0	9	Mutations	mutation	NNS
10	12	in	in	IN
13	16	the	the	DT
17	22	Pit-1	pit-1	NN
23	27	gene	gene	NN
28	30	in	in	IN
31	39	children	child	NNS
40	44	with	with	IN
45	53	combined	combined	JJ
54	63	pituitary	pituitary	JJ
64	71	hormone	hormone	NN
72	82	deficiency	deficiency	NN
82	83	.	.	.

85	90	Pit-1	Pit-1	NNP
91	93	is	be	VBZ
94	95	a	a	DT
96	114	pituitary-specific	pituitary-specific	JJ
115	128	transcription	transcription	NN
129	135	factor	factor	NN
136	140	that	that	WDT
141	146	binds	bind	VBZ
147	149	to	to	TO
150	153	and	and	CC
154	168	transactivates	transactivate	VBZ
169	178	promoters	promoter	NNS
179	181	of	of	IN
182	188	growth	growth	NN
189	196	hormone	hormone	NN
197	200	and	and	CC
201	210	prolactin	prolactin	NN
211	216	genes	gene	NNS
216	217	.	.	.

218	220	In	in	IN
221	226	three	three	CD
227	236	unrelated	unrelated	JJ
237	245	Japanese	japanese	JJ
246	254	children	child	NNS
255	259	with	with	IN
260	268	combined	combined	JJ
269	278	pituitary	pituitary	JJ
279	286	hormone	hormone	NN
287	297	deficiency	deficiency	NN
297	298	,	,	,
299	301	we	we	PRP
302	312	identified	identify	VBD
313	318	three	three	CD
319	324	point	point	NN
325	334	mutations	mutation	NNS
335	337	in	in	IN
338	341	the	the	DT
342	347	Pit-1	pit-1	NN
348	352	gene	gene	NN
352	353	,	,	,
354	362	Pro24Leu	Pro24Leu	NNP
362	363	,	,	,
364	373	Arg143Gln	Arg143Gln	NNP
373	374	,	,	,
375	378	and	and	CC
379	388	Arg271Trp	Arg271Trp	NNP
388	389	,	,	,
390	397	located	located	JJ
398	400	on	on	IN
401	404	the	the	DT
405	410	major	major	JJ
411	426	transactivation	transactivation	NN
427	433	region	region	NN
433	434	,	,	,
435	447	POU-specific	pou-specific	JJ
448	454	domain	domain	NN
454	455	,	,	,
456	459	and	and	CC
460	475	POU-homeodomain	POU-homeodomain	NNP
475	476	,	,	,
477	489	respectively	respectively	RB
489	490	.	.	.