0 5 Human human JJ 6 12 T-cell T-cell NNP 13 21 leukemia leukemia NN 22 27 virus virus NN 28 32 type type NN 33 34 1 1 CD 35 38 Tax tax NN 39 46 protein protein NN 47 54 induces induce VBZ 55 58 the the DT 59 69 expression expression NN 70 72 of of IN 73 78 STAT1 STAT1 NNP 79 82 and and CC 83 88 STAT5 stat5 NN 89 94 genes gene NNS 95 97 in in IN 98 105 T-cells T-cell NNP 105 106 . . . 108 113 Human human JJ 114 120 T-cell T-cell NNP 121 129 leukemia leukemia NN 130 135 virus virus NN 136 140 type type NN 141 142 1 1 CD 143 144 ( ( ( 144 150 HTLV-1 HTLV-1 NNP 150 151 ) ) ) 152 155 Tax Tax NNP 156 166 transforms transform VBZ 167 173 normal normal JJ 174 181 T-cells t-cell NNS 182 184 in in IN 185 188 the the DT 189 197 presence presence NN 198 200 of of IN 201 212 interleukin interleukin NN 213 214 ( ( ( 214 219 IL)-2 il)-2 NN 220 222 in in FW 223 228 vitro vitro FW 228 229 . . . 230 234 STAT stat NN 235 237 is be VBZ 238 239 a a DT 240 246 family family NN 247 249 of of IN 250 263 transcription transcription NN 264 271 factors factor NNS 272 276 that that WDT 277 281 play play VBP 282 283 a a DT 284 291 pivotal pivotal JJ 292 296 role role NN 297 299 in in IN 300 316 cytokine-induced cytokine-induced JJ 317 326 functions function NNS 327 329 of of IN 330 331 a a DT 332 339 various various JJ 340 344 type type NN 345 347 of of IN 348 353 cells cell NNS 353 354 . . . 355 357 We we PRP 358 370 investigated investigate VBD 371 374 the the DT 375 386 involvement involvement NN 387 389 of of IN 390 395 STATs stat NNS 396 398 in in IN 399 402 the the DT 403 417 transformation transformation NN 418 420 of of IN 421 428 T-cells T-cell NNP 429 431 by by IN 432 438 HTLV-1 HTLV-1 NNP 438 439 . . . 440 458 HTLV-1-transformed htlv-1-transformed JJ 459 465 T-cell T-cell NNP 466 471 lines line NNS 472 481 expressed express VBD 482 488 higher high JJR 489 496 amounts amount NNS 497 499 of of IN 500 505 STAT1 STAT1 NNP 505 506 , , , 507 512 STAT3 STAT3 NNP 513 516 and and CC 517 522 STAT5 STAT5 NNP 523 526 RNA RNA NNP 527 530 and and CC 531 539 proteins protein NNS 540 544 than than IN 545 559 virus-negative virus-negative JJ 560 561 T t NN 562 567 cells cell NNS 567 568 . . . 569 572 The the DT 573 583 expression expression NN 584 586 of of IN 587 592 STAT1 STAT1 NNP 593 596 and and CC 597 602 STAT5 STAT5 NNP 603 605 in in IN 606 607 a a DT 608 613 human human JJ 614 620 T-cell t-cell NN 621 625 line line NN 626 629 was be VBD 630 637 induced induce VBN 638 640 by by IN 641 644 Tax Tax NNP 644 645 . . . 646 650 IL-2 il-2 NN 651 658 induced induce VBD 659 662 the the DT 663 666 DNA dna NN 667 674 binding binding NN 675 683 activity activity NN 684 686 of of IN 687 692 STAT3 STAT3 NNP 693 696 and and CC 697 702 STAT5 STAT5 NNP 703 705 of of IN 706 707 a a DT 708 726 HTLV-1-transformed htlv-1-transformed JJ 727 731 cell cell NN 732 736 line line NN 737 740 and and CC 741 745 then then RB 746 756 stimulated stimulate VBD 757 760 its its PRP$ 761 774 proliferation proliferation NN 774 775 . . . 776 778 In in IN 779 787 contrast contrast NN 787 788 , , , 789 793 IL-2 IL-2 NNP 794 797 did do VBD 798 805 neither neither CC 806 808 in in IN 809 810 a a DT 811 815 cell cell NN 816 820 line line NN 821 828 lacking lack VBG 829 834 STAT3 STAT3 NNP 835 838 and and CC 839 844 STAT5 STAT5 NNP 844 845 . . . 846 849 The the DT 850 860 expression expression NN 861 863 of of IN 864 869 STAT1 STAT1 NNP 869 870 , , , 871 876 STAT3 STAT3 NNP 877 880 and and CC 881 886 STAT5 STAT5 NNP 887 892 mRNAs mrna NNS 893 897 were be VBD 898 902 also also RB 903 910 induced induce VBN 911 913 by by IN 914 915 a a DT 916 922 T-cell t-cell NN 923 930 mitogen mitogen NN 931 933 in in IN 934 940 normal normal JJ 941 946 human human JJ 947 957 peripheral peripheral JJ 958 963 blood blood NN 964 975 mononuclear mononuclear JJ 976 981 cells cell NNS 981 982 . . . 983 986 Our our PRP$ 987 994 results result NNS 995 1002 suggest suggest VBP 1003 1007 that that IN 1008 1011 the the DT 1012 1021 induction induction NN 1022 1024 of of IN 1025 1030 STAT1 STAT1 NNP 1031 1034 and and CC 1035 1040 STAT5 STAT5 NNP 1041 1043 by by IN 1044 1047 Tax Tax NNP 1048 1056 enhances enhance VBZ 1057 1073 cytokine-induced cytokine-induced JJ 1074 1083 functions function NNS 1084 1086 of of IN 1087 1101 virus-infected virus-infected JJ 1102 1109 T-cells t-cell NNS 1109 1110 , , , 1111 1116 hence hence RB 1117 1120 the the DT 1121 1130 induction induction NN 1131 1134 may may MD 1135 1139 play play VB 1140 1141 a a DT 1142 1146 role role NN 1147 1149 in in IN 1150 1164 IL-2-dependent il-2-dependent JJ 1165 1179 transformation transformation NN 1180 1185 steps step NNS 1186 1188 of of IN 1189 1196 T-cells T-cell NNP 1197 1199 by by IN 1200 1206 HTLV-1 HTLV-1 NNP 1206 1207 . . .