0	3	The	the	DT
4	13	rhombotin	rhombotin	NN
14	20	family	family	NN
21	23	of	of	IN
24	37	cysteine-rich	cysteine-rich	JJ
38	48	LIM-domain	LIM-domain	NNP
49	58	oncogenes	oncogene	NNS
58	59	:	:	:
60	68	distinct	distinct	JJ
69	76	members	member	NNS
77	80	are	be	VBP
81	89	involved	involve	VBN
90	92	in	in	IN
93	99	T-cell	t-cell	NN
100	114	translocations	translocation	NNS
115	117	to	to	TO
118	123	human	human	JJ
124	135	chromosomes	chromosome	NNS
136	141	11p15	11p15	NN
142	145	and	and	CC
146	151	11p13	11p13	NN
151	152	.	.	.

154	155	A	a	DT
156	167	chromosomal	chromosomal	JJ
168	181	translocation	translocation	NN
182	184	in	in	IN
185	186	a	a	DT
187	193	T-cell	t-cell	NN
194	202	leukemia	leukemia	NN
203	212	involving	involve	VBG
213	216	the	the	DT
217	222	short	short	JJ
223	226	arm	arm	NN
227	229	of	of	IN
230	235	human	human	JJ
236	246	chromosome	chromosome	NN
247	249	11	11	CD
250	252	at	at	IN
253	257	band	band	NN
258	263	11p15	11p15	CD
264	272	disrupts	disrupt	VBZ
273	276	the	the	DT
277	286	rhombotin	rhombotin	NN
287	291	gene	gene	NN
291	292	.	.	.

293	297	This	this	DT
298	302	gene	gene	NN
303	310	encodes	encode	VBZ
311	312	a	a	DT
313	320	protein	protein	NN
321	325	with	with	IN
326	336	duplicated	duplicated	JJ
337	350	cysteine-rich	cysteine-rich	JJ
351	358	regions	region	NNS
359	365	called	call	VBN
366	369	LIM	LIM	NNP
370	377	domains	domain	NNS
377	378	,	,	,
379	384	which	which	WDT
385	389	show	show	VBP
390	398	homology	homology	NN
399	401	to	to	TO
402	414	zinc-binding	zinc-binding	JJ
415	423	proteins	protein	NNS
424	427	and	and	CC
428	430	to	to	TO
431	442	iron-sulfur	iron-sulfur	NN
443	450	centers	center	NNS
451	453	of	of	IN
454	465	ferredoxins	ferredoxin	NNS
465	466	.	.	.

467	470	Two	two	CD
471	481	homologues	homologue	NNS
482	484	of	of	IN
485	488	the	the	DT
489	498	rhombotin	rhombotin	NN
499	503	gene	gene	NN
504	508	have	have	VBP
509	512	now	now	RB
513	517	been	be	VBN
518	526	isolated	isolate	VBN
526	527	.	.	.

528	531	One	one	CD
532	534	of	of	IN
535	540	these	these	DT
540	541	,	,	,
542	552	designated	designate	VBN
553	559	Rhom-2	rhom-2	NN
559	560	,	,	,
561	563	is	be	VBZ
564	571	located	located	JJ
572	574	on	on	IN
575	580	human	human	JJ
581	591	chromosome	chromosome	NN
592	594	11	11	CD
595	597	at	at	IN
598	602	band	band	NN
603	608	11p13	11p13	NN
608	609	,	,	,
610	615	where	where	WRB
616	617	a	a	DT
618	625	cluster	cluster	NN
626	628	of	of	IN
629	635	T-cell	t-cell	NN
636	653	leukemia-specific	leukemia-specific	JJ
654	668	translocations	translocation	NNS
669	674	occur	occur	VBP
674	675	;	;	:
676	679	all	all	DT
680	693	translocation	translocation	NN
694	705	breakpoints	breakpoint	NNS
706	708	at	at	IN
709	714	11p13	11p13	NN
715	718	are	be	VBP
719	727	upstream	upstream	JJ
728	730	of	of	IN
731	734	the	the	DT
735	741	Rhom-2	rhom-2	NN
742	746	gene	gene	NN
746	747	.	.	.

748	753	Human	human	JJ
754	757	and	and	CC
758	763	mouse	mouse	NN
764	770	Rhom-2	rhom-2	NN
771	774	are	be	VBP
775	781	highly	highly	RB
782	791	conserved	conserve	VBN
792	795	and	and	CC
795	796	,	,	,
797	801	like	like	IN
802	811	rhombotin	rhombotin	NN
811	812	,	,	,
813	819	encode	encode	VBP
820	823	two	two	CD
824	830	tandem	tandem	JJ
831	844	cysteine-rich	cysteine-rich	JJ
845	848	LIM	LIM	NNP
849	856	domains	domain	NNS
856	857	.	.	.

