0 1 [ [ ( 1 4 The the DT 5 11 effect effect NN 12 14 of of IN 15 37 24,25-dihydroxyvitamin 24,25-dihydroxyvitamin NN 38 40 D3 d3 NN 41 42 ( ( ( 42 50 dioxyvit dioxyvit NN 50 51 ) ) ) 52 54 on on IN 55 57 Ca ca NN 58 68 metabolism metabolism NN 69 72 and and CC 73 79 immune immune JJ 80 86 status status NN 87 93 during during IN 94 101 chronic chronic JJ 102 108 kidney kidney NN 109 116 failure failure NN 116 117 ] ] ) 119 125 Active active JJ 126 136 metabolite metabolite NN 137 139 of of IN 140 147 vitamin vitamin NN 148 150 D3 d3 NN 150 151 , , , 152 158 24R,25 24R,25 NNP 159 160 ( ( ( 160 166 OH)2D3 OH)2D3 NNP 167 168 ( ( ( 168 176 dioxyvit dioxyvit NN 176 177 ) ) ) 178 181 was be VBD 182 186 used use VBN 187 189 at at IN 190 191 a a DT 192 197 daily daily JJ 198 202 dose dose NN 203 205 of of IN 206 209 100 100 CD 210 220 micrograms microgram NNS 221 223 in in IN 224 233 treatment treatment NN 234 236 of of IN 237 245 children child NNS 246 254 affected affect VBN 255 259 with with IN 260 278 tubulointerstitial tubulointerstitial JJ 279 286 disease disease NN 287 289 of of IN 290 296 kidney kidney NN 297 300 and and CC 301 305 with with IN 306 313 chronic chronic JJ 314 332 glomerulonephritis glomerulonephritis NN 333 338 under under IN 339 349 conditions condition NNS 350 352 of of IN 353 359 kidney kidney NN 360 373 insufficiency insufficiency NN 373 374 . . . 375 378 The the DT 379 383 drug drug NN 384 393 exhibited exhibit VBD 394 402 distinct distinct JJ 403 414 normalizing normalize VBG 415 421 effect effect NN 422 424 on on IN 425 433 patterns pattern NNS 434 436 of of IN 437 444 calcium calcium NN 445 455 metabolism metabolism NN 455 456 : : : 457 465 increase increase NN 466 468 of of IN 469 474 total total JJ 475 478 and and CC 479 486 ionized ionized JJ 487 491 Ca2+ ca2+ NN 492 495 and and CC 496 498 of of IN 499 505 25-OHD 25-ohd NN 505 506 , , , 507 515 decrease decrease NN 516 518 in in IN 519 532 concentration concentration NN 533 535 of of IN 536 542 parath parath NN 543 550 hormone hormone NN 551 554 and and CC 555 567 osteocalcine osteocalcine NN 568 570 in in IN 571 576 blood blood NN 577 582 serum serum NN 583 585 as as RB 586 590 well well RB 591 593 as as IN 594 596 on on IN 597 610 immunological immunological JJ 611 621 parameters parameter NNS 621 622 : : : 623 634 restoration restoration NN 635 637 of of IN 638 647 decreased decrease VBN 648 655 content content NN 656 658 of of IN 659 661 T- t- NN 662 665 and and CC 666 679 0-lymphocytes 0-lymphocyte NNS 679 680 . . . 681 694 Concentration concentration NN 695 697 of of IN 698 707 receptors receptor NNS 708 710 of of IN 711 719 hormonal hormonal JJ 720 724 form form NN 725 727 of of IN 728 739 1,25(OH)2D3 1,25(OH)2D3 NNP 740 743 was be VBD 744 749 found find VBN 750 752 to to TO 753 755 be be VB 756 763 minimal minimal JJ 764 766 in in IN 767 778 lymphocytes lymphocyte NNS 779 784 under under IN 785 795 conditions condition NNS 796 798 of of IN 799 806 chronic chronic JJ 807 813 kidney kidney NN 814 827 insufficiency insufficiency NN 827 828 , , , 829 834 while while IN 835 840 their their PRP$ 841 851 expression expression NN 851 852 , , , 853 858 after after IN 859 862 the the DT 863 871 dioxyvit dioxyvit NN 872 878 action action NN 878 879 , , , 880 883 was be VBD 884 892 detected detect VBN 893 897 only only RB 898 900 in in IN 901 909 patients patient NNS 910 914 with with IN 915 933 glomerulonephritis glomerulonephritis NN 933 934 . . . 935 943 Specific specific JJ 944 955 calcitropic calcitropic JJ 956 962 effect effect NN 963 965 of of IN 966 974 dioxyvit dioxyvit NN 975 979 with with IN 980 992 simultaneous simultaneous JJ 993 1003 correction correction NN 1004 1006 of of IN 1007 1014 vitamin vitamin NN 1015 1016 D D NNP 1017 1027 deficiency deficiency NN 1028 1032 were be VBD 1033 1043 apparently apparently RB 1044 1055 responsible responsible JJ 1056 1059 for for IN 1060 1064 high high JJ 1065 1073 efficacy efficacy NN 1074 1076 of of IN 1077 1080 the the DT 1081 1085 drug drug NN 1086 1088 in in IN 1089 1098 treatment treatment NN 1099 1101 of of IN 1102 1109 calcium calcium NN 1110 1120 metabolism metabolism NN 1121 1124 and and CC 1125 1133 immunity immunity NN 1134 1145 impairments impairment NNS 1146 1148 in in IN 1149 1157 children child NNS 1158 1162 with with IN 1163 1168 renal renal JJ 1169 1183 deteriorations deterioration NNS 1184 1186 at at IN 1187 1190 the the DT 1191 1195 step step NN 1196 1198 of of IN 1199 1206 chronic chronic JJ 1207 1213 kidney kidney NN 1214 1227 insufficiency insufficiency NN 1227 1228 . . .