0	3	The	the	DT
4	14	functional	functional	JJ
15	22	synergy	synergy	NN
23	30	between	between	IN
31	36	IL-12	il-12	NN
37	40	and	and	CC
41	45	IL-2	il-2	NN
46	54	involves	involve	VBZ
55	58	p38	p38	NN
59	76	mitogen-activated	mitogen-activated	JJ
77	84	protein	protein	NN
85	91	kinase	kinase	NNP
92	95	and	and	CC
96	98	is	be	VBZ
99	109	associated	associate	VBN
110	114	with	with	IN
115	118	the	the	DT
119	131	augmentation	augmentation	NN
132	134	of	of	IN
135	139	STAT	STAT	NNP
140	146	serine	serine	NN
147	162	phosphorylation	phosphorylation	NN
162	163	.	.	.

165	170	IL-12	il-12	NN
171	174	and	and	CC
175	179	IL-2	il-2	NN
180	183	can	can	MD
184	193	stimulate	stimulate	VB
194	202	mitogen-	mitogen-	NN
203	205	or	or	CC
206	219	CD3-activated	cd3-activated	JJ
220	221	T	t	NN
222	227	cells	cell	NNS
228	230	to	to	TO
231	242	proliferate	proliferate	VB
242	243	,	,	,
244	251	produce	produce	VB
252	261	IFN-gamma	IFN-gamma	NNP
261	262	,	,	,
263	266	and	and	CC
267	271	kill	kill	VBP
272	277	tumor	tumor	NN
278	283	cells	cell	NNS
283	284	.	.	.

285	288	The	the	DT
289	298	magnitude	magnitude	NN
299	301	of	of	IN
302	307	these	these	DT
308	318	functional	functional	JJ
319	328	responses	response	NNS
329	331	is	be	VBZ
332	339	greatly	greatly	RB
340	349	augmented	augmented	JJ
350	354	when	when	WRB
355	356	T	t	NN
357	362	cells	cell	NNS
363	366	are	be	VBP
367	376	activated	activate	VBN
377	379	by	by	IN
380	383	the	the	DT
384	395	combination	combination	NN
396	398	of	of	IN
399	404	IL-12	il-12	NN
405	408	and	and	CC
409	413	IL-2	il-2	NN
413	414	.	.	.

415	423	Although	although	IN
424	434	peripheral	peripheral	JJ
435	440	blood	blood	NN
441	442	T	t	NN
443	448	cells	cell	NNS
449	452	are	be	VBP
453	460	largely	largely	RB
461	473	unresponsive	unresponsive	JJ
474	476	to	to	TO
477	482	these	these	DT
483	492	cytokines	cytokine	NNS
493	500	without	without	IN
501	506	prior	prior	JJ
507	517	activation	activation	NN
517	518	,	,	,
519	520	a	a	DT
521	526	small	small	JJ
527	533	subset	subset	NN
534	536	of	of	IN
537	541	CD8+	cd8+	JJ
542	543	T	t	NN
544	549	cells	cell	NNS
550	551	(	(	(
551	565	CD8+CD18bright	CD8+CD18bright	NNP
565	566	)	)	)
567	569	is	be	VBZ
570	578	strongly	strongly	RB
579	588	activated	activate	VBN
589	591	by	by	IN
592	595	the	the	DT
596	607	combination	combination	NN
608	610	of	of	IN
611	616	IL-12	il-12	NN
617	620	and	and	CC
621	625	IL-2	il-2	NN
625	626	.	.	.

627	629	In	in	IN
630	634	this	this	DT
635	641	report	report	NN
642	644	we	we	PRP
645	649	show	show	VBP
650	654	that	that	IN
655	658	the	the	DT
659	669	functional	functional	JJ
670	677	synergy	synergy	NN
678	685	between	between	IN
686	691	IL-12	il-12	NN
692	695	and	and	CC
696	700	IL-2	il-2	NN
701	703	in	in	IN
704	718	CD8+CD18bright	cd8+cd18bright	JJ
719	720	T	t	NN
721	726	cells	cell	NNS
727	737	correlates	correlate	VBZ
738	742	with	with	IN
743	746	the	the	DT
747	757	activation	activation	NN
758	760	of	of	IN
761	764	the	the	DT
765	771	stress	stress	NN
772	779	kinases	kinase	NNS
779	780	,	,	,
781	784	p38	p38	NN
785	802	mitogen-activated	mitogen-activated	JJ
803	810	protein	protein	NN
811	812	(	(	(
812	815	MAP	MAP	NNP
815	816	)	)	)
817	823	kinase	kinase	NNP
824	827	and	and	CC
828	844	stress-activated	stress-activated	JJ
845	852	protein	protein	NN
853	859	kinase	kinase	NNP
860	861	(	(	(
861	870	SAPK)/Jun	SAPK)/Jun	NNP
871	881	N-terminal	n-terminal	JJ
882	888	kinase	kinase	NNP
888	889	,	,	,
890	893	but	but	CC
894	897	not	not	RB
898	902	with	with	IN
903	906	the	the	DT
907	917	activation	activation	NN
918	920	of	of	IN
921	924	the	the	DT
925	938	extracellular	extracellular	JJ
939	955	signal-regulated	signal-regulated	JJ
956	963	kinases	kinase	NNS
963	964	.	.	.

