0 9 Circadian circadian JJ 10 16 rhythm rhythm NN 17 19 of of IN 20 34 glucocorticoid glucocorticoid NN 35 44 receptors receptor NNS 45 47 in in IN 48 53 human human JJ 54 64 peripheral peripheral JJ 65 75 leukocytes leukocyte NNS 76 79 and and CC 80 85 their their PRP$ 86 96 reactivity reactivity NN 97 99 to to TO 100 115 glucocorticoids glucocorticoid NNS 115 116 . . . 118 119 1 1 LS 119 120 ) ) ) 121 126 There there EX 127 133 exists exist VBZ 134 135 a a DT 136 138 CR cr NN 139 141 of of IN 142 144 GR GR NNP 145 147 in in IN 148 153 human human JJ 154 164 leukocytes leukocyte NNS 164 165 , , , 166 169 PMN PMN NNP 169 170 , , , 171 174 and and CC 175 184 monocytes monocyte NNS 185 189 with with IN 190 193 the the DT 194 198 peak peak JJ 199 205 values value NNS 206 210 from from IN 211 215 0400 0400 CD 216 218 to to TO 219 223 0800 0800 CD 224 226 hr hr NN 227 230 and and CC 231 234 the the DT 235 241 trough trough NN 242 248 values value NNS 249 256 between between IN 257 261 2300 2300 CD 262 265 and and CC 266 270 0000 0000 CD 271 273 hr hr NN 273 274 . . . 275 278 The the DT 279 289 difference difference NN 290 297 between between IN 298 302 them them PRP 303 306 was be VBD 307 318 significant significant JJ 319 332 statistically statistically RB 332 333 . . . 334 335 2 2 LS 335 336 ) ) ) 337 340 The the DT 341 343 FI FI NNP 344 346 of of IN 347 350 the the DT 351 362 chemotactic chemotactic JJ 363 372 migration migration NN 373 377 rate rate NN 378 380 of of IN 381 384 PMN PMN NNP 385 387 by by IN 388 396 cortisol cortisol NN 397 401 also also RB 402 408 showed show VBD 409 416 diurnal diurnal JJ 417 424 changes change NNS 425 430 which which WDT 431 435 were be VBD 436 447 synchronous synchronous JJ 448 452 with with IN 453 457 that that DT 458 460 of of IN 461 463 GR GR NNP 463 464 . . . 465 469 This this DT 470 479 indicates indicate VBZ 480 484 that that IN 485 488 the the DT 489 491 CR CR NNP 492 494 of of IN 495 497 GR GR NNP 498 501 may may MD 502 504 be be VB 505 507 of of IN 508 518 functional functional JJ 519 531 significance significance NN 531 532 . . . 533 534 3 3 LS 534 535 ) ) ) 536 538 In in IN 539 546 Cushing cushing NN 546 548 ’s 's POS 549 557 syndrome syndrome NN 557 558 , , , 559 562 the the DT 563 565 CR CR NNP 566 568 of of IN 569 571 GR GR NNP 572 575 was be VBD 576 582 normal normal JJ 583 585 in in IN 586 591 spite spite NN 592 594 of of IN 595 598 the the DT 599 603 fact fact NN 604 608 that that IN 609 612 the the DT 613 615 CR cr NN 616 618 of of IN 619 625 plasma plasma NN 626 634 cortisol cortisol NN 635 638 was be VBD 639 648 disturbed disturb VBN 648 649 . . . 650 654 This this DT 655 664 indicates indicate VBZ 665 668 the the DT 669 681 independency independency NN 682 684 of of IN 685 688 the the DT 689 691 CR cr NN 692 694 of of IN 695 697 GR GR NNP 698 702 from from IN 703 707 that that DT 708 710 of of IN 711 719 cortisol cortisol NN 719 720 . . . 721 722 4 4 LS 722 723 ) ) ) 724 726 In in IN 727 735 apoplexy apoplexy NN 736 742 caused cause VBN 743 745 by by IN 746 751 brain brain NN 752 760 ischemia ischemia NN 760 761 , , , 762 765 the the DT 766 768 CR CR NNP 769 771 of of IN 772 774 GR GR NNP 775 778 was be VBD 779 788 abolished abolish VBN 789 791 in in IN 792 800 patients patient NNS 801 805 with with IN 806 811 basal basal JJ 812 819 lesions lesion NNS 820 823 but but CC 824 833 preserved preserve VBN 834 838 when when WRB 839 842 the the DT 843 850 lesions lesion NNS 851 855 were be VBD 856 863 located locate VBN 864 866 in in IN 867 870 the the DT 871 879 cerebral cerebral JJ 880 886 cortex cortex NN 886 887 . . . 888 893 These these DT 894 901 results result NNS 902 910 strongly strongly RB 911 918 suggest suggest VBP 919 923 that that IN 924 927 the the DT 928 932 main main JJ 933 934 “ `` `` 934 943 circadian circadian JJ 944 953 pacemaker pacemaker NN 953 954 ” '' '' 955 957 of of IN 958 960 GR GR NNP 961 963 is be VBZ 964 971 located locate VBN 972 974 in in IN 975 978 the the DT 979 984 basal basal JJ 985 990 brain brain NN 990 991 , , , 992 996 most most RBS 997 1005 probably probably RB 1006 1008 in in IN 1009 1012 the the DT 1013 1028 suprachiasmatic suprachiasmatic JJ 1029 1035 nuclei nucleus NNS 1036 1038 as as IN 1039 1042 has have VBZ 1043 1047 been be VBN 1048 1057 suggested suggest VBN 1058 1061 for for IN 1062 1069 rodents rodent NNS 1069 1070 . . .