN 1114 1116 of of IN 1117 1122 Oct-1 Oct-1 NNP 1123 1126 was be VBD 1127 1137 unaffected unaffected JJ 1137 1138 . . . 1139 1142 The the DT 1143 1150 finding finding NN 1151 1155 that that IN 1156 1161 Oct-2 oct-2 NN 1162 1164 is be VBZ 1165 1170 under under IN 1171 1180 NF-kappaB NF-kappaB NNP 1181 1188 control control NN 1189 1199 highlights highlight VBZ 1200 1202 an an DT 1203 1212 important important JJ 1213 1223 cross-talk cross-talk NN 1224 1233 mechanism mechanism NN 1234 1243 involving involve VBG 1244 1247 two two CD 1248 1256 distinct distinct JJ 1257 1270 transcription transcription NN 1271 1277 factor factor NN 1278 1286 families family NNS 1287 1291 that that WDT 1292 1300 regulate regulate VBP 1301 1302 B B NNP 1303 1313 lymphocyte lymphocyte NN 1314 1322 function function NN 1322 1323 . . .