0 5 Block Block NNP 6 8 of of IN 9 21 granulocytic granulocytic JJ 22 37 differentiation differentiation NN 38 40 of of IN 41 47 32Dcl3 32dcl3 NN 48 53 cells cell NNS 54 56 by by IN 57 71 AML1/ETO(MTG8) AML1/ETO(MTG8) NNP 72 75 but but CC 76 79 not not RB 80 82 by by IN 83 89 highly highly RB 90 99 expressed express VBN 100 105 Bcl-2 bcl-2 NN 105 106 . . . 108 111 The the DT 112 120 chimeric chimeric JJ 121 125 gene gene NN 125 126 , , , 127 135 AML1/ETO AML1/ETO NNP 136 137 ( ( ( 137 141 MTG8 MTG8 NNP 141 142 ) ) ) 142 143 , , , 144 153 generated generate VBN 154 156 in in IN 157 164 t(8;21) t(8;21) NN 165 170 acute acute JJ 171 178 myeloid myeloid JJ 179 187 leukemia leukemia NN 188 196 enhances enhance VBZ 197 200 the the DT 201 211 expression expression NN 212 214 of of IN 215 220 Bcl-2 bcl-2 NN 220 221 . . . 222 224 To to TO 225 233 evaluate evaluate VB 234 241 whether whether IN 242 246 this this DT 247 258 enhancement enhancement NN 259 261 is be VBZ 262 265 the the DT 266 273 primary primary JJ 274 278 role role NN 279 281 of of IN 282 290 AML1/ETO AML1/ETO NNP 291 293 in in IN 294 308 leukemogenesis leukemogenesis NN 308 309 , , , 310 317 effects effect NNS 318 320 of of IN 321 336 over-expression over-expression NN 337 339 of of IN 340 345 Bcl-2 bcl-2 NN 346 348 in in IN 349 352 the the DT 353 359 murine murine JJ 360 367 myeloid myeloid JJ 368 377 precursor precursor NN 378 382 cell cell NN 383 387 line line NN 387 388 , , , 389 395 32Dcl3 32Dcl3 NNP 395 396 , , , 397 401 were be VBD 402 410 examined examine VBN 410 411 . . . 412 416 When when WRB 417 423 32Dcl3 32dcl3 NN 424 429 cells cell NNS 430 440 expressing express VBG 441 450 exogenous exogenous JJ 451 456 Bcl-2 bcl-2 NN 457 461 were be VBD 462 469 induced induce VBN 470 472 to to TO 473 486 differentiate differentiate VB 486 487 , , , 488 491 the the DT 492 497 onset onset NN 498 500 of of IN 501 514 morphological morphological JJ 515 530 differentiation differentiation NN 531 534 was be VBD 535 542 delayed delay VBN 542 543 . . . 544 551 However however RB 551 552 , , , 553 557 even even RB 558 561 the the DT 562 567 cells cell NNS 568 578 expressing express VBG 579 583 very very RB 584 588 high high JJ 589 595 levels level NNS 596 598 of of IN 599 608 exogenous exogenous JJ 609 614 Bcl-2 bcl-2 NN 615 625 eventually eventually RB 626 635 underwent undergo VBD 636 651 differentiation differentiation NN 652 659 without without IN 660 661 a a DT 662 673 significant significant JJ 674 682 decrease decrease NN 683 685 in in IN 686 689 the the DT 690 699 synthesis synthesis NN 700 702 of of IN 703 708 Bcl-2 bcl-2 NN 708 709 . . . 710 712 On on IN 713 716 the the DT 717 725 contrary contrary NN 725 726 , , , 727 733 32Dcl3 32dcl3 NN 734 739 cells cell NNS 740 746 stably stably RB 747 757 expressing express VBG 758 766 AML1/ETO aml1/eto NN 767 771 were be VBD 772 782 completely completely RB 783 792 resistant resistant JJ 793 795 to to TO 796 811 differentiation differentiation NN 812 815 and and CC 816 825 continued continue VBD 826 828 to to TO 829 833 grow grow VB 834 836 in in IN 837 840 the the DT 841 849 presence presence NN 850 852 of of IN 853 858 G-CSF G-CSF NNP 858 859 . . . 860 865 These these DT 866 873 results result NNS 874 877 are be VBP 878 888 consistent consistent JJ 889 893 with with IN 894 897 the the DT 898 912 interpretation interpretation NN 913 917 that that IN 918 929 stimulation stimulation NN 930 932 of of IN 933 938 Bcl-2 bcl-2 NN 939 949 expression expression NN 950 952 is be VBZ 953 956 not not RB 957 960 the the DT 961 968 primary primary JJ 969 975 target target NN 976 978 of of IN 979 987 AML1/ETO AML1/ETO NNP 987 988 . . .