0 13 Interleukin-7 Interleukin-7 NNP 14 17 can can MD 18 24 induce induce VB 25 28 the the DT 29 39 activation activation NN 40 42 of of IN 43 46 Jak Jak NNP 47 48 1 1 CD 48 49 , , , 50 53 Jak Jak NNP 54 55 3 3 CD 56 59 and and CC 60 64 STAT STAT NNP 65 66 5 5 CD 67 75 proteins protein NNS 76 78 in in IN 79 85 murine murine JJ 86 87 T t NN 88 93 cells cell NNS 93 94 . . . 96 99 The the DT 100 110 activation activation NN 111 113 of of IN 114 119 Janus Janus NNP 120 127 protein protein NN 128 136 tyrosine tyrosine NN 137 144 kinases kinase NNS 145 146 ( ( ( 146 149 Jak Jak NNP 149 150 ) ) ) 151 154 and and CC 155 159 STAT STAT NNP 160 161 ( ( ( 161 167 signal signal NN 168 178 transducer transducer NN 179 182 and and CC 183 192 activator activator NN 193 195 of of IN 196 209 transcription transcription NN 209 210 ) ) ) 211 219 proteins protein NNS 220 223 has have VBZ 224 232 recently recently RB 233 237 been be VBN 238 244 linked link VBN 245 247 to to TO 248 251 the the DT 252 258 signal signal NN 259 271 transduction transduction NN 272 281 mechanism mechanism NN 282 284 of of IN 285 292 several several JJ 293 302 cytokines cytokine NNS 302 303 . . . 304 308 IL-7 IL-7 NNP 309 312 was be VBD 313 321 observed observe VBN 322 324 to to TO 325 331 induce induce VB 332 333 a a DT 334 339 rapid rapid JJ 340 343 and and CC 344 358 dose-dependent dose-dependent JJ 359 367 tyrosine tyrosine NN 368 383 phosphorylation phosphorylation NN 384 386 of of IN 387 390 Jak Jak NNP 391 392 1 1 CD 393 396 and and CC 397 400 Jak Jak NNP 401 402 3 3 CD 403 406 and and CC 407 420 concomitantly concomitantly RB 420 421 , , , 422 425 the the DT 426 434 tyrosine tyrosine NN 435 450 phosphorylation phosphorylation NN 451 454 and and CC 455 458 DNA dna NN 459 466 binding binding NN 467 475 activity activity NN 476 478 of of IN 479 487 multiple multiple JJ 488 492 STAT stat NN 493 501 proteins protein NNS 501 502 . . . 503 506 The the DT 507 511 STAT STAT NNP 512 520 proteins protein NNS 521 529 utilized utilize VBN 530 532 by by IN 533 537 IL-7 IL-7 NNP 538 542 were be VBD 543 552 identical identical JJ 553 555 to to TO 556 561 those those DT 562 569 induced induce VBN 570 572 by by IN 573 577 IL-2 il-2 NN 578 581 and and CC 582 587 could could MD 588 590 be be VB 591 601 identified identify VBN 602 604 as as IN 605 612 various various JJ 613 617 STAT STAT NNP 618 619 5 5 CD 620 628 isoforms isoform NNS 628 629 . . . 630 638 Moreover moreover RB 638 639 , , , 640 643 the the DT 644 653 induction induction NN 654 656 of of IN 657 661 both both CC 662 665 Jak Jak NNP 666 667 1 1 CD 668 671 and and CC 672 673 3 3 CD 673 674 , , , 675 678 and and CC 679 683 STAT STAT NNP 684 685 5 5 CD 686 694 activity activity NN 695 703 strongly strongly RB 704 714 correlated correlate VBD 715 719 with with IN 720 723 the the DT 724 740 growth-promoting growth-promoting JJ 741 748 effects effect NNS 749 751 of of IN 752 756 IL-7 IL-7 NNP 756 757 , , , 758 768 suggesting suggest VBG 769 773 that that IN 774 778 this this DT 779 785 signal signal NN 786 798 transduction transduction NN 799 808 mechanism mechanism NN 809 812 may may MD 813 817 play play VB 818 819 a a DT 820 823 key key JJ 824 828 role role NN 829 831 in in IN 832 844 IL-7-induced il-7-induced JJ 845 858 proliferation proliferation NN 858 859 . . .