0 12 Oncogenicity oncogenicity NN 13 15 of of IN 16 21 human human JJ 22 37 papillomavirus- papillomavirus- NN 38 40 or or CC 41 63 adenovirus-transformed adenovirus-transformed JJ 64 69 cells cell NNS 70 80 correlates correlate VBZ 81 85 with with IN 86 96 resistance resistance NN 97 99 to to TO 100 105 lysis lysis NN 106 108 by by IN 109 116 natural natural JJ 117 123 killer killer NN 124 129 cells cell NNS 129 130 . . . 132 135 The the DT 136 143 reasons reason NNS 144 147 for for IN 148 151 the the DT 152 162 dissimilar dissimilar JJ 163 177 oncogenicities oncogenicity NNS 178 180 of of IN 181 186 human human JJ 187 199 adenoviruses adenovirus NNS 200 203 and and CC 204 209 human human JJ 210 226 papillomaviruses papillomavirus NNS 227 228 ( ( ( 228 231 HPV HPV NNP 231 232 ) ) ) 233 235 in in IN 236 242 humans human NNS 243 246 are be VBP 247 254 unknown unknown JJ 255 258 but but CC 259 262 may may MD 263 269 relate relate VB 270 272 to to TO 273 284 differences difference NNS 285 287 in in IN 288 291 the the DT 292 302 capacities capacity NNS 303 305 of of IN 306 309 the the DT 310 313 E1A E1A NNP 314 317 and and CC 318 320 E7 E7 NNP 321 329 proteins protein NNS 330 332 to to TO 333 339 target target NN 340 345 cells cell NNS 346 349 for for IN 350 359 rejection rejection NN 360 362 by by IN 363 366 the the DT 367 371 host host NN 372 379 natural natural JJ 380 386 killer killer NN 387 388 ( ( ( 388 390 NK NK NNP 390 391 ) ) ) 392 396 cell cell NN 397 405 response response NN 405 406 . . . 407 409 As as IN 410 413 one one CD 414 418 test test NN 419 421 of of IN 422 426 this this DT 427 437 hypothesis hypothesis NN 437 438 , , , 439 441 we we PRP 442 450 compared compare VBD 451 454 the the DT 455 464 abilities ability NNS 465 467 of of IN 468 472 E1A- e1a- NN 473 476 and and CC 477 490 E7-expressing e7-expressing JJ 491 496 human human JJ 497 509 fibroblastic fibroblastic JJ 510 512 or or CC 513 533 keratinocyte-derived keratinocyte-derived JJ 534 539 human human JJ 540 545 cells cell NNS 546 548 to to TO 549 551 be be VB 552 563 selectively selectively RB 564 570 killed kill VBN 571 573 by by IN 574 580 either either CC 581 593 unstimulated unstimulated JJ 594 596 or or CC 597 607 interferon interferon NN 608 609 ( ( ( 609 623 IFN)-activated ifn)-activated JJ 624 626 NK NK NNP 627 632 cells cell NNS 632 633 . . . 634 639 Cells cell NNS 640 650 expressing express VBG 651 654 the the DT 655 658 E1A E1A NNP 659 670 oncoprotein oncoprotein NN 671 675 were be VBD 676 687 selectively selectively RB 688 694 killed kill VBN 695 697 by by IN 698 710 unstimulated unstimulated JJ 711 713 NK nk NN 714 719 cells cell NNS 719 720 , , , 721 726 while while IN 727 730 the the DT 731 735 same same JJ 736 744 parental parental JJ 745 750 cells cell NNS 751 754 but but CC 755 765 expressing express VBG 766 769 the the DT 770 773 HPV HPV NNP 774 778 type type NN 779 781 16 16 CD 782 783 ( ( ( 783 789 HPV-16 hpv-16 NN 789 790 ) ) ) 791 793 or or CC 794 800 HPV-18 hpv-18 NN 801 803 E7 e7 NN 804 815 oncoprotein oncoprotein NN 816 820 were be VBD 821 830 resistant resistant JJ 831 833 to to TO 834 836 NK NK NNP 837 841 cell cell NN 842 847 lysis lysis NN 847 848 . . . 