0 8 Cytokine Cytokine NNP 9 15 rescue rescue NN 16 20 from from IN 21 35 glucocorticoid glucocorticoid NN 36 43 induced induce VBD 44 53 apoptosis apoptosis NN 54 56 in in IN 57 58 T t NN 59 64 cells cell NNS 65 67 is be VBZ 68 76 mediated mediate VBN 77 84 through through IN 85 95 inhibition inhibition NN 96 98 of of IN 99 111 IkappaBalpha IkappaBalpha NNP 111 112 . . . 114 116 We we PRP 117 127 previously previously RB 128 136 reported report VBD 137 141 that that IN 142 155 dexamethasone dexamethasone NN 156 157 ( ( ( 157 160 DEX DEX NNP 160 161 ) ) ) 161 162 , , , 163 164 a a DT 165 174 synthetic synthetic JJ 175 189 glucocorticoid glucocorticoid NN 189 190 , , , 191 197 causes cause VBZ 198 207 apoptosis apoptosis NN 208 210 in in IN 211 217 mature mature JJ 218 220 Th Th NNP 221 225 cell cell NN 226 231 lines line NNS 231 232 , , , 233 236 and and CC 237 241 that that IN 242 246 this this DT 247 256 induction induction NN 257 259 of of IN 260 264 cell cell NN 265 270 death death NN 271 273 is be VBZ 274 283 prevented prevent VBN 284 286 by by IN 287 295 specific specific JJ 296 305 cytokines cytokine NNS 305 306 , , , 307 313 namely namely RB 313 314 , , , 315 317 by by IN 318 322 IL-2 il-2 NN 323 325 in in IN 326 329 Th1 th1 NN 330 335 cells cell NNS 336 339 and and CC 340 342 by by IN 343 347 IL-4 il-4 NN 348 350 in in IN 351 354 Th2 th2 NN 355 360 cells cell NNS 360 361 . . . 362 364 We we PRP 365 368 now now RB 369 373 show show VBP 374 378 that that IN 379 383 this this DT 384 396 differential differential JJ 397 403 rescue rescue NN 404 406 by by IN 407 415 specific specific JJ 416 425 cytokines cytokine NNS 426 428 in in IN 429 431 Th th NN 432 437 cells cell NNS 438 448 correlates correlate VBZ 449 453 with with IN 454 457 the the DT 458 463 level level NN 464 466 of of IN 467 479 IkappaBalpha IkappaBalpha NNP 480 484 that that WDT 485 487 is be VBZ 488 497 regulated regulate VBN 498 500 by by IN 501 504 DEX dex NN 505 508 and and CC 509 518 cytokines cytokine NNS 518 519 . . . 520 522 In in IN 523 527 both both DT 528 532 cell cell NN 533 538 types type NNS 539 542 the the DT 543 551 cellular cellular JJ 552 558 levels level NNS 559 561 of of IN 562 574 IkappaBalpha IkappaBalpha NNP 575 579 mRNA mRNA NNP 580 583 and and CC 584 591 protein protein NN 592 596 were be VBD 597 606 evaluated evaluate VBN 607 609 by by IN 610 613 DEX dex NN 614 623 treatment treatment NN 623 624 . . . 625 638 Interestingly interestingly RB 638 639 , , , 640 643 the the DT 644 656 DEX-mediated dex-mediated JJ 657 669 IkappaBalpha IkappaBalpha NNP 670 679 induction induction NN 680 683 was be VBD 684 694 completely completely RB 695 704 inhibited inhibit VBN 705 707 by by IN 708 712 IL-2 il-2 NN 712 713 , , , 714 717 but but CC 718 721 not not RB 722 726 IL-4 il-4 NN 726 727 , , , 728 730 in in IN 731 734 Th1 th1 NN 735 740 cells cell NNS 740 741 , , , 742 747 while while IN 748 751 the the DT 752 759 reverse reverse NN 760 767 profile profile NN 768 771 was be VBD 772 776 seen see VBN 777 779 in in IN 780 783 Th2 th2 NN 784 789 cells cell NNS 789 790 . . . 791 793 In in IN 794 798 both both DT 799 803 cell cell NN 804 809 types type NNS 809 810 , , , 811 814 the the DT 815 823 cytokine cytokine NN 824 828 that that WDT 829 837 inhibits inhibit VBZ 838 841 the the DT 842 851 induction induction NN 852 854 of of IN 855 867 IkappaBalpha IkappaBalpha NNP 868 870 by by IN 871 874 DEX DEX NNP 874 875 , , , 876 880 also also RB 881 888 rescues rescue VBZ 889 894 these these DT 895 900 cells cell NNS 901 905 from from IN 906 917 DEX-induced dex-induced JJ 918 927 apoptosis apoptosis NN 927 928 , , , 929 937 although although IN 938 941 the the DT 942 948 rescue rescue NN 949 957 cytokine cytokine NN 958 960 is be VBZ 961 970 different different JJ 971 973 in in IN 974 977 Th1 th1 NN 978 981 and and CC 982 985 Th2 th2 NN 986 991 cells cell NNS 991 992 . . . 993 996 Our our PRP$ 997 1004 results result NNS 1005 1010 imply imply VBP 1011 1015 that that IN 1016 1017 T t NN 1018 1023 cells cell NNS 1024 1028 need need VBP 1029 1031 to to TO 1032 1040 maintain maintain VB 1041 1042 a a DT 1043 1050 certain certain JJ 1051 1056 level level NN 1057 1059 of of IN 1060 1069 NF-kappaB NF-kappaB NNP 1070 1085 transcriptional transcriptional JJ 1086 1094 activity activity NN 1095 1097 in in IN 1098 1103 order order NN 1104 1106 to to TO 1107 1114 survive survive VB 1114 1115 ; ; : 1116 1119 up- up- NN 1120 1122 or or CC 1123 1138 down-regulation down-regulation NN 1139 1141 of of IN 1142 1149 nuclear nuclear JJ 1150 1152 NF NF NNP 1153 1159 kappaB kappab NN 1160 1167 through through IN 1168 1178 modulation modulation NN 1179 1181 of of IN 1182 1194 IkappaBalpha IkappaBalpha NNP 1195 1205 expression expression NN 1206 1208 by by IN 1209 1218 cytokines cytokine NNS 1219 1221 or or CC 1222 1225 DEX dex NN 1226 1229 may may MD 1230 1234 lead lead VB 1235 1237 to to TO 1238 1242 cell cell NN 1243 1251 survival survival NN 1252 1254 or or CC 1255 1259 cell cell NN 1260 1265 death death NN 1265 1266 , , , 1267 1279 respectively respectively RB 1279 1280 . . .