0 1 [ [ ( 1 10 Induction Induction NNP 11 13 of of IN 14 23 apoptosis apoptosis NN 24 26 in in IN 27 38 lymphocytes lymphocyte NNS 39 41 by by IN 42 57 glucocorticoids glucocorticoid NNS 57 58 : : : 59 66 between between IN 67 77 physiology physiology NN 78 81 and and CC 82 94 pharmacology pharmacology NN 94 95 ] ] ) 97 112 Glucocorticoids glucocorticoid NNS 113 116 are be VBP 117 130 physiological physiological JJ 131 140 molecules molecule NNS 141 145 that that WDT 146 149 are be VBP 150 154 also also RB 155 166 extensively extensively RB 167 171 used use VBN 172 174 in in IN 175 182 clinics clinic NNS 183 185 as as IN 186 203 anti-inflammatory anti-inflammatory JJ 203 204 , , , 205 222 immunosuppressive immunosuppressive JJ 223 225 or or CC 226 238 anti-tumoral anti-tumoral JJ 239 245 agents agent NNS 245 246 . . . 247 262 Glucocorticoids glucocorticoid NNS 263 266 can can MD 267 273 induce induce VB 274 283 apoptosis apoptosis NN 284 286 on on IN 287 293 normal normal JJ 294 302 lymphoid lymphoid JJ 303 308 cells cell NNS 309 312 and and CC 313 317 play play VB 318 319 a a DT 320 323 key key JJ 324 328 role role NN 329 331 in in IN 332 335 the the DT 336 346 physiology physiology NN 347 349 of of IN 350 356 thymic thymic JJ 357 366 selection selection NN 366 367 . . . 368 370 In in IN 371 378 clinics clinic NNS 379 384 these these DT 385 394 molecules molecule NNS 395 398 are be VBP 399 403 also also RB 404 408 used use VBN 409 412 for for IN 413 418 their their PRP$ 419 428 potencies potency NNS 429 431 in in IN 432 440 inducing induce VBG 441 450 apoptosis apoptosis NN 451 453 of of IN 454 463 malignant malignant JJ 464 472 lymphoid lymphoid JJ 473 478 cells cell NNS 478 479 . . . 480 495 Glucocorticoids glucocorticoid NNS 496 499 are be VBP 500 509 mediating mediate VBG 510 515 their their PRP$ 516 523 effects effect NNS 524 529 after after IN 530 537 binding bind VBG 538 540 to to TO 541 543 an an DT 544 557 intracellular intracellular JJ 558 566 receptor receptor NN 567 576 belonging belong VBG 577 579 to to TO 580 583 the the DT 584 591 steroid steroid NN 592 600 receptor receptor NN 601 612 superfamily superfamily NN 612 613 : : : 614 617 the the DT 618 632 glucocorticoid glucocorticoid NN 633 641 receptor receptor NN 642 643 ( ( ( 643 645 GR GR NNP 645 646 ) ) ) 646 647 . . . 648 652 Once once RB 653 662 activated activate VBN 662 663 , , , 664 667 the the DT 668 670 GR gr NN 670 671 , , , 672 675 can can MD 676 683 mediate mediate VB 684 687 his his PRP$ 688 695 effects effect NNS 696 703 through through IN 704 710 direct direct JJ 711 718 binding binding NN 719 721 on on IN 722 725 the the DT 726 729 DNA dna NN 730 732 or or CC 733 736 via via IN 737 752 protein/protein protein/protein NN 753 765 interactions interaction NNS 766 770 with with IN 771 784 transcription transcription NN 785 792 factors factor NNS 792 793 . . . 794 803 Depending depend VBG 804 806 on on IN 807 810 the the DT 811 815 type type NN 816 818 of of IN 819 830 lymphocytes lymphocyte NNS 830 831 , , , 832 835 the the DT 836 845 mechanism mechanism NN 846 848 of of IN 849 858 apoptosis apoptosis NN 859 866 induced induce VBN 867 869 by by IN 870 885 glucocorticoids glucocorticoid NNS 886 890 fall fall VBP 891 898 roughly roughly RB 899 901 in in IN 902 905 two two CD 906 916 categories category NNS 916 917 : : : 918 927 induction induction NN 928 930 of of IN 931 932 “ `` `` 932 937 death death NN 938 943 genes gene NNS 943 944 ” '' '' 945 947 by by IN 948 951 the the DT 952 961 activated activate VBN 962 964 GR gr NN 965 966 ( ( ( 966 967 I i NN 968 973 kappa kappa NN 974 975 B B NNP 975 976 , , , 977 982 c-jun c-jun NN 982 983 ) ) ) 984 986 or or CC 987 997 repression repression NN 998 1000 of of IN 1001 1009 survival survival NN 1010 1017 factors factor NNS 1018 1019 ( ( ( 1019 1023 AP-1 AP-1 NNP 1023 1024 , , , 1025 1030 c-Myc c-myc NN 1030 1031 ) ) ) 1031 1032 . . . 1033 1035 In in IN 1036 1039 the the DT 1040 1044 case case NN 1045 1047 of of IN 1048 1054 thymic thymic JJ 1055 1064 selection selection NN 1065 1068 the the DT 1069 1078 mechanism mechanism NN 1079 1081 is be VBZ 1082 1086 more more RBR 1087 1093 subtle subtle JJ 1094 1103 depending depend VBG 1104 1106 on on IN 1107 1110 the the DT 1111 1117 mutual mutual JJ 1118 1128 repression repression NN 1129 1131 of of IN 1132 1137 Nur77 Nur77 NNP 1138 1141 and and CC 1142 1144 GR GR NNP 1144 1145 . . .