0 7 Vitamin Vitamin NNP 8 9 D D NNP 10 18 receptor receptor NN 19 34 3’-untranslated 3'-untranslated JJ 35 41 region region NN 42 55 polymorphisms polymorphism NNS 55 56 : : : 57 61 lack lack NN 62 64 of of IN 65 71 effect effect NN 72 74 on on IN 75 79 mRNA mrna NN 80 89 stability stability NN 89 90 . . . 92 99 Allelic allelic JJ 100 109 variation variation NN 110 112 at at IN 113 116 the the DT 117 123 3’-end 3'-end NN 124 126 of of IN 127 130 the the DT 131 138 vitamin vitamin NN 139 140 D D NNP 141 149 receptor receptor NN 150 151 ( ( ( 151 154 VDR VDR NNP 154 155 ) ) ) 156 160 gene gene NN 161 164 has have VBZ 165 169 been be VBN 170 180 associated associate VBN 181 185 with with IN 186 187 a a DT 188 196 3-5-fold 3-5-fold RB 197 206 increased increase VBN 207 211 risk risk NN 212 214 of of IN 215 225 developing develop VBG 226 234 prostate prostate NN 235 241 cancer cancer NN 242 245 and and CC 246 250 with with IN 251 262 differences difference NNS 263 265 in in IN 266 270 bone bone NN 271 285 mineralization mineralization NN 285 286 . . . 287 291 This this DT 292 299 genetic genetic JJ 300 309 diversity diversity NN 310 314 does do VBZ 315 318 not not RB 319 324 alter alter VB 325 328 the the DT 329 332 VDR VDR NNP 333 340 protein protein NN 341 353 structurally structurally RB 353 354 , , , 355 358 but but CC 359 366 instead instead RB 367 370 may may MD 371 373 be be VB 374 375 a a DT 376 385 marker(s) marker(s) NN 386 388 of of IN 389 394 other other JJ 394 395 , , , 396 402 nearby nearby JJ 403 416 polymorphisms polymorphism NNS 417 421 that that WDT 422 431 influence influence VBP 432 439 message message NN 440 449 stability stability NN 450 452 or or CC 453 464 translation translation NN 464 465 . . . 466 469 The the DT 470 474 work work NN 475 483 reported report VBN 484 488 here here RB 489 492 was be VBD 493 503 instigated instigate VBN 504 506 to to TO 507 515 identify identify VB 516 526 additional additional JJ 527 530 VDR VDR NNP 531 537 3’-UTR 3'-UTR NNP 538 551 polymorphisms polymorphism NNS 552 556 that that WDT 557 560 may may MD 561 565 have have VB 566 576 functional functional JJ 577 589 significance significance NN 590 593 and and CC 594 596 to to TO 597 601 then then RB 602 606 test test VB 607 614 whether whether IN 615 620 these these DT 621 628 genetic genetic JJ 629 637 variants variant NNS 638 643 alter alter VBP 644 651 message message NN 652 661 stability stability NN 661 662 . . . 663 672 Initially initially RB 672 673 , , , 674 678 four four CD 679 684 novel novel JJ 684 685 , , , 686 696 frequently frequently RB 697 706 occurring occur VBG 707 715 sequence sequence NN 716 724 variants variant NNS 725 729 were be VBD 730 740 identified identify VBN 741 745 that that WDT 746 756 associated associate VBD 757 761 with with IN 762 765 two two CD 766 772 common common JJ 773 783 haplotypes haplotype NNS 784 788 that that WDT 789 793 were be VBD 794 803 described describe VBN 804 814 previously previously RB 814 815 . . . 816 821 These these DT 822 828 common common JJ 829 837 sequence sequence NN 838 846 variants variant NNS 847 851 were be VBD 852 855 not not RB 856 861 found find VBN 862 868 within within IN 869 874 three three CD 875 896 message-destabilizing message-destabilizing JJ 897 905 elements element NNS 906 910 that that IN 911 913 we we PRP 914 920 mapped map VBD 921 927 within within IN 928 931 the the DT 932 938 3’-UTR 3'-UTR NNP 939 941 of of IN 942 945 the the DT 946 953 vitamin vitamin NN 954 955 D D NNP 956 964 receptor receptor NN 965 969 mRNA mRNA NNP 969 970 . . . 971 982 Furthermore furthermore RB 982 983 , , , 984 987 the the DT 988 991 two two CD 992 995 VDR VDR NNP 996 1002 3’-UTR 3'-UTR NNP 1003 1013 haplotypes haplotype NNS 1014 1023 conferred confer VBD 1024 1026 an an DT 1027 1036 identical identical JJ 1037 1046 half-life half-life NN 1047 1049 on on IN 1050 1051 a a DT 1052 1064 heterologous heterologous JJ 1065 1076 beta-globin beta-globin NN 1077 1085 reporter reporter NN 1086 1090 gene gene NN 1090 1091 , , , 1092 1094 in in IN 1095 1097 an an DT 1098 1100 in in FW 1101 1106 vitro vitro FW 1107 1112 assay assay NN 1112 1113 . . . 1114 1116 We we PRP 1117 1126 therefore therefore RB 1127 1135 conclude conclude VBP 1136 1140 that that IN 1141 1147 common common JJ 1148 1161 polymorphisms polymorphism NNS 1162 1168 within within IN 1169 1172 the the DT 1173 1176 VDR VDR NNP 1177 1183 3’-UTR 3'-UTR NNP 1184 1186 do do VBP 1187 1190 not not RB 1191 1200 influence influence VB 1201 1208 message message NN 1209 1218 stability stability NN 1218 1219 . . .