0 13 Heterogeneity Heterogeneity NNP 14 16 of of IN 17 24 antigen antigen NN 25 34 molecules molecule NNS 35 45 recognized recognize VBN 46 48 by by IN 49 58 anti-tax1 anti-tax1 JJ 59 69 monoclonal monoclonal JJ 70 78 antibody antibody NN 79 83 Lt-4 lt-4 NN 84 86 in in IN 87 91 cell cell NN 92 97 lines line NNS 98 105 bearing bear VBG 106 111 human human JJ 112 113 T t NN 114 118 cell cell NN 119 127 leukemia leukemia NN 128 133 virus virus NN 134 138 type type NN 139 140 I i CD 141 144 and and CC 145 152 related relate VBN 153 165 retroviruses retrovirus NNS 165 166 . . . 168 173 Using use VBG 174 175 a a DT 176 186 monoclonal monoclonal JJ 187 195 antibody antibody NN 195 196 , , , 197 201 Lt-4 lt-4 NN 201 202 , , , 203 211 directed direct VBN 212 219 against against IN 220 225 human human JJ 226 227 T t NN 228 232 cell cell NN 233 241 leukemia leukemia NN 242 247 virus virus NN 248 252 type type NN 253 254 I i CD 255 256 ( ( ( 256 262 HTLV-I HTLV-I NNP 262 263 ) ) ) 264 279 trans-activator trans-activator NN 280 281 ( ( ( 281 285 tax1 tax1 NN 285 286 ) ) ) 287 294 antigen antigen NN 294 295 , , , 296 298 we we PRP 299 307 examined examine VBD 308 311 the the DT 312 322 expression expression NN 323 325 of of IN 326 330 tax1 tax1 NN 331 334 and and CC 335 342 related related JJ 343 351 antigens antigen NNS 352 354 in in IN 355 356 a a DT 357 364 variety variety NN 365 367 of of IN 368 369 T t NN 370 374 cell cell NN 375 380 lines line NNS 381 388 bearing bear VBG 389 395 HTLV-I HTLV-I NNP 396 399 and and CC 400 407 related related JJ 408 420 retroviruses retrovirus NNS 420 421 , , , 422 428 simian simian JJ 429 430 T t NN 431 435 cell cell NN 436 444 leukemia leukemia NN 445 450 virus virus NN 451 455 type type NN 456 457 I i CD 458 459 ( ( ( 459 465 STLV-I STLV-I NNP 465 466 ) ) ) 467 470 and and CC 471 478 HTLV-II HTLV-II NNP 478 479 , , , 480 482 by by IN 483 501 immunofluorescence immunofluorescence NN 502 505 and and CC 506 516 immunoblot immunoblot NN 517 523 assays assay NNS 523 524 . . . 525 529 Lt-4 lt-4 NN 530 537 reacted react VBD 538 542 with with IN 543 546 all all DT 547 561 HTLV-I-bearing htlv-i-bearing JJ 562 566 cell cell NN 567 572 lines line NNS 573 579 tested test VBN 580 583 and and CC 584 588 five five CD 589 592 out out IN 593 595 of of IN 596 601 eight eight CD 602 608 simian simian JJ 609 613 cell cell NN 614 619 lines line NNS 620 627 bearing bear VBG 628 634 STLV-I STLV-I NNP 634 635 , , , 636 639 but but CC 640 643 not not RB 644 648 with with IN 649 651 an an DT 652 667 HTLV-II-bearing htlv-ii-bearing NN 668 672 cell cell NN 673 677 line line NN 677 678 . . . 679 683 Lt-4 lt-4 NN 684 692 detected detect VBD 693 695 40 40 CD 696 698 kd kd NN 699 703 tax1 tax1 NN 704 711 antigen antigen NN 712 721 molecules molecule NNS 722 724 in in IN 725 729 most most JJS 730 744 HTLV-I-bearing htlv-i-bearing NN 745 749 cell cell NN 750 755 lines line NNS 756 762 except except IN 763 766 one one CD 767 771 cell cell NN 772 776 line line NN 777 781 that that WDT 782 791 expressed express VBD 792 794 39 39 CD 795 797 kd kd NN 798 802 tax1 tax1 NN 803 810 antigen antigen NN 810 811 . . . 812 814 In in IN 815 818 the the DT 819 833 STLV-I-bearing stlv-i-bearing JJ 834 835 T t NN 836 840 cell cell NN 841 846 lines line NNS 846 847 , , , 848 860 tax1-related tax1-related JJ 861 868 antigen antigen NN 869 878 molecules molecule NNS 879 887 detected detect VBN 888 890 by by IN 891 895 Lt-4 lt-4 NN 896 900 were be VBD 901 914 heterogeneous heterogeneous JJ 914 915 , , , 916 922 having have VBG 923 932 molecular molecular JJ 933 940 weights weight NNS 941 943 in in IN 944 947 the the DT 948 953 range range NN 954 956 of of IN 957 962 36-41 36-41 CD 963 965 kd kd NN 965 966 . . .