0 10 Expression expression NN 11 13 of of IN 14 17 Th1 th1 NN 18 21 and and CC 22 25 Th2 th2 NN 26 30 type type NN 31 40 cytokines cytokine NNS 41 51 responding respond VBG 52 54 to to TO 55 60 HBsAg hbsag NN 61 64 and and CC 65 70 HBxAg hbxag NN 71 73 in in IN 74 81 chronic chronic JJ 82 91 hepatitis hepatitis NNP 92 93 B B NNP 94 102 patients patient NNS 102 103 . . . 105 108 The the DT 109 117 cytokine cytokine NN 118 125 pattern pattern NN 126 128 on on IN 129 134 viral viral JJ 135 142 antigen antigen NN 143 154 recognition recognition NN 155 157 is be VBZ 158 166 believed believe VBN 167 169 to to TO 170 175 exert exert VB 176 177 a a DT 178 186 profound profound JJ 187 196 influence influence NN 197 199 on on IN 200 203 the the DT 204 214 resolution resolution NN 215 217 of of IN 218 223 viral viral JJ 224 234 infections infection NNS 235 238 and and CC 239 244 viral viral JJ 245 254 clearance clearance NN 254 255 . . . 256 260 This this DT 261 266 study study NN 267 270 was be VBD 271 280 initiated initiate VBN 281 283 to to TO 284 295 investigate investigate VB 296 303 whether whether IN 304 305 a a DT 306 314 cytokine cytokine NN 315 324 imbalance imbalance NN 325 333 oriented orient VBN 334 340 toward toward IN 341 344 Th2 th2 NN 345 349 type type NN 350 358 response response NN 359 364 plays play VBZ 365 366 a a DT 367 371 role role NN 372 374 in in IN 375 382 chronic chronic JJ 383 392 hepatitis hepatitis NNP 393 395 B. B. NNP 396 404 Cytokine Cytokine NNP 405 413 profiles profile NNS 414 416 of of IN 417 427 peripheral peripheral JJ 428 433 blood blood NN 434 445 mononuclear mononuclear JJ 446 451 cells cell NNS 452 462 associated associate VBN 463 467 with with IN 468 475 chronic chronic JJ 476 485 hepatitis hepatitis NNP 486 487 B B NNP 488 492 were be VBD 493 501 analysed analyse VBN 502 504 by by IN 505 511 RT-PCR RT-PCR NNP 511 512 . . . 513 517 Upon upon IN 518 523 HBsAg hbsag NN 524 535 stimulation stimulation NN 535 536 , , , 537 547 expression expression NN 548 550 of of IN 551 560 IFN-gamma IFN-gamma NNP 560 561 , , , 562 566 IL-2 IL-2 NNP 566 567 , , , 568 572 IL-4 il-4 NN 572 573 , , , 574 577 and and CC 578 583 IL-10 IL-10 NNP 584 587 was be VBD 588 596 detected detect VBN 597 599 in in IN 600 602 41 41 CD 602 603 % % NN 603 604 , , , 605 606 8 8 CD 606 607 % % NN 607 608 , , , 609 611 41 41 CD 611 612 % % NN 612 613 , , , 614 617 and and CC 618 620 50 50 CD 620 621 % % NN 622 624 of of IN 625 628 the the DT 629 637 patients patient NNS 637 638 , , , 639 651 respectively respectively RB 651 652 . . . 653 658 Among among IN 659 664 these these DT 665 674 cytokines cytokine NNS 674 675 , , , 676 679 the the DT 680 690 expression expression NN 691 693 of of IN 694 703 IFN-gamma IFN-gamma NNP 704 707 was be VBD 708 718 associated associate VBN 719 723 with with IN 724 728 high high JJ 729 735 levels level NNS 736 738 of of IN 739 744 serum serum NN 745 752 AST/ALT ast/alt NN 752 753 . . . 754 761 However however RB 761 762 , , , 763 765 we we PRP 766 771 could could MD 772 775 not not RB 776 781 prove prove VB 782 786 that that IN 787 790 Th2 th2 NN 791 795 type type NN 796 805 cytokines cytokine NNS 806 809 had have VBD 810 811 a a DT 812 822 protective protective JJ 823 829 effect effect NN 830 832 on on IN 833 844 hepatocytes hepatocyte NNS 844 845 . . . 846 850 Upon upon IN 851 856 HBxAg hbxag NN 857 868 stimulation stimulation NN 868 869 , , , 870 875 there there EX 876 879 was be VBD 880 882 no no DT 883 895 recognizable recognizable JJ 896 907 association association NN 908 910 of of IN 911 919 cytokine cytokine NN 920 928 patterns pattern NNS 929 933 with with IN 934 941 AST/ALT AST/ALT NNP 942 948 levels level NNS 948 949 . . . 950 952 In in IN 953 963 conclusion conclusion NN 963 964 , , , 965 975 production production NN 976 978 of of IN 979 980 a a DT 981 984 Th1 th1 NN 985 993 cytokine cytokine NN 993 994 , , , 995 1004 IFN-gamma IFN-gamma NNP 1004 1005 , , , 1006 1008 by by IN 1009 1023 HBsAg-reactive hbsag-reactive JJ 1024 1029 cells cell NNS 1030 1033 was be VBD 1034 1044 associated associate VBN 1045 1049 with with IN 1050 1060 hepatocyte hepatocyte NN 1061 1067 damage damage NN 1068 1070 in in IN 1071 1078 chronic chronic JJ 1079 1088 hepatitis hepatitis NNP 1089 1090 B B NNP 1090 1091 , , , 1092 1097 while while IN 1098 1100 no no DT 1101 1114 counteracting counteract VBG 1115 1121 effect effect NN 1122 1124 of of IN 1125 1128 Th2 th2 NN 1129 1138 cytokines cytokine NNS 1139 1147 produced produce VBN 1148 1150 by by IN 1151 1156 those those DT 1157 1162 cells cell NNS 1163 1166 was be VBD 1167 1175 observed observe VBN 1175 1176 . . .