0	6	20-Epi	20-epi	NN
7	16	analogues	analogue	NNS
17	19	of	of	IN
20	41	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN
42	44	D3	d3	NN
45	48	are	be	VBP
49	55	highly	highly	RB
56	62	potent	potent	JJ
63	71	inducers	inducer	NNS
72	74	of	of	IN
75	79	DRIP	DRIP	NNP
80	91	coactivator	coactivator	NN
92	99	complex	complex	NN
100	107	binding	bind	VBG
108	110	to	to	TO
111	114	the	the	DT
115	122	vitamin	vitamin	NN
123	125	D3	d3	NN
126	134	receptor	receptor	NN
134	135	.	.	.

137	158	1,25-Dihydroxyvitamin	1,25-Dihydroxyvitamin	NNP
159	161	D3	D3	NNP
162	163	(	(	(
163	175	1,25(OH)2D3)	1,25(OH)2D3)	NNP
176	181	plays	play	VBZ
182	183	a	a	DT
184	189	major	major	JJ
190	194	role	role	NN
195	197	in	in	IN
198	201	the	the	DT
202	213	stimulation	stimulation	NN
214	216	of	of	IN
217	221	bone	bone	NN
222	228	growth	growth	NN
228	229	,	,	,
230	244	mineralization	mineralization	NN
244	245	,	,	,
246	249	and	and	CC
250	260	intestinal	intestinal	JJ
261	268	calcium	calcium	NN
269	272	and	and	CC
273	282	phosphate	phosphate	NN
283	293	absorption	absorption	NN
293	294	;	;	:
295	297	it	it	PRP
298	302	also	also	RB
303	307	acts	act	VBZ
308	310	as	as	IN
311	312	a	a	DT
313	320	general	general	JJ
321	330	inhibitor	inhibitor	NN
331	333	of	of	IN
334	342	cellular	cellular	JJ
343	356	proliferation	proliferation	NN
356	357	.	.	.

358	365	Several	several	JJ
366	369	new	new	JJ
369	370	,	,	,
371	381	clinically	clinically	RB
382	390	relevant	relevant	JJ
391	400	compounds	compound	NNS
401	411	dissociate	dissociate	VBP
412	429	antiproliferative	antiproliferative	JJ
430	433	and	and	CC
434	442	calcemic	calcemic	JJ
443	453	activities	activity	NNS
454	456	of	of	IN
457	468	1,25(OH)2D3	1,25(OH)2D3	NNP
468	469	,	,	,
470	473	but	but	CC
474	477	the	the	DT
478	487	molecular	molecular	JJ
488	493	basis	basis	NN
494	497	for	for	IN
498	502	this	this	DT
503	506	has	have	VBZ
507	510	not	not	RB
511	515	been	be	VBN
516	523	clearly	clearly	RB
524	534	elucidated	elucidate	VBN
534	535	.	.	.

536	540	Here	here	RB
540	541	,	,	,
542	544	we	we	PRP
545	551	tested	test	VBD
552	559	whether	whether	IN
560	563	the	the	DT
564	571	potency	potency	NN
572	574	of	of	IN
575	578	one	one	CD
579	584	class	class	NN
585	587	of	of	IN
588	597	compounds	compound	NNS
597	598	,	,	,
599	605	20-epi	20-epi	NN
606	615	analogues	analogue	NNS
615	616	,	,	,
617	619	to	to	TO
620	626	induce	induce	VB
627	634	myeloid	myeloid	JJ
635	639	cell	cell	NN
640	655	differentiation	differentiation	NN
655	656	,	,	,
657	659	is	be	VBZ
660	667	because	because	IN
668	670	of	of	IN
671	677	direct	direct	JJ
678	687	molecular	molecular	JJ
688	695	effects	effect	NNS
696	698	on	on	IN
699	706	vitamin	vitamin	NN
707	708	D	D	NNP
709	717	receptor	receptor	NN
718	719	(	(	(
719	722	VDR	VDR	NNP
722	723	)	)	)
723	724	.	.	.

