0	14	Staphylococcal	staphylococcal	JJ
15	27	enterotoxins	enterotoxin	NNS
28	36	modulate	modulate	VBP
37	48	interleukin	interleukin	NN
49	50	2	2	CD
51	59	receptor	receptor	NN
60	70	expression	expression	NN
71	74	and	and	CC
75	89	ligand-induced	ligand-induced	JJ
90	98	tyrosine	tyrosine	NN
99	114	phosphorylation	phosphorylation	NN
115	117	of	of	IN
118	121	the	the	DT
122	127	Janus	Janus	NNP
128	144	protein-tyrosine	protein-tyrosine	NN
145	151	kinase	kinase	NNP
152	153	3	3	CD
154	155	(	(	(
155	159	Jak3	jak3	NN
159	160	)	)	)
161	164	and	and	CC
165	171	signal	signal	NN
172	183	transducers	transducer	NNS
184	187	and	and	CC
188	198	activators	activator	NNS
199	201	of	of	IN
202	215	transcription	transcription	NN
216	217	(	(	(
217	221	Stat	Stat	NNP
222	230	proteins	protein	NNS
230	231	)	)	)
231	232	.	.	.

234	248	Staphylococcal	staphylococcal	JJ
249	261	enterotoxins	enterotoxin	NNS
262	263	(	(	(
263	265	SE	SE	NNP
265	266	)	)	)
267	276	stimulate	stimulate	VBP
277	278	T	t	NN
279	284	cells	cell	NNS
285	295	expressing	express	VBG
296	299	the	the	DT
300	311	appropriate	appropriate	JJ
312	320	variable	variable	JJ
321	327	region	region	NN
328	332	beta	beta	NN
333	338	chain	chain	NN
339	341	of	of	IN
342	343	(	(	(
343	344	V	V	NNP
345	349	beta	beta	NN
349	350	)	)	)
351	357	T-cell	t-cell	NN
358	367	receptors	receptor	NNS
368	371	and	and	CC
372	376	have	have	VBP
377	381	been	be	VBN
382	392	implicated	implicate	VBN
393	395	in	in	IN
396	399	the	the	DT
400	412	pathogenesis	pathogenesis	NN
413	415	of	of	IN
416	423	several	several	JJ
424	434	autoimmune	autoimmune	JJ
435	443	diseases	disease	NNS
443	444	.	.	.

445	454	Depending	depend	VBG
455	457	on	on	IN
458	471	costimulatory	costimulatory	JJ
472	479	signals	signal	NNS
479	480	,	,	,
481	483	SE	SE	NNP
484	490	induce	induce	VBP
491	497	either	either	CC
498	511	proliferation	proliferation	NN
512	514	or	or	CC
515	521	anergy	anergy	NN
522	524	in	in	IN
525	526	T	t	NN
527	532	cells	cell	NNS
532	533	.	.	.

534	536	In	in	IN
537	545	addition	addition	NN
545	546	,	,	,
547	549	SE	SE	NNP
550	553	can	can	MD
554	560	induce	induce	VB
561	563	an	an	DT
564	577	interleukin-2	interleukin-2	NN
578	579	(	(	(
579	583	IL-2	il-2	NN
583	584	)	)	)
585	598	nonresponsive	nonresponsive	JJ
599	604	state	state	NN
605	608	and	and	CC
609	618	apoptosis	apoptosis	NN
618	619	.	.	.

620	624	Here	here	RB
624	625	,	,	,
626	628	we	we	PRP
629	633	show	show	VBP
634	638	that	that	IN
639	641	SE	SE	NNP
642	648	induce	induce	VBP
649	656	dynamic	dynamic	JJ
657	664	changes	change	NNS
665	667	in	in	IN
668	671	the	the	DT
672	682	expression	expression	NN
683	685	of	of	IN
686	689	and	and	CC
690	696	signal	signal	NN
697	709	transduction	transduction	NN
710	717	through	through	IN
718	721	the	the	DT
722	726	IL-2	il-2	NN
727	735	receptor	receptor	NN
736	737	(	(	(
737	742	IL-2R	IL-2R	NNP
742	743	)	)	)
744	748	beta	beta	NN
749	752	and	and	CC
753	758	gamma	gamma	NN
759	765	chains	chain	NNS
766	767	(	(	(
767	772	IL-2R	IL-2R	NNP
773	777	beta	beta	NN
778	781	and	and	CC
782	787	IL-2R	il-2r	NN
788	793	gamma	gamma	NN
793	794	)	)	)
795	797	in	in	IN
798	803	human	human	JJ
804	820	antigen-specific	antigen-specific	JJ
821	825	CD4+	cd4+	JJ
826	832	T-cell	t-cell	NN
833	838	lines	line	NNS
838	839	.	.	.

840	844	Thus	thus	RB
844	845	,	,	,
846	851	after	after	IN
852	853	4	4	CD
854	856	hr	hr	NN
857	859	of	of	IN
860	868	exposure	exposure	NN
869	871	to	to	TO
872	875	SEA	SEA	NNP
876	879	and	and	CC
880	883	SEB	SEB	NNP
883	884	,	,	,
885	888	the	the	DT
889	899	expression	expression	NN
900	902	of	of	IN
903	908	IL-2R	IL-2R	NNP
909	913	beta	beta	NN
914	917	was	be	VBD
918	932	down-regulated	down-regulate	VBN
932	933	,	,	,
934	939	IL-2R	IL-2R	NNP
940	945	gamma	gamma	NN
946	949	was	be	VBD
950	958	slightly	slightly	RB
959	971	up-regulated	up-regulate	VBN
971	972	,	,	,
973	978	while	while	IN
979	984	IL-2R	IL-2R	NNP
985	990	alpha	alpha	NN
991	999	remained	remain	VBD
1000	1007	largely	largely	RB
1008	1018	unaffected	unaffected	JJ
1018	1019	.	.	.

