0 6 Latent latent JJ 7 15 membrane membrane NN 16 23 protein protein NN 24 25 1 1 CD 26 28 of of IN 29 41 Epstein-Barr epstein-barr JJ 42 47 virus virus NN 48 57 interacts interact VBZ 58 62 with with IN 63 67 JAK3 jak3 NN 68 71 and and CC 72 81 activates activate VBZ 82 86 STAT stat NN 87 95 proteins protein NNS 95 96 . . . 98 104 Latent latent JJ 105 113 membrane membrane NN 114 121 protein protein NN 122 123 1 1 CD 124 125 ( ( ( 125 129 LMP1 lmp1 NN 129 130 ) ) ) 131 135 acts act VBZ 136 140 like like IN 141 142 a a DT 143 154 permanently permanently RB 155 164 activated activate VBN 165 173 receptor receptor NN 174 176 of of IN 177 180 the the DT 181 186 tumor tumor NN 187 195 necrosis necrosis NN 196 202 factor factor NN 203 204 ( ( ( 204 217 TNF)-receptor TNF)-receptor NNP 218 229 superfamily superfamily NN 230 233 and and CC 234 236 is be VBZ 237 247 absolutely absolutely RB 248 256 required require VBN 257 260 for for IN 261 262 B B NNP 263 267 cell cell NN 268 283 immortalization immortalization NN 284 286 by by IN 287 299 Epstein-Barr epstein-barr JJ 300 305 virus virus NN 305 306 . . . 307 316 Molecular molecular JJ 317 320 and and CC 321 332 biochemical biochemical JJ 333 343 approaches approach NNS 344 356 demonstrated demonstrate VBD 357 361 that that IN 362 366 LMP1 lmp1 NN 367 373 usurps usurp VBZ 374 382 cellular cellular JJ 383 392 signaling signaling NN 393 401 pathways pathway NNS 402 411 resulting result VBG 412 414 in in IN 415 418 the the DT 419 428 induction induction NN 429 431 of of IN 432 441 NF-kappaB NF-kappaB NNP 442 445 and and CC 446 450 AP-1 ap-1 NN 451 454 via via IN 455 458 two two CD 459 469 C-terminal c-terminal JJ 470 480 activating activate VBG 481 488 regions region NNS 488 489 . . . 490 492 We we PRP 493 504 demonstrate demonstrate VBP 505 509 here here RB 510 514 that that IN 515 516 a a DT 517 522 third third JJ 523 529 region region NN 530 542 encompassing encompass VBG 543 544 a a DT 545 552 proline proline NN 553 557 rich rich JJ 558 566 sequence sequence NN 567 573 within within IN 574 577 the the DT 578 580 33 33 CD 581 583 bp bp NN 584 594 repetitive repetitive JJ 595 602 stretch stretch NN 603 605 of of IN 606 610 LMP1 lmp1 NN 610 612 ’s 's POS 613 623 C-terminus C-terminus NNP 624 626 is be VBZ 627 635 required require VBN 636 639 for for IN 640 643 the the DT 644 654 activation activation NN 655 657 of of IN 658 663 Janus Janus NNP 664 670 kinase kinase NNP 671 672 3 3 CD 673 674 ( ( ( 674 678 JAK3 jak3 NN 678 679 ) ) ) 679 680 . . . 681 684 The the DT 685 696 interaction interaction NN 697 699 of of IN 700 704 LMP1 LMP1 NNP 705 708 and and CC 709 713 JAK3 JAK3 NNP 714 719 leads lead VBZ 720 722 to to TO 723 726 the the DT 727 735 enhanced enhance VBN 736 744 tyrosine tyrosine NN 745 770 auto/transphosphorylation auto/transphosphorylation NN 771 773 of of IN 774 778 JAK3 jak3 NN 779 785 within within IN 786 793 minutes minute NNS 794 799 after after IN 800 812 crosslinking crosslinke VBG 813 815 of of IN 816 817 a a DT 818 829 conditional conditional JJ 830 840 NGF-R:LMP1 ngf-r:lmp1 NN 841 848 chimera chimera NN 849 852 and and CC 853 855 is be VBZ 856 857 a a DT 858 870 prerequisite prerequisite NN 871 874 for for IN 875 878 the the DT 879 889 activation activation NN 890 892 of of IN 893 897 STAT STAT NNP 898 911 transcription transcription NN 912 919 factors factor NNS 919 920 . . . 921 926 These these DT 927 934 results result NNS 935 941 reveal reveal VBP 942 943 a a DT 944 949 novel novel JJ 950 960 activating activate VBG 961 967 region region NN 968 970 in in IN 971 974 the the DT 975 979 LMP1 LMP1 NNP 980 990 C-terminus C-terminus NNP 991 994 and and CC 995 1003 identify identify VBP 1004 1007 the the DT 1008 1016 JAK/STAT jak/stat NN 1017 1024 pathway pathway NN 1025 1027 as as IN 1028 1029 a a DT 1030 1036 target target NN 1037 1039 of of IN 1040 1044 this this DT 1045 1050 viral viral JJ 1051 1059 integral integral JJ 1060 1068 membrane membrane NN 1069 1076 protein protein NN 1077 1079 in in IN 1080 1081 B B NNP 1082 1087 cells cell NNS 1087 1088 . . .