725	727	We	we	PRP
728	734	report	report	VBP
735	739	that	that	IN
740	743	two	two	CD
744	750	20-epi	20-epi	NN
751	760	analogues	analogue	NNS
760	761	,	,	,
762	768	MC1627	mc1627	NN
769	772	and	and	CC
773	779	MC1288	mc1288	NN
779	780	,	,	,
781	788	induced	induce	VBD
789	804	differentiation	differentiation	NN
805	808	and	and	CC
809	822	transcription	transcription	NN
823	825	of	of	IN
826	840	p21(Waf1,Cip1)	p21(Waf1,Cip1)	NNP
840	841	,	,	,
842	843	a	a	DT
844	847	key	key	JJ
848	851	VDR	vdr	NN
852	858	target	target	NN
859	863	gene	gene	NN
864	872	involved	involve	VBN
873	875	in	in	IN
876	882	growth	growth	NN
883	893	inhibition	inhibition	NN
893	894	,	,	,
895	897	at	at	IN
898	899	a	a	DT
900	913	concentration	concentration	NN
914	922	100-fold	100-fold	RB
923	928	lower	low	JJR
929	933	than	than	IN
934	938	that	that	DT
939	941	of	of	IN
942	953	1,25(OH)2D3	1,25(OH)2D3	NNP
953	954	.	.	.

955	957	We	we	PRP
958	966	compared	compare	VBD
967	971	this	this	DT
972	983	sensitivity	sensitivity	NN
984	986	to	to	TO
987	995	analogue	analogue	NN
996	1003	effects	effect	NNS
1004	1006	on	on	IN
1007	1010	VDR	VDR	NNP
1011	1022	interacting	interacting	NN
1023	1031	proteins	protein	NNS
1031	1032	:	:	:
1033	1036	RXR	RXR	NNP
1036	1037	,	,	,
1038	1044	GRIP-1	grip-1	NN
1044	1045	,	,	,
1046	1049	and	and	CC
1050	1057	DRIP205	drip205	NN
1057	1058	,	,	,
1059	1060	a	a	DT
1061	1068	subunit	subunit	NN
1069	1071	of	of	IN
1072	1075	the	the	DT
1076	1080	DRIP	DRIP	NNP
1081	1092	coactivator	coactivator	NN
1093	1100	complex	complex	NN
1100	1101	.	.	.

1102	1110	Compared	compare	VBN
1111	1115	with	with	IN
1116	1119	the	the	DT
1120	1131	interaction	interaction	NN
1132	1134	of	of	IN
1135	1138	VDR	VDR	NNP
1139	1143	with	with	IN
1144	1147	RXR	RXR	NNP
1148	1150	or	or	CC
1151	1157	GRIP-1	GRIP-1	NNP
1157	1158	,	,	,
1159	1162	the	the	DT
1163	1178	differentiation	differentiation	NN
1179	1192	dose-response	dose-response	NN
1193	1197	most	most	RBS
1198	1205	closely	closely	RB
1206	1216	correlated	correlate	VBN
1217	1219	to	to	TO
1220	1223	the	the	DT
1224	1240	ligand-dependent	ligand-dependent	JJ
1241	1252	recruitment	recruitment	NN
1253	1255	of	of	IN
1256	1259	the	the	DT
1260	1264	DRIP	DRIP	NNP
1265	1276	coactivator	coactivator	NN
1277	1284	complex	complex	NN
1285	1287	to	to	TO
1288	1291	VDR	VDR	NNP
1292	1295	and	and	CC
1296	1298	to	to	TO
1299	1302	the	the	DT
1303	1310	ability	ability	NN
1311	1313	of	of	IN
1314	1317	the	the	DT
1318	1326	receptor	receptor	NN
1327	1329	to	to	TO
1330	1338	activate	activate	VB
1339	1352	transcription	transcription	NN
1353	1355	in	in	IN
1356	1357	a	a	DT
1358	1367	cell-free	cell-free	JJ
1368	1374	system	system	NN
1374	1375	.	.	.

1376	1381	These	these	DT
1382	1389	results	result	NNS
1390	1397	provide	provide	VBP
1398	1408	compelling	compelling	JJ
1409	1414	links	link	NNS
1415	1422	between	between	IN
1423	1426	the	the	DT
1427	1437	efficiency	efficiency	NN
1438	1440	of	of	IN
1441	1444	the	the	DT
1445	1451	20-epi	20-epi	JJ
1452	1460	analogue	analogue	NN
1461	1463	in	in	IN
1464	1472	inducing	induce	VBG
1473	1481	VDR/DRIP	VDR/DRIP	NNP
1482	1494	interactions	interaction	NNS
1494	1495	,	,	,
1496	1511	transactivation	transactivation	NN
1512	1514	in	in	FW
1515	1520	vitro	vitro	FW
1520	1521	,	,	,
1522	1525	and	and	CC
1526	1529	its	its	PRP$
1530	1538	enhanced	enhance	VBN
1539	1546	ability	ability	NN
1547	1549	to	to	TO
1550	1556	induce	induce	VB
1557	1565	cellular	cellular	JJ
1566	1581	differentiation	differentiation	NN
1581	1582	.	.	.