1020	1023	The	the	DT
1024	1031	changes	change	NNS
1032	1034	in	in	IN
1035	1038	the	the	DT
1039	1050	composition	composition	NN
1051	1053	of	of	IN
1054	1060	IL-2Rs	IL-2R	NNP
1061	1065	were	be	VBD
1066	1077	accompanied	accompany	VBN
1078	1080	by	by	IN
1081	1091	inhibition	inhibition	NN
1092	1094	of	of	IN
1095	1107	IL-2-induced	il-2-induced	JJ
1108	1116	tyrosine	tyrosine	NN
1117	1132	phosphorylation	phosphorylation	NN
1133	1135	of	of	IN
1136	1139	the	the	DT
1140	1145	Janus	Janus	NNP
1146	1162	protein-tyrosine	protein-tyrosine	NN
1163	1169	kinase	kinase	NNP
1170	1171	3	3	CD
1172	1173	(	(	(
1173	1177	Jak3	jak3	NN
1177	1178	)	)	)
1179	1182	and	and	CC
1183	1189	signal	signal	NN
1190	1201	transducers	transducer	NNS
1202	1205	and	and	CC
1206	1216	activators	activator	NNS
1217	1219	of	of	IN
1220	1233	transcription	transcription	NN
1234	1240	called	call	VBN
1241	1246	Stat3	Stat3	NNP
1247	1250	and	and	CC
1251	1256	Stat5	Stat5	NNP
1256	1257	.	.	.

1258	1260	In	in	IN
1261	1269	parallel	parallel	JJ
1270	1281	experiments	experiment	NNS
1281	1282	,	,	,
1283	1294	IL-2-driven	il-2-driven	JJ
1295	1308	proliferation	proliferation	NN
1309	1312	was	be	VBD
1313	1322	inhibited	inhibit	VBN
1323	1336	significantly	significantly	RB
1336	1337	.	.	.

1338	1343	After	after	IN
1344	1346	16	16	CD
1347	1349	hr	hr	NN
1350	1352	of	of	IN
1353	1361	exposure	exposure	NN
1362	1364	to	to	TO
1365	1367	SE	SE	NNP
1367	1368	,	,	,
1369	1372	the	the	DT
1373	1383	expression	expression	NN
1384	1386	of	of	IN
1387	1392	IL-2R	IL-2R	NNP
1393	1397	beta	beta	NN
1398	1406	remained	remain	VBD
1407	1410	low	low	JJ
1410	1411	,	,	,
1412	1417	while	while	IN
1418	1422	that	that	DT
1423	1425	of	of	IN
1426	1430	IL2R	IL2R	NNP
1431	1436	alpha	alpha	NN
1437	1440	and	and	CC
1441	1445	IL2R	il2r	NN
1446	1451	gamma	gamma	NN
1452	1455	was	be	VBD
1456	1463	further	further	RBR
1464	1476	up-regulated	up-regulate	VBN
1476	1477	,	,	,
1478	1481	and	and	CC
1482	1496	ligand-induced	ligand-induced	JJ
1497	1505	tyrosine	tyrosine	NN
1506	1521	phosphorylation	phosphorylation	NN
1522	1524	of	of	IN
1525	1529	Jak3	Jak3	NNP
1530	1533	and	and	CC
1534	1538	Stat	Stat	NNP
1539	1547	proteins	protein	NNS
1548	1551	was	be	VBD
1552	1558	partly	partly	RB
1559	1569	normalized	normalize	VBN
1569	1570	.	.	.

1571	1574	Yet	yet	RB
1574	1575	,	,	,
1576	1587	IL-2-driven	il-2-driven	JJ
1588	1601	proliferation	proliferation	NN
1602	1610	remained	remain	VBD
1611	1621	profoundly	profoundly	RB
1622	1631	inhibited	inhibit	VBN
1631	1632	,	,	,
1633	1643	suggesting	suggest	VBG
1644	1648	that	that	IN
1649	1658	signaling	signaling	NN
1659	1665	events	event	NNS
1666	1671	other	other	JJ
1672	1676	than	than	IN
1677	1686	Jak3/Stat	Jak3/Stat	NNP
1687	1697	activation	activation	NN
1698	1701	had	have	VBD
1702	1706	also	also	RB
1707	1711	been	be	VBN
1712	1719	changed	change	VBN
1720	1729	following	follow	VBG
1730	1732	SE	SE	NNP
1733	1744	stimulation	stimulation	NN
1744	1745	.	.	.

1746	1748	In	in	IN
1749	1759	conclusion	conclusion	NN
1759	1760	,	,	,
1761	1764	our	our	PRP$
1765	1769	data	datum	NNS
1770	1777	suggest	suggest	VBP
1778	1782	that	that	IN
1783	1785	SE	SE	NNP
1786	1789	can	can	MD
1790	1798	modulate	modulate	VB
1799	1804	IL-2R	IL-2R	NNP
1805	1815	expression	expression	NN
1816	1819	and	and	CC
1820	1826	signal	signal	NN
1827	1839	transduction	transduction	NN
1840	1849	involving	involve	VBG
1850	1853	the	the	DT
1854	1862	Jak/Stat	Jak/Stat	NNP
1863	1870	pathway	pathway	NN
1871	1873	in	in	IN
1874	1878	CD4+	cd4+	JJ
1879	1885	T-cell	t-cell	NN
1886	1891	lines	line	NNS
1891	1892	.	.	.