0 10 Expression expression NN 11 13 of of IN 14 19 c-fos c-fos NN 19 20 , , , 21 26 c-jun c-jun NN 27 30 and and CC 31 34 jun jun NN 35 36 B b NN 37 39 in in IN 40 50 peripheral peripheral JJ 51 56 blood blood NN 57 68 lymphocytes lymphocyte NNS 69 73 from from IN 74 79 young young JJ 80 83 and and CC 84 91 elderly elderly JJ 92 98 adults adult NNS 98 99 . . . 101 104 The the DT 105 115 expression expression NN 116 118 of of IN 119 124 c-fos c-fos NN 124 125 , , , 126 131 c-jun c-jun NN 132 135 and and CC 136 139 jun jun NN 140 141 B B NNP 142 157 proto-oncogenes proto-oncogene NNS 158 161 was be VBD 162 169 studied study VBN 170 172 in in IN 173 191 phytohemagglutinin phytohemagglutinin NN 192 193 ( ( ( 193 196 PHA PHA NNP 196 197 ) ) ) 198 207 activated activate VBN 208 218 peripheral peripheral JJ 219 224 blood blood NN 225 236 lymphocytes lymphocyte NNS 237 238 ( ( ( 238 241 PBL PBL NNP 241 242 ) ) ) 243 247 from from IN 248 253 young young JJ 254 257 and and CC 258 262 aged aged JJ 263 269 humans human NNS 269 270 . . . 271 279 Specific specific JJ 280 285 mRNAs mrna NNS 286 289 for for IN 290 295 c-fos c-fos NN 296 299 and and CC 300 305 c-jun c-jun NN 306 310 were be VBD 311 321 detectable detectable JJ 322 328 within within IN 329 331 30 30 CD 332 335 min min NN 336 341 after after IN 342 346 cell cell NN 347 357 activation activation NN 358 361 and and CC 362 369 reached reach VBD 370 377 maximal maximal JJ 378 384 levels level NNS 385 391 within within IN 392 393 2 2 CD 394 395 h h NN 395 396 . . . 397 401 Both both CC 402 407 c-fos c-fos NN 408 411 and and CC 412 415 jun jun NN 416 417 B B NNP 418 423 mRNAs mrna NNS 424 433 decreased decrease VBD 434 436 to to TO 437 451 pre-activation pre-activation JJ 452 458 levels level NNS 459 465 within within IN 466 467 6 6 CD 468 469 h h NN 469 470 , , , 471 476 while while IN 477 482 c-jun c-jun NN 483 487 mRNA mRNA NNP 488 496 remained remain VBD 497 505 elevated elevated JJ 505 506 . . . 507 509 In in IN 510 523 PHA-activated pha-activated JJ 524 527 PBL PBL NNP 527 528 , , , 529 531 no no DT 532 543 age-related age-related JJ 544 555 differences difference NNS 556 560 were be VBD 561 569 observed observe VBN 570 572 in in IN 573 578 c-fos c-fos NN 579 581 or or CC 582 585 jun jun NN 586 587 B B NNP 588 592 mRNA mRNA NNP 593 603 expression expression NN 603 604 . . . 605 612 However however RB 612 613 , , , 614 619 c-jun c-jun NN 620 624 mRNA mrna NN 625 631 levels level NNS 632 641 decreased decrease VBD 642 655 significantly significantly RB 656 657 ( ( ( 657 661 1.73 1.73 CD 662 665 +/- +/- SYM 666 670 0.08 0.08 CD 671 674 vs. vs. IN 675 679 1.16 1.16 CD 680 683 +/- +/- SYM 684 688 0.09 0.09 CD 689 698 arbitrary arbitrary JJ 699 704 units unit NNS 704 705 , , , 706 707 P p NN 708 709 < < SYM 710 714 0.01 0.01 CD 714 715 , , , 716 721 young young JJ 722 725 vs. vs. CC 726 729 old old JJ 729 730 ) ) ) 731 733 in in IN 734 737 PBL PBL NNP 738 742 from from IN 743 750 elderly elderly JJ 751 762 individuals individual NNS 763 772 activated activate VBN 773 777 with with IN 778 781 PHA PHA NNP 781 782 . . . 783 790 Because because IN 791 799 previous previous JJ 800 804 work work NN 805 808 has have VBZ 809 821 demonstrated demonstrate VBN 822 826 that that IN 827 828 T t NN 829 834 cells cell NNS 835 839 from from IN 840 847 elderly elderly JJ 848 859 individuals individual NNS 860 863 may may MD 864 871 display display VB 872 878 normal normal JJ 879 892 proliferative proliferative JJ 893 902 responses response NNS 903 907 when when WRB 908 917 activated activate VBN 918 921 via via IN 922 925 the the DT 926 934 anti-CD2 anti-cd2 JJ 935 942 pathway pathway NN 942 943 , , , 944 949 c-jun c-jun NN 950 953 and and CC 954 957 jun jun NN 958 959 B B NNP 960 964 mRNA mRNA NNP 965 975 expression expression NN 976 979 was be VBD 980 984 also also RB 985 992 studied study VBN 993 995 in in IN 996 1014 anti-CD2-activated anti-cd2-activated JJ 1015 1023 purified purify VBN 1024 1025 T t NN 1026 1031 cells cell NNS 1031 1032 . . . 1033 1035 No no DT 1036 1047 age-related age-related JJ 1048 1059 differences difference NNS 1060 1064 were be VBD 1065 1070 found find VBN 1071 1073 in in IN 1074 1077 the the DT 1078 1088 expression expression NN 1089 1091 of of IN 1092 1098 either either DT 1099 1101 of of IN 1102 1107 these these DT 1108 1111 two two CD 1112 1127 proto-oncogenes proto-oncogene NNS 1128 1130 by by IN 1131 1139 anti-CD2 anti-cd2 JJ 1140 1149 activated activate VBN 1150 1151 T t NN 1152 1157 cells cell NNS 1157 1158 . . . 1159 1164 These these DT 1165 1172 results result NNS 1173 1180 suggest suggest VBP 1181 1185 that that IN 1186 1189 the the DT 1190 1199 decreased decrease VBN 1200 1204 IL-2 il-2 NN 1205 1215 production production NN 1216 1219 and and CC 1220 1233 proliferative proliferative JJ 1234 1242 response response NN 1243 1252 displayed display VBN 1253 1255 by by IN 1256 1269 PHA-activated pha-activated JJ 1270 1273 PBL PBL NNP 1274 1278 from from IN 1279 1286 elderly elderly JJ 1287 1293 adults adult NNS 1294 1297 may may MD 1298 1300 be be VB 1301 1308 related related JJ 1309 1311 to to TO 1312 1323 age-related age-related JJ 1324 1331 changes change NNS 1332 1334 in in IN 1335 1340 c-jun c-jun NN 1341 1345 mRNA mrna NN 1346 1356 expression expression NN 1357 1360 and and CC 1361 1363 in in IN 1364 1367 the the DT 1368 1373 ratio ratio NN 1374 1376 of of IN 1377 1382 c-fos c-fos NN 1383 1385 to to TO 1386 1391 c-jun c-jun NN 1392 1396 mRNA mrna NN 1396 1397 . . .