0	5	Grf40	Grf40	NNP
5	6	,	,	,
7	8	A	a	DT
9	14	novel	novel	JJ
15	19	Grb2	grb2	NN
20	26	family	family	NN
27	33	member	member	NN
33	34	,	,	,
35	37	is	be	VBZ
38	46	involved	involve	VBN
47	49	in	in	IN
50	51	T	t	NN
52	56	cell	cell	NN
57	66	signaling	signaling	NN
67	74	through	through	IN
75	86	interaction	interaction	NN
87	91	with	with	IN
92	98	SLP-76	SLP-76	NNP
99	102	and	and	CC
103	106	LAT	LAT	NNP
106	107	.	.	.

109	111	We	we	PRP
112	123	molecularly	molecularly	RB
124	130	cloned	clone	VBD
131	132	a	a	DT
133	136	new	new	JJ
137	141	Grb2	grb2	NN
142	148	family	family	NN
149	155	member	member	NN
155	156	,	,	,
157	162	named	name	VBN
163	168	Grf40	grf40	NN
168	169	,	,	,
170	180	containing	contain	VBG
181	184	the	the	DT
185	191	common	common	JJ
192	203	SH3-SH2-SH3	sh3-sh2-sh3	NN
204	209	motif	motif	NN
209	210	.	.	.

211	221	Expression	expression	NN
222	224	of	of	IN
225	230	Grf40	Grf40	NNP
231	233	is	be	VBZ
234	245	predominant	predominant	JJ
246	248	in	in	IN
249	262	hematopoietic	hematopoietic	JJ
263	268	cells	cell	NNS
268	269	,	,	,
270	282	particularly	particularly	RB
283	284	T	t	NN
285	290	cells	cell	NNS
290	291	.	.	.

292	297	Grf40	Grf40	NNP
298	303	binds	bind	VBZ
304	306	to	to	TO
307	310	the	the	DT
311	314	SH2	sh2	NN
315	332	domain-containing	domain-containing	JJ
333	342	leukocyte	leukocyte	NN
343	350	protein	protein	NN
351	353	of	of	IN
354	356	76	76	CD
357	359	kD	kd	NN
360	361	(	(	(
361	367	SLP-76	SLP-76	NNP
367	368	)	)	)
369	372	via	via	IN
373	376	its	its	PRP$
377	380	SH3	sh3	NN
381	387	domain	domain	NN
388	392	more	more	RBR
393	400	tightly	tightly	RB
401	405	than	than	IN
406	410	Grb2	grb2	NN
410	411	.	.	.

412	424	Incidentally	incidentally	RB
424	425	,	,	,
426	431	Grf40	Grf40	NNP
432	437	binds	bind	VBZ
438	440	to	to	TO
441	447	linker	linker	NN
448	451	for	for	IN
452	462	activation	activation	NN
463	465	of	of	IN
466	467	T	t	NN
468	473	cells	cell	NNS
474	475	(	(	(
475	478	LAT	LAT	NNP
478	479	)	)	)
480	488	possibly	possibly	RB
489	492	via	via	IN
493	496	its	its	PRP$
497	500	SH2	sh2	NN
501	507	domain	domain	NN
507	508	.	.	.

509	523	Overexpression	overexpression	NN
524	526	of	of	IN
527	536	wild-type	wild-type	JJ
537	542	Grf40	grf40	NN
543	545	in	in	IN
546	552	Jurkat	Jurkat	NNP
553	558	cells	cell	NNS
559	566	induced	induce	VBD
567	568	a	a	DT
569	580	significant	significant	JJ
581	589	increase	increase	NN
590	592	of	of	IN
593	609	SLP-76-dependent	slp-76-dependent	JJ
610	621	interleukin	interleukin	NN
622	623	(	(	(
623	628	IL)-2	il)-2	NN
629	637	promoter	promoter	NN
638	641	and	and	CC
642	649	nuclear	nuclear	JJ
650	656	factor	factor	NN
657	659	of	of	IN
660	669	activated	activate	VBN
670	671	T	t	NN
672	676	cell	cell	NN
677	678	(	(	(
678	683	NF-AT	NF-AT	NNP
683	684	)	)	)
685	695	activation	activation	NN
696	700	upon	upon	IN
701	702	T	t	NN
703	707	cell	cell	NN
708	716	receptor	receptor	NN
717	718	(	(	(
718	721	TCR	TCR	NNP
721	722	)	)	)
723	734	stimulation	stimulation	NN
734	735	,	,	,
736	743	whereas	whereas	IN
744	747	the	the	DT
748	761	COOH-terminal	cooh-terminal	JJ
762	773	SH3-deleted	sh3-deleted	JJ
774	779	Grf40	Grf40	NNP
780	786	mutant	mutant	NN
787	793	lacked	lack	VBD
794	797	any	any	DT
798	810	recognizable	recognizable	JJ
811	819	increase	increase	NN
820	822	in	in	IN
823	827	IL-2	il-2	NN
828	836	promoter	promoter	NN
837	845	activity	activity	NN
845	846	.	.	.

847	858	Furthermore	furthermore	RB
858	859	,	,	,
860	863	the	the	DT
864	875	SH2-deleted	sh2-deleted	JJ
876	881	Grf40	grf40	NN
882	888	mutant	mutant	NN
889	892	led	lead	VBD
893	895	to	to	TO
896	897	a	a	DT
898	904	marked	marked	JJ
905	915	inhibition	inhibition	NN
916	918	of	of	IN
919	924	these	these	DT
925	935	regulatory	regulatory	JJ
936	946	activities	activity	NNS
946	947	,	,	,
948	951	the	the	DT
952	958	effect	effect	NN
959	961	of	of	IN
962	967	which	which	WDT
968	970	is	be	VBZ
971	981	apparently	apparently	RB
982	990	stronger	strong	JJR
991	995	than	than	IN
996	1000	that	that	DT
1001	1003	of	of	IN
1004	1007	the	the	DT
1008	1019	SH2-deleted	sh2-deleted	JJ
1020	1024	Grb2	grb2	NN
1025	1031	mutant	mutant	NN
1031	1032	.	.	.

1033	1036	Our	our	PRP$
1037	1041	data	datum	NNS
1042	1049	suggest	suggest	VBP
1050	1054	that	that	IN
1055	1060	Grf40	grf40	NN
1061	1063	is	be	VBZ
1064	1066	an	an	DT
1067	1074	adaptor	adaptor	NN
1075	1083	molecule	molecule	NN
1084	1092	involved	involve	VBN
1093	1095	in	in	IN
1096	1108	TCR-mediated	tcr-mediated	JJ
1109	1118	signaling	signaling	NN
1119	1126	through	through	IN
1127	1128	a	a	DT
1129	1133	more	more	RBR
1134	1143	efficient	efficient	JJ
1144	1155	interaction	interaction	NN
1156	1160	than	than	IN
1161	1165	Grb2	grb2	NN
1166	1170	with	with	IN
1171	1177	SLP-76	SLP-76	NNP
1178	1181	and	and	CC
1182	1185	LAT	LAT	NNP
1185	1186	.	.	.