0 10 Regulation regulation NN 11 13 of of IN 14 17 the the DT 18 25 balance balance NN 26 28 of of IN 29 37 cytokine cytokine NN 38 48 production production NN 49 52 and and CC 53 56 the the DT 57 63 signal signal NN 64 74 transducer transducer NN 75 78 and and CC 79 88 activator activator NN 89 91 of of IN 92 105 transcription transcription NN 106 107 ( ( ( 107 111 STAT STAT NNP 111 112 ) ) ) 113 126 transcription transcription NN 127 133 factor factor NN 134 142 activity activity NN 143 145 by by IN 146 155 cytokines cytokine NNS 156 159 and and CC 160 172 inflammatory inflammatory JJ 173 181 synovial synovial JJ 182 188 fluids fluid NNS 188 189 . . . 191 194 The the DT 195 202 balance balance NN 203 210 between between IN 211 215 type type NN 216 217 1 1 CD 218 221 and and CC 222 223 2 2 CD 224 225 T t NN 226 232 helper helper NN 233 237 cell cell NN 238 246 cytokine cytokine NN 247 257 production production NN 258 263 plays play VBZ 264 266 an an DT 267 276 important important JJ 277 281 role role NN 282 284 in in IN 285 292 several several JJ 293 299 animal animal NN 300 306 models model NNS 307 309 of of IN 310 322 autoimmunity autoimmunity NN 322 323 , , , 324 327 and and CC 328 334 skewed skew VBD 335 343 patterns pattern NNS 344 346 of of IN 347 355 cytokine cytokine NN 356 366 expression expression NN 367 371 have have VBP 372 376 been be VBN 377 386 described describe VBN 387 389 in in IN 390 395 human human JJ 396 408 inflammatory inflammatory JJ 409 417 diseases disease NNS 417 418 . . . 419 423 Many many JJ 424 433 cytokines cytokine NNS 434 442 activate activate VBP 443 449 signal signal NN 450 460 transducer transducer NN 461 464 and and CC 465 475 activation activation NN 476 478 of of IN 479 492 transcription transcription NN 493 494 ( ( ( 494 498 STAT STAT NNP 498 499 ) ) ) 500 513 transcription transcription NN 514 521 factors factor NNS 521 522 , , , 523 528 which which WDT 528 529 , , , 530 532 in in IN 533 537 turn turn NN 537 538 , , , 539 547 activate activate VBP 548 561 transcription transcription NN 562 564 of of IN 565 577 inflammatory inflammatory JJ 578 586 effector effector NN 587 592 genes gene NNS 592 593 . . . 594 596 We we PRP 597 601 used use VBD 602 613 mononuclear mononuclear JJ 614 618 cell cell NN 619 626 priming priming NN 627 635 cultures culture NNS 636 639 and and CC 640 652 inflammatory inflammatory JJ 653 661 synovial synovial JJ 662 668 fluids fluid NNS 669 670 ( ( ( 670 673 SFs SF NNP 673 674 ) ) ) 675 682 derived derive VBN 683 687 from from IN 688 697 arthritis arthritis NN 698 706 patients patient NNS 707 709 to to TO 710 717 examine examine VB 718 721 the the DT 722 732 regulation regulation NN 733 735 of of IN 736 744 cytokine cytokine NN 745 755 production production NN 756 759 and and CC 760 764 STAT stat NN 765 773 activity activity NN 774 776 by by IN 777 779 an an DT 780 792 inflammatory inflammatory JJ 793 801 synovial synovial JJ 802 818 microenvironment microenvironment NN 818 819 . . . 