0 1 c c SYM 1 2 - - : 2 5 Myc Myc NNP 6 9 and and CC 10 13 E1A E1A NNP 14 21 induced induce VBD 22 30 cellular cellular JJ 31 42 sensitivity sensitivity NN 43 45 to to TO 46 55 activated activate VBN 56 58 NK nk NN 59 64 cells cell NNS 65 73 involves involve VBZ 74 83 cytotoxic cytotoxic JJ 84 92 granules granule NNS 93 95 as as IN 96 101 death death NN 102 111 effectors effector NNS 111 112 . . . 114 117 The the DT 118 125 contact contact NN 126 128 of of IN 129 136 natural natural JJ 137 143 killer killer NN 144 145 ( ( ( 145 147 NK NK NNP 147 148 ) ) ) 149 154 cells cell NNS 155 159 with with IN 160 167 foreign foreign JJ 168 173 cells cell NNS 174 177 and and CC 178 182 with with IN 183 190 certain certain JJ 191 205 virus-infected virus-infected JJ 206 208 or or CC 209 214 tumor tumor NN 215 220 cells cell NNS 221 229 triggers trigger VBZ 230 233 the the DT 234 243 cytolytic cytolytic JJ 244 253 machinery machinery NN 254 256 of of IN 257 259 NK NK NNP 260 265 cells cell NNS 265 266 . . . 267 271 This this DT 272 282 triggering triggering NN 283 288 leads lead VBZ 289 291 to to TO 292 302 exocytosis exocytosis NN 303 305 of of IN 306 309 the the DT 310 319 cytotoxic cytotoxic JJ 320 322 NK nk NN 323 327 cell cell NN 328 336 granules granule NNS 336 337 . . . 338 341 The the DT 342 354 oncoproteins oncoprotein NNS 355 360 c-Myc c-myc NN 361 364 and and CC 365 368 E1A E1A NNP 369 375 render render VBP 376 381 cells cell NNS 382 392 vulnerable vulnerable JJ 393 395 to to TO 396 398 NK NK NNP 399 403 cell cell NN 404 412 mediated mediated JJ 413 422 cytolysis cytolysis NN 423 426 yet yet RB 427 430 the the DT 431 441 mechanisms mechanism NNS 442 444 of of IN 445 458 sensitization sensitization NN 459 462 are be VBP 463 466 not not RB 467 471 well well RB 472 482 understood understand VBN 482 483 . . . 484 486 In in IN 487 488 a a DT 489 494 model model NN 495 500 where where WRB 501 508 foreign foreign JJ 509 514 cells cell NNS 515 516 ( ( ( 516 519 rat rat NN 520 531 fibroblasts fibroblast NNS 531 532 ) ) ) 533 537 were be VBD 538 548 cocultured coculture VBN 549 553 with with IN 554 559 human human JJ 560 564 IL-2 il-2 NN 565 574 activated activate VBD 575 577 NK NK NNP 578 583 cells cell NNS 583 584 , , , 585 587 we we PRP 588 596 observed observe VBD 597 601 that that IN 602 604 NK NK NNP 605 610 cells cell NNS 611 615 were be VBD 616 623 capable capable JJ 624 626 of of IN 627 638 efficiently efficiently RB 639 646 killing kill VBG 647 652 their their PRP$ 653 660 targets target NNS 661 665 only only RB 666 668 if if IN 669 672 the the DT 673 678 cells cell NNS 679 692 overexpressed overexpresse VBD 693 696 the the DT 697 705 oncogene oncogene NN 706 711 c-Myc c-myc NN 712 714 or or CC 715 718 E1A E1A NNP 718 719 . . . 