849 852 The the DT 853 860 ability ability NN 861 863 of of IN 864 877 IFN-activated ifn-activated JJ 878 880 NK NK NNP 881 886 cells cell NNS 887 889 to to TO 890 901 selectively selectively RB 902 906 kill kill VB 907 914 virally virally RB 915 926 transformed transform VBN 927 932 cells cell NNS 933 940 depends depend VBZ 941 943 on on IN 944 947 IFN ifn NN 947 949 ’s 's POS 950 957 ability ability NN 958 960 to to TO 961 967 induce induce VB 968 978 resistance resistance NN 979 981 to to TO 982 984 NK NK NNP 985 989 cell cell NN 990 995 lysis lysis NN 996 998 in in IN 999 1005 normal normal JJ 1006 1007 ( ( ( 1007 1011 i.e. i.e. FW 1011 1012 , , , 1013 1022 non-viral non-viral JJ 1023 1042 oncogene-expressing oncogene-expressing JJ 1042 1043 ) ) ) 1044 1047 but but CC 1048 1051 not not RB 1052 1059 virally virally RB 1060 1071 transformed transform VBN 1072 1077 cells cell NNS 1077 1078 . . . 1079 1082 E1A E1A NNP 1083 1090 blocked block VBD 1091 1094 IFN ifn NN 1094 1096 ’s 's POS 1097 1106 induction induction NN 1107 1109 of of IN 1110 1119 cytolytic cytolytic JJ 1120 1130 resistance resistance NN 1130 1131 , , , 1132 1141 resulting result VBG 1142 1144 in in IN 1145 1148 the the DT 1149 1158 selective selective JJ 1159 1164 lysis lysis NN 1165 1167 of of IN 1168 1190 adenovirus-transformed adenovirus-transformed JJ 1191 1196 cells cell NNS 1197 1199 by by IN 1200 1213 IFN-activated ifn-activated JJ 1214 1216 NK NK NNP 1217 1222 cells cell NNS 1222 1223 . . . 1224 1227 The the DT 1228 1234 extent extent NN 1235 1237 of of IN 1238 1249 IFN-induced ifn-induced JJ 1250 1252 NK NK NNP 1253 1257 cell cell NN 1258 1265 killing killing NN 1266 1268 of of IN 1269 1283 E1A-expressing e1a-expressing JJ 1284 1289 cells cell NNS 1290 1293 was be VBD 1294 1306 proportional proportional JJ 1307 1309 to to TO 1310 1313 the the DT 1314 1319 level level NN 1320 1322 of of IN 1323 1326 E1A E1A NNP 1327 1337 expression expression NN 1338 1341 and and CC 1342 1352 correlated correlate VBD 1353 1357 with with IN 1358 1361 the the DT 1362 1369 ability ability NN 1370 1372 of of IN 1373 1376 E1A E1A NNP 1377 1379 to to TO 1380 1385 block block VB 1386 1400 IFN-stimulated ifn-stimulated JJ 1401 1405 gene gene NN 1406 1416 expression expression NN 1417 1419 in in IN 1420 1426 target target NN 1427 1432 cells cell NNS 1432 1433 . . . 1434 1436 In in IN 1437 1445 contrast contrast NN 1445 1446 , , , 1447 1449 E7 E7 NNP 1450 1457 blocked block VBD 1458 1465 neither neither CC 1466 1480 IFN-stimulated ifn-stimulated JJ 1481 1485 gene gene NN 1486 1496 expression expression NN 1497 1500 nor nor CC 1501 1504 IFN ifn NN 1504 1506 ’s 's POS 1507 1516 induction induction NN 1517 1519 of of IN 1520 1529 cytolytic cytolytic JJ 1530 1540 resistance resistance NN 1540 1541 , , , 1542 1549 thereby thereby RB 1550 1560 precluding preclude VBG 1561 1564 the the DT 1565 1574 selective selective JJ 1575 1580 lysis lysis NN 1581 1583 of of IN 1584 1599 HPV-transformed hpv-transformed JJ 1600 1605 cells cell NNS 1606 1608 by by IN 1609 1622 IFN-activated ifn-activated JJ 1623 1625 NK NK NNP 1626 1631 cells cell NNS 1631 1632 . . . 1633 1635 In in IN 1636 1646 conclusion conclusion NN 1646 1647 , , , 1648 1651 E1A E1A NNP 1652 1662 expression expression NN 1663 1668 marks mark VBZ 1669 1674 cells cell NNS 1675 1678 for for IN 1679 1690 destruction destruction NN 1691 1693 by by IN 1694 1697 the the DT 1698 1702 host host NN 1703 1705 NK nk NN 1706 1710 cell cell NN 1711 1719 response response NN 1719 1720 , , , 1721 1728 whereas whereas IN 1729 1732 the the DT 1733 1735 E7 e7 NN 1736 1747 oncoprotein oncoprotein NN 1748 1753 lacks lack VBZ 1754 1758 this this DT 1759 1767 activity activity NN 1767 1768 . . .