0 8 CBP/p300 CBP/p300 NNP 9 19 integrates integrate VBZ 20 37 Raf/Rac-signaling raf/rac-signaling JJ 38 46 pathways pathway NNS 47 49 in in IN 50 53 the the DT 54 69 transcriptional transcriptional JJ 70 79 induction induction NN 80 82 of of IN 83 89 NF-ATc NF-ATc NNP 90 96 during during IN 97 98 T t NN 99 103 cell cell NN 104 114 activation activation NN 114 115 . . . 117 123 NF-ATc NF-ATc NNP 123 124 , , , 125 127 an an DT 128 137 inducibly inducibly RB 138 147 expressed express VBN 148 161 transcription transcription NN 162 168 factor factor NN 168 169 , , , 170 178 controls control VBZ 179 183 gene gene NN 184 194 expression expression NN 195 197 in in IN 198 199 T t NN 200 211 lymphocytes lymphocyte NNS 212 215 and and CC 216 230 cardiomyocytes cardiomyocyte NNS 230 231 . . . 232 234 We we PRP 235 239 show show VBP 240 244 here here RB 245 249 that that IN 250 253 the the DT 254 269 transcriptional transcriptional JJ 270 283 co-activators co-activator NNS 284 292 CBP/p300 cbp/p300 NN 293 297 bind bind VBP 298 300 to to TO 301 304 and and CC 305 312 control control VB 313 316 the the DT 317 325 activity activity NN 326 328 of of IN 329 332 the the DT 333 342 inducible inducible JJ 343 353 N-terminal n-terminal JJ 354 369 transactivation transactivation NN 370 376 domain domain NN 377 379 of of IN 380 386 NF-ATc NF-ATc NNP 386 387 , , , 388 393 TAD-A TAD-A NNP 393 394 . . . 395 402 Similar similar JJ 403 405 to to TO 406 409 the the DT 410 411 N N NNP 412 420 terminal terminal JJ 421 436 transactivation transactivation NN 437 443 domain domain NN 444 446 of of IN 447 452 c-Jun c-jun NN 452 453 , , , 454 459 TAD-A TAD-A NNP 460 462 is be VBZ 463 472 inducibly inducibly RB 473 487 phosphorylated phosphorylate VBN 487 488 , , , 489 492 but but CC 493 497 this this DT 498 513 phosphorylation phosphorylation NN 514 516 is be VBZ 517 528 dispensable dispensable JJ 529 532 for for IN 533 536 the the DT 537 548 interaction interaction NN 549 553 with with IN 554 562 CBP/p300 CBP/p300 NNP 562 563 . . . 564 576 Constitutive constitutive JJ 577 583 active active JJ 584 592 versions version NNS 593 595 of of IN 596 601 c-Raf c-raf NN 602 605 and and CC 606 609 Rac Rac NNP 610 625 synergistically synergistically RB 626 633 enhance enhance VBP 634 637 the the DT 638 655 CBP/p300-mediated cbp/p300-mediated JJ 656 664 increase increase NN 665 667 of of IN 668 673 TAD-A TAD-A NNP 674 682 activity activity NN 682 683 , , , 684 694 indicating indicate VBG 695 698 the the DT 699 708 important important JJ 709 713 role role NN 714 722 CBP/p300 cbp/p300 NN 723 728 plays play VBZ 729 731 in in IN 732 735 the the DT 736 747 integration integration NN 748 750 of of IN 751 752 T t NN 753 757 cell cell NN 758 768 activation activation NN 769 776 signals signal NNS 776 777 . . . 778 783 Since since IN 784 785 a a DT 786 794 mutation mutation NN 795 797 of of IN 798 801 CBP CBP NNP 802 812 abolishing abolish VBG 813 816 HAT hat NN 817 825 activity activity NN 826 828 is be VBZ 829 835 almost almost RB 836 838 as as RB 839 845 active active JJ 846 848 as as IN 849 858 wild-type wild-type JJ 859 862 CBP CBP NNP 863 865 in in IN 866 867 T t NN 868 873 cells cell NNS 873 874 , , , 875 884 functions function NNS 885 887 of of IN 888 896 CBP/p300 cbp/p300 NN 897 902 other other JJ 903 907 than than IN 908 915 histone histone NN 916 927 acetylation acetylation NN 928 934 appear appear VBP 935 937 to to TO 938 945 control control VB 946 949 the the DT 950 965 NF-AT-dependent nf-at-dependent JJ 966 979 transcription transcription NN 980 982 in in IN 983 984 T t NN 985 990 cells cell NNS 990 991 . . .