0	9	Bacterial	bacterial	JJ
10	23	peptidoglycan	peptidoglycan	NN
24	31	induces	induce	VBZ
32	46	CD14-dependent	cd14-dependent	JJ
47	57	activation	activation	NN
58	60	of	of	IN
61	74	transcription	transcription	NN
75	82	factors	factor	NNS
83	91	CREB/ATF	CREB/ATF	NNP
92	95	and	and	CC
96	100	AP-1	ap-1	NN
100	101	.	.	.

103	116	Peptidoglycan	Peptidoglycan	NNP
117	118	(	(	(
118	121	PGN	PGN	NNP
121	122	)	)	)
122	123	,	,	,
124	127	the	the	DT
128	133	major	major	JJ
134	138	cell	cell	NN
139	143	wall	wall	NN
144	153	component	component	NN
154	156	of	of	IN
157	170	Gram-positive	gram-positive	JJ
171	179	bacteria	bacteria	NNS
179	180	,	,	,
181	188	induces	induce	VBZ
189	198	secretion	secretion	NN
199	201	of	of	IN
202	211	cytokines	cytokine	NNS
212	214	in	in	IN
215	226	macrophages	macrophage	NNS
227	234	through	through	IN
235	239	CD14	cd14	NN
239	240	,	,	,
241	244	the	the	DT
245	252	pattern	pattern	NN
253	264	recognition	recognition	NN
265	273	receptor	receptor	NN
274	278	that	that	WDT
279	284	binds	bind	VBZ
285	303	lipopolysaccharide	lipopolysaccharide	NN
304	307	and	and	CC
308	313	other	other	JJ
314	323	microbial	microbial	JJ
324	332	products	product	NNS
332	333	.	.	.

334	336	To	to	TO
337	342	begin	begin	VB
343	345	to	to	TO
346	355	elucidate	elucidate	VB
356	359	the	the	DT
360	370	mechanisms	mechanism	NNS
371	375	that	that	WDT
376	384	regulate	regulate	VBP
385	388	the	the	DT
389	402	transcription	transcription	NN
403	405	of	of	IN
406	414	cytokine	cytokine	NN
415	420	genes	gene	NNS
420	421	,	,	,
422	424	we	we	PRP
425	431	wanted	want	VBD
432	434	to	to	TO
435	444	determine	determine	VB
445	450	which	which	WDT
451	464	transcription	transcription	NN
465	472	factors	factor	NNS
473	476	are	be	VBP
477	486	activated	activate	VBN
487	489	by	by	IN
490	493	PGN	PGN	NNP
494	496	in	in	IN
497	502	mouse	mouse	NN
503	511	RAW264.7	raw264.7	NN
512	515	and	and	CC
516	521	human	human	JJ
522	527	THP-1	thp-1	NN
528	538	macrophage	macrophage	NN
539	544	cells	cell	NNS
544	545	.	.	.

546	549	Our	our	PRP$
550	557	results	result	NNS
558	570	demonstrated	demonstrate	VBD
571	575	that	that	IN
575	576	:	:	:
577	578	(	(	(
578	579	i	i	LS
579	580	)	)	)
581	584	PGN	PGN	NNP
585	592	induced	induce	VBD
593	608	phosphorylation	phosphorylation	NN
609	611	of	of	IN
612	615	the	the	DT
616	629	transcription	transcription	NN
630	637	factors	factor	NNS
638	643	ATF-1	ATF-1	NNP
644	647	and	and	CC
648	652	CREB	CREB	NNP
652	653	;	;	:
654	655	(	(	(
655	657	ii	ii	LS
657	658	)	)	)
659	664	ATF-1	ATF-1	NNP
665	668	and	and	CC
669	673	CREB	CREB	NNP
674	679	bound	bind	VBD
680	683	DNA	dna	NN
684	686	as	as	IN
687	688	a	a	DT
689	694	dimer	dimer	NN
695	698	and	and	CC
699	706	induced	induce	VBD
707	722	transcriptional	transcriptional	JJ
723	733	activation	activation	NN
734	736	of	of	IN
737	738	a	a	DT
739	742	CRE	CRE	NNP
743	751	reporter	reporter	NN
752	759	plasmid	plasmid	NN
759	760	,	,	,
761	766	which	which	WDT
767	770	was	be	VBD
771	780	inhibited	inhibit	VBN
781	783	by	by	IN
784	792	dominant	dominant	JJ
793	801	negative	negative	JJ
802	806	CREB	creb	NN
807	810	and	and	CC
811	816	ATF-1	atf-1	NN
816	817	;	;	:
818	819	(	(	(
819	822	iii	iii	LS
822	823	)	)	)
824	827	PGN	PGN	NNP
828	835	induced	induce	VBD
836	851	phosphorylation	phosphorylation	NN
852	854	of	of	IN
855	860	c-Jun	c-jun	NN
860	861	,	,	,
862	869	protein	protein	NN
870	879	synthesis	synthesis	NN
880	882	of	of	IN
883	887	JunB	JunB	NNP
888	891	and	and	CC
892	897	c-Fos	c-fos	NN
897	898	,	,	,
899	902	and	and	CC
903	918	transcriptional	transcriptional	JJ
919	929	activation	activation	NN
930	932	of	of	IN
933	936	the	the	DT
937	941	AP-1	ap-1	NN
942	950	reporter	reporter	NN
951	958	plasmid	plasmid	NN
958	959	,	,	,
960	965	which	which	WDT
966	969	was	be	VBD
970	979	inhibited	inhibit	VBN
980	982	by	by	IN
983	991	dominant	dominant	JJ
992	1000	negative	negative	JJ
1001	1006	c-Fos	c-fos	NN
1006	1007	;	;	:
1008	1011	and	and	CC
1012	1013	(	(	(
1013	1015	iv	iv	LS
1015	1016	)	)	)
1017	1028	PGN-induced	pgn-induced	JJ
1029	1039	activation	activation	NN
1040	1042	of	of	IN
1043	1051	CREB/ATF	CREB/ATF	NNP
1052	1055	and	and	CC
1056	1060	AP-1	AP-1	NNP
1061	1064	was	be	VBD
1065	1073	mediated	mediate	VBN
1074	1081	through	through	IN
1082	1086	CD14	cd14	NN
1086	1087	.	.	.

1088	1092	This	this	DT
1093	1095	is	be	VBZ
1096	1099	the	the	DT
1100	1105	first	first	JJ
1106	1111	study	study	NN
1112	1114	to	to	TO
1115	1126	demonstrate	demonstrate	VB
1127	1137	activation	activation	NN
1138	1140	of	of	IN
1141	1149	CREB/ATF	CREB/ATF	NNP
1150	1153	and	and	CC
1154	1158	AP-1	ap-1	NN
1159	1172	transcription	transcription	NN
1173	1180	factors	factor	NNS
1181	1183	by	by	IN
1184	1187	PGN	PGN	NNP
1188	1190	or	or	CC
1191	1193	by	by	IN
1194	1197	any	any	DT
1198	1203	other	other	JJ
1204	1213	component	component	NN
1214	1216	of	of	IN
1217	1230	Gram-positive	gram-positive	JJ
1231	1239	bacteria	bacteria	NNS
1239	1240	.	.	.