0 10 Lymphocyte Lymphocyte NNP 11 25 glucocorticoid glucocorticoid NN 26 34 receptor receptor NN 34 35 : : : 36 45 predictor predictor NN 46 48 of of IN 49 59 sertraline sertraline NN 60 68 response response NN 69 71 in in IN 72 82 adolescent adolescent JJ 83 88 major major JJ 89 99 depressive depressive JJ 100 108 disorder disorder NN 109 110 ( ( ( 110 113 MDD MDD NNP 113 114 ) ) ) 114 115 . . . 117 122 Major major JJ 123 133 depressive depressive JJ 134 142 disorder disorder NN 143 144 ( ( ( 144 147 MDD MDD NNP 147 148 ) ) ) 149 151 in in IN 152 163 adolescents adolescent NNS 164 176 demonstrates demonstrate VBZ 177 187 resistance resistance NN 188 190 to to TO 191 200 tricyclic tricyclic JJ 201 216 antidepressants antidepressant NNS 217 220 and and CC 221 228 absence absence NN 229 231 of of IN 232 249 hypercortisolemia hypercortisolemia NN 249 250 . . . 251 254 The the DT 255 263 efficacy efficacy NN 264 266 of of IN 267 276 serotonin serotonin NN 277 285 reuptake reuptake NN 286 296 inhibitors inhibitor NNS 297 298 ( ( ( 298 302 SRIs SRI NNP 302 303 ) ) ) 304 306 is be VBZ 307 316 uncertain uncertain JJ 316 317 , , , 318 321 and and CC 322 330 response response NN 331 341 predictors predictor NNS 342 345 are be VBP 346 357 unavailable unavailable JJ 357 358 . . . 359 367 Abnormal abnormal JJ 368 372 fast fast JJ 373 381 feedback feedback NN 382 385 and and CC 386 394 negative negative JJ 395 403 feedback feedback NN 404 406 of of IN 407 410 the the DT 411 441 hypothalamic-pituitary-adrenal hypothalamic-pituitary-adrenal JJ 442 446 axis axis NN 447 457 implicates implicate VBZ 458 459 a a DT 460 468 dampened dampened JJ 469 487 limbic-hippocampal limbic-hippocampal JJ 488 502 glucocorticoid glucocorticoid NN 503 507 type type NN 508 510 II ii CD 511 519 receptor receptor NN 520 521 ( ( ( 521 525 GCII GCII NNP 525 526 ) ) ) 526 527 . . . 528 530 We we PRP 531 543 hypothesized hypothesize VBD 544 548 that that IN 549 559 lymphocyte lymphocyte NN 560 564 GCII GCII NNP 565 567 is be VBZ 568 575 altered alter VBN 576 578 in in IN 579 589 adolescent adolescent JJ 590 593 MDD MDD NNP 594 597 and and CC 598 603 could could MD 604 609 serve serve VB 610 612 as as IN 613 614 a a DT 615 621 marker marker NN 622 625 for for IN 626 634 response response NN 635 637 to to TO 638 642 SRIs sri NNS 642 643 . . . 644 646 In in IN 647 649 an an DT 650 660 open-label open-label JJ 661 666 study study NN 666 667 , , , 668 679 adolescents adolescent NNS 680 681 ( ( ( 681 682 n n NN 683 684 = = SYM 685 687 20 20 CD 687 688 ) ) ) 689 696 meeting meet VBG 697 706 DSM-III-R dsm-iii-r NN 707 715 criteria criterion NNS 716 719 for for IN 720 723 MDD MDD NNP 724 730 showed show VBD 731 739 baseline baseline NN 740 750 lymphocyte lymphocyte NN 751 755 GCII GCII NNP 756 761 sites site NNS 762 765 per per IN 766 770 cell cell NN 771 772 ( ( ( 772 782 sites/cell sites/cell NN 782 783 ) ) ) 784 790 values value NNS 791 793 of of IN 794 797 793 793 CD 798 801 +/- +/- SYM 802 805 106 106 CD 806 812 versus versus IN 813 818 2,563 2,563 CD 819 822 +/- +/- SYM 823 826 499 499 CD 827 828 ( ( ( 828 831 +/- +/- SYM 832 835 SEM SEM NNP 835 836 ) ) ) 837 840 for for IN 841 848 matched match VBN 849 857 controls control NNS 858 859 ( ( ( 859 860 n n NN 861 862 = = SYM 863 865 18 18 CD 865 866 ) ) ) 867 868 ( ( ( 868 869 t t NN 870 871 = = JJ 872 875 3.5 3.5 CD 875 876 ; ; : 877 879 df df NN 880 881 = = JJ 882 884 36 36 CD 884 885 ; ; : 886 887 p p NN 888 889 < < JJR 890 894 .001 .001 CD 894 895 ) ) ) 895 896 . . . 897 901 GCII GCII NNP 902 905 was be VBD 906 915 bimodally bimodally RB 916 927 distributed distribute VBN 927 928 , , , 929 933 with with IN 934 937 SRI SRI NNP 938 948 responders responder NNS 949 958 differing differ VBG 959 963 from from IN 964 977 nonresponders nonresponder NNS 978 979 ( ( ( 979 980 t t NN 981 982 = = JJ 983 986 3.9 3.9 CD 986 987 ; ; : 988 990 df df NN 991 992 = = JJ 993 995 14 14 CD 995 996 ; ; : 997 998 p p NN 999 1000 < < JJR 1001 1005 .001 .001 CD 1005 1006 ) ) ) 1006 1007 . . . 1008 1012 GCII GCII NNP 1013 1023 accurately accurately RB 1024 1034 classified classify VBD 1035 1037 90 90 CD 1038 1045 percent percent NN 1046 1048 of of IN 1049 1059 sertraline sertraline NN 1060 1070 responders responder NNS 1071 1074 and and CC 1075 1077 80 80 CD 1078 1085 percent percent NN 1086 1088 of of IN 1089 1102 nonresponders nonresponder NNS 1102 1103 . . . 1104 1108 Only only RB 1109 1112 SRI SRI NNP 1113 1123 responders responder NNS 1124 1130 showed show VBD 1131 1135 GCII GCII NNP 1136 1146 sites/cell sites/cell NNS 1147 1158 upregulated upregulate VBN 1159 1164 after after IN 1165 1166 6 6 CD 1167 1172 weeks week NNS 1173 1175 of of IN 1176 1185 treatment treatment NN 1186 1187 ( ( ( 1187 1188 t t NN 1189 1190 = = JJ 1191 1194 2.1 2.1 CD 1194 1195 , , , 1196 1198 df df NN 1199 1200 = = JJ 1201 1203 10 10 CD 1203 1204 ; ; : 1205 1206 p p NN 1207 1208 < < JJR 1209 1212 .05 .05 CD 1212 1213 ) ) ) 1213 1214 . . .