0 15 Interferon-beta Interferon-beta NNP 16 24 mediates mediate VBZ 25 32 stromal stromal JJ 33 37 cell cell NN 38 44 rescue rescue NN 45 47 of of IN 48 49 T t NN 50 55 cells cell NNS 56 60 from from IN 61 70 apoptosis apoptosis NN 70 71 . . . 73 76 The the DT 77 87 resolution resolution NN 88 90 of of IN 91 97 immune immune JJ 98 107 responses response NNS 108 110 is be VBZ 111 124 characterized characterize VBN 125 127 by by IN 128 137 extensive extensive JJ 138 147 apoptosis apoptosis NN 148 150 of of IN 151 160 activated activate VBN 161 162 T t NN 163 168 cells cell NNS 168 169 . . . 170 177 However however RB 177 178 , , , 179 181 to to TO 182 190 generate generate VB 191 194 and and CC 195 203 maintain maintain VB 204 217 immunological immunological JJ 218 224 memory memory NN 224 225 , , , 226 230 some some DT 231 247 antigen-specific antigen-specific JJ 248 249 T t NN 250 255 cells cell NNS 256 260 must must MD 261 268 survive survive VB 269 272 and and CC 273 279 revert revert VB 280 282 to to TO 283 284 a a DT 285 292 resting resting JJ 293 298 G0/G1 g0/g1 NN 299 304 state state NN 304 305 . . . 306 315 Cytokines cytokine NNS 316 320 that that WDT 321 325 bind bind VBP 326 328 to to TO 329 332 the the DT 333 339 common common JJ 340 345 gamma gamma NN 346 351 chain chain NN 352 354 of of IN 355 358 the the DT 359 363 IL-2 il-2 NN 364 372 receptor receptor NN 373 380 promote promote VBP 381 384 the the DT 385 393 survival survival NN 394 396 of of IN 397 398 T t NN 399 403 cell cell NN 404 410 blasts blast NNS 410 411 , , , 412 415 but but CC 416 420 also also RB 421 427 induce induce VBP 428 441 proliferation proliferation NN 441 442 . . . 443 445 In in IN 446 454 contrast contrast NN 454 455 , , , 456 463 soluble soluble JJ 464 471 factors factor NNS 472 480 secreted secrete VBN 481 483 by by IN 484 491 stromal stromal JJ 492 497 cells cell NNS 498 504 induce induce VBP 505 510 Tcell tcell NN 511 519 survival survival NN 520 522 in in IN 523 524 a a DT 525 532 resting resting JJ 533 538 G0/G1 g0/g1 NN 539 544 state state NN 544 545 . . . 546 548 We we PRP 549 552 now now RB 553 559 report report VBP 560 564 that that IN 565 580 interferon-beta interferon-beta NN 581 583 is be VBZ 584 587 the the DT 588 597 principal principal JJ 598 606 mediator mediator NN 607 609 of of IN 610 617 stromal stromal JJ 618 631 cell-mediated cell-mediated JJ 632 637 Tcell Tcell NNP 638 644 rescue rescue NN 645 649 from from IN 650 659 apoptosis apoptosis NN 659 660 . . . 661 677 Interferon-alpha Interferon-alpha NNP 678 681 and and CC 682 687 -beta -beta NN 688 695 promote promote VBP 696 699 the the DT 700 709 reversion reversion NN 710 712 of of IN 713 718 blast blast NN 719 725 Tcells tcell NNS 726 728 to to TO 729 730 a a DT 731 738 resting resting JJ 739 744 G0/G1 g0/g1 NN 745 758 configuration configuration NN 759 763 with with IN 764 767 all all PDT 768 771 the the DT 772 786 characteristic characteristic JJ 787 795 features feature NNS 796 798 of of IN 799 806 stromal stromal JJ 807 811 cell cell NN 812 818 rescue rescue NN 818 819 ; ; : 820 824 such such JJ 825 827 as as IN 828 832 high high JJ 833 839 Bcl-XL Bcl-XL NNP 840 850 expression expression NN 851 854 and and CC 855 858 low low JJ 859 864 Bcl-2 bcl-2 NN 864 865 . . . 866 870 Type type NN 871 872 I i CD 873 884 interferons interferon NNS 885 888 and and CC 889 896 stromal stromal JJ 897 902 cells cell NNS 903 912 stimulate stimulate VBP 913 923 apparently apparently RB 924 933 identical identical JJ 934 943 signaling signaling NN 944 952 pathways pathway NNS 952 953 , , , 954 961 leading lead VBG 962 964 to to TO 965 971 STAT-1 stat-1 NN 972 982 activation activation NN 982 983 . . . 984 986 We we PRP 987 991 also also RB 992 996 show show VBP 997 1001 that that IN 1002 1006 this this DT 1007 1016 mechanism mechanism NN 1017 1020 may may MD 1021 1025 play play VB 1026 1027 a a DT 1028 1039 fundamental fundamental JJ 1040 1044 role role NN 1045 1047 in in IN 1048 1051 the the DT 1052 1063 persistence persistence NN 1064 1066 of of IN 1067 1068 T t NN 1069 1074 cells cell NNS 1075 1077 at at IN 1078 1083 sites site NNS 1084 1086 of of IN 1087 1094 chronic chronic JJ 1095 1107 inflammation inflammation NN 1107 1108 ; ; : 1109 1119 suggesting suggest VBG 1120 1124 that that IN 1125 1132 chronic chronic JJ 1133 1145 inflammation inflammation NN 1146 1148 is be VBZ 1149 1151 an an DT 1152 1160 aberrant aberrant JJ 1161 1172 consequence consequence NN 1173 1175 of of IN 1176 1189 immunological immunological JJ 1190 1196 memory memory NN 1196 1197 . . .