858	864	Rhom-2	Rhom-2	NNP
865	869	mRNA	mRNA	NNP
870	872	is	be	VBZ
873	882	expressed	express	VBN
883	885	in	in	IN
886	891	early	early	JJ
892	897	mouse	mouse	NN
898	909	development	development	NN
910	912	in	in	IN
913	920	central	central	JJ
921	928	nervous	nervous	JJ
929	935	system	system	NN
935	936	,	,	,
937	941	lung	lung	NN
941	942	,	,	,
943	949	kidney	kidney	NN
949	950	,	,	,
951	956	liver	liver	NN
956	957	,	,	,
958	961	and	and	CC
962	968	spleen	spleen	NN
969	972	but	but	CC
973	977	only	only	RB
978	982	very	very	RB
983	986	low	low	JJ
987	993	levels	level	NNS
994	999	occur	occur	VBP
1000	1002	in	in	IN
1003	1009	thymus	thymus	NN
1009	1010	.	.	.

1011	1014	The	the	DT
1015	1020	other	other	JJ
1021	1025	gene	gene	NN
1025	1026	,	,	,
1027	1037	designated	designate	VBN
1038	1044	Rhom-3	Rhom-3	NNP
1044	1045	,	,	,
1046	1048	is	be	VBZ
1049	1052	not	not	RB
1053	1055	on	on	IN
1056	1066	chromosome	chromosome	NN
1067	1069	11	11	CD
1070	1073	but	but	CC
1074	1078	also	also	RB
1079	1086	retains	retain	VBZ
1087	1095	homology	homology	NN
1096	1098	to	to	TO
1099	1102	the	the	DT
1103	1106	LIM	LIM	NNP
1107	1113	domain	domain	NN
1114	1116	of	of	IN
1117	1126	rhombotin	rhombotin	NN
1126	1127	.	.	.

1128	1133	Since	since	IN
1134	1137	the	the	DT
1138	1144	Rhom-2	rhom-2	NN
1145	1149	gene	gene	NN
1150	1152	is	be	VBZ
1153	1157	such	such	JJ
1158	1159	a	a	DT
1160	1166	common	common	JJ
1167	1171	site	site	NN
1172	1174	of	of	IN
1175	1186	chromosomal	chromosomal	JJ
1187	1193	damage	damage	NN
1194	1196	in	in	IN
1197	1203	T-cell	t-cell	NN
1204	1210	tumors	tumor	NNS
1210	1211	,	,	,
1212	1215	the	the	DT
1216	1227	consistency	consistency	NN
1228	1230	of	of	IN
1231	1245	translocations	translocation	NNS
1246	1250	near	near	IN
1251	1254	the	the	DT
1255	1264	rhombotin	rhombotin	NN
1265	1269	gene	gene	NN
1270	1273	was	be	VBD
1274	1281	further	further	RB
1282	1290	examined	examine	VBN
1290	1291	.	.	.

1292	1293	A	a	DT
1294	1300	second	second	JJ
1301	1314	translocation	translocation	NN
1315	1323	adjacent	adjacent	JJ
1324	1326	to	to	TO
1327	1336	rhombotin	rhombotin	NN
1337	1340	was	be	VBD
1341	1346	found	find	VBN
1347	1350	and	and	CC
1351	1353	at	at	IN
1354	1357	the	the	DT
1358	1362	same	same	JJ
1363	1371	position	position	NN
1372	1374	as	as	IN
1375	1377	in	in	IN
1378	1381	the	the	DT
1382	1390	previous	previous	JJ
1391	1398	example	example	NN
1398	1399	.	.	.

1400	1409	Therefore	therefore	RB
1409	1410	,	,	,
1411	1421	chromosome	chromosome	NN
1422	1427	bands	band	NNS
1428	1433	11p15	11p15	NN
1434	1435	(	(	(
1435	1444	rhombotin	rhombotin	NN
1444	1445	)	)	)
1446	1449	and	and	CC
1450	1455	11p13	11p13	NN
1456	1457	(	(	(
1457	1463	Rhom-2	rhom-2	NN
1463	1464	)	)	)
1465	1468	are	be	VBP
1469	1479	consistent	consistent	JJ
1480	1485	sites	site	NNS
1486	1488	of	of	IN
1489	1499	chromosome	chromosome	NN
1500	1513	translocation	translocation	NN
1514	1516	in	in	IN
1517	1523	T-cell	t-cell	NN
1524	1532	leukemia	leukemia	NN
1532	1533	,	,	,
1534	1538	with	with	IN
1539	1542	the	the	DT
1543	1548	11p15	11p15	CD
1549	1555	target	target	NN
1556	1560	more	more	RBR
1561	1567	rarely	rarely	RB
1568	1576	involved	involve	VBN
1576	1577	.	.	.

1578	1581	The	the	DT
1582	1589	results	result	NNS
1590	1596	define	define	VBP
1597	1600	the	the	DT
1601	1610	rhombotin	rhombotin	NN
1611	1615	gene	gene	NN
1616	1622	family	family	NN
1623	1625	as	as	IN
1626	1627	a	a	DT
1628	1633	class	class	NN
1634	1636	of	of	IN
1637	1643	T-cell	t-cell	NN
1644	1653	oncogenes	oncogene	NNS
1654	1658	with	with	IN
1659	1669	duplicated	duplicate	VBN
1670	1683	cysteine-rich	cysteine-rich	JJ
1684	1687	LIM	LIM	NNP
1688	1695	domains	domain	NNS
1695	1696	.	.	.