0 14 Glucocorticoid glucocorticoid NN 15 22 hormone hormone NN 23 34 suppression suppression NN 35 37 of of IN 38 43 human human JJ 44 63 neutrophil-mediated neutrophil-mediated JJ 64 69 tumor tumor NN 70 74 cell cell NN 75 85 cytostasis cytostasis NN 85 86 . . . 88 90 In in IN 91 94 the the DT 95 102 present present JJ 103 108 study study NN 108 109 , , , 110 112 we we PRP 113 117 have have VBP 118 130 investigated investigate VBN 131 134 the the DT 135 141 effect effect NN 142 144 of of IN 145 159 glucocorticoid glucocorticoid NN 160 168 hormones hormone NNS 169 171 on on IN 172 191 neutrophil-mediated neutrophil-mediated JJ 192 197 tumor tumor NN 198 202 cell cell NN 203 213 cytostasis cytostasis NN 214 217 and and CC 218 223 found find VBD 224 228 that that IN 229 243 hydrocortisone hydrocortisone NN 244 247 and and CC 248 249 a a DT 250 259 synthetic synthetic JJ 260 267 hormone hormone NN 267 268 , , , 269 282 dexamethasone dexamethasone NN 283 284 ( ( ( 284 287 Dex Dex NNP 287 288 ) ) ) 288 289 , , , 290 299 inhibited inhibit VBD 300 310 cytostasis cytostasis NN 311 313 in in IN 314 317 the the DT 318 326 presence presence NN 327 329 or or CC 330 337 absence absence NN 338 340 of of IN 341 346 tumor tumor NN 347 355 necrosis necrosis NN 356 368 factor-alpha factor-alpha NN 368 369 . . . 370 373 The the DT 374 380 effect effect NN 381 383 of of IN 384 387 Dex Dex NNP 388 391 was be VBD 392 402 completely completely RB 403 411 reversed reverse VBN 412 414 by by IN 415 416 a a DT 417 431 glucocorticoid glucocorticoid NN 432 440 receptor receptor NN 441 451 antagonist antagonist NN 451 452 , , , 453 460 RU38486 RU38486 NNP 460 461 . . . 462 464 To to TO 465 472 clarify clarify VB 473 476 the the DT 477 487 underlying underlying JJ 488 498 mechanisms mechanism NNS 498 499 , , , 500 502 we we PRP 503 511 examined examine VBD 512 519 effects effect NNS 520 522 of of IN 523 526 Dex Dex NNP 527 529 on on IN 530 533 the the DT 534 541 binding binding NN 542 549 avidity avidity NN 550 552 of of IN 553 558 beta2 beta2 NN 559 567 integrin integrin NN 568 570 on on IN 571 574 the the DT 575 585 neutrophil neutrophil NN 586 593 surface surface NN 594 597 and and CC 598 601 how how WRB 602 607 these these DT 608 613 might might NN 614 616 in in IN 617 621 turn turn NN 622 628 affect affect VBP 629 648 neutrophil-to-tumor neutrophil-to-tumor NN 649 653 cell cell NN 654 661 binding binding NN 661 662 . . . 663 666 Dex Dex NNP 667 670 was be VBD 671 676 found find VBN 677 679 to to TO 680 687 inhibit inhibit VB 688 693 these these DT 694 704 neutrophil neutrophil NN 705 715 properties property NNS 715 716 , , , 717 720 and and CC 721 728 RU38486 RU38486 NNP 729 739 completely completely RB 740 750 suppressed suppress VBD 751 755 both both DT 756 761 forms form NNS 762 764 of of IN 765 768 Dex Dex NNP 769 779 inhibition inhibition NN 779 780 . . . 781 786 Taken take VBN 787 795 together together RB 795 796 , , , 797 800 our our PRP$ 801 809 findings finding NNS 810 817 suggest suggest VBP 818 822 that that IN 823 837 glucocorticoid glucocorticoid NN 838 845 hormone hormone NN 846 856 inhibition inhibition NN 857 859 of of IN 860 879 neutrophil-mediated neutrophil-mediated JJ 880 885 tumor tumor NN 886 890 cell cell NN 891 901 cytostasis cytostasis NN 902 904 is be VBZ 905 907 at at IN 908 913 least least JJS 914 923 partially partially RB 924 927 due due JJ 928 930 to to TO 931 932 a a DT 933 941 lowering lowering NN 942 944 of of IN 945 948 the the DT 949 955 ligand ligand NN 956 963 binding binding NN 964 971 avidity avidity NN 972 974 of of IN 975 980 beta2 beta2 NN 981 989 integrin integrin NN 990 992 on on IN 993 996 the the DT 997 1007 neutrophil neutrophil NN 1008 1015 surface surface NN 1015 1016 . . .