0 10 Functional functional JJ 11 22 association association NN 23 25 of of IN 26 29 Nmi Nmi NNP 30 34 with with IN 35 40 Stat5 Stat5 NNP 41 44 and and CC 45 50 Stat1 Stat1 NNP 51 53 in in IN 54 59 IL-2- IL-2- NNP 60 63 and and CC 64 81 IFNgamma-mediated ifngamma-mediated JJ 82 91 signaling signaling NN 91 92 . . . 94 99 Using use VBG 100 103 the the DT 104 115 coiled-coil coiled-coil JJ 116 122 region region NN 123 125 of of IN 126 132 Stat5b Stat5b NNP 133 135 as as IN 136 139 the the DT 140 144 bait bait NN 145 147 in in IN 148 149 a a DT 150 155 yeast yeast NN 156 166 two-hybrid two-hybrid JJ 167 173 screen screen NN 173 174 , , , 175 177 we we PRP 178 188 identified identify VBD 189 192 the the DT 193 204 association association NN 205 207 of of IN 208 211 Nmi Nmi NNP 211 212 , , , 213 214 a a DT 215 222 protein protein NN 223 225 of of IN 226 233 unknown unknown JJ 234 242 function function NN 243 253 previously previously RB 254 262 reported report VBN 263 265 as as IN 266 268 an an DT 269 274 N-Myc N-Myc NNP 275 285 interactor interactor NN 285 286 . . . 287 289 We we PRP 290 297 further further RB 298 302 show show VBP 303 307 that that IN 308 311 Nmi Nmi NNP 312 321 interacts interact VBZ 322 326 with with IN 327 330 all all DT 331 336 STATs stat NNS 337 343 except except IN 344 349 Stat2 stat2 NN 349 350 . . . 351 353 We we PRP 354 363 evaluated evaluate VBD 364 367 two two CD 368 376 cytokine cytokine NN 377 384 systems system NNS 384 385 , , , 386 390 IL-2 IL-2 NNP 391 394 and and CC 395 403 IFNgamma IFNgamma NNP 403 404 , , , 405 408 and and CC 409 420 demonstrate demonstrate VBP 421 425 that that IN 426 429 Nmi Nmi NNP 430 438 augments augment VBZ 439 452 STAT-mediated stat-mediated JJ 453 466 transcription transcription NN 467 469 in in IN 470 478 response response NN 479 481 to to TO 482 487 these these DT 488 497 cytokines cytokine NNS 497 498 . . . 499 512 Interestingly interestingly RB 512 513 , , , 514 517 Nmi Nmi NNP 518 523 lacks lack VBZ 524 526 an an DT 527 536 intrinsic intrinsic JJ 537 552 transcriptional transcriptional JJ 553 563 activation activation NN 564 570 domain domain NN 570 571 ; ; : 572 579 instead instead RB 579 580 , , , 581 584 Nmi Nmi NNP 585 593 enhances enhance VBZ 594 597 the the DT 598 609 association association NN 610 612 of of IN 613 621 CBP/p300 cbp/p300 NN 622 633 coactivator coactivator NN 634 642 proteins protein NNS 643 647 with with IN 648 653 Stat1 Stat1 NNP 654 657 and and CC 658 663 Stat5 Stat5 NNP 663 664 , , , 665 668 and and CC 669 677 together together RB 678 682 with with IN 683 691 CBP/p300 CBP/p300 NNP 692 695 can can MD 696 703 augment augment VB 704 709 IL-2- il-2- NN 710 713 and and CC 714 732 IFNgamma-dependent ifngamma-dependent JJ 733 746 transcription transcription NN 746 747 . . . 748 757 Therefore therefore RB 757 758 , , , 759 762 our our PRP$ 763 767 data datum NNS 768 771 not not RB 772 776 only only RB 777 783 reveal reveal VBP 784 788 that that IN 789 792 Nmi Nmi NNP 793 796 can can MD 797 807 potentiate potentiate VB 808 822 STAT-dependent stat-dependent JJ 823 836 transcription transcription NN 836 837 , , , 838 841 but but CC 842 846 also also RB 847 854 suggest suggest VBP 855 859 that that IN 860 862 it it PRP 863 866 can can MD 867 874 augment augment VB 875 886 coactivator coactivator NN 887 894 protein protein NN 895 906 recruitment recruitment NN 907 909 to to TO 910 912 at at IN 913 918 least least JJS 919 923 some some DT 924 931 members member NNS 932 934 of of IN 935 936 a a DT 937 942 group group NN 943 945 of of IN 946 963 sequence-specific sequence-specific JJ 964 977 transcription transcription NN 978 985 factors factor NNS 985 986 . . .