0 8 Impaired impaired JJ 9 16 binding binding NN 17 19 of of IN 20 21 a a DT 22 25 DQ2 dq2 NN 26 29 and and CC 30 41 DQ8-binding dq8-binding JJ 42 45 HSV HSV NNP 46 50 VP16 VP16 NNP 51 58 peptide peptide NN 59 61 to to TO 62 63 a a DT 64 83 DQA1*0501/DQB1*0302 dqa1*0501/dqb1*0302 NN 84 89 trans trans JJ 90 95 class class NN 96 98 II ii CD 99 110 heterodimer heterodimer NN 110 111 . . . 113 120 DQalpha DQalpha NNP 121 124 and and CC 125 131 DQbeta DQbeta NNP 132 137 trans trans JJ 138 151 heterodimeric heterodimeric JJ 152 158 HLA-DQ HLA-DQ NNP 159 168 molecules molecule NNS 169 173 form form VBP 174 176 in in IN 177 188 individuals individual NNS 189 201 heterozygous heterozygous JJ 202 205 for for IN 206 209 the the DT 210 213 DQ2 dq2 NN 214 217 and and CC 218 221 DQ8 dq8 NN 222 235 specificities specificity NNS 235 236 . . . 237 243 Unique unique JJ 244 253 functions function NNS 254 257 and and CC 258 265 disease disease NN 266 278 associations association NNS 279 283 have have VBP 284 288 been be VBN 289 299 postulated postulate VBN 300 303 for for IN 304 308 such such JJ 309 321 trans-dimers trans-dimer NNS 321 322 , , , 323 328 which which WDT 329 332 may may MD 333 335 be be VB 336 345 different different JJ 346 350 from from IN 351 362 cis-encoded cis-encoded JJ 363 365 DQ DQ NNP 366 375 molecules molecule NNS 376 383 encoded encode VBN 384 386 by by IN 387 390 the the DT 391 404 corresponding correspond VBG 405 415 haplotypes haplotype NNS 415 416 . . . 417 419 We we PRP 420 428 analyzed analyze VBD 429 432 the the DT 433 440 ability ability NN 441 443 of of IN 444 447 the the DT 448 459 trans-dimer trans-dimer NN 460 467 encoded encode VBN 468 470 by by IN 471 494 HLA-DQA1*0501/DQB1*0302 hla-dqa1*0501/dqb1*0302 NN 495 497 to to TO 498 502 bind bind VB 503 504 a a DT 505 512 peptide peptide NN 513 520 antigen antigen NN 521 526 which which WDT 527 536 interacts interact VBZ 537 541 with with IN 542 544 DQ DQ NNP 545 554 molecules molecule NNS 555 562 encoded encode VBN 563 565 by by IN 566 570 both both DT 571 579 parental parental JJ 580 590 haplotypes haplotype NNS 590 591 . . . 592 600 Markedly markedly RB 601 609 impaired impaired JJ 610 617 binding binding NN 618 621 was be VBD 622 630 observed observe VBN 630 631 , , , 632 642 consistent consistent JJ 643 647 with with IN 648 652 both both CC 653 656 the the DT 657 660 use use NN 661 663 of of IN 664 673 different different JJ 674 680 anchor anchor NN 681 689 residues residue NNS 690 693 and and CC 694 698 with with IN 699 706 changes change NNS 707 709 in in IN 710 716 levels level NNS 717 719 of of IN 720 722 DQ DQ NNP 723 732 cis-dimer cis-dimer NN 733 745 availability availability NN 746 749 for for IN 750 757 peptide peptide NN 758 765 binding binding NN 766 778 interactions interaction NNS 778 779 . . .