965	968	The	the	DT
969	979	functional	functional	JJ
980	987	synergy	synergy	NN
988	995	between	between	IN
996	1000	IL-2	il-2	NN
1001	1004	and	and	CC
1005	1010	IL-12	il-12	NN
1011	1013	is	be	VBZ
1014	1018	also	also	RB
1019	1029	associated	associate	VBN
1030	1034	with	with	IN
1035	1036	a	a	DT
1037	1046	prominent	prominent	JJ
1047	1055	increase	increase	NN
1056	1058	in	in	IN
1059	1064	STAT1	stat1	NN
1065	1068	and	and	CC
1069	1074	STAT3	stat3	NN
1075	1081	serine	serine	NN
1082	1097	phosphorylation	phosphorylation	NN
1098	1102	over	over	IN
1103	1107	that	that	DT
1108	1116	observed	observe	VBN
1117	1121	with	with	IN
1122	1127	IL-12	il-12	NN
1128	1130	or	or	CC
1131	1135	IL-2	il-2	NN
1136	1141	alone	alone	RB
1141	1142	.	.	.

1143	1145	By	by	IN
1146	1154	contrast	contrast	NN
1154	1155	,	,	,
1156	1160	STAT	STAT	NNP
1161	1169	tyrosine	tyrosine	NN
1170	1185	phosphorylation	phosphorylation	NN
1186	1188	is	be	VBZ
1189	1192	not	not	RB
1193	1202	augmented	augment	VBN
1203	1207	over	over	IN
1208	1212	that	that	DT
1213	1217	seen	see	VBN
1218	1222	with	with	IN
1223	1229	either	either	DT
1230	1238	cytokine	cytokine	NN
1239	1244	alone	alone	RB
1244	1245	.	.	.

1246	1247	A	a	DT
1248	1256	specific	specific	JJ
1257	1266	inhibitor	inhibitor	NN
1267	1269	of	of	IN
1270	1273	p38	p38	NN
1274	1277	MAP	MAP	NNP
1278	1284	kinase	kinase	NNP
1285	1295	completely	completely	RB
1296	1304	inhibits	inhibit	VBZ
1305	1308	the	the	DT
1309	1315	serine	serine	NN
1316	1331	phosphorylation	phosphorylation	NN
1332	1334	of	of	IN
1335	1340	STAT1	STAT1	NNP
1341	1344	and	and	CC
1345	1350	STAT3	STAT3	NNP
1351	1358	induced	induce	VBN
1359	1361	by	by	IN
1362	1367	IL-12	il-12	NN
1368	1371	and	and	CC
1372	1376	IL-2	il-2	NN
1377	1380	and	and	CC
1381	1390	abrogates	abrogate	VBZ
1391	1394	the	the	DT
1395	1405	functional	functional	JJ
1406	1413	synergy	synergy	NN
1414	1421	between	between	IN
1422	1427	IL-12	il-12	NN
1428	1431	and	and	CC
1432	1436	IL-2	il-2	NN
1437	1444	without	without	IN
1445	1454	affecting	affect	VBG
1455	1459	STAT	STAT	NNP
1460	1468	tyrosine	tyrosine	NN
1469	1484	phosphorylation	phosphorylation	NN
1484	1485	.	.	.

1486	1490	This	this	DT
1491	1499	suggests	suggest	VBZ
1500	1504	that	that	IN
1505	1508	p38	p38	NN
1509	1512	MAP	MAP	NNP
1513	1519	kinase	kinase	NNP
1520	1523	may	may	MD
1524	1528	play	play	VB
1529	1531	an	an	DT
1532	1541	important	important	JJ
1542	1546	role	role	NN
1547	1549	in	in	IN
1550	1560	regulating	regulate	VBG
1561	1565	STAT	STAT	NNP
1566	1572	serine	serine	NN
1573	1588	phosphorylation	phosphorylation	NN
1589	1591	in	in	IN
1592	1600	response	response	NN
1601	1603	to	to	TO
1604	1607	the	the	DT
1608	1619	combination	combination	NN
1620	1622	of	of	IN
1623	1628	IL-12	il-12	NN
1629	1632	and	and	CC
1633	1637	IL-2	il-2	NN
1637	1638	.	.	.

1639	1650	Furthermore	furthermore	RB
1650	1651	,	,	,
1652	1657	these	these	DT
1658	1666	findings	finding	NNS
1667	1675	indicate	indicate	VBP
1676	1680	that	that	IN
1681	1684	the	the	DT
1685	1692	optimal	optimal	JJ
1693	1703	activation	activation	NN
1704	1706	of	of	IN
1707	1708	T	t	NN
1709	1714	cells	cell	NNS
1715	1717	by	by	IN
1718	1723	IL-12	il-12	NN
1724	1727	and	and	CC
1728	1732	IL-2	il-2	NN
1733	1736	may	may	MD
1737	1743	depend	depend	VB
1744	1746	on	on	IN
1747	1749	an	an	DT
1750	1761	interaction	interaction	NN
1762	1769	between	between	IN
1770	1773	the	the	DT
1774	1777	p38	p38	NN
1778	1781	MAP	MAP	NNP
1782	1788	kinase	kinase	NNP
1789	1792	and	and	CC
1793	1798	Janus	Janus	NNP
1799	1810	kinase/STAT	kinase/stat	NN
1811	1820	signaling	signaling	NN
1821	1829	pathways	pathway	NNS
1829	1830	.	.	.