0 7 Cutting cutting JJ 8 12 edge edge NN 12 13 : : : 14 24 expression expression NN 25 27 of of IN 28 31 the the DT 32 34 NF nf NN 35 37 of of IN 38 47 activated activate VBN 48 49 T t NN 50 55 cells cell NNS 56 58 in in IN 59 70 eosinophils eosinophil NNS 70 71 : : : 72 82 regulation regulation NN 83 85 by by IN 86 90 IL-4 il-4 NN 91 94 and and CC 95 99 IL-5 il-5 NN 99 100 . . . 102 104 We we PRP 105 111 report report VBP 112 116 that that IN 117 123 NF-AT1 NF-AT1 NNP 124 127 and and CC 128 134 NF-AT4 NF-AT4 NNP 135 138 are be VBP 139 148 expressed express VBN 149 164 cytoplasmically cytoplasmically RB 165 167 in in IN 168 175 resting rest VBG 176 187 eosinophils eosinophil NNS 187 188 , , , 189 196 whereas whereas IN 197 203 NF-AT2 NF-AT2 NNP 204 207 and and CC 208 214 NF-AT3 NF-AT3 NNP 215 219 have have VBP 220 223 not not RB 224 228 been be VBN 229 233 seen see VBN 233 234 . . . 235 243 Likewise likewise RB 243 244 , , , 245 251 NF-AT1 NF-AT1 NNP 252 256 mRNA mRNA NNP 257 260 and and CC 261 267 NF-AT4 NF-AT4 NNP 268 272 mRNA mRNA NNP 273 277 have have VBP 278 282 been be VBN 283 291 detected detect VBN 292 294 in in IN 295 302 resting rest VBG 303 314 eosinophils eosinophil NNS 314 315 , , , 316 319 and and CC 320 325 their their PRP$ 326 332 levels level NNS 333 336 can can MD 337 339 be be VB 340 353 significantly significantly RB 354 366 up-regulated up-regulate VBN 367 369 by by IN 370 373 the the DT 374 388 Th2-associated th2-associated JJ 389 398 cytokines cytokine NNS 399 403 IL-4 il-4 NN 404 407 and and CC 408 412 IL-5 il-5 NN 412 413 . . . 414 419 There there EX 420 422 is be VBZ 423 425 no no DT 426 436 detectable detectable JJ 437 442 NF-AT NF-AT NNP 443 450 protein protein NN 451 461 expression expression NN 462 464 in in IN 465 468 the the DT 469 475 nuclei nucleus NNS 476 478 of of IN 479 486 resting rest VBG 487 498 eosinophils eosinophil NNS 498 499 . . . 500 507 However however RB 508 514 NF-ATs NF-AT NNPS 515 521 appear appear VBP 522 524 in in IN 525 528 the the DT 529 535 nuclei nucleus NNS 536 538 of of IN 539 544 IL-4- IL-4- NNP 544 545 , , , 546 551 IL-5- il-5- NN 551 552 , , , 553 555 or or CC 556 576 ionomycin-stimulated ionomycin-stimulated JJ 577 588 eosinophils eosinophil NNS 588 589 . . . 590 594 Only only RB 595 601 NF-AT1 nf-at1 NN 602 605 and and CC 606 612 NF-AT4 nf-at4 NN 612 613 , , , 614 617 but but CC 618 621 not not RB 622 628 NF-AT2 nf-at2 NN 629 632 and and CC 633 639 NF-AT3 NF-AT3 NNP 639 640 , , , 641 645 have have VBP 646 658 translocated translocate VBN 659 663 into into IN 664 667 the the DT 668 674 nuclei nucleus NNS 675 677 in in IN 678 683 IL-4- il-4- NN 684 686 or or CC 687 702 IL-5-stimulated il-5-stimulated JJ 703 714 eosinophils eosinophil NNS 714 715 . . . 716 721 These these DT 722 730 findings finding NNS 731 740 delineate delineate VBP 741 742 a a DT 743 748 novel novel JJ 749 756 pathway pathway NN 757 759 in in IN 760 763 the the DT 764 772 cytokine cytokine NN 773 780 network network NN 781 783 in in IN 784 789 which which WDT 790 793 Th2 th2 NN 794 805 lymphocytes lymphocyte NNS 806 807 “ `` `` 807 814 control control NN 814 815 ” '' '' 816 827 eosinophils eosinophil NNS 828 831 via via IN 832 835 the the DT 836 843 release release NN 844 846 of of IN 847 851 IL-4 il-4 NN 852 855 and and CC 856 860 IL-5 il-5 NN 860 861 , , , 862 865 and and CC 866 876 activation activation NN 877 879 of of IN 880 885 NF-AT NF-AT NNP 886 888 in in IN 889 900 eosinophils eosinophil NNS 900 901 . . . 902 905 The the DT 906 914 findings finding NNS 915 919 also also RB 920 927 suggest suggest VBP 928 932 that that IN 933 934 a a DT 935 940 later later JJ 941 949 feedback feedback NN 950 951 “ `` `` 951 958 talking talk VBG 958 959 ” '' '' 960 963 may may MD 964 969 exist exist VB 970 977 between between IN 978 989 eosinophils eosinophil NNS 990 993 and and CC 994 997 Th2 th2 NN 998 1009 lymphocytes lymphocyte NNS 1009 1010 . . .