0 7 Binding binding NN 8 10 of of IN 11 16 c-Rel c-rel NN 17 19 to to TO 20 25 STAT5 STAT5 NNP 26 32 target target NN 33 42 sequences sequence NNS 43 45 in in IN 46 64 HTLV-I-transformed htlv-i-transformed JJ 65 66 T t NN 67 72 cells cell NNS 72 73 . . . 75 78 The the DT 79 83 type type NN 84 85 I i CD 86 91 human human JJ 92 98 T-cell t-cell NN 99 107 leukemia leukemia NN 108 113 virus virus NN 114 115 ( ( ( 115 121 HTLV-I HTLV-I NNP 121 122 ) ) ) 123 130 induces induce VBZ 131 139 abnormal abnormal JJ 140 146 growth growth NN 147 150 and and CC 151 161 subsequent subsequent JJ 162 176 transformation transformation NN 177 179 of of IN 180 181 T t NN 182 187 cells cell NNS 187 188 , , , 189 194 which which WDT 195 197 is be VBZ 198 208 associated associate VBN 209 213 with with IN 214 217 the the DT 218 229 development development NN 230 232 of of IN 233 235 an an DT 236 241 acute acute JJ 242 248 T-cell t-cell NN 249 259 malignancy malignancy NN 260 266 termed term VBN 267 272 adult adult JJ 273 279 T-cell t-cell NN 280 288 leukemia leukemia NN 288 289 . . . 290 291 A a DT 292 306 characteristic characteristic NN 307 309 of of IN 310 328 HTLV-I-transformed htlv-i-transformed JJ 329 330 T t NN 331 336 cells cell NNS 337 339 is be VBZ 340 343 the the DT 344 356 constitutive constitutive JJ 357 364 nuclear nuclear JJ 365 375 expression expression NN 376 378 of of IN 379 392 NF-kappaB/Rel NF-kappaB/Rel NNP 393 399 family family NN 400 402 of of IN 403 416 transcription transcription NN 417 424 factors factor NNS 424 425 , , , 426 431 which which WDT 432 439 appears appear VBZ 440 442 to to TO 443 445 be be VB 446 455 essential essential JJ 456 459 for for IN 460 463 the the DT 464 470 growth growth NN 471 473 of of IN 474 479 these these DT 480 491 transformed transform VBN 492 497 cells cell NNS 497 498 . . . 499 507 Although although IN 508 521 NF-kappaB/Rel NF-kappaB/Rel NNP 522 529 factors factor NNS 530 533 are be VBP 534 539 known know VBN 540 542 to to TO 543 549 induce induce VB 550 553 the the DT 554 564 expression expression NN 565 567 of of IN 568 574 T-cell t-cell NN 575 581 growth growth NN 582 588 factor factor NN 589 600 interleukin interleukin NN 601 602 ( ( ( 602 607 IL)-2 IL)-2 NNP 607 608 , , , 609 611 it it PRP 612 614 is be VBZ 615 622 unclear unclear JJ 623 626 how how WRB 627 631 they they PRP 632 643 participate participate VBP 644 646 in in IN 647 650 the the DT 651 667 IL-2-independent il-2-independent JJ 668 674 growth growth NN 675 677 of of IN 678 696 HTLV-I-transformed htlv-i-transformed JJ 697 702 cells cell NNS 702 703 . . . 704 706 In in IN 707 711 this this DT 712 717 study study NN 717 718 , , , 719 721 we we PRP 722 726 show show VBP 727 731 that that IN 732 739 certain certain JJ 740 753 NF-kappaB/Rel NF-kappaB/Rel NNP 754 761 members member NNS 761 762 , , , 763 776 predominantly predominantly RB 777 782 c-Rel c-rel NN 782 783 , , , 784 792 interact interact VBP 793 797 with with IN 798 806 enhancer enhancer NN 807 816 sequences sequence NNS 817 820 for for IN 821 826 STAT5 STAT5 NNP 826 827 , , , 828 829 a a DT 830 833 key key JJ 834 847 transcription transcription NN 848 854 factor factor NN 855 864 mediating mediate VBG 865 877 IL-2-induced il-2-induced JJ 878 884 T-cell t-cell NN 885 898 proliferation proliferation NN 898 899 . . . 900 908 Reporter reporter NN 909 913 gene gene NN 914 920 assays assay NNS 921 927 reveal reveal VBP 928 932 that that IN 933 936 the the DT 937 944 binding binding NN 945 947 of of IN 948 953 c-Rel c-rel NN 954 956 to to TO 957 960 the the DT 961 966 STAT5 STAT5 NNP 967 971 site site NN 972 979 present present JJ 980 982 in in IN 983 986 the the DT 987 989 Fc Fc NNP 990 997 gammaR1 gammar1 NN 998 1002 gene gene NN 1003 1008 leads lead VBZ 1009 1011 to to TO 1012 1018 potent potent JJ 1019 1034 transactivation transactivation NN 1035 1037 of of IN 1038 1042 this this DT 1043 1051 enhancer enhancer NN 1051 1052 . . . 1053 1060 Binding binding NN 1061 1063 of of IN 1064 1069 c-Rel c-rel NN 1070 1072 to to TO 1073 1076 the the DT 1077 1079 Fc Fc NNP 1080 1087 gammaR1 gammar1 NN 1088 1092 STAT stat NN 1093 1097 site site NN 1098 1102 also also RB 1103 1109 occurs occur VBZ 1110 1112 in in IN 1113 1118 human human JJ 1119 1129 peripheral peripheral JJ 1130 1135 blood blood NN 1136 1137 T t NN 1138 1143 cells cell NNS 1144 1156 immortalized immortalize VBN 1157 1161 with with IN 1162 1168 HTLV-I HTLV-I NNP 1169 1171 in in FW 1172 1177 vitro vitro FW 1178 1181 and and CC 1182 1184 is be VBZ 1185 1195 correlated correlate VBN 1196 1200 with with IN 1201 1209 enhanced enhance VBN 1210 1216 levels level NNS 1217 1219 of of IN 1220 1233 proliferation proliferation NN 1234 1236 of of IN 1237 1242 these these DT 1243 1248 cells cell NNS 1248 1249 . . . 1250 1255 These these DT 1256 1263 results result NNS 1264 1269 raise raise VBP 1270 1273 the the DT 1274 1285 possibility possibility NN 1286 1290 that that IN 1291 1304 NF-kappaB/Rel NF-kappaB/Rel NNP 1305 1308 may may MD 1309 1320 participate participate VB 1321 1323 in in IN 1324 1327 the the DT 1328 1334 growth growth NN 1335 1342 control control NN 1343 1345 of of IN 1346 1364 HTLV-I-transformed htlv-i-transformed JJ 1365 1366 T t NN 1367 1372 cells cell NNS 1373 1375 by by IN 1376 1386 regulating regulate VBG 1387 1392 genes gene NNS 1393 1399 driven drive VBN 1400 1402 by by IN 1403 1407 both both CC 1408 1414 kappaB kappab NN 1415 1418 and and CC 1419 1426 certain certain JJ 1427 1431 STAT stat NN 1432 1441 enhancers enhancer NNS 1441 1442 . . .