0 6 HTLV-1 HTLV-1 NNP 7 10 Tax Tax NNP 11 18 induces induce VBZ 19 29 expression expression NN 30 32 of of IN 33 40 various various JJ 41 50 immediate immediate JJ 51 56 early early JJ 57 62 serum serum NN 63 73 responsive responsive JJ 74 79 genes gene NNS 79 80 . . . 82 87 Human human JJ 88 94 T-cell T-cell NNP 95 103 leukemia leukemia NN 104 109 virus virus NN 110 114 type type NN 115 116 1 1 CD 117 118 ( ( ( 118 124 HTLV-1 htlv-1 NN 124 125 ) ) ) 126 128 is be VBZ 129 131 an an DT 132 143 etiological etiological JJ 144 149 agent agent NN 150 152 of of IN 153 158 adult adult JJ 159 165 T-cell t-cell NN 166 174 leukemia leukemia NN 175 176 ( ( ( 176 179 ATL ATL NNP 179 180 ) ) ) 180 181 . . . 182 184 We we PRP 185 191 showed show VBD 192 196 here here RB 197 199 by by IN 200 214 mobility-shift mobility-shift NN 215 220 assay assay NN 221 225 that that IN 226 232 T-cell t-cell NN 233 238 lines line NNS 239 250 transformed transform VBN 251 255 with with IN 256 259 the the DT 260 265 virus virus NN 266 275 contained contain VBD 276 280 high high JJ 281 287 levels level NNS 288 290 of of IN 291 295 AP-1 ap-1 NN 296 306 activities activity NNS 306 307 . . . 308 318 Consistent consistent JJ 319 323 with with IN 324 328 this this DT 329 335 result result NN 335 336 , , , 337 342 these these DT 343 347 cell cell NN 348 353 lines line NNS 354 363 expressed express VBD 364 373 increased increase VBN 374 380 levels level NNS 381 383 of of IN 384 389 mRNAs mrna NNS 390 398 encoding encode VBG 399 402 the the DT 403 407 AP-1 ap-1 NN 408 416 proteins protein NNS 416 417 , , , 418 423 c-Fos c-fos NN 423 424 , , , 425 430 Fra-1 fra-1 NN 430 431 , , , 432 437 c-Jun c-jun NN 437 438 , , , 439 443 JunB JunB NNP 443 444 , , , 445 448 and and CC 449 453 JunD JunD NNP 453 454 . . . 455 465 Previously previously RB 465 466 , , , 467 480 transcription transcription NN 481 483 of of IN 484 487 the the DT 488 493 c-fos c-fos NN 494 498 gene gene NN 499 502 has have VBZ 503 507 been be VBN 508 516 reported report VBN 517 519 to to TO 520 522 be be VB 523 537 transactivated transactivate VBN 538 540 by by IN 541 544 the the DT 545 550 viral viral JJ 551 564 transcription transcription NN 565 571 factor factor NN 571 572 , , , 573 577 Tax1 Tax1 NNP 577 578 . . . 579 581 By by IN 582 587 using use VBG 588 591 the the DT 592 597 human human JJ 598 604 T-cell t-cell NN 605 609 line line NN 610 611 ( ( ( 611 616 JPX-9 JPX-9 NNP 616 617 ) ) ) 617 618 , , , 619 621 in in IN 622 627 which which WDT 628 638 expression expression NN 639 641 of of IN 642 645 the the DT 646 650 Tax1 tax1 NN 651 653 is be VBZ 654 663 inducible inducible JJ 663 664 , , , 665 667 we we PRP 668 674 showed show VBD 675 679 that that IN 680 690 expression expression NN 691 693 of of IN 694 699 mRNAs mrna NNS 700 703 for for IN 704 709 Fra-1 fra-1 NN 709 710 , , , 711 716 c-Jun c-jun NN 716 717 , , , 718 721 and and CC 722 726 JunD JunD NNP 727 730 was be VBD 731 735 also also RB 736 750 transactivated transactivate VBN 751 753 by by IN 754 758 Tax1 Tax1 NNP 758 759 . . . 760 768 Moreover moreover RB 768 769 , , , 770 774 Tax1 tax1 NN 775 784 activated activate VBD 785 795 expression expression NN 796 798 of of IN 799 802 two two CD 803 808 other other JJ 809 822 transcription transcription NN 823 830 factors factor NNS 831 837 having have VBG 838 842 zinc zinc NN 843 849 finger finger NN 850 856 motifs motif NNS 856 857 , , , 858 863 Egr-1 egr-1 NN 864 867 and and CC 868 873 Egr-2 egr-2 NN 873 874 , , , 875 877 in in IN 878 881 the the DT 882 886 same same JJ 887 892 cells cell NNS 892 893 . . . 894 897 The the DT 898 912 Tax1-inducible tax1-inducible JJ 913 926 transcription transcription NN 927 934 factors factor NNS 935 945 identified identify VBN 946 950 here here RB 951 954 are be VBP 955 962 encoded encode VBN 963 965 by by IN 966 969 the the DT 970 977 members member NNS 978 980 of of IN 981 990 immediate immediate JJ 991 996 early early JJ 997 1002 genes gene NNS 1003 1008 under under IN 1009 1012 the the DT 1013 1020 control control NN 1021 1023 of of IN 1024 1030 growth growth NN 1031 1038 signals signal NNS 1038 1039 . . . 1040 1044 Thus thus RB 1044 1045 , , , 1046 1050 Tax1 Tax1 NNP 1051 1054 was be VBD 1055 1064 suggested suggest VBN 1065 1067 to to TO 1068 1075 replace replace VB 1076 1082 growth growth NN 1083 1090 signals signal NNS 1090 1091 , , , 1092 1094 at at IN 1095 1100 least least JJS 1101 1103 in in IN 1104 1108 part part NN 1108 1109 , , , 1110 1112 by by IN 1113 1117 this this DT 1118 1127 mechanism mechanism NN 1127 1128 . . .