820 828 Exposure exposure NN 829 831 to to TO 832 835 SFs sf NNS 836 842 during during IN 843 850 priming priming NN 851 859 resulted result VBD 860 862 in in IN 863 865 an an DT 866 868 81 81 CD 868 869 % % NN 870 880 inhibition inhibition NN 881 883 of of IN 884 894 interferon interferon NN 895 896 ( ( ( 896 906 IFN)-gamma IFN)-gamma NNP 906 907 , , , 908 911 but but CC 912 915 not not RB 916 927 interleukin interleukin NN 928 929 ( ( ( 929 931 IL IL NNP 931 932 ) ) ) 933 934 4 4 CD 934 935 , , , 936 946 production production NN 947 949 by by IN 950 958 effector effector NN 959 964 cells cell NNS 965 974 generated generate VBN 975 977 in in IN 978 985 priming priming NN 986 994 cultures culture NNS 994 995 . . . 996 998 SF SF NNP 999 1010 suppression suppression NN 1011 1014 was be VBD 1015 1023 mediated mediate VBN 1024 1026 by by IN 1027 1031 IL-4 il-4 NN 1032 1035 and and CC 1036 1041 IL-10 il-10 NN 1042 1045 and and CC 1046 1056 inhibition inhibition NN 1057 1059 of of IN 1060 1065 IL-12 il-12 NN 1066 1076 expression expression NN 1076 1077 , , , 1078 1081 and and CC 1082 1084 it it PRP 1085 1088 was be VBD 1089 1097 reversed reverse VBN 1098 1100 in in IN 1101 1102 a a DT 1103 1111 dominant dominant JJ 1112 1119 fashion fashion NN 1120 1122 by by IN 1123 1132 exogenous exogenous JJ 1133 1138 IL-12 il-12 NN 1138 1139 . . . 1140 1143 SFs SF NNP 1144 1151 blocked block VBD 1152 1155 the the DT 1156 1165 sustained sustained JJ 1166 1174 activity activity NN 1175 1177 of of IN 1178 1191 transcription transcription NN 1192 1198 factor factor NN 1199 1204 Stat1 stat1 NN 1204 1205 , , , 1206 1209 but but CC 1210 1213 not not RB 1214 1219 Stat3 stat3 NN 1219 1220 , , , 1221 1227 during during IN 1228 1231 the the DT 1232 1239 priming priming NN 1240 1246 period period NN 1246 1247 , , , 1248 1251 and and CC 1252 1257 Stat1 stat1 NN 1258 1266 activity activity NN 1267 1270 was be VBD 1271 1285 differentially differentially RB 1286 1295 regulated regulate VBN 1296 1298 by by IN 1299 1308 cytokines cytokine NNS 1309 1311 in in IN 1312 1320 parallel parallel NN 1321 1325 with with IN 1326 1331 their their PRP$ 1332 1340 positive positive JJ 1341 1343 or or CC 1344 1352 negative negative JJ 1353 1363 regulation regulation NN 1364 1366 of of IN 1367 1376 IFN-gamma IFN-gamma NNP 1377 1387 production production NN 1387 1388 . . . 1389 1395 Active active JJ 1396 1401 Stat3 stat3 NN 1401 1402 , , , 1403 1406 but but CC 1407 1410 not not RB 1411 1416 Stat1 stat1 NN 1416 1417 , , , 1418 1421 was be VBD 1422 1430 detected detect VBN 1431 1433 in in IN 1434 1439 cells cell NNS 1440 1444 from from IN 1445 1453 inflamed inflamed JJ 1454 1460 joints joint NNS 1460 1461 . . . 1462 1467 These these DT 1468 1475 results result NNS 1476 1483 suggest suggest VBP 1484 1485 a a DT 1486 1490 role role NN 1491 1494 for for IN 1495 1502 altered altered JJ 1503 1510 balance balance NN 1511 1513 of of IN 1514 1519 Stat1 stat1 NN 1520 1523 and and CC 1524 1529 Stat3 stat3 NN 1530 1545 transcriptional transcriptional JJ 1546 1554 activity activity NN 1555 1557 in in IN 1558 1561 the the DT 1562 1572 regulation regulation NN 1573 1575 of of IN 1576 1577 T t NN 1578 1582 cell cell NN 1583 1598 differentiation differentiation NN 1599 1602 and and CC 1603 1605 in in IN 1606 1609 the the DT 1610 1622 pathogenesis pathogenesis NN 1623 1625 of of IN 1626 1638 inflammatory inflammatory JJ 1639 1648 synovitis synovitis NN 1648 1649 . . .