720 724 Both both CC 725 728 the the DT 729 737 parental parental JJ 738 741 and and CC 742 745 the the DT 746 754 oncogene oncogene NN 755 765 expressing express VBG 766 777 fibroblasts fibroblast NNS 778 787 similarly similarly RB 788 797 triggered trigger VBD 798 814 phosphoinositide phosphoinositide NN 815 825 hydrolysis hydrolysis NN 826 828 in in IN 829 832 the the DT 833 838 bound bind VBN 839 841 NK nk NN 842 847 cells cell NNS 847 848 , , , 849 862 demonstrating demonstrate VBG 863 867 that that IN 868 870 NK NK NNP 871 876 cells cell NNS 877 881 were be VBD 882 895 cytolytically cytolytically RB 896 905 activated activate VBN 906 908 in in IN 909 916 contact contact NN 917 921 with with IN 922 926 both both CC 927 936 resistant resistant JJ 937 945 parental parental JJ 946 949 and and CC 950 958 oncogene oncogene NN 959 969 expressing express VBG 970 979 sensitive sensitive JJ 980 986 target target NN 987 998 fibroblasts fibroblast NNS 998 999 . . . 1000 1003 The the DT 1004 1008 cell cell NN 1009 1014 death death NN 1015 1018 was be VBD 1019 1030 independent independent JJ 1031 1033 of of IN 1034 1043 wild-type wild-type JJ 1044 1047 p53 p53 NN 1048 1051 and and CC 1052 1055 was be VBD 1056 1059 not not RB 1060 1069 inhibited inhibit VBN 1070 1072 by by IN 1073 1075 an an DT 1076 1090 anti-apoptotic anti-apoptotic JJ 1091 1098 protein protein NN 1099 1106 EIB19K. EIB19K. NNP 1107 1112 These these DT 1113 1120 results result NNS 1121 1129 provided provide VBD 1130 1138 evidence evidence NN 1139 1143 that that IN 1144 1149 c-Myc c-myc NN 1150 1153 and and CC 1154 1157 E1A E1A NNP 1158 1167 activated activate VBD 1168 1171 the the DT 1172 1174 NK NK NNP 1175 1179 cell cell NN 1180 1187 induced induced JJ 1188 1197 cytolysis cytolysis NN 1198 1200 at at IN 1201 1202 a a DT 1203 1218 post-triggering post-triggering JJ 1219 1224 stage stage NN 1225 1227 of of IN 1228 1230 NK NK NNP 1231 1242 cell-target cell-target NN 1243 1247 cell cell NN 1248 1259 interaction interaction NN 1259 1260 . . . 1261 1263 In in IN 1264 1275 consistence consistence NN 1275 1276 , , , 1277 1280 the the DT 1281 1286 c-Myc c-myc NN 1287 1290 and and CC 1291 1294 E1A E1A NNP 1295 1309 overexpressing overexpresse VBG 1310 1321 fibroblasts fibroblast NNS 1322 1326 were be VBD 1327 1331 more more RBR 1332 1341 sensitive sensitive JJ 1342 1344 to to TO 1345 1348 the the DT 1349 1358 cytolytic cytolytic JJ 1359 1366 effects effect NNS 1367 1369 of of IN 1370 1378 isolated isolate VBN 1379 1381 NK NK NNP 1382 1394 cell-derived cell-derived JJ 1395 1403 granules granule NNS 1404 1408 than than IN 1409 1417 parental parental JJ 1418 1423 cells cell NNS 1423 1424 . . . 1425 1428 The the DT 1429 1433 data datum NNS 1434 1442 indicate indicate VBP 1443 1447 that that IN 1448 1457 oncogenes oncogene NNS 1458 1466 activate activate VBP 1467 1470 the the DT 1471 1483 cytotoxicity cytotoxicity NN 1484 1486 of of IN 1487 1489 NK NK NNP 1490 1494 cell cell NN 1495 1503 granules granule NNS 1503 1504 . . . 1505 1509 This this DT 1510 1519 mechanism mechanism NN 1520 1523 can can MD 1524 1528 have have VB 1529 1530 a a DT 1531 1535 role role NN 1536 1538 in in IN 1539 1548 directing direct VBG 1549 1552 the the DT 1553 1562 cytolytic cytolytic JJ 1563 1569 action action NN 1570 1572 of of IN 1573 1575 NK NK NNP 1576 1581 cells cell NNS 1582 1589 towards towards IN 1590 1593 the the DT 1594 1608 virus-infected virus-infected JJ 1609 1612 and and CC 1613 1619 cancer cancer NN 1620 1625 cells cell NNS 1625